JP2015502177A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015502177A5 JP2015502177A5 JP2014549157A JP2014549157A JP2015502177A5 JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5 JP 2014549157 A JP2014549157 A JP 2014549157A JP 2014549157 A JP2014549157 A JP 2014549157A JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human animal
- gene segments
- item
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578097P | 2011-12-20 | 2011-12-20 | |
| US61/578,097 | 2011-12-20 | ||
| PCT/US2012/069981 WO2013096142A1 (en) | 2011-12-20 | 2012-12-17 | Humanized light chain mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Division JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502177A JP2015502177A (ja) | 2015-01-22 |
| JP2015502177A5 true JP2015502177A5 (enExample) | 2016-02-12 |
| JP6327750B2 JP6327750B2 (ja) | 2018-05-23 |
Family
ID=47501484
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549157A Active JP6327750B2 (ja) | 2011-12-20 | 2012-12-17 | ヒト化軽鎖マウス |
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US9706759B2 (enExample) |
| EP (3) | EP4696716A3 (enExample) |
| JP (6) | JP6327750B2 (enExample) |
| KR (5) | KR101924805B1 (enExample) |
| CN (1) | CN104159444B (enExample) |
| AU (6) | AU2012323987B2 (enExample) |
| BR (2) | BR122021007339B1 (enExample) |
| CA (1) | CA2859408C (enExample) |
| CY (1) | CY1121638T1 (enExample) |
| DK (2) | DK3527070T3 (enExample) |
| ES (2) | ES2720186T3 (enExample) |
| FI (1) | FI3527070T3 (enExample) |
| HR (2) | HRP20190897T1 (enExample) |
| HU (1) | HUE044266T2 (enExample) |
| IL (3) | IL233153B (enExample) |
| IN (1) | IN2014DN06094A (enExample) |
| LT (2) | LT2793567T (enExample) |
| ME (1) | ME03477B (enExample) |
| MX (3) | MX378871B (enExample) |
| MY (1) | MY173936A (enExample) |
| PL (2) | PL3527070T3 (enExample) |
| PT (2) | PT3527070T (enExample) |
| RS (2) | RS67678B1 (enExample) |
| RU (2) | RU2664181C2 (enExample) |
| SG (3) | SG11201403326VA (enExample) |
| SI (2) | SI3527070T1 (enExample) |
| SM (2) | SMT202500496T1 (enExample) |
| TR (1) | TR201903439T4 (enExample) |
| WO (1) | WO2013096142A1 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| LT2738259T (lt) | 2011-02-25 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Adam6 pelės |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| KR20140082824A (ko) * | 2011-10-17 | 2014-07-02 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US20180295821A1 (en) * | 2011-12-02 | 2018-10-18 | Kymab Limited | Transgenic Animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| NZ810648A (en) * | 2012-02-01 | 2025-11-28 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP3912464A1 (en) | 2012-06-12 | 2021-11-24 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| MY185881A (en) | 2013-02-20 | 2021-06-14 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| CA2925723A1 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| CN106255410B (zh) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | 产生单结构域结合蛋白的非人动物 |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| IL257411B2 (en) * | 2015-08-24 | 2024-05-01 | Trianni Inc | Enhanced production of immunoglobulins |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| WO2017214089A1 (en) * | 2016-06-06 | 2017-12-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing antibodies with human lambda light chains |
| PT4082334T (pt) * | 2016-11-04 | 2025-05-21 | Regeneron Pharma | Animais não humanos possuindo um lócus da cadeia leve lambda de immunoglobulina geneticamente modificada |
| US12016313B2 (en) * | 2017-01-19 | 2024-06-25 | Omniab Operations, Inc. | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| ES3065816T3 (en) | 2017-06-07 | 2026-05-08 | Regeneron Pharma | Compositions and methods for internalizing enzymes |
| TW202438676A (zh) * | 2017-12-05 | 2024-10-01 | 美商再生元醫藥公司 | 具有經改造免疫球蛋白λ輕鏈的非人類動物及其用途 |
| CN112040985A (zh) | 2018-02-07 | 2020-12-04 | 瑞泽恩制药公司 | 用于递送治疗性蛋白质的方法和组合物 |
| SG11202008799PA (en) * | 2018-03-24 | 2020-10-29 | Regeneron Pharma | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| BR112020023145A2 (pt) | 2018-05-17 | 2021-02-02 | Regeneron Pharmaceuticals, Inc. | anticorpo anti-cd63 ou fragmento de ligação ao antígeno do mesmo, molécula de ligação ao antígeno biespecífica, proteína terapêutica de múltiplos domínios, polinucleotídeo composição farmacêutica, e, composto |
| CN109359045B (zh) * | 2018-10-16 | 2022-01-04 | 武汉斗鱼网络科技有限公司 | 一种测试方法、装置、设备和存储介质 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146310A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| SG11202111258TA (en) * | 2019-06-05 | 2021-11-29 | Regeneron Pharma | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
| FI3993623T3 (fi) * | 2019-07-01 | 2025-05-25 | Zoetis Services Llc | Muuntogeeniset jyrsijät ja niiden käyttömenetelmät |
| DK3785536T4 (da) * | 2019-08-28 | 2025-10-27 | Trianni Inc | Adam6-knockin-mus |
| JP2023535345A (ja) * | 2020-07-13 | 2023-08-17 | キソジ・バイオテクノロジー・インコーポレイテッド | 重鎖抗体を発現するトランスジェニック動物 |
| KR20230066386A (ko) * | 2020-09-11 | 2023-05-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항원 특이적 항체의 확인 및 제조 |
| CN116249934A (zh) | 2020-10-02 | 2023-06-09 | 日亚化学工业株式会社 | 光源装置和导光阵列部 |
| KR20230084157A (ko) * | 2020-10-08 | 2023-06-12 | 주식회사 휴맵 | 인간화 면역글로불린 유전자좌를 포함하는 게놈을 가지는 형질전환 비인간-동물 제조방법 |
| AU2021400584A1 (en) | 2020-12-16 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| WO2022225985A1 (en) | 2021-04-20 | 2022-10-27 | Regeneron Pharmaceuticals, Inc. | Human antibodies to artemin and methods of use thereof |
| WO2024015816A1 (en) | 2022-07-12 | 2024-01-18 | Regeneron Pharmaceuticals, Inc. | Antibodies to ciliary neurotrophic factor receptor (cntfr) and methods of use thereof |
| KR20250150011A (ko) | 2023-02-13 | 2025-10-17 | 리제너론 파마슈티칼스 인코포레이티드 | 항-인간 cacng1 항체를 이용한 근육 관련 장애 치료 |
| CN121039163A (zh) | 2023-05-02 | 2025-11-28 | 瑞泽恩制药公司 | 抗人m-钙粘蛋白（cdh15）抗体、缀合物及其用于将遗传有效负载递送至肌肉细胞的用途 |
| IL325400A (en) | 2023-07-10 | 2026-02-01 | Regeneron Pharma | Anti-human CACNG1 antibody-drug conjugates and their uses |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| US20260123608A1 (en) | 2024-08-06 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
| WO2026096736A1 (en) | 2024-10-31 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Rodents expressing humanized polymeric immunoglobulin receptor |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU662148B2 (en) | 1991-04-10 | 1995-08-24 | Scripps Research Institute, The | Heterodimeric receptor libraries using phagemids |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| AU3328493A (en) * | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2149025A1 (en) | 1992-12-01 | 1994-06-09 | Man Sung Co | Humanized antibodies reactive with l-selectin |
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| EP0907726A4 (en) | 1996-06-26 | 2001-11-07 | Baylor College Medicine | CHROMOSOMAL REORDERING BY INSERTING TWO RECOMBINATION SUBSTRATES |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| CN1203922A (zh) | 1997-03-21 | 1999-01-06 | 三共株式会社 | 人源化抗人fas抗体 |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| AU754699C (en) * | 1998-03-30 | 2003-05-15 | Research Development Foundation | Corticotropin releasing factor receptor 1-deficient mice |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| RU10506U1 (ru) | 1999-04-08 | 1999-08-16 | Кривулин Виталий Николаевич | Ручной культиватор |
| JP2003501016A (ja) | 1999-05-27 | 2003-01-14 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | Ａｄａｍのポリヌクレオチドおよびポリペプチド |
| GB0001448D0 (en) | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| IL155977A0 (en) | 2000-11-30 | 2003-12-23 | Medarex Inc | Transgenic transchromosomal rodents for making human antibodies |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| GB0031284D0 (en) | 2000-12-21 | 2001-01-31 | Ks Biomedix Ltd | High affinity antibodies |
| US7034134B2 (en) | 2001-04-26 | 2006-04-25 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
| EP1970448A1 (en) | 2001-05-11 | 2008-09-17 | Kirin Pharma Kabushiki Kaisha | Human artificial chromosome containting human antibody lambda light chain and non-human animal containting the human artificial chromosome capable of genetic transmission |
| US7473557B2 (en) | 2001-06-06 | 2009-01-06 | Regeneron Pharmaceuticals, Inc. | Method for targeting transcriptionally active loci |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| AU2002319402B2 (en) | 2001-06-28 | 2008-09-11 | Domantis Limited | Dual-specific ligand and its use |
| US20030108925A1 (en) | 2001-10-05 | 2003-06-12 | U.S. Epa | Genetic testing for male factor infertility |
| US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
| EP3698626A1 (en) | 2001-11-30 | 2020-08-26 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
| US20030217171A1 (en) | 2002-05-17 | 2003-11-20 | Von Stuermer Wolfgang R. | Self-replicating and self-installing software apparatus |
| JP4099646B2 (ja) | 2002-06-04 | 2008-06-11 | 株式会社安川電機 | ボイスコイルモータ |
| EP1600459A3 (en) | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| EP2314629B2 (en) | 2002-07-18 | 2022-11-16 | Merus N.V. | Recombinant production of mixtures of antibodies |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| JP2006523090A (ja) | 2002-12-27 | 2006-10-12 | ドマンティス リミテッド | リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体 |
| GB0230201D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Retargeting |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| CN103205436B (zh) | 2003-07-15 | 2016-05-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| CN1605628A (zh) | 2003-09-03 | 2005-04-13 | 中国疾病预防控制中心病毒病预防控制所 | Cho细胞生产的人源抗甲肝病毒基因工程抗体 |
| RU2251699C1 (ru) | 2003-09-25 | 2005-05-10 | Киселев Всеволод Иванович | Способ ранней и доклинической диагностики цервикального рака |
| WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| ATE416465T1 (de) | 2005-06-30 | 2008-12-15 | Borealis Tech Oy | Überzug-schicht für energie- oder kommunikationskabel |
| GB0618345D0 (en) | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
| SG169348A1 (en) | 2006-01-25 | 2011-03-30 | Univ Erasmus Medical Ct | Generation of heavy-chain only antibodies in transgenic animals |
| GB0615327D0 (en) * | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| NZ587107A (en) | 2006-06-02 | 2012-05-25 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| WO2008022391A1 (en) | 2006-08-22 | 2008-02-28 | G2 Inflammation Pty Ltd | Method for producing antibodies |
| LT2769992T (lt) | 2006-10-02 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| WO2009097006A2 (en) | 2007-08-10 | 2009-08-06 | Medarex, Inc. | Hco32 and hco27 and related examples |
| US7659842B2 (en) | 2007-10-24 | 2010-02-09 | Infineon Technologies Ag | Quantization error reduction in PWM full-MASH converters |
| EP2271758B1 (en) | 2008-04-14 | 2018-09-12 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
| ES2436044T3 (es) | 2008-05-23 | 2013-12-26 | Ablexis, Llc | Procedimiento de generación de anticuerpos de dominio VL individual en animales transgénicos |
| WO2010039900A2 (en) | 2008-09-30 | 2010-04-08 | Aliva Biopharmaceuticals, Inc. | Non-human mammals for the production of chimeric antibodies |
| CA2747534C (en) | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| DK2509409T3 (en) | 2009-12-10 | 2016-11-14 | Regeneron Pharma | MICE, WHICH PRODUCES HEAVY CHAIN ANTIBODIES |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
| SI2480675T1 (sl) | 2010-06-22 | 2016-08-31 | Regeneron Pharmaceuticals, Inc. | Miši, ki izražajo lahko verigo s spremenljivo regijo humanega lambda in konstantno mišjo regijo |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| WO2012063048A1 (en) | 2010-11-08 | 2012-05-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
| LT2738259T (lt) * | 2011-02-25 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Adam6 pelės |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| KR20140082824A (ko) | 2011-10-17 | 2014-07-02 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| NZ810648A (en) | 2012-02-01 | 2025-11-28 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
-
2012
- 2012-12-17 PT PT191514710T patent/PT3527070T/pt unknown
- 2012-12-17 WO PCT/US2012/069981 patent/WO2013096142A1/en not_active Ceased
- 2012-12-17 CA CA2859408A patent/CA2859408C/en active Active
- 2012-12-17 IN IN6094DEN2014 patent/IN2014DN06094A/en unknown
- 2012-12-17 PL PL19151471.0T patent/PL3527070T3/pl unknown
- 2012-12-17 US US13/716,238 patent/US9706759B2/en active Active
- 2012-12-17 PL PL12809955T patent/PL2793567T3/pl unknown
- 2012-12-17 KR KR1020147020454A patent/KR101924805B1/ko active Active
- 2012-12-17 ME MEP-2019-143A patent/ME03477B/me unknown
- 2012-12-17 DK DK19151471.0T patent/DK3527070T3/da active
- 2012-12-17 RS RS20260066A patent/RS67678B1/sr unknown
- 2012-12-17 SI SI201232100T patent/SI3527070T1/sl unknown
- 2012-12-17 LT LTEP12809955.3T patent/LT2793567T/lt unknown
- 2012-12-17 SG SG11201403326VA patent/SG11201403326VA/en unknown
- 2012-12-17 HU HUE12809955 patent/HUE044266T2/hu unknown
- 2012-12-17 HR HRP20190897TT patent/HRP20190897T1/hr unknown
- 2012-12-17 FI FIEP19151471.0T patent/FI3527070T3/fi active
- 2012-12-17 RS RS20190641A patent/RS58761B1/sr unknown
- 2012-12-17 SG SG10201913164YA patent/SG10201913164YA/en unknown
- 2012-12-17 LT LTEP19151471.0T patent/LT3527070T/lt unknown
- 2012-12-17 MX MX2018006537A patent/MX378871B/es unknown
- 2012-12-17 SM SM20250496T patent/SMT202500496T1/it unknown
- 2012-12-17 HR HRP20260031TT patent/HRP20260031T1/hr unknown
- 2012-12-17 CN CN201280070209.4A patent/CN104159444B/zh active Active
- 2012-12-17 JP JP2014549157A patent/JP6327750B2/ja active Active
- 2012-12-17 AU AU2012323987A patent/AU2012323987B2/en active Active
- 2012-12-17 BR BR122021007339-2A patent/BR122021007339B1/pt active IP Right Grant
- 2012-12-17 EP EP25210833.7A patent/EP4696716A3/en active Pending
- 2012-12-17 ES ES12809955T patent/ES2720186T3/es active Active
- 2012-12-17 EP EP12809955.3A patent/EP2793567B1/en active Active
- 2012-12-17 KR KR1020187034431A patent/KR102038974B1/ko active Active
- 2012-12-17 KR KR1020207026010A patent/KR102186822B1/ko active Active
- 2012-12-17 SI SI201231572T patent/SI2793567T1/sl unknown
- 2012-12-17 KR KR1020207004911A patent/KR102156139B1/ko active Active
- 2012-12-17 SG SG10201605675WA patent/SG10201605675WA/en unknown
- 2012-12-17 PT PT12809955T patent/PT2793567T/pt unknown
- 2012-12-17 BR BR112014015238-1A patent/BR112014015238B1/pt active IP Right Grant
- 2012-12-17 KR KR1020197031617A patent/KR102081657B1/ko active Active
- 2012-12-17 DK DK12809955.3T patent/DK2793567T3/en active
- 2012-12-17 RU RU2014127339A patent/RU2664181C2/ru active
- 2012-12-17 MY MYPI2014001743A patent/MY173936A/en unknown
- 2012-12-17 SM SM20190296T patent/SMT201900296T1/it unknown
- 2012-12-17 RU RU2018119366A patent/RU2761639C2/ru active
- 2012-12-17 TR TR2019/03439T patent/TR201903439T4/tr unknown
- 2012-12-17 MX MX2014007682A patent/MX356429B/es active IP Right Grant
- 2012-12-17 ES ES19151471T patent/ES3057292T3/es active Active
- 2012-12-17 EP EP19151471.0A patent/EP3527070B1/en active Active
-
2013
- 2013-07-26 US US13/951,996 patent/US9622459B2/en active Active
-
2014
- 2014-06-16 IL IL233153A patent/IL233153B/en active IP Right Grant
- 2014-06-20 MX MX2021000298A patent/MX2021000298A/es unknown
-
2015
- 2015-10-07 AU AU2015238803A patent/AU2015238803B2/en active Active
-
2016
- 2016-12-13 JP JP2016240915A patent/JP2017046722A/ja not_active Withdrawn
-
2017
- 2017-05-02 US US15/585,023 patent/US10561124B2/en active Active
- 2017-10-26 AU AU2017251797A patent/AU2017251797B2/en active Active
-
2018
- 2018-04-09 IL IL258561A patent/IL258561B/en active IP Right Grant
- 2018-11-16 JP JP2018215387A patent/JP6728308B2/ja active Active
-
2019
- 2019-04-28 IL IL266268A patent/IL266268B/en active IP Right Grant
- 2019-05-17 CY CY20191100525T patent/CY1121638T1/el unknown
- 2019-12-30 US US16/729,852 patent/US11612151B2/en active Active
- 2019-12-30 US US16/729,798 patent/US11617357B2/en active Active
-
2020
- 2020-03-04 AU AU2020201596A patent/AU2020201596B2/en active Active
- 2020-07-01 JP JP2020113809A patent/JP7152447B2/ja active Active
-
2022
- 2022-08-24 AU AU2022221449A patent/AU2022221449A1/en not_active Abandoned
- 2022-09-29 JP JP2022156704A patent/JP7507823B2/ja active Active
-
2023
- 2023-02-15 US US18/110,276 patent/US12433266B2/en active Active
-
2024
- 2024-06-18 JP JP2024098071A patent/JP2024113207A/ja active Pending
-
2025
- 2025-04-17 AU AU2025202709A patent/AU2025202709A1/en active Pending
- 2025-09-08 US US19/322,193 patent/US20260123612A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015505477A5 (enExample) | ||
| RU2014127339A (ru) | Мыши с гуманизированной легкой цепью | |
| US20240057572A1 (en) | Animal Models and Therapeutic Molecules | |
| JP2018138047A5 (enExample) | ||
| IL268675A (en) | Humanized rodents that express heavy chains that include VL complexes | |
| JP2014524243A5 (enExample) | ||
| JP2015519076A5 (enExample) | ||
| JP2015525071A5 (enExample) | ||
| HRP20170322T1 (hr) | Miševi koji stvaraju vl vezne proteine | |
| JP2014110814A5 (enExample) | ||
| HRP20191680T1 (hr) | Neljudske životinje koje izražavaju antitijela sa zajedničkim lakim lancem | |
| RU2019121863A (ru) | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения | |
| JP2020530760A5 (enExample) | ||
| HRP20201403T1 (hr) | Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca | |
| HRP20160497T1 (hr) | Mišji hibridni laki lanac | |
| RU2014153673A (ru) | Гуманизированные не относящиеся к человеку животные с ограниченными локусами тяжелой цепи иммуноглобулина | |
| JP2015509380A5 (enExample) | ||
| JP2019047806A5 (enExample) | ||
| JP2013535213A5 (enExample) | ||
| JP2013532974A5 (enExample) | ||
| HRP20161551T4 (hr) | Miš sa zajedničkim lakim lancem | |
| HRP20230490T1 (hr) | Miševi koji izražavaju ograničeni repertoar lakog lanca imunoglobulina | |
| JP2014516518A5 (enExample) | ||
| JP2011182801A5 (enExample) | ||
| RU2016139418A (ru) | Мыши с ограниченной тяжелой цепью иммуноглобулина |