|
US4603112A
(en)
|
1981-12-24 |
1986-07-29 |
Health Research, Incorporated |
Modified vaccinia virus
|
|
US4769330A
(en)
|
1981-12-24 |
1988-09-06 |
Health Research, Incorporated |
Modified vaccinia virus and methods for making and using the same
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
GB8508845D0
(en)
|
1985-04-04 |
1985-05-09 |
Hoffmann La Roche |
Vaccinia dna
|
|
US4777127A
(en)
|
1985-09-30 |
1988-10-11 |
Labsystems Oy |
Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
|
|
GB8702816D0
(en)
|
1987-02-07 |
1987-03-11 |
Al Sumidaie A M K |
Obtaining retrovirus-containing fraction
|
|
WO1989001973A2
(en)
|
1987-09-02 |
1989-03-09 |
Applied Biotechnology, Inc. |
Recombinant pox virus for immunization against tumor-associated antigens
|
|
AP129A
(en)
|
1988-06-03 |
1991-04-17 |
Smithkline Biologicals S A |
Expression of retrovirus gag protein eukaryotic cells
|
|
AU648261B2
(en)
|
1989-08-18 |
1994-04-21 |
Novartis Vaccines And Diagnostics, Inc. |
Recombinant retroviruses delivering vector constructs to target cells
|
|
DE4228162C1
(de)
*
|
1992-08-25 |
1994-01-13 |
Rajewsky Klaus Dr |
Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
|
KR100308764B1
(ko)
|
1995-08-29 |
2001-12-17 |
마나배게이사꾸 |
키메라동물및그의제작법
|
|
CA2722378C
(en)
*
|
1996-12-03 |
2015-02-03 |
Amgen Fremont Inc. |
Human antibodies that bind tnf.alpha.
|
|
TWI255853B
(en)
*
|
1998-08-21 |
2006-06-01 |
Kirin Brewery |
Method for modifying chromosomes
|
|
CA2362098C
(en)
|
1999-02-05 |
2011-10-11 |
Jens-Ulrich Bulow |
Human polyclonal antibodies from genetically engineered animals
|
|
EA013564B1
(ru)
|
2000-08-03 |
2010-06-30 |
Терапеутик Хьюман Поликлоналз Инк. |
Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
|
|
US20050144655A1
(en)
|
2000-10-31 |
2005-06-30 |
Economides Aris N. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7105348B2
(en)
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
CA2430013C
(en)
|
2000-11-30 |
2011-11-22 |
Medarex, Inc. |
Transgenic transchromosomal rodents for making human antibodies
|
|
GB0115256D0
(en)
|
2001-06-21 |
2001-08-15 |
Babraham Inst |
Mouse light chain locus
|
|
DK2314629T4
(da)
|
2002-07-18 |
2023-02-06 |
Merus Nv |
Rekombinant produktion af blandinger af antistoffer
|
|
CA2501068C
(en)
|
2002-10-04 |
2014-12-16 |
Kirin Beer Kabushiki Kaisha |
Human artificial chromosome (hac) vector
|
|
US20050266008A1
(en)
|
2004-03-29 |
2005-12-01 |
Medarex, Inc. |
Human anti-IRTA-5 antibodies
|
|
AU2007235496B2
(en)
|
2006-03-31 |
2013-11-21 |
E. R. Squibb & Sons, L.L.C. |
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
GB0700194D0
(en)
|
2007-01-05 |
2007-02-14 |
Univ Edinburgh |
Humanisation of animals
|
|
EP2583551A1
(en)
*
|
2007-03-13 |
2013-04-24 |
National Jewish Health |
Methods for generation of antibodies
|
|
PL2602323T3
(pl)
|
2007-06-01 |
2018-06-29 |
Open Monoclonal Technology, Inc. |
Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
EP2147594B1
(en)
|
2008-06-27 |
2013-11-13 |
Merus B.V. |
Antibody producing non-human mammals
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
DK3622815T3
(da)
|
2009-07-08 |
2023-06-26 |
Kymab Ltd |
Gnavermodeller og terapeutiske molekyler
|
|
US20130185821A1
(en)
|
2010-02-08 |
2013-07-18 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
SMT202600080T1
(it)
|
2010-02-08 |
2026-03-09 |
Regeneron Pharma |
Topo con catena leggera comune
|
|
CN103228130B
(zh)
*
|
2010-06-17 |
2016-03-16 |
科马布有限公司 |
动物模型及治疗分子
|
|
CN103025884B
(zh)
|
2010-07-26 |
2015-11-25 |
特里安尼公司 |
转基因动物和使用方法
|
|
AU2015203288C1
(en)
*
|
2010-08-02 |
2017-11-23 |
Regeneron Pharmaceuticals, Inc. |
Mice that make binding proteins comprising vl domains
|
|
ME02106B
(me)
|
2011-02-25 |
2015-10-20 |
Regeneron Pharma |
Miševi sa adam6
|
|
HUE047278T2
(hu)
*
|
2011-08-05 |
2020-04-28 |
Regeneron Pharma |
Humanizált univerzális könnyûláncú egerek
|
|
BR112014006394A2
(pt)
|
2011-09-19 |
2017-03-28 |
Kymab Ltd |
manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
|
|
EP2758534B1
(en)
|
2011-09-19 |
2020-04-29 |
Kymab Limited |
Animals, repertoires & methods for the production of human antibodies
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
MX353278B
(es)
|
2012-03-06 |
2018-01-05 |
Regeneron Pharma |
Raton con cadena ligera comun.
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
SG11201405059XA
(en)
|
2012-03-28 |
2014-09-26 |
Kymab Ltd |
Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
|
|
ME03551B
(me)
*
|
2012-06-12 |
2020-07-20 |
Regeneron Pharma |
Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca
|
|
CN103571872B
(zh)
*
|
2012-08-09 |
2016-11-23 |
山东国际生物科技园发展有限公司 |
一种能够表达人抗体的转基因动物的制备方法
|
|
PT2931030T
(pt)
*
|
2012-12-14 |
2020-08-03 |
Open Monoclonal Tech Inc |
Polinucleótidos que codificam anticorpos de roedores com idiótipos humanos e animais que os compreendem
|
|
AU2014214863B2
(en)
|
2013-02-06 |
2019-03-21 |
Duke University |
B cell lineage based immunogen design with humanized animals
|
|
MY178882A
(en)
|
2013-02-20 |
2020-10-21 |
Regeneron Pharma |
Non-human animals with modified immunoglobulin heavy chain sequences
|
|
EP4545567A3
(en)
|
2013-03-13 |
2025-08-13 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
DK3456831T3
(da)
*
|
2013-04-16 |
2021-09-06 |
Regeneron Pharma |
Målrettet modifikation af rottegenom
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
AU2014330922A1
(en)
|
2013-10-01 |
2016-03-03 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
CN113831407B
(zh)
|
2016-05-20 |
2024-06-11 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
WO2018001241A1
(zh)
|
2016-06-28 |
2018-01-04 |
北京百奥赛图基因生物技术有限公司 |
一种pd-1基因修饰人源化动物模型的构建方法及其应用
|
|
WO2018041121A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric ctla-4
|
|
US11279948B2
(en)
|
2016-08-31 |
2022-03-22 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animal with human or chimeric OX40
|
|
WO2018041120A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric tigit
|
|
WO2018041118A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric pd-l1
|
|
WO2018068756A1
(en)
|
2016-10-14 |
2018-04-19 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric btla
|
|
WO2018086583A1
(en)
|
2016-11-11 |
2018-05-17 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric lag-3
|
|
WO2018086594A1
(en)
|
2016-11-11 |
2018-05-17 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric tim-3
|
|
WO2018121787A1
(en)
|
2016-12-30 |
2018-07-05 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric cd137
|
|
IL268049B2
(en)
*
|
2017-01-19 |
2025-08-01 |
Omniab Inc |
Transgenic rodent human antibodies with multiple immunoglobulin heavy chain loci
|
|
CN108588126B
(zh)
|
2017-03-31 |
2020-04-10 |
北京百奥赛图基因生物技术有限公司 |
Cd47基因人源化改造动物模型的制备方法及应用
|
|
WO2018177441A1
(en)
|
2017-03-31 |
2018-10-04 |
Beijing Biocytogen Co., Ltd |
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
|
|
GB201710984D0
(en)
|
2017-07-07 |
2017-08-23 |
Kymab Ltd |
Cells, vertebrates, populations & methods
|
|
CN109837307B
(zh)
|
2017-11-24 |
2023-09-19 |
中国科学院脑科学与智能技术卓越创新中心 |
建立含外源染色体的胚胎干细胞的方法
|
|
CA3125380A1
(en)
|
2019-02-18 |
2020-08-27 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animals with humanized immunoglobulin locus
|
|
JP2023529846A
(ja)
|
2020-06-02 |
2023-07-12 |
バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド |
共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物
|
|
JP2024525991A
(ja)
|
2021-07-16 |
2024-07-12 |
バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド |
ヒト又はキメラｔｆｒ１を有する遺伝子組換え非ヒト動物
|