JP2021526828A5 - - Google Patents

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Publication number
JP2021526828A5
JP2021526828A5 JP2020568981A JP2020568981A JP2021526828A5 JP 2021526828 A5 JP2021526828 A5 JP 2021526828A5 JP 2020568981 A JP2020568981 A JP 2020568981A JP 2020568981 A JP2020568981 A JP 2020568981A JP 2021526828 A5 JP2021526828 A5 JP 2021526828A5
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JP
Japan
Prior art keywords
transgenic animal
heavy chain
variable domain
animal according
pseudogene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020568981A
Other languages
English (en)
Japanese (ja)
Other versions
JP7572861B2 (ja
JP2021526828A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/035521 external-priority patent/WO2019240998A1/en
Publication of JP2021526828A publication Critical patent/JP2021526828A/ja
Publication of JP2021526828A5 publication Critical patent/JP2021526828A5/ja
Priority to JP2024036618A priority Critical patent/JP2024081672A/ja
Application granted granted Critical
Publication of JP7572861B2 publication Critical patent/JP7572861B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2020568981A 2018-06-13 2019-06-05 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生 Active JP7572861B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024036618A JP2024081672A (ja) 2018-06-13 2024-03-11 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862684607P 2018-06-13 2018-06-13
US62/684,607 2018-06-13
PCT/US2019/035521 WO2019240998A1 (en) 2018-06-13 2019-06-05 Production of antibodies by modification of an autonomous heavy chain variable domain by gene conversion

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024036618A Division JP2024081672A (ja) 2018-06-13 2024-03-11 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生

Publications (3)

Publication Number Publication Date
JP2021526828A JP2021526828A (ja) 2021-10-11
JP2021526828A5 true JP2021526828A5 (enExample) 2022-06-09
JP7572861B2 JP7572861B2 (ja) 2024-10-24

Family

ID=68842067

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020568981A Active JP7572861B2 (ja) 2018-06-13 2019-06-05 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生
JP2024036618A Pending JP2024081672A (ja) 2018-06-13 2024-03-11 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024036618A Pending JP2024081672A (ja) 2018-06-13 2024-03-11 遺伝子変換による自律型重鎖可変ドメインの改変による抗体の産生

Country Status (7)

Country Link
US (1) US12588664B2 (enExample)
EP (1) EP3806630A4 (enExample)
JP (2) JP7572861B2 (enExample)
KR (1) KR20210021024A (enExample)
AU (2) AU2019284252B2 (enExample)
CA (1) CA3101859A1 (enExample)
WO (1) WO2019240998A1 (enExample)

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE229046T1 (de) 1985-03-30 1987-12-17 Marc Genf/Geneve Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3600905A1 (de) 1986-01-15 1987-07-16 Ant Nachrichtentech Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4977081A (en) 1987-05-04 1990-12-11 Adi Diagnostics, Inc. Stable rabbit-mouse hybridomas and secretion products thereof
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2016841C (en) 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
AU652539B2 (en) 1989-05-16 1994-09-01 Medical Research Council Co-expression of heteromeric receptors
AU8212291A (en) 1990-07-10 1992-02-04 Nkk Corporation Hybridoma which produces avian specific immunoglobulin g
EP0571613B1 (en) 1991-12-13 2003-09-17 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
EP0583980A1 (en) 1992-08-20 1994-02-23 Eli Lilly And Company Method for generating monoclonal antibodies from rabbits
AU7326796A (en) 1995-10-30 1997-05-22 Spectral Diagnostics Inc. Stable chicken b-cell line and method of use thereof
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
WO2005005604A2 (en) 2003-06-30 2005-01-20 Centocor, Inc. Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
KR101151957B1 (ko) * 2004-07-22 2012-06-01 로저 킹돈 크레이그 결합 분자
AU2007219159B8 (en) 2006-01-25 2012-06-28 Roger Kingdon Craig Generation of heavy-chain only antibodies in transgenic animals
EP2183381A1 (en) * 2007-06-01 2010-05-12 Buelow Research Enterprises Llc Compositions and methods for producing antibodies having human idiotypes in transgenic birds
JP5470817B2 (ja) 2008-03-10 2014-04-16 日産自動車株式会社 電池用電極およびこれを用いた電池、並びにその製造方法
WO2010101802A2 (en) 2009-03-02 2010-09-10 University Of Georgia Research Foundation, Inc. Method to alter sex ratios in avian offspring
GB0905023D0 (en) * 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
AU2010282508B2 (en) 2009-08-13 2015-05-28 Crystal Bioscience Inc. Transgenic animal for production of antibodies having minimal CDRs
ES2724975T3 (es) * 2009-12-10 2019-09-18 Regeneron Pharma Ratones que producen anticuerpos de cadena pesada
US9394372B2 (en) 2011-10-21 2016-07-19 Crystal Bioscience Inc. In vivo method for generating diversity in a protein scaffold
JP6136279B2 (ja) 2013-01-15 2017-05-31 株式会社ジェイテクト 転がり軸受装置
WO2014141192A1 (en) 2013-03-15 2014-09-18 Erasmus University Medical Center Generation of heavy chain-only antibodies
TWI503850B (zh) 2013-03-22 2015-10-11 Polytronics Technology Corp 過電流保護元件
TWI510996B (zh) 2013-10-03 2015-12-01 Acer Inc 控制觸控面板的方法以及使用該方法的可攜式電腦
EP3138903B1 (en) * 2014-05-02 2022-02-09 Chiome Bioscience Inc. Cells for producing human antibody
IL322083A (en) 2016-08-24 2025-09-01 Teneobio Inc Non-human transgenic animals that produce modified heavy chain antibodies only
US9816280B1 (en) 2016-11-02 2017-11-14 Matthew Reitnauer Portable floor

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