CA2532117C - Humanized immunoglobulin loci - Google Patents
Humanized immunoglobulin loci Download PDFInfo
- Publication number
- CA2532117C CA2532117C CA2532117A CA2532117A CA2532117C CA 2532117 C CA2532117 C CA 2532117C CA 2532117 A CA2532117 A CA 2532117A CA 2532117 A CA2532117 A CA 2532117A CA 2532117 C CA2532117 C CA 2532117C
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- human
- spacer
- humanized
- gene
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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Landscapes
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Applications Claiming Priority (3)
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| US48773303P | 2003-07-15 | 2003-07-15 | |
| US60/487,733 | 2003-07-15 | ||
| PCT/US2004/023226 WO2005007696A2 (en) | 2003-07-15 | 2004-07-15 | Humanized immunoglobulin loci |
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| CA2532117A1 CA2532117A1 (en) | 2005-01-27 |
| CA2532117C true CA2532117C (en) | 2012-07-10 |
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| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| WO2007140457A2 (en) * | 2006-05-31 | 2007-12-06 | Genzyme Corporation | Methods of using anti-thymocyte globulin and related agents |
| WO2008027986A2 (en) * | 2006-09-01 | 2008-03-06 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| US20090053210A1 (en) | 2006-09-01 | 2009-02-26 | Roland Buelow | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| EP2602323B1 (en) * | 2007-06-01 | 2018-02-28 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies |
| US9693539B2 (en) * | 2007-08-10 | 2017-07-04 | E. R. Squibb & Sons, L.L.C. | HCO32 and HCO27 and related examples |
| KR101563017B1 (ko) * | 2007-08-14 | 2015-10-23 | 오리겐 테라퓨틱스 인코포레이티드 | 불활성화된 내인성 유전자좌를 갖는 트랜스제닉 닭 |
| EP2108696A1 (en) * | 2008-04-10 | 2009-10-14 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Cis-acting diversification activator and method for selective diversification of nucleic acids |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| EP3028565B1 (en) * | 2009-07-08 | 2017-09-27 | Kymab Limited | Animal models and therapeutic molecules |
| EP2464220A4 (en) * | 2009-08-13 | 2014-05-07 | Crystal Bioscience Inc | Transgenic animal for the production of antibodies with minimal complementarity-determining regions |
| US8865462B2 (en) * | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT201900372T1 (it) | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| KR102004106B1 (ko) | 2010-03-31 | 2019-07-25 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| SI2480676T1 (sl) | 2010-06-22 | 2016-10-28 | Regeneron Pharmaceuticals, Inc. | Hibridna mišja lahka veriga |
| RU2612903C2 (ru) | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
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- 2004-07-15 ES ES04778633.0T patent/ES2473596T3/es not_active Expired - Lifetime
- 2004-07-15 CN CN201210390234.2A patent/CN103205436B/zh not_active Expired - Lifetime
- 2004-07-15 CN CNA2004800261928A patent/CN1852925A/zh active Pending
- 2004-07-15 US US10/893,483 patent/US7585668B2/en active Active
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| US8410333B2 (en) | 2013-04-02 |
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| US7585668B2 (en) | 2009-09-08 |
| WO2005007696A2 (en) | 2005-01-27 |
| CN103205436A (zh) | 2013-07-17 |
| AU2004257292A1 (en) | 2005-01-27 |
| ES2473596T3 (es) | 2014-07-07 |
| WO2005007696A3 (en) | 2005-11-03 |
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