CY1126063T1 - Τρωκτικα που εκφραζουν εξωγενη τερματικη δεοξυνουκλεοτιδυλοτρανσφεραση - Google Patents

Τρωκτικα που εκφραζουν εξωγενη τερματικη δεοξυνουκλεοτιδυλοτρανσφεραση

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Publication number
CY1126063T1
CY1126063T1 CY20231100257T CY231100257T CY1126063T1 CY 1126063 T1 CY1126063 T1 CY 1126063T1 CY 20231100257 T CY20231100257 T CY 20231100257T CY 231100257 T CY231100257 T CY 231100257T CY 1126063 T1 CY1126063 T1 CY 1126063T1
Authority
CY
Cyprus
Prior art keywords
terminal
deoxynucleotidyltransfer
exogeneous
rodents expressing
rodents
Prior art date
Application number
CY20231100257T
Other languages
English (en)
Inventor
Lynn Macdonald
Andrew J. Murphy
Chunguang GUO
Natasha Levenkova
Naxin Tu
John Mcwhirter
Vera VORONINA
Faith HARRIS
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of CY1126063T1 publication Critical patent/CY1126063T1/el

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07031—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal deoxynucleotidyl transferase
    • A—HUMAN NECESSITIES
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
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    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/10—Mammal
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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Abstract

Παρέχονται εδώ μέθοδοι και συνθέσεις που σχετίζονται με μη ανθρώπινα ζώα που εκφράζουν εξωγενή Τερματική Δεοξονουκλεοτιδυλοτρανσφεράση (TdT).
CY20231100257T 2016-06-03 2023-05-31 Τρωκτικα που εκφραζουν εξωγενη τερματικη δεοξυνουκλεοτιδυλοτρανσφεραση CY1126063T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662345524P 2016-06-03 2016-06-03
PCT/US2017/035731 WO2017210586A1 (en) 2016-06-03 2017-06-02 Non-human animals expressing exogenous terminal deoxynucleotidyltransferase

Publications (1)

Publication Number Publication Date
CY1126063T1 true CY1126063T1 (el) 2023-11-15

Family

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Family Applications (1)

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CY20231100257T CY1126063T1 (el) 2016-06-03 2023-05-31 Τρωκτικα που εκφραζουν εξωγενη τερματικη δεοξυνουκλεοτιδυλοτρανσφεραση

Country Status (24)

Country Link
US (2) US10980221B2 (el)
EP (2) EP4218408A1 (el)
JP (3) JP7053499B2 (el)
KR (3) KR20230156162A (el)
CN (3) CN113907043B (el)
AU (2) AU2017272337C1 (el)
BR (1) BR112018074794A2 (el)
CA (1) CA3026088A1 (el)
CY (1) CY1126063T1 (el)
DK (1) DK3462853T3 (el)
ES (1) ES2941810T3 (el)
FI (1) FI3462853T3 (el)
HR (1) HRP20230497T1 (el)
HU (1) HUE061619T2 (el)
IL (2) IL263160B2 (el)
LT (1) LT3462853T (el)
MX (3) MX2018014982A (el)
PL (1) PL3462853T3 (el)
PT (1) PT3462853T (el)
RS (1) RS64216B1 (el)
RU (1) RU2753585C2 (el)
SG (2) SG10201914014XA (el)
SI (1) SI3462853T1 (el)
WO (1) WO2017210586A1 (el)

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SI3462853T1 (sl) 2016-06-03 2023-05-31 Regeneron Pharmaceuticals, Inc. Glodavci, ki izražajo eksogeno terminalno deoksinukleotidiltransferazo
CA3084049A1 (en) 2017-12-05 2019-06-13 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof
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CN112312766A (zh) 2018-06-14 2021-02-02 瑞泽恩制药公司 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物
CA3127153A1 (en) * 2019-02-22 2020-08-27 Regeneron Pharmaceuticals, Inc. Rodents having genetically modified sodium channels and methods of use thereof
US20220330532A1 (en) 2019-06-05 2022-10-20 Regeneron Pharmaceuticals, Inc. Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof
WO2021116270A1 (en) * 2019-12-12 2021-06-17 Dna Script Chimeric terminal deoxynucleotidyl transferases for template-free enzymatic synthesis of polynucleotides
CN111057754B (zh) * 2019-12-27 2021-01-12 四川省医学科学院.四川省人民医院实验动物研究所 鉴定适用于hbv研究的动物模型的方法和应用
WO2022056276A1 (en) 2020-09-11 2022-03-17 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
KR20230147048A (ko) 2020-12-16 2023-10-20 리제너론 파마슈티칼스 인코포레이티드 인간화 Fc 알파 수용체를 발현하는 마우스
MX2023007401A (es) 2020-12-23 2023-07-06 Regeneron Pharma Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos.
KR20230164150A (ko) * 2021-03-31 2023-12-01 리제너론 파아마슈티컬스, 인크. TCRβ 레퍼토리의 다양성이 개선된 인간화 세포 면역 시스템 성분을 포함하는 유전자 변형된 마우스
WO2024064860A1 (en) * 2022-09-22 2024-03-28 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing components of human cellular immune system

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