JP2021528057A5 - - Google Patents
Info
- Publication number
- JP2021528057A5 JP2021528057A5 JP2020569099A JP2020569099A JP2021528057A5 JP 2021528057 A5 JP2021528057 A5 JP 2021528057A5 JP 2020569099 A JP2020569099 A JP 2020569099A JP 2020569099 A JP2020569099 A JP 2020569099A JP 2021528057 A5 JP2021528057 A5 JP 2021528057A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segment
- human
- unreconstructed
- rodent
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022056227A JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2026028161A JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862685203P | 2018-06-14 | 2018-06-14 | |
| US62/685,203 | 2018-06-14 | ||
| US201862702206P | 2018-07-23 | 2018-07-23 | |
| US62/702,206 | 2018-07-23 | ||
| US201962812580P | 2019-03-01 | 2019-03-01 | |
| US62/812,580 | 2019-03-01 | ||
| PCT/US2019/037285 WO2019241692A1 (en) | 2018-06-14 | 2019-06-14 | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022056227A Division JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021528057A JP2021528057A (ja) | 2021-10-21 |
| JP2021528057A5 true JP2021528057A5 (enExample) | 2022-04-08 |
| JP7182647B2 JP7182647B2 (ja) | 2022-12-02 |
Family
ID=67220854
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020569099A Active JP7182647B2 (ja) | 2018-06-14 | 2019-06-14 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2022056227A Withdrawn JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A Withdrawn JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A Active JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A Pending JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2026028161A Pending JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022056227A Withdrawn JP2022079617A (ja) | 2018-06-14 | 2022-03-30 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2023215643A Withdrawn JP2024019660A (ja) | 2018-06-14 | 2023-12-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2024100324A Active JP7815335B2 (ja) | 2018-06-14 | 2024-06-21 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2025188198A Pending JP2026016787A (ja) | 2018-06-14 | 2025-11-07 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
| JP2026028161A Pending JP2026069737A (ja) | 2018-06-14 | 2026-02-25 | 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20190380316A1 (enExample) |
| EP (3) | EP3629720B1 (enExample) |
| JP (6) | JP7182647B2 (enExample) |
| KR (4) | KR102933824B1 (enExample) |
| CN (2) | CN112312766A (enExample) |
| AU (3) | AU2019287727B2 (enExample) |
| CA (1) | CA3103646C (enExample) |
| CY (1) | CY1125121T1 (enExample) |
| DK (2) | DK3629720T3 (enExample) |
| ES (2) | ES2994581T3 (enExample) |
| FI (1) | FI4023059T3 (enExample) |
| HR (2) | HRP20220509T8 (enExample) |
| HU (1) | HUE069544T2 (enExample) |
| IL (3) | IL318469A (enExample) |
| LT (2) | LT4023059T (enExample) |
| MX (2) | MX391767B (enExample) |
| PL (2) | PL3629720T3 (enExample) |
| PT (2) | PT4023059T (enExample) |
| RS (2) | RS63117B1 (enExample) |
| SG (1) | SG11202012084WA (enExample) |
| SI (2) | SI3629720T1 (enExample) |
| SM (2) | SMT202400501T1 (enExample) |
| TW (2) | TW202500752A (enExample) |
| WO (1) | WO2019241692A1 (enExample) |
| ZA (1) | ZA202007560B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107858333B (zh) | 2011-10-28 | 2022-05-27 | 瑞泽恩制药公司 | T细胞受体基因修饰小鼠 |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CN116848254B (zh) | 2020-12-16 | 2026-03-17 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
| TW202430558A (zh) * | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白重鏈長cdr3轉殖基因構築體及其用途 |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ATE192275T1 (de) | 1993-12-03 | 2000-05-15 | Terumo Corp | Stereoskopisches bildanzeigesystem |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2002076196A1 (en) | 2001-03-22 | 2002-10-03 | Abbott Gmbh & Co. Kg | Transgenic animals expressing antibodies specific for genes of interest and uses thereof |
| US7744893B2 (en) * | 2002-06-05 | 2010-06-29 | Baylor College Of Medicine | T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| AU2007235496B2 (en) | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| PL2602323T3 (pl) | 2007-06-01 | 2018-06-29 | Open Monoclonal Technology, Inc. | Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego |
| TWI476280B (zh) | 2008-03-07 | 2015-03-11 | Regeneron Pharma | 來自二倍體宿主胚胎注射之ｅｓ－細胞衍生的老鼠 |
| EP2147594B1 (en) | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| AU2009298458B2 (en) | 2008-09-30 | 2015-10-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| ES2724975T3 (es) | 2009-12-10 | 2019-09-18 | Regeneron Pharma | Ratones que producen anticuerpos de cadena pesada |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| ES2984483T3 (es) | 2010-03-31 | 2024-10-29 | Ablexis Llc | Ingeniería genética de ratones para la producción de anticuerpos quiméricos |
| PT3034608T (pt) | 2010-06-22 | 2019-05-28 | Regeneron Pharma | Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana |
| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| SMT201700023T1 (it) | 2010-08-02 | 2017-03-08 | Regeneron Pharma | Topi che producono proteine leganti vl |
| ME02106B (me) | 2011-02-25 | 2015-10-20 | Regeneron Pharma | Miševi sa adam6 |
| BR112014006394A2 (pt) * | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| SG11201401181YA (en) | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| BR112014010580B1 (pt) | 2011-11-04 | 2021-01-12 | Zymeworks, Inc. | constructo de fc heteromultimérico isolado, composição, uso de um constructo de fc heteromultimérico isolado, composição de ácido nucléico e método para expressar o constructo de fc heteromultimérico isolado |
| EP3597038B1 (en) * | 2012-02-01 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Humanized rodents that express heavy chains containing vl domains |
| MX353278B (es) | 2012-03-06 | 2018-01-05 | Regeneron Pharma | Raton con cadena ligera comun. |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| WO2013138681A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| EP3539374A1 (en) | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| MX2014014891A (es) | 2012-06-05 | 2015-06-17 | Regeneron Pharma | Metodos para hacer anticuerpos biespecificos completamente humanos usando una cadena ligera comun. |
| ME03551B (me) * | 2012-06-12 | 2020-07-20 | Regeneron Pharma | Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca |
| PT2931030T (pt) | 2012-12-14 | 2020-08-03 | Open Monoclonal Tech Inc | Polinucleótidos que codificam anticorpos de roedores com idiótipos humanos e animais que os compreendem |
| MY178882A (en) * | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| HK1218550A1 (zh) | 2013-03-13 | 2017-02-24 | Regeneron Pharmaceuticals, Inc. | 常見輕鏈小鼠 |
| EP4545567A3 (en) | 2013-03-13 | 2025-08-13 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| US9475559B2 (en) | 2013-07-03 | 2016-10-25 | Hobie Cat Company | Foot operated propulsion system for watercraft |
| AU2015231025A1 (en) * | 2014-03-21 | 2016-09-15 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
| CA3124228C (en) | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| ES2781323T3 (es) | 2014-06-23 | 2020-09-01 | Regeneron Pharma | Montaje de ADN mediado por nucleasas |
| KR102531016B1 (ko) | 2014-11-21 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
| US9410301B2 (en) | 2014-12-09 | 2016-08-09 | Theophile Bourgeois | Patch system and method for oil boom |
| ES2947714T3 (es) | 2014-12-19 | 2023-08-17 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida a través de múltiples direccionamientos en un solo paso |
| CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| SG10201913483XA (en) | 2016-11-04 | 2020-03-30 | Regeneron Pharma | Non-human animals having an engineered immunoglobulin lambda light chain locus |
| CN207626880U (zh) | 2017-05-19 | 2018-07-20 | 厦门汇成峰户外用品有限公司 | 一种导演椅 |
| DK3476942T3 (da) * | 2017-10-27 | 2022-04-19 | Trianni Inc | Lange kimlinje-dh-gener og antistoffer med lang hcdr3 |
| HUE060608T2 (hu) | 2017-12-05 | 2023-03-28 | Regeneron Pharma | Genetikailag módosított immunglobulin lambda könnyûlánccal rendelkezõ egerek és azok alkalmazása |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
-
2019
- 2019-06-13 IL IL318469A patent/IL318469A/en unknown
- 2019-06-14 RS RS20220366A patent/RS63117B1/sr unknown
- 2019-06-14 HR HRP20220509TT patent/HRP20220509T8/hr unknown
- 2019-06-14 ES ES21213824T patent/ES2994581T3/es active Active
- 2019-06-14 PL PL19737613T patent/PL3629720T3/pl unknown
- 2019-06-14 KR KR1020237034902A patent/KR102933824B1/ko active Active
- 2019-06-14 CA CA3103646A patent/CA3103646C/en active Active
- 2019-06-14 HU HUE21213824A patent/HUE069544T2/hu unknown
- 2019-06-14 SM SM20240501T patent/SMT202400501T1/it unknown
- 2019-06-14 IL IL279311A patent/IL279311B2/en unknown
- 2019-06-14 US US16/442,063 patent/US20190380316A1/en active Pending
- 2019-06-14 AU AU2019287727A patent/AU2019287727B2/en active Active
- 2019-06-14 EP EP19737613.0A patent/EP3629720B1/en active Active
- 2019-06-14 CN CN201980039940.2A patent/CN112312766A/zh active Pending
- 2019-06-14 KR KR1020227031578A patent/KR102617284B1/ko active Active
- 2019-06-14 SM SM20220126T patent/SMT202200126T1/it unknown
- 2019-06-14 IL IL305557A patent/IL305557B2/en unknown
- 2019-06-14 KR KR1020207036226A patent/KR102444180B1/ko active Active
- 2019-06-14 EP EP21213824.2A patent/EP4023059B1/en active Active
- 2019-06-14 ES ES19737613T patent/ES2907067T3/es active Active
- 2019-06-14 HR HRP20241705TT patent/HRP20241705T1/hr unknown
- 2019-06-14 RS RS20241384A patent/RS66298B1/sr unknown
- 2019-06-14 US US17/252,014 patent/US20210251202A1/en active Pending
- 2019-06-14 MX MX2020013652A patent/MX391767B/es unknown
- 2019-06-14 CN CN202110654221.0A patent/CN113430207A/zh active Pending
- 2019-06-14 SI SI201930180T patent/SI3629720T1/sl unknown
- 2019-06-14 FI FIEP21213824.2T patent/FI4023059T3/fi active
- 2019-06-14 DK DK19737613.0T patent/DK3629720T3/da active
- 2019-06-14 LT LTEP21213824.2T patent/LT4023059T/lt unknown
- 2019-06-14 TW TW113118339A patent/TW202500752A/zh unknown
- 2019-06-14 PL PL21213824.2T patent/PL4023059T3/pl unknown
- 2019-06-14 TW TW108120728A patent/TWI840372B/zh active
- 2019-06-14 LT LTEPPCT/US2019/037285T patent/LT3629720T/lt unknown
- 2019-06-14 PT PT212138242T patent/PT4023059T/pt unknown
- 2019-06-14 SI SI201930863T patent/SI4023059T1/sl unknown
- 2019-06-14 EP EP24203669.7A patent/EP4464720A3/en active Pending
- 2019-06-14 DK DK21213824.2T patent/DK4023059T3/da active
- 2019-06-14 PT PT197376130T patent/PT3629720T/pt unknown
- 2019-06-14 SG SG11202012084WA patent/SG11202012084WA/en unknown
- 2019-06-14 JP JP2020569099A patent/JP7182647B2/ja active Active
- 2019-06-14 WO PCT/US2019/037285 patent/WO2019241692A1/en not_active Ceased
- 2019-06-14 KR KR1020267006032A patent/KR20260046460A/ko active Pending
-
2020
- 2020-12-04 ZA ZA2020/07560A patent/ZA202007560B/en unknown
- 2020-12-14 MX MX2022004537A patent/MX2022004537A/es unknown
-
2022
- 2022-03-30 JP JP2022056227A patent/JP2022079617A/ja not_active Withdrawn
- 2022-04-18 CY CY20221100288T patent/CY1125121T1/el unknown
- 2022-11-10 AU AU2022268350A patent/AU2022268350B2/en active Active
-
2023
- 2023-12-21 JP JP2023215643A patent/JP2024019660A/ja not_active Withdrawn
-
2024
- 2024-06-21 JP JP2024100324A patent/JP7815335B2/ja active Active
-
2025
- 2025-01-07 AU AU2025200075A patent/AU2025200075A1/en active Pending
- 2025-11-07 JP JP2025188198A patent/JP2026016787A/ja active Pending
-
2026
- 2026-02-25 JP JP2026028161A patent/JP2026069737A/ja active Pending
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