JP2022535418A5 - - Google Patents
Info
- Publication number
- JP2022535418A5 JP2022535418A5 JP2021571945A JP2021571945A JP2022535418A5 JP 2022535418 A5 JP2022535418 A5 JP 2022535418A5 JP 2021571945 A JP2021571945 A JP 2021571945A JP 2021571945 A JP2021571945 A JP 2021571945A JP 2022535418 A5 JP2022535418 A5 JP 2022535418A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- rodent
- human
- light chain
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025108133A JP2025138773A (ja) | 2019-06-05 | 2025-06-26 | カッパ遺伝子座から発現される限られたラムダ軽鎖レパートリーを有する非ヒト動物及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962857712P | 2019-06-05 | 2019-06-05 | |
| US62/857,712 | 2019-06-05 | ||
| PCT/US2020/036114 WO2020247623A1 (en) | 2019-06-05 | 2020-06-04 | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025108133A Division JP2025138773A (ja) | 2019-06-05 | 2025-06-26 | カッパ遺伝子座から発現される限られたラムダ軽鎖レパートリーを有する非ヒト動物及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022535418A JP2022535418A (ja) | 2022-08-08 |
| JP2022535418A5 true JP2022535418A5 (enExample) | 2023-06-12 |
Family
ID=71895172
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021571945A Pending JP2022535418A (ja) | 2019-06-05 | 2020-06-04 | カッパ遺伝子座から発現される限られたラムダ軽鎖レパートリーを有する非ヒト動物及びその使用 |
| JP2025108133A Pending JP2025138773A (ja) | 2019-06-05 | 2025-06-26 | カッパ遺伝子座から発現される限られたラムダ軽鎖レパートリーを有する非ヒト動物及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025108133A Pending JP2025138773A (ja) | 2019-06-05 | 2025-06-26 | カッパ遺伝子座から発現される限られたラムダ軽鎖レパートリーを有する非ヒト動物及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20220330532A1 (enExample) |
| EP (1) | EP3979790B1 (enExample) |
| JP (2) | JP2022535418A (enExample) |
| KR (1) | KR20220016880A (enExample) |
| CN (1) | CN113874511A (enExample) |
| AU (1) | AU2020289554A1 (enExample) |
| BR (1) | BR112021023683A2 (enExample) |
| CA (1) | CA3136478A1 (enExample) |
| IL (2) | IL324580A (enExample) |
| MA (1) | MA56117A (enExample) |
| MX (1) | MX2021014893A (enExample) |
| SG (1) | SG11202111258TA (enExample) |
| TW (1) | TW202110323A (enExample) |
| WO (1) | WO2020247623A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CN116848254B (zh) | 2020-12-16 | 2026-03-17 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
| US20250185635A1 (en) * | 2022-03-21 | 2025-06-12 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin and mhc loci |
| CN117986356B (zh) * | 2022-10-27 | 2025-07-22 | 纽迈生物科技(苏州)有限公司 | 一种制备抗体的方法 |
| TW202430641A (zh) * | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途 |
| AU2024354039A1 (en) * | 2023-09-26 | 2026-02-19 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| CN121065267A (zh) * | 2024-06-04 | 2025-12-05 | 赛业（苏州）生物科技有限公司 | 用于制备四元固定轻链的基因修饰的啮齿动物及其制备方法 |
| WO2026002184A1 (en) * | 2024-06-28 | 2026-01-02 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal and uses thereof |
| WO2026019824A1 (en) * | 2024-07-16 | 2026-01-22 | Gilead Sciences, Inc. | Human immunoglobulin common light chain transgene constructs and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP2319301B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| AU2009298458B2 (en) | 2008-09-30 | 2015-10-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| DK3622815T3 (da) * | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| US9445581B2 (en) * | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| PT3034608T (pt) | 2010-06-22 | 2019-05-28 | Regeneron Pharma | Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana |
| ME02106B (me) | 2011-02-25 | 2015-10-20 | Regeneron Pharma | Miševi sa adam6 |
| HUE047278T2 (hu) | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| SG11201401181YA (en) | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| SG10201605675WA (en) * | 2011-12-20 | 2016-09-29 | Regeneron Pharma | Humanized light chain mice |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| MX384291B (es) | 2013-02-20 | 2025-03-14 | Regeneron Pharma | Modificación genética de ratas. |
| MY178882A (en) * | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| HK1218550A1 (zh) * | 2013-03-13 | 2017-02-24 | Regeneron Pharmaceuticals, Inc. | 常見輕鏈小鼠 |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| AU2014330922A1 (en) * | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| ES2781323T3 (es) | 2014-06-23 | 2020-09-01 | Regeneron Pharma | Montaje de ADN mediado por nucleasas |
| KR102531016B1 (ko) | 2014-11-21 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
| ES2947714T3 (es) | 2014-12-19 | 2023-08-17 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida a través de múltiples direccionamientos en un solo paso |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| GB201710984D0 (en) * | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
-
2020
- 2020-06-04 MX MX2021014893A patent/MX2021014893A/es unknown
- 2020-06-04 CA CA3136478A patent/CA3136478A1/en active Pending
- 2020-06-04 EP EP20750000.0A patent/EP3979790B1/en active Active
- 2020-06-04 IL IL324580A patent/IL324580A/en unknown
- 2020-06-04 KR KR1020217041822A patent/KR20220016880A/ko not_active Ceased
- 2020-06-04 MA MA056117A patent/MA56117A/fr unknown
- 2020-06-04 WO PCT/US2020/036114 patent/WO2020247623A1/en not_active Ceased
- 2020-06-04 TW TW109118837A patent/TW202110323A/zh unknown
- 2020-06-04 SG SG11202111258TA patent/SG11202111258TA/en unknown
- 2020-06-04 JP JP2021571945A patent/JP2022535418A/ja active Pending
- 2020-06-04 US US17/616,295 patent/US20220330532A1/en active Pending
- 2020-06-04 CN CN202080040135.4A patent/CN113874511A/zh active Pending
- 2020-06-04 IL IL288516A patent/IL288516B2/en unknown
- 2020-06-04 AU AU2020289554A patent/AU2020289554A1/en active Pending
- 2020-06-04 BR BR112021023683A patent/BR112021023683A2/pt unknown
-
2025
- 2025-06-26 JP JP2025108133A patent/JP2025138773A/ja active Pending
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