JP7182647B2 - 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 - Google Patents

免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 Download PDF

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JP7182647B2
JP7182647B2 JP2020569099A JP2020569099A JP7182647B2 JP 7182647 B2 JP7182647 B2 JP 7182647B2 JP 2020569099 A JP2020569099 A JP 2020569099A JP 2020569099 A JP2020569099 A JP 2020569099A JP 7182647 B2 JP7182647 B2 JP 7182647B2
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JP2021528057A (ja
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アンドリュー ジェイ． マーフィー，
リン マクドナルド，
チュングァン グオ，
ジョン マクウィルター，
ベラ ボロニナ，
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Regeneron Pharmaceuticals Inc
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Priority to JP2024100324A priority patent/JP7815335B2/ja
Priority to JP2025188198A priority patent/JP2026016787A/ja
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • C12N2517/00—Cells related to new breeds of animals
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2020569099A 2018-06-14 2019-06-14 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物 Active JP7182647B2 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2022056227A JP2022079617A (ja) 2018-06-14 2022-03-30 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2023215643A JP2024019660A (ja) 2018-06-14 2023-12-21 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2024100324A JP7815335B2 (ja) 2018-06-14 2024-06-21 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2025188198A JP2026016787A (ja) 2018-06-14 2025-11-07 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2026028161A JP2026069737A (ja) 2018-06-14 2026-02-25 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物

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US201862685203P 2018-06-14 2018-06-14
US62/685,203 2018-06-14
US201862702206P 2018-07-23 2018-07-23
US62/702,206 2018-07-23
US201962812580P 2019-03-01 2019-03-01
US62/812,580 2019-03-01
PCT/US2019/037285 WO2019241692A1 (en) 2018-06-14 2019-06-14 Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences

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JP2021528057A JP2021528057A (ja) 2021-10-21
JP2021528057A5 JP2021528057A5 (enExample) 2022-04-08
JP7182647B2 true JP7182647B2 (ja) 2022-12-02

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JP2020569099A Active JP7182647B2 (ja) 2018-06-14 2019-06-14 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2022056227A Withdrawn JP2022079617A (ja) 2018-06-14 2022-03-30 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2023215643A Withdrawn JP2024019660A (ja) 2018-06-14 2023-12-21 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2024100324A Active JP7815335B2 (ja) 2018-06-14 2024-06-21 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2025188198A Pending JP2026016787A (ja) 2018-06-14 2025-11-07 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2026028161A Pending JP2026069737A (ja) 2018-06-14 2026-02-25 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物

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JP2022056227A Withdrawn JP2022079617A (ja) 2018-06-14 2022-03-30 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2023215643A Withdrawn JP2024019660A (ja) 2018-06-14 2023-12-21 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2024100324A Active JP7815335B2 (ja) 2018-06-14 2024-06-21 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2025188198A Pending JP2026016787A (ja) 2018-06-14 2025-11-07 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物
JP2026028161A Pending JP2026069737A (ja) 2018-06-14 2026-02-25 免疫グロブリン重鎖コーディング配列におけるｄｈ－ｄｈ再構成が可能な非ヒト動物

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US (2) US20190380316A1 (enExample)
EP (3) EP3629720B1 (enExample)
JP (6) JP7182647B2 (enExample)
KR (4) KR102933824B1 (enExample)
CN (2) CN112312766A (enExample)
AU (3) AU2019287727B2 (enExample)
CA (1) CA3103646C (enExample)
CY (1) CY1125121T1 (enExample)
DK (2) DK3629720T3 (enExample)
ES (2) ES2994581T3 (enExample)
FI (1) FI4023059T3 (enExample)
HR (2) HRP20220509T8 (enExample)
HU (1) HUE069544T2 (enExample)
IL (3) IL318469A (enExample)
LT (2) LT4023059T (enExample)
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PL (2) PL3629720T3 (enExample)
PT (2) PT4023059T (enExample)
RS (2) RS63117B1 (enExample)
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SI (2) SI3629720T1 (enExample)
SM (2) SMT202400501T1 (enExample)
TW (2) TW202500752A (enExample)
WO (1) WO2019241692A1 (enExample)
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CN107858333B (zh) 2011-10-28 2022-05-27 瑞泽恩制药公司 T细胞受体基因修饰小鼠
IL318469A (en) * 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
US20220090060A1 (en) 2020-09-11 2022-03-24 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
CN116848254B (zh) 2020-12-16 2026-03-17 瑞泽恩制药公司 表达人源化Fcα受体的小鼠
TW202430558A (zh) * 2023-01-18 2024-08-01 美商基利科學股份有限公司 人類免疫球蛋白重鏈長cdr3轉殖基因構築體及其用途
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof
WO2026035843A2 (en) 2024-08-06 2026-02-12 Regeneron Pharmaceuticals, Inc. Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof

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