JP2015502177A5 - - Google Patents
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- JP2015502177A5 JP2015502177A5 JP2014549157A JP2014549157A JP2015502177A5 JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5 JP 2014549157 A JP2014549157 A JP 2014549157A JP 2014549157 A JP2014549157 A JP 2014549157A JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human animal
- gene segments
- item
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578097P | 2011-12-20 | 2011-12-20 | |
| US61/578,097 | 2011-12-20 | ||
| PCT/US2012/069981 WO2013096142A1 (en) | 2011-12-20 | 2012-12-17 | Humanized light chain mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Division JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502177A JP2015502177A (ja) | 2015-01-22 |
| JP2015502177A5 true JP2015502177A5 (enExample) | 2016-02-12 |
| JP6327750B2 JP6327750B2 (ja) | 2018-05-23 |
Family
ID=47501484
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549157A Active JP6327750B2 (ja) | 2011-12-20 | 2012-12-17 | ヒト化軽鎖マウス |
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US9706759B2 (enExample) |
| EP (3) | EP4696716A3 (enExample) |
| JP (6) | JP6327750B2 (enExample) |
| KR (5) | KR102081657B1 (enExample) |
| CN (1) | CN104159444B (enExample) |
| AU (6) | AU2012323987B2 (enExample) |
| BR (2) | BR122021007339B1 (enExample) |
| CA (1) | CA2859408C (enExample) |
| CY (1) | CY1121638T1 (enExample) |
| DK (2) | DK3527070T3 (enExample) |
| ES (2) | ES2720186T3 (enExample) |
| FI (1) | FI3527070T3 (enExample) |
| HR (2) | HRP20260031T1 (enExample) |
| HU (1) | HUE044266T2 (enExample) |
| IL (3) | IL233153B (enExample) |
| IN (1) | IN2014DN06094A (enExample) |
| LT (2) | LT2793567T (enExample) |
| ME (1) | ME03477B (enExample) |
| MX (3) | MX356429B (enExample) |
| MY (1) | MY173936A (enExample) |
| PL (2) | PL3527070T3 (enExample) |
| PT (2) | PT3527070T (enExample) |
| RS (2) | RS58761B1 (enExample) |
| RU (2) | RU2664181C2 (enExample) |
| SG (3) | SG11201403326VA (enExample) |
| SI (2) | SI3527070T1 (enExample) |
| SM (2) | SMT201900296T1 (enExample) |
| TR (1) | TR201903439T4 (enExample) |
| WO (1) | WO2013096142A1 (enExample) |
Families Citing this family (78)
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| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| DK3241435T3 (da) | 2009-07-08 | 2021-08-23 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| EP2601298B1 (en) | 2010-08-02 | 2016-11-30 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| CN105861548B (zh) | 2011-02-25 | 2020-01-10 | 瑞泽恩制药公司 | Adam6小鼠 |
| ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| EP4074833A1 (en) * | 2011-10-17 | 2022-10-19 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
| US20180295821A1 (en) * | 2011-12-02 | 2018-10-18 | Kymab Limited | Transgenic Animals |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SMT201900296T1 (it) | 2011-12-20 | 2019-07-11 | Regeneron Pharma | Topi di catena leggera umanizzata |
| RU2664185C2 (ru) * | 2012-02-01 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl |
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| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| NZ703689A (en) | 2012-06-12 | 2016-05-27 | Regeneron Pharma | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2015049517A2 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| SG10201808083VA (en) | 2014-03-21 | 2018-10-30 | Regeneron Pharma | Vl antigen binding proteins exhibiting distinct binding characteristics |
| AU2015230938C1 (en) | 2014-03-21 | 2021-10-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
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| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| SG10202102885UA (en) | 2016-05-20 | 2021-05-28 | Regeneron Pharma | Methods for breaking immunological tolerance using multiple guide rnas |
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| EP4567119A3 (en) * | 2016-11-04 | 2025-09-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered immunoglobulin lambda light chain locus |
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| CN112040985A (zh) | 2018-02-07 | 2020-12-04 | 瑞泽恩制药公司 | 用于递送治疗性蛋白质的方法和组合物 |
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| EP3793591A1 (en) | 2018-05-17 | 2021-03-24 | Regeneron Pharmaceuticals, Inc. | Anti-cd63 antibodies, conjugates, and uses thereof |
| CN109359045B (zh) * | 2018-10-16 | 2022-01-04 | 武汉斗鱼网络科技有限公司 | 一种测试方法、装置、设备和存储介质 |
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| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
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| PT3979790T (pt) * | 2019-06-05 | 2026-05-05 | Regeneron Pharma | Roedores possuindo um reportrio limitado de cadeias leves lambda expressadas a partir do lcus kappa e suas utilizaes |
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