JP2023529846A5 - - Google Patents

Info

Publication number
JP2023529846A5
JP2023529846A5 JP2022574491A JP2022574491A JP2023529846A5 JP 2023529846 A5 JP2023529846 A5 JP 2023529846A5 JP 2022574491 A JP2022574491 A JP 2022574491A JP 2022574491 A JP2022574491 A JP 2022574491A JP 2023529846 A5 JP2023529846 A5 JP 2023529846A5
Authority
JP
Japan
Prior art keywords
human
gene
animal
light chain
endogenous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022574491A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023529846A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2021/097652 external-priority patent/WO2021244522A1/en
Publication of JP2023529846A publication Critical patent/JP2023529846A/ja
Publication of JP2023529846A5 publication Critical patent/JP2023529846A5/ja
Pending legal-status Critical Current

Links

JP2022574491A 2020-06-02 2021-06-01 共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物 Pending JP2023529846A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/094000 2020-06-02
CN2020094000 2020-06-02
CN2021085839 2021-04-07
CNPCT/CN2021/085839 2021-04-07
PCT/CN2021/097652 WO2021244522A1 (en) 2020-06-02 2021-06-01 Genetically modified non-human animals with common light chain immunoglobulin locus

Publications (2)

Publication Number Publication Date
JP2023529846A JP2023529846A (ja) 2023-07-12
JP2023529846A5 true JP2023529846A5 (enExample) 2024-06-10

Family

ID=78830108

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022574491A Pending JP2023529846A (ja) 2020-06-02 2021-06-01 共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物

Country Status (10)

Country Link
US (2) US11997994B2 (enExample)
EP (1) EP4158034A4 (enExample)
JP (1) JP2023529846A (enExample)
KR (1) KR20230018439A (enExample)
CN (1) CN115667532A (enExample)
AU (1) AU2021283564B2 (enExample)
CA (1) CA3182925A1 (enExample)
IL (1) IL298632A (enExample)
WO (1) WO2021244522A1 (enExample)
ZA (1) ZA202213503B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3125380A1 (en) 2019-02-18 2020-08-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animals with humanized immunoglobulin locus
EP4469485A4 (en) * 2022-01-26 2026-04-08 Biocytogen Pharmaceuticals Beijing Co Ltd ANTI-HER2/TROP2 ANTIBODIES AND THEIR USES
WO2023192936A2 (en) * 2022-03-30 2023-10-05 Fred Hutchinson Cancer Center Systems and methods to produce b cells that express selected antibodies and gene products
WO2024237868A1 (en) * 2023-05-18 2024-11-21 Chiang Mai University Prefabricated sperm-sex separation kit of animal semen by use of nanofibers from polymer-based material
AU2024354039A1 (en) * 2023-09-26 2026-02-19 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animals with humanized immunoglobulin locus
KR20250108092A (ko) * 2024-01-02 2025-07-15 젬파마테크 컴퍼니 리미티드 인간화 항체를 생성하는 동물 모델 및 그 제작 방법
WO2025223455A1 (en) * 2024-04-24 2025-10-30 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-ptk7/b7h3 antibodies and uses thereof
CN121065267A (zh) * 2024-06-04 2025-12-05 赛业(苏州)生物科技有限公司 用于制备四元固定轻链的基因修饰的啮齿动物及其制备方法
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof
WO2026035843A2 (en) 2024-08-06 2026-02-12 Regeneron Pharmaceuticals, Inc. Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof
CN121628915A (zh) * 2024-08-29 2026-03-10 上海泰槿生物技术有限公司 产生限制的免疫球蛋白轻链库的细胞、动物和方法

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
WO1989001973A2 (en) 1987-09-02 1989-03-09 Applied Biotechnology, Inc. Recombinant pox virus for immunization against tumor-associated antigens
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
AU648261B2 (en) 1989-08-18 1994-04-21 Novartis Vaccines And Diagnostics, Inc. Recombinant retroviruses delivering vector constructs to target cells
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6632976B1 (en) 1995-08-29 2003-10-14 Kirin Beer Kabushiki Kaisha Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
KR100308764B1 (ko) 1995-08-29 2001-12-17 마나배게이사꾸 키메라동물및그의제작법
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
CA2362098C (en) 1999-02-05 2011-10-11 Jens-Ulrich Bulow Human polyclonal antibodies from genetically engineered animals
EA013564B1 (ru) 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CA2430013C (en) 2000-11-30 2011-11-22 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
WO2003014728A1 (fr) * 2001-08-10 2003-02-20 Mitsubishi Pharma Corporation Medicaments contre l'hepatite c
DK2314629T4 (da) * 2002-07-18 2023-02-06 Merus Nv Rekombinant produktion af blandinger af antistoffer
CA2501068C (en) 2002-10-04 2014-12-16 Kirin Beer Kabushiki Kaisha Human artificial chromosome (hac) vector
US20050266008A1 (en) * 2004-03-29 2005-12-01 Medarex, Inc. Human anti-IRTA-5 antibodies
AU2007235496B2 (en) 2006-03-31 2013-11-21 E. R. Squibb & Sons, L.L.C. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
GB0700194D0 (en) 2007-01-05 2007-02-14 Univ Edinburgh Humanisation of animals
EP2583551A1 (en) 2007-03-13 2013-04-24 National Jewish Health Methods for generation of antibodies
PL2602323T3 (pl) 2007-06-01 2018-06-29 Open Monoclonal Technology, Inc. Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego
US8877688B2 (en) * 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2147594B1 (en) * 2008-06-27 2013-11-13 Merus B.V. Antibody producing non-human mammals
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
DK3622815T3 (da) 2009-07-08 2023-06-26 Kymab Ltd Gnavermodeller og terapeutiske molekyler
US20130185821A1 (en) * 2010-02-08 2013-07-18 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
SMT202600080T1 (it) * 2010-02-08 2026-03-09 Regeneron Pharma Topo con catena leggera comune
CN103228130B (zh) 2010-06-17 2016-03-16 科马布有限公司 动物模型及治疗分子
CN103025884B (zh) 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
ME02106B (me) 2011-02-25 2015-10-20 Regeneron Pharma Miševi sa adam6
HUE047278T2 (hu) 2011-08-05 2020-04-28 Regeneron Pharma Humanizált univerzális könnyûláncú egerek
BR112014006394A2 (pt) 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
EP2758534B1 (en) 2011-09-19 2020-04-29 Kymab Limited Animals, repertoires & methods for the production of human antibodies
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
MX353278B (es) * 2012-03-06 2018-01-05 Regeneron Pharma Raton con cadena ligera comun.
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
SG11201405059XA (en) 2012-03-28 2014-09-26 Kymab Ltd Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
ME03551B (me) 2012-06-12 2020-07-20 Regeneron Pharma Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca
CN103571872B (zh) 2012-08-09 2016-11-23 山东国际生物科技园发展有限公司 一种能够表达人抗体的转基因动物的制备方法
PT2931030T (pt) 2012-12-14 2020-08-03 Open Monoclonal Tech Inc Polinucleótidos que codificam anticorpos de roedores com idiótipos humanos e animais que os compreendem
AU2014214863B2 (en) 2013-02-06 2019-03-21 Duke University B cell lineage based immunogen design with humanized animals
MY178882A (en) * 2013-02-20 2020-10-21 Regeneron Pharma Non-human animals with modified immunoglobulin heavy chain sequences
EP4545567A3 (en) 2013-03-13 2025-08-13 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
DK3456831T3 (da) 2013-04-16 2021-09-06 Regeneron Pharma Målrettet modifikation af rottegenom
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
EP3988649B1 (en) 2013-09-18 2024-11-27 Kymab Limited Methods, cells and organisms
AU2014330922A1 (en) 2013-10-01 2016-03-03 Kymab Limited Animal models and therapeutic molecules
TW201710286A (zh) * 2015-06-15 2017-03-16 艾伯維有限公司 抗vegf、pdgf及/或其受體之結合蛋白
SG11201802698XA (en) * 2015-10-29 2018-05-30 Hoffmann La Roche Transgenic rabbit with common light chain
CN113831407B (zh) 2016-05-20 2024-06-11 瑞泽恩制药公司 用于使用多个引导rna来破坏免疫耐受性的方法
WO2018001241A1 (zh) 2016-06-28 2018-01-04 北京百奥赛图基因生物技术有限公司 一种pd-1基因修饰人源化动物模型的构建方法及其应用
US11279948B2 (en) 2016-08-31 2022-03-22 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric OX40
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
WO2018041118A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric pd-l1
WO2018041120A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
WO2018068756A1 (en) 2016-10-14 2018-04-19 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric btla
SG10201913483XA (en) * 2016-11-04 2020-03-30 Regeneron Pharma Non-human animals having an engineered immunoglobulin lambda light chain locus
WO2018086594A1 (en) 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tim-3
WO2018086583A1 (en) 2016-11-11 2018-05-17 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric lag-3
WO2018121787A1 (en) 2016-12-30 2018-07-05 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric cd137
IL268049B2 (en) 2017-01-19 2025-08-01 Omniab Inc Transgenic rodent human antibodies with multiple immunoglobulin heavy chain loci
CN108588126B (zh) 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Cd47基因人源化改造动物模型的制备方法及应用
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
GB201709970D0 (en) * 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
GB201710984D0 (en) * 2017-07-07 2017-08-23 Kymab Ltd Cells, vertebrates, populations & methods
CN109837307B (zh) 2017-11-24 2023-09-19 中国科学院脑科学与智能技术卓越创新中心 建立含外源染色体的胚胎干细胞的方法
US20240254252A1 (en) * 2018-07-13 2024-08-01 Genmab A/S Trogocytosis-mediated therapy using cd38 antibodies
US20200017600A1 (en) * 2018-07-13 2020-01-16 Genmab A/S Variants of cd38 antibody and uses thereof
CA3125380A1 (en) * 2019-02-18 2020-08-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animals with humanized immunoglobulin locus
JP2024525991A (ja) 2021-07-16 2024-07-12 バイオサイトジェン ファーマシューティカルズ (ベイジン) カンパニー リミテッド ヒト又はキメラtfr1を有する遺伝子組換え非ヒト動物

Similar Documents

Publication Publication Date Title
JP2023529846A5 (enExample)
JP2022521358A5 (enExample)
JP2025105667A5 (enExample)
US11997994B2 (en) Genetically modified non-human animals with common light chain immunoglobulin locus
JP2010529042A5 (enExample)
US20170094956A1 (en) Animal models and therapeutic molecules
JP2018164465A (ja) 修飾された免疫グロブリン重鎖配列を有する非ヒト動物
FI2560993T3 (fi) Heterodimeeristä vasta-ainetta FC sisältävät proteiinit ja menetelmät niiden tuottamiseksi
JP2011182801A5 (enExample)
JP2015505477A5 (enExample)
US20240032514A1 (en) Preparation method and application of non-human mammals or their progenies
EP4588345A1 (en) Genetically modified non-human mammals, preparation methods therefor, and applications thereof
Ching et al. Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics
US20240206440A1 (en) Animal models and therapeutic molecules
CN118946265A (zh) 具有人源化免疫球蛋白和mhc基因座的经基因修饰的非人动物
EP4606901A1 (en) Animal model for producing humanized antibody, and construction method therefor
KR20250022132A (ko) 동물 모델과 치료 분자
JP7799706B2 (ja) 抗体を産生するための組換え非ヒト動物
RU2021127342A (ru) Генетически модифицированные, не являющиеся человеком животные с гуманизированным иммуноглобулиновым локусом
Satofuka et al. Comparative analysis of trans-chromosomic rodent models reveals improved somatic hypermutation and class-switch recombination in rats
Yuskevich et al. Expression of humanized anti-Her2/neu single-chain IgG1-like antibody in mammary glands of transgenic mice
Li et al. Genetic removal of the CH1 exon leads to the production of hypofunctional heavy chain-only IgG2a in rats
CN120174004A (zh) 一种用于生产人源化抗体的经遗传修饰的非人哺乳动物的制备方法及应用
JP2025537422A (ja) 共通軽鎖を発現するげっ歯類
RU2020127564A (ru) Продуцирующие антитела млекопитающие, не являющиеся человеком