JP2010527622A5 - - Google Patents
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- Publication number
- JP2010527622A5 JP2010527622A5 JP2010509681A JP2010509681A JP2010527622A5 JP 2010527622 A5 JP2010527622 A5 JP 2010527622A5 JP 2010509681 A JP2010509681 A JP 2010509681A JP 2010509681 A JP2010509681 A JP 2010509681A JP 2010527622 A5 JP2010527622 A5 JP 2010527622A5
- Authority
- JP
- Japan
- Prior art keywords
- region
- human
- replaced
- ala
- monovalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241001465754 Metazoa Species 0.000 claims description 74
- 230000009261 transgenic effect Effects 0.000 claims description 65
- 239000000427 antigen Substances 0.000 claims description 35
- 108091007433 antigens Proteins 0.000 claims description 35
- 102000036639 antigens Human genes 0.000 claims description 35
- 125000000539 amino acid group Chemical group 0.000 claims description 33
- 238000006467 substitution reaction Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 230000000638 stimulation Effects 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 6
- 210000004408 hybridoma Anatomy 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000003053 immunization Effects 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 description 54
- 108700019146 Transgenes Proteins 0.000 description 51
- 235000001014 amino acid Nutrition 0.000 description 13
- 239000012634 fragment Substances 0.000 description 8
- 210000001671 embryonic stem cell Anatomy 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 210000002459 blastocyst Anatomy 0.000 description 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 210000003101 oviduct Anatomy 0.000 description 4
- 230000008707 rearrangement Effects 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
- 108700026220 vif Genes Proteins 0.000 description 3
- 241000711549 Hepacivirus C Species 0.000 description 2
- 101001055227 Homo sapiens Cytokine receptor common subunit gamma Proteins 0.000 description 2
- -1 c-Met Proteins 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- AETVBWZVKDOWHH-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(1-ethylazetidin-3-yl)oxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OC1CN(C1)CC AETVBWZVKDOWHH-UHFFFAOYSA-N 0.000 description 1
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 1
- 235000002198 Annona diversifolia Nutrition 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 108010009685 Cholinergic Receptors Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 101150064015 FAS gene Proteins 0.000 description 1
- 101150089023 FASLG gene Proteins 0.000 description 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 1
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 description 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 description 1
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 description 1
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 description 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 102000004890 Interleukin-8 Human genes 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000282842 Lama glama Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
- 108700012411 TNFSF10 Proteins 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000012452 Xenomouse strains Methods 0.000 description 1
- 102000034337 acetylcholine receptors Human genes 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940012413 factor vii Drugs 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700795 | 2007-05-31 | ||
| DKPA200700795 | 2007-05-31 | ||
| PCT/DK2008/050127 WO2008145140A2 (en) | 2007-05-31 | 2008-05-30 | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527622A JP2010527622A (ja) | 2010-08-19 |
| JP2010527622A5 true JP2010527622A5 (enExample) | 2011-07-14 |
| JP5570974B2 JP5570974B2 (ja) | 2014-08-13 |
Family
ID=39671787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509681A Active JP5570974B2 (ja) | 2007-05-31 | 2008-05-30 | 一価ヒト抗体を産生するトランスジェニック動物およびこれらの動物から得ることのできる抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9322035B2 (enExample) |
| EP (2) | EP2167669A2 (enExample) |
| JP (1) | JP5570974B2 (enExample) |
| AU (1) | AU2008255350B2 (enExample) |
| CA (1) | CA2689695A1 (enExample) |
| WO (1) | WO2008145140A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2593484T3 (es) | 2007-03-29 | 2016-12-09 | Genmab A/S | Anticuerpos biespecíficos y métodos de producción de los mismos |
| US9322035B2 (en) | 2007-05-31 | 2016-04-26 | Genmab A/S | Recombinant IgG4 monovalent antibodies |
| JP5746040B2 (ja) * | 2008-12-03 | 2015-07-08 | ゲンマブ エー／エス | 定常領域の中に改変を有する抗体変種 |
| EP4477668A3 (en) | 2010-04-20 | 2025-03-19 | Genmab A/S | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| EP2638066A4 (en) * | 2010-11-09 | 2015-06-03 | Medimmune Llc | ANTIBODY EQUIPMENT FOR HOMOGENEOUS CONJUGATION |
| WO2013060867A2 (en) | 2011-10-27 | 2013-05-02 | Genmab A/S | Production of heterodimeric proteins |
| GB2496375A (en) * | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| EP3233907B1 (en) | 2014-12-19 | 2021-03-03 | Genmab A/S | Rodent bispecific heterodimeric proteins |
| CN114478792A (zh) * | 2015-01-08 | 2022-05-13 | 根马布股份公司 | 针对cd3和cd20的双特异性抗体 |
| MA45919A (fr) | 2016-08-12 | 2019-06-19 | Janssen Biotech Inc | Conception d'anticorps modifiés et d'autres molécules contenant un domaine fc présentant des fonctions d'agonisme et d'effecteur améliorées |
| CN107581155A (zh) * | 2017-11-08 | 2018-01-16 | 成都新柯力化工科技有限公司 | 一种用于母猪繁殖的led灯及利用该led灯促进母猪繁殖的方法 |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| US20230148574A1 (en) * | 2020-04-01 | 2023-05-18 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd38 |
| CN115916166A (zh) | 2020-05-08 | 2023-04-04 | 健玛保 | 针对cd3和cd20的双特异性抗体 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DK0710719T3 (da) | 1990-01-12 | 2007-07-09 | Amgen Fremont Inc | Frembringelse af xenogene antistoffer |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69127627T2 (de) | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| AU2235992A (en) | 1991-06-14 | 1993-01-12 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
| CA2113113A1 (en) | 1991-07-08 | 1993-01-21 | Simon W. Kantor | Thermotropic liquid crystal segmented block copolymer |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DE69920897T2 (de) | 1998-04-28 | 2005-10-13 | Smithkline Beecham Corp. | Monoklonale antikörper mit verringerter immunisierungsfähigkeit |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| MXPA02000962A (es) | 1999-07-29 | 2002-07-02 | Medarex Inc | Anticuerpos monoclonales humanos para her2/neu. |
| WO2002012437A2 (en) * | 2000-08-03 | 2002-02-14 | Schooten Wim Van | Production of humanized antibodies in transgenic animals |
| DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| JP4298498B2 (ja) | 2001-06-13 | 2009-07-22 | ゲンマブ エー／エス | 上皮成長因子受容体（ｅｇｆｒ）に対するヒトモノクローナル抗体 |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| US20020197694A1 (en) | 2001-06-20 | 2002-12-26 | Weiping Shao | Conjugates of reduced antibodies and biomolecules |
| WO2003047336A2 (en) | 2001-11-30 | 2003-06-12 | Abgenix, Inc. | TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES |
| US20040092719A1 (en) * | 2002-09-17 | 2004-05-13 | Eszter Birck-Wilson | Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds |
| DE60334141D1 (de) * | 2002-10-15 | 2010-10-21 | Facet Biotech Corp | VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE |
| ATE540978T1 (de) | 2002-10-17 | 2012-01-15 | Genmab As | Humane monoklonale antikörper gegen cd20 |
| CA2499300A1 (en) * | 2002-10-31 | 2004-05-21 | Genentech, Inc. | Methods and compositions for increasing antibody production |
| US7438907B2 (en) * | 2002-11-15 | 2008-10-21 | Genmab A/S | Human monoclonal antibodies against CD25 |
| AU2004282984B2 (en) * | 2003-11-13 | 2011-07-14 | Hanmi Science Co., Ltd. | Protein complex using immunoglobulin fragment andmethod for the preparation thereof |
| ES2384569T3 (es) | 2003-12-19 | 2012-07-09 | Genentech, Inc. | Fragmentos de anticuerpos monovalentes útiles como agentes terapéuticos |
| US20080181892A1 (en) * | 2004-08-11 | 2008-07-31 | Trubion Pharmaceuticals | Binding Domain Fusion Protein |
| US8911726B2 (en) * | 2004-09-22 | 2014-12-16 | Kyowa Hakko Kirin Co., Ltd | Stabilized human Igg4 antibodies |
| NZ612578A (en) * | 2005-08-19 | 2014-11-28 | Abbvie Inc | Dual variable domain immunoglobin and uses thereof |
| AR056142A1 (es) * | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
| WO2007059782A1 (en) * | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| WO2007068255A1 (en) | 2005-12-15 | 2007-06-21 | Genmab A/S | Use of effector-function-deficient antibodies for treatment of auto-immune diseases |
| EP2170951A2 (en) | 2007-05-31 | 2010-04-07 | Genmab A/S | Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering |
| CA2688275A1 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Stable igg4 antibodies |
| US20100255012A1 (en) * | 2007-05-31 | 2010-10-07 | Genmab A/S | Recombinant fucose modified monovalent half-antibodies obtained by molecular engineering |
| EP2155790A1 (en) * | 2007-05-31 | 2010-02-24 | Genmab A/S | Method for extending the half-life of exogenous or endogenous soluble molecules |
| US20110045007A1 (en) * | 2007-05-31 | 2011-02-24 | Genmab A/S | Fusion or linked proteins with extended half life |
| US9322035B2 (en) | 2007-05-31 | 2016-04-26 | Genmab A/S | Recombinant IgG4 monovalent antibodies |
| JP5746040B2 (ja) | 2008-12-03 | 2015-07-08 | ゲンマブ エー／エス | 定常領域の中に改変を有する抗体変種 |
-
2008
- 2008-05-30 US US12/602,419 patent/US9322035B2/en active Active
- 2008-05-30 EP EP08748826A patent/EP2167669A2/en not_active Withdrawn
- 2008-05-30 JP JP2010509681A patent/JP5570974B2/ja active Active
- 2008-05-30 EP EP13153847.2A patent/EP2615175B1/en active Active
- 2008-05-30 AU AU2008255350A patent/AU2008255350B2/en not_active Ceased
- 2008-05-30 CA CA2689695A patent/CA2689695A1/en not_active Abandoned
- 2008-05-30 WO PCT/DK2008/050127 patent/WO2008145140A2/en not_active Ceased
-
2016
- 2016-03-17 US US15/072,983 patent/US10351629B2/en active Active
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