|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US7041871B1
(en)
|
1995-10-10 |
2006-05-09 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
GB9119338D0
(en)
|
1991-09-10 |
1991-10-23 |
Inst Of Animal Physiology And |
Control of gene expression
|
|
US5523226A
(en)
*
|
1993-05-14 |
1996-06-04 |
Biotechnology Research And Development Corp. |
Transgenic swine compositions and methods
|
|
US5512295A
(en)
|
1994-11-10 |
1996-04-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Synthetic liposomes for enhanced uptake and delivery
|
|
US6001349A
(en)
|
1995-02-22 |
1999-12-14 |
Therion Biologics Corporation |
Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US7001614B2
(en)
|
1996-08-19 |
2006-02-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
US6770291B2
(en)
|
1996-08-30 |
2004-08-03 |
The United States Of America As Represented By The Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
EP2305027B1
(en)
|
1996-12-03 |
2014-07-02 |
Amgen Fremont Inc. |
Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
|
|
US7112338B2
(en)
|
1997-03-12 |
2006-09-26 |
The Regents Of The University Of California |
Cationic liposome delivery of taxanes to angiogenic blood vessels
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6749863B1
(en)
|
1997-11-19 |
2004-06-15 |
Georgetown University |
Targeted liposome gene delivery
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
GB9823930D0
(en)
|
1998-11-03 |
1998-12-30 |
Babraham Inst |
Murine expression of human ig\ locus
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7105348B2
(en)
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
CA2440676A1
(en)
|
2001-03-22 |
2002-10-03 |
Abbott Gmbh & Co. Kg |
Transgenic animals expressing antibodies specific for genes of interest and uses thereof
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20090042291A1
(en)
|
2002-03-01 |
2009-02-12 |
Xencor, Inc. |
Optimized Fc variants
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
EP1575601B1
(en)
|
2002-12-16 |
2015-07-01 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Recombinant vaccine viruses expressing il-15 and methods of using the same
|
|
WO2004067753A2
(en)
|
2003-01-28 |
2004-08-12 |
Cellectis |
Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
US8218805B2
(en)
|
2003-10-11 |
2012-07-10 |
Charles Hornback |
Wireless speaker system for use with ceiling fans
|
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
|
US20060034850A1
(en)
|
2004-05-27 |
2006-02-16 |
Weidanz Jon A |
Antibodies as T cell receptor mimics, methods of production and uses thereof
|
|
AU2005295269B2
(en)
|
2004-10-19 |
2010-05-13 |
Regeneron Pharmaceuticals, Inc. |
Method for generating an animal homozygous for a genetic modification
|
|
US7632497B2
(en)
|
2004-11-10 |
2009-12-15 |
Macrogenics, Inc. |
Engineering Fc Antibody regions to confer effector function
|
|
US20060222653A1
(en)
|
2004-11-12 |
2006-10-05 |
Xencor, Inc. |
Antibodies operably linked to selected chemoattractants
|
|
US20060275282A1
(en)
|
2005-01-12 |
2006-12-07 |
Xencor, Inc. |
Antibodies and Fc fusion proteins with altered immunogenicity
|
|
CA2616069C
(en)
*
|
2005-08-03 |
2018-07-31 |
Therapeutic Human Polyclonals, Inc. |
Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin
|
|
WO2007022520A2
(en)
|
2005-08-19 |
2007-02-22 |
Cerus Corporation |
Antibody-mediated enhancement of immune response
|
|
RS63964B1
(sr)
|
2005-08-23 |
2023-03-31 |
Univ Pennsylvania |
Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu
|
|
AU2007235496B2
(en)
|
2006-03-31 |
2013-11-21 |
E. R. Squibb & Sons, L.L.C. |
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
|
|
KR102096731B1
(ko)
|
2007-06-01 |
2020-04-02 |
오픈 모노클로날 테크놀로지, 인코포레이티드 |
내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
|
|
US7867483B2
(en)
|
2007-10-18 |
2011-01-11 |
Bn Immunotherapeutics, Inc. |
Use of MVA to treat prostate cancer
|
|
US8225343B2
(en)
|
2008-01-11 |
2012-07-17 |
Sony Computer Entertainment America Llc |
Gesture cataloging and recognition
|
|
PT3456190T
(pt)
|
2008-06-27 |
2022-02-15 |
Merus Nv |
Animal murino transgénico produtor de anticorpo
|
|
KR101987351B1
(ko)
|
2008-09-30 |
2019-06-10 |
아블렉시스, 엘엘씨 |
키메라 항체의 제조를 위한 인간 이외의 포유동물
|
|
US8691502B2
(en)
|
2008-10-31 |
2014-04-08 |
Tremrx, Inc. |
T-cell vaccination with viral vectors via mechanical epidermal disruption
|
|
CN102638971B
(zh)
|
2009-07-08 |
2015-10-07 |
科马布有限公司 |
动物模型及治疗分子
|
|
RU2425880C2
(ru)
*
|
2009-07-30 |
2011-08-10 |
Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН |
Способ получения трансгенных мышей
|
|
WO2011072204A1
(en)
|
2009-12-10 |
2011-06-16 |
Regeneron Pharmaceuticals, Inc. |
Mice that make heavy chain antibodies
|
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
|
US10143186B2
(en)
|
2010-02-08 |
2018-12-04 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
US20130185821A1
(en)
|
2010-02-08 |
2013-07-18 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
MX341925B
(es)
|
2010-03-29 |
2016-09-07 |
Zymeworks Inc |
Anticuerpos con funcion efectora suprimida o mejorada.
|
|
KR101830020B1
(ko)
|
2010-03-31 |
2018-02-19 |
아블렉시스, 엘엘씨 |
키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
|
|
SG10201504568YA
(en)
|
2010-06-22 |
2015-07-30 |
Regeneron Pharma |
Hybrid light chain mice
|
|
DK2597945T3
(da)
|
2010-07-26 |
2020-09-21 |
Trianni Inc |
Transgene dyr og fremgangsmåder til anvendelse deraf
|
|
EP3960865A1
(en)
|
2010-08-02 |
2022-03-02 |
Regeneron Pharmaceuticals, Inc. |
Mice that make binding proteins comprising vl domains
|
|
ME03732B
(me)
|
2011-02-25 |
2021-01-20 |
Regeneron Pharma |
Miševi s ADAM6
|
|
JP5893258B2
(ja)
|
2011-03-31 |
2016-03-23 |
フェリカネットワークス株式会社 |
情報処理装置および方法、並びにプログラム
|
|
US20130018582A1
(en)
|
2011-07-13 |
2013-01-17 |
Miller Paul A |
Inertial Navigation Common Azimuth Reference Determination System and Method
|
|
HRP20192255T1
(hr)
|
2011-08-05 |
2020-03-06 |
Regeneron Pharmaceuticals, Inc. |
Humanizirani miševi s univerzalnim lakim lancem
|
|
BR112014006390A2
(pt)
|
2011-09-19 |
2017-03-28 |
Kymab Ltd |
anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano
|
|
CA2791109C
(en)
|
2011-09-26 |
2021-02-16 |
Merus B.V. |
Generation of binding molecules
|
|
HRP20220253T1
(hr)
|
2011-10-17 |
2022-04-29 |
Regeneron Pharmaceuticals, Inc. |
Miševi s ograničenim teškim lancem imunoglobulina
|
|
US9591835B2
(en)
|
2011-10-28 |
2017-03-14 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex animals
|
|
CN114891797A
(zh)
|
2011-10-28 |
2022-08-12 |
瑞泽恩制药公司 |
T细胞受体基因修饰小鼠
|
|
RS56656B1
(sr)
|
2011-10-28 |
2018-03-30 |
Regeneron Pharma |
Miševi sa genetski modifikovanim glavnim kompleksom gena tkivne podudarnosti
|
|
RS56330B1
(sr)
|
2011-10-28 |
2017-12-29 |
Regeneron Pharma |
Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc)
|
|
MY186903A
(en)
|
2011-10-28 |
2021-08-26 |
Regeneron Pharma |
Humanized il-6 and il-6 receptor
|
|
US9043996B2
(en)
|
2011-10-28 |
2015-06-02 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex animals
|
|
AU2012332021B8
(en)
|
2011-11-04 |
2017-10-12 |
Zymeworks Bc Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
US9120662B2
(en)
|
2011-11-14 |
2015-09-01 |
Susan A. Thomson |
Gathering and dispensing scoop with gate valve
|
|
US9547499B2
(en)
|
2011-12-09 |
2017-01-17 |
Microsoft Technology Licensing, Llc |
Device configuration with cached pre-assembled driver state
|
|
RU2014141536A
(ru)
|
2012-03-16 |
2016-05-10 |
Регенерон Фармасьютикалз, Инк. |
Мыши, которые продуцируют антигенсвязывающие белки с зависимыми от величины ph характеристиками связывания
|
|
PT2825037T
(pt)
|
2012-03-16 |
2019-08-07 |
Regeneron Pharma |
Animais não humanos que expressam sequências de imunoglobulinas sensíveis ao ph
|
|
SMT201800395T1
(it)
|
2012-03-16 |
2018-09-13 |
Regeneron Pharma |
Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi
|
|
US20140013456A1
(en)
|
2012-03-16 |
2014-01-09 |
Regeneron Pharmaceuticals, Inc. |
Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
|
|
JP5920830B2
(ja)
|
2012-09-28 |
2016-05-18 |
シスメックス株式会社 |
試料調製装置および細胞分析装置
|
|
EP4269602A3
(en)
|
2012-12-14 |
2023-12-27 |
OmniAB, Inc. |
Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
|
|
KR20240147707A
(ko)
|
2013-02-20 |
2024-10-08 |
리제너론 파아마슈티컬스, 인크. |
사람화된 t-세포 보조-수용체를 발현하는 마우스
|
|
LT2840892T
(lt)
*
|
2013-02-20 |
2018-07-25 |
Regeneron Pharmaceuticals, Inc. |
Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis
|
|
CN110192541B
(zh)
|
2013-02-22 |
2022-02-18 |
瑞泽恩制药公司 |
表达人源化主要组织相容性复合物的小鼠
|
|
CA2908697C
(en)
|
2013-04-16 |
2023-12-12 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
|
US9783618B2
(en)
*
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
SG10201700961TA
(en)
|
2013-12-11 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for the targeted modification of a genome
|
|
SG10201808225TA
(en)
|
2014-03-21 |
2018-10-30 |
Regeneron Pharma |
Non-human animals that make single domain binding proteins
|
|
BR112016021679A2
(pt)
|
2014-03-21 |
2018-12-04 |
Regeneron Pharmaceuticals, Inc. |
proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado.
|
|
HUE049776T2
(hu)
|
2014-06-06 |
2020-10-28 |
Regeneron Pharma |
Módszerek és készítmények egy célzott lókusz módosítására
|
|
HUE048677T2
(hu)
*
|
2014-06-19 |
2020-07-28 |
Regeneron Pharma |
Humanizált programozott sejthalál 1 génnel rendelkezõ nem-humán állatok
|
|
MX384887B
(es)
|
2014-06-23 |
2025-03-14 |
Regeneron Pharma |
Ensamblaje de adn mediado por nucleasa.
|
|
EP3161128B1
(en)
|
2014-06-26 |
2018-09-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modifications and methods of use
|
|
WO2016044745A1
(en)
*
|
2014-09-19 |
2016-03-24 |
Regeneron Pharmaceuticals, Inc. |
Chimeric antigen receptors
|
|
KR20240132525A
(ko)
|
2015-04-06 |
2024-09-03 |
리제너론 파아마슈티컬스, 인크. |
비인간 동물에서의 인간화 t 세포 매개 면역반응
|
|
SI3462853T1
(sl)
|
2016-06-03 |
2023-05-31 |
Regeneron Pharmaceuticals, Inc. |
Glodavci, ki izražajo eksogeno terminalno deoksinukleotidiltransferazo
|