JP2015502177A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015502177A5 JP2015502177A5 JP2014549157A JP2014549157A JP2015502177A5 JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5 JP 2014549157 A JP2014549157 A JP 2014549157A JP 2014549157 A JP2014549157 A JP 2014549157A JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human animal
- gene segments
- item
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578097P | 2011-12-20 | 2011-12-20 | |
| US61/578,097 | 2011-12-20 | ||
| PCT/US2012/069981 WO2013096142A1 (en) | 2011-12-20 | 2012-12-17 | Humanized light chain mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Division JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502177A JP2015502177A (ja) | 2015-01-22 |
| JP2015502177A5 true JP2015502177A5 (enExample) | 2016-02-12 |
| JP6327750B2 JP6327750B2 (ja) | 2018-05-23 |
Family
ID=47501484
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549157A Active JP6327750B2 (ja) | 2011-12-20 | 2012-12-17 | ヒト化軽鎖マウス |
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9706759B2 (enExample) |
| EP (2) | EP2793567B1 (enExample) |
| JP (6) | JP6327750B2 (enExample) |
| KR (5) | KR102038974B1 (enExample) |
| CN (1) | CN104159444B (enExample) |
| AU (6) | AU2012323987B2 (enExample) |
| BR (2) | BR122021007339B1 (enExample) |
| CA (1) | CA2859408C (enExample) |
| CY (1) | CY1121638T1 (enExample) |
| DK (1) | DK2793567T3 (enExample) |
| ES (1) | ES2720186T3 (enExample) |
| FI (1) | FI3527070T3 (enExample) |
| HR (1) | HRP20190897T1 (enExample) |
| HU (1) | HUE044266T2 (enExample) |
| IL (3) | IL233153B (enExample) |
| IN (1) | IN2014DN06094A (enExample) |
| LT (1) | LT2793567T (enExample) |
| ME (1) | ME03477B (enExample) |
| MX (3) | MX378871B (enExample) |
| MY (1) | MY173936A (enExample) |
| PL (1) | PL2793567T3 (enExample) |
| PT (2) | PT3527070T (enExample) |
| RS (1) | RS58761B1 (enExample) |
| RU (2) | RU2761639C2 (enExample) |
| SG (3) | SG10201913164YA (enExample) |
| SI (1) | SI2793567T1 (enExample) |
| SM (2) | SMT202500496T1 (enExample) |
| TR (1) | TR201903439T4 (enExample) |
| WO (1) | WO2013096142A1 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2564695E (pt) | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| RU2612903C2 (ru) | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| PL4067496T3 (pl) | 2011-02-25 | 2023-07-31 | Regeneron Pharmaceuticals, Inc. | Myszy adam6 |
| RS66089B1 (sr) | 2011-08-05 | 2024-11-29 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| EP3839049A3 (en) | 2011-09-19 | 2021-10-20 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| JP2014531452A (ja) | 2011-09-19 | 2014-11-27 | カイマブ・リミテッド | 動物、レパートリーおよび方法 |
| EP2761008A1 (en) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| RU2743589C2 (ru) * | 2011-10-17 | 2021-02-20 | Регенерон Фармасьютикалс, Инк. | Мыши с ограниченной тяжелой цепью иммуноглобулина |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US20180295821A1 (en) * | 2011-12-02 | 2018-10-18 | Kymab Limited | Transgenic Animals |
| SI2793567T1 (sl) | 2011-12-20 | 2019-05-31 | Regeneron Pharmaceuticals, Inc. | Humanizirane lahkoverižne miši |
| HRP20192218T1 (hr) * | 2012-02-01 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi koji izražavaju teške lance koji sadrže vl domene |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| JP2015519076A (ja) * | 2012-06-12 | 2015-07-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| CN105734081A (zh) | 2013-02-20 | 2016-07-06 | 瑞泽恩制药公司 | 具有修饰的免疫球蛋白重链序列的非人类动物 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| EP3895528A1 (en) | 2014-03-21 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| JP2018508224A (ja) | 2015-03-19 | 2018-03-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗原を結合する軽鎖可変領域を選択する非ヒト動物 |
| CN108138200A (zh) * | 2015-08-24 | 2018-06-08 | 特里安尼公司 | 增强的免疫球蛋白产生 |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| CN109475109B (zh) | 2016-05-20 | 2021-10-29 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| WO2017214089A1 (en) * | 2016-06-06 | 2017-12-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing antibodies with human lambda light chains |
| SMT202000558T1 (it) * | 2016-11-04 | 2020-11-10 | Regeneron Pharma | Animali non umani aventi un locus di catena leggera di immunoglobulina lambda ingegnerizzata |
| EP3570668A1 (en) * | 2017-01-19 | 2019-11-27 | Open Monoclonal Technology, Inc. | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| IL271193B2 (en) | 2017-06-07 | 2025-01-01 | Regeneron Pharma | Preparations and methods for internalizing enzymes |
| PL4140297T3 (pl) * | 2017-12-05 | 2025-08-25 | Regeneron Pharmaceuticals, Inc. | Myszy mające zmodyfikowany sposobami inżynierii łańcuch lekki lambda immunoglobuliny i ich zastosowania |
| WO2019157224A1 (en) | 2018-02-07 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for therapeutic protein delivery |
| US20210051929A1 (en) * | 2018-03-24 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| AU2019269685B2 (en) | 2018-05-17 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Anti-CD63 antibodies, conjugates, and uses thereof |
| CN109359045B (zh) * | 2018-10-16 | 2022-01-04 | 武汉斗鱼网络科技有限公司 | 一种测试方法、装置、设备和存储介质 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146310A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2022535418A (ja) * | 2019-06-05 | 2022-08-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | カッパ遺伝子座から発現される限られたラムダ軽鎖レパートリーを有する非ヒト動物及びその使用 |
| DK3993623T3 (da) * | 2019-07-01 | 2025-05-26 | Zoetis Services Llc | Transgene gnavere og fremgangsmåder til anvendelse deraf |
| DK3785536T4 (da) * | 2019-08-28 | 2025-10-27 | Trianni Inc | Adam6-knockin-mus |
| CA3171186A1 (en) * | 2020-07-13 | 2022-01-20 | Wenyang HOU | Transgenic animals expressing heavy chain antibodies |
| JP2023540808A (ja) | 2020-09-11 | 2023-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗原特異的抗体の同定及び産生 |
| CN116249934A (zh) | 2020-10-02 | 2023-06-09 | 日亚化学工业株式会社 | 光源装置和导光阵列部 |
| US20240268360A1 (en) * | 2020-10-08 | 2024-08-15 | Humab Co., Ltd. | Method for preparing transgenic non-human animal having genome including humanized immunoglobulin gene locus |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| IL306128A (en) | 2021-04-20 | 2023-11-01 | Regeneron Pharma | Human antibodies to artemin and methods of using them |
| EP4554977A1 (en) | 2022-07-12 | 2025-05-21 | Regeneron Pharmaceuticals, Inc. | Antibodies to ciliary neurotrophic factor receptor (cntfr) and methods of use thereof |
| IL322397A (en) | 2023-02-13 | 2025-09-01 | Regeneron Pharma | Treating muscle-related disorders with anti-human CACNG1 antibodies |
| WO2024229105A1 (en) | 2023-05-02 | 2024-11-07 | Regeneron Pharmaceuticals, Inc. | Anti-human m-cadherin (cdh15) antibodies, conjugates, and uses thereof for delivery of genetic payloads to muscle cells |
| WO2025014533A1 (en) | 2023-07-10 | 2025-01-16 | Regeneron Pharmaceuticals, Inc. | Anti-human cacng1 antibody-drug conjugates and uses thereof |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| JPH07503132A (ja) * | 1991-12-17 | 1995-04-06 | ジェンファーム インターナショナル，インコーポレイティド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| HUT71790A (en) | 1992-12-01 | 1996-02-28 | Protein Design Labs | Humanized antibodies reactive with l-selectin |
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| CA2250830A1 (en) | 1996-06-26 | 1997-12-31 | Binhai Zheng | Chromosomal rearrangement by insertion of two recombination substrates |
| DK1500329T3 (da) | 1996-12-03 | 2012-07-09 | Amgen Fremont Inc | Humane antistoffer, der specifikt binder TNF-alfa |
| CN1203922A (zh) | 1997-03-21 | 1999-01-06 | 三共株式会社 | 人源化抗人fas抗体 |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| RU2236127C2 (ru) * | 1998-03-30 | 2004-09-20 | Рисерч Дивелопмент Фаундейшн | Способ получения трансгенной мыши, не содержащей функциональный рецептор-1 рилизинг-фактора кортикотропина, способ идентификации агониста или антагониста рилизинг-фактора кортикотропина, урокортина или лиганда семейства рилизинг-фактора кортикотропина и способ скрининга соединений, которые являются аналогами или агонистами кортикостерона или кортикотропина, с использованием такой мыши |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| RU10506U1 (ru) | 1999-04-08 | 1999-08-16 | Кривулин Виталий Николаевич | Ручной культиватор |
| EP1183344A4 (en) | 1999-05-27 | 2003-06-25 | Human Genome Sciences Inc | ADAM POLYNUCLEOTIDES AND POLYPEPTIDES |
| GB0001448D0 (en) | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7041870B2 (en) | 2000-11-30 | 2006-05-09 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| GB0031284D0 (en) | 2000-12-21 | 2001-01-31 | Ks Biomedix Ltd | High affinity antibodies |
| US7034134B2 (en) | 2001-04-26 | 2006-04-25 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
| CN100448992C (zh) | 2001-05-11 | 2009-01-07 | 麒麟医药株式会社 | 含人抗体λ轻链基因的人类人工染色体 |
| US7473557B2 (en) | 2001-06-06 | 2009-01-06 | Regeneron Pharmaceuticals, Inc. | Method for targeting transcriptionally active loci |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
| WO2003031656A1 (en) | 2001-10-05 | 2003-04-17 | United States Environmental Protection Agency | Genetic testing for male factor infertility |
| EP1461442B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
| US20030217171A1 (en) | 2002-05-17 | 2003-11-20 | Von Stuermer Wolfgang R. | Self-replicating and self-installing software apparatus |
| JP4099646B2 (ja) | 2002-06-04 | 2008-06-11 | 株式会社安川電機 | ボイスコイルモータ |
| PT2314629E (pt) | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| AU2003290330A1 (en) | 2002-12-27 | 2004-07-22 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| GB0230201D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Retargeting |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP1644417B1 (en) | 2003-07-15 | 2014-04-30 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| CN1605628A (zh) | 2003-09-03 | 2005-04-13 | 中国疾病预防控制中心病毒病预防控制所 | Cho细胞生产的人源抗甲肝病毒基因工程抗体 |
| RU2251699C1 (ru) | 2003-09-25 | 2005-05-10 | Киселев Всеволод Иванович | Способ ранней и доклинической диагностики цервикального рака |
| DK2767161T3 (en) | 2004-10-19 | 2018-05-07 | Regeneron Pharma | Method of generating an animal homozygous for genetic modification |
| PL1739691T3 (pl) | 2005-06-30 | 2009-06-30 | Borealis Tech Oy | Zewnętrzne osłony dla kabli elektroenergetycznych lub telekomunikacyjnych |
| GB0618345D0 (en) | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
| EP1991580A2 (en) | 2006-01-25 | 2008-11-19 | Erasmus University Medical Center Rotterdam | Generation of heavy-chain only antibodies in transgenic animals |
| GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| JP2010501165A (ja) | 2006-08-22 | 2010-01-21 | ジーツー インフラメイション プロプライエタリー リミテッド | 抗体の作製方法 |
| CA2664343C (en) | 2006-10-02 | 2016-04-26 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| EP2185692A4 (en) | 2007-08-10 | 2012-05-02 | Medarex Inc | HCO32 AND HCO27 AND RELATED EXAMPLES |
| US7659842B2 (en) | 2007-10-24 | 2010-02-09 | Infineon Technologies Ag | Quantization error reduction in PWM full-MASH converters |
| WO2009129247A2 (en) | 2008-04-14 | 2009-10-22 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
| EP2669298A3 (en) | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| LT2346994T (lt) * | 2008-09-30 | 2022-03-10 | Ablexis, Llc | Knock-in pelė, skirta chimerinių antikūnų gamybai |
| MX2011007660A (es) | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| PT2564695E (pt) | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| MY172472A (en) | 2009-12-10 | 2019-11-26 | Regeneron Pharma | Mice that make heavy chain antibodies |
| CA2789154C (en) | 2010-02-08 | 2024-06-11 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
| ME03386B (me) | 2010-06-22 | 2020-01-20 | Regeneron Pharma | Hibridni laki lanac imunoglobulina koji ispoljavaju miševi |
| RU2612903C2 (ru) | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| EP2638155A1 (en) | 2010-11-08 | 2013-09-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
| PL4067496T3 (pl) | 2011-02-25 | 2023-07-31 | Regeneron Pharmaceuticals, Inc. | Myszy adam6 |
| RS66089B1 (sr) | 2011-08-05 | 2024-11-29 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| JP2014531452A (ja) | 2011-09-19 | 2014-11-27 | カイマブ・リミテッド | 動物、レパートリーおよび方法 |
| EP3839049A3 (en) | 2011-09-19 | 2021-10-20 | Kymab Limited | Antibodies, variable domains & chains tailored for human use |
| EP2761008A1 (en) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| RU2743589C2 (ru) | 2011-10-17 | 2021-02-20 | Регенерон Фармасьютикалс, Инк. | Мыши с ограниченной тяжелой цепью иммуноглобулина |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| SI2793567T1 (sl) | 2011-12-20 | 2019-05-31 | Regeneron Pharmaceuticals, Inc. | Humanizirane lahkoverižne miši |
| HRP20192218T1 (hr) | 2012-02-01 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi koji izražavaju teške lance koji sadrže vl domene |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
-
2012
- 2012-12-17 SI SI201231572T patent/SI2793567T1/sl unknown
- 2012-12-17 WO PCT/US2012/069981 patent/WO2013096142A1/en not_active Ceased
- 2012-12-17 RS RS20190641A patent/RS58761B1/sr unknown
- 2012-12-17 TR TR2019/03439T patent/TR201903439T4/tr unknown
- 2012-12-17 RU RU2018119366A patent/RU2761639C2/ru active
- 2012-12-17 PT PT191514710T patent/PT3527070T/pt unknown
- 2012-12-17 KR KR1020187034431A patent/KR102038974B1/ko active Active
- 2012-12-17 MX MX2018006537A patent/MX378871B/es unknown
- 2012-12-17 BR BR122021007339-2A patent/BR122021007339B1/pt active IP Right Grant
- 2012-12-17 KR KR1020147020454A patent/KR101924805B1/ko active Active
- 2012-12-17 SG SG10201913164YA patent/SG10201913164YA/en unknown
- 2012-12-17 SG SG11201403326VA patent/SG11201403326VA/en unknown
- 2012-12-17 PL PL12809955T patent/PL2793567T3/pl unknown
- 2012-12-17 RU RU2014127339A patent/RU2664181C2/ru active
- 2012-12-17 US US13/716,238 patent/US9706759B2/en active Active
- 2012-12-17 KR KR1020197031617A patent/KR102081657B1/ko active Active
- 2012-12-17 IN IN6094DEN2014 patent/IN2014DN06094A/en unknown
- 2012-12-17 AU AU2012323987A patent/AU2012323987B2/en active Active
- 2012-12-17 KR KR1020207026010A patent/KR102186822B1/ko active Active
- 2012-12-17 HU HUE12809955 patent/HUE044266T2/hu unknown
- 2012-12-17 LT LTEP12809955.3T patent/LT2793567T/lt unknown
- 2012-12-17 ME MEP-2019-143A patent/ME03477B/me unknown
- 2012-12-17 MX MX2014007682A patent/MX356429B/es active IP Right Grant
- 2012-12-17 EP EP12809955.3A patent/EP2793567B1/en active Active
- 2012-12-17 SM SM20250496T patent/SMT202500496T1/it unknown
- 2012-12-17 CN CN201280070209.4A patent/CN104159444B/zh active Active
- 2012-12-17 JP JP2014549157A patent/JP6327750B2/ja active Active
- 2012-12-17 PT PT12809955T patent/PT2793567T/pt unknown
- 2012-12-17 SM SM20190296T patent/SMT201900296T1/it unknown
- 2012-12-17 CA CA2859408A patent/CA2859408C/en active Active
- 2012-12-17 HR HRP20190897TT patent/HRP20190897T1/hr unknown
- 2012-12-17 DK DK12809955.3T patent/DK2793567T3/en active
- 2012-12-17 SG SG10201605675WA patent/SG10201605675WA/en unknown
- 2012-12-17 FI FIEP19151471.0T patent/FI3527070T3/fi active
- 2012-12-17 KR KR1020207004911A patent/KR102156139B1/ko active Active
- 2012-12-17 ES ES12809955T patent/ES2720186T3/es active Active
- 2012-12-17 MY MYPI2014001743A patent/MY173936A/en unknown
- 2012-12-17 EP EP19151471.0A patent/EP3527070B1/en active Active
- 2012-12-17 BR BR112014015238-1A patent/BR112014015238B1/pt active IP Right Grant
-
2013
- 2013-07-26 US US13/951,996 patent/US9622459B2/en active Active
-
2014
- 2014-06-16 IL IL233153A patent/IL233153B/en active IP Right Grant
- 2014-06-20 MX MX2021000298A patent/MX2021000298A/es unknown
-
2015
- 2015-10-07 AU AU2015238803A patent/AU2015238803B2/en active Active
-
2016
- 2016-12-13 JP JP2016240915A patent/JP2017046722A/ja not_active Withdrawn
-
2017
- 2017-05-02 US US15/585,023 patent/US10561124B2/en active Active
- 2017-10-26 AU AU2017251797A patent/AU2017251797B2/en active Active
-
2018
- 2018-04-09 IL IL258561A patent/IL258561B/en active IP Right Grant
- 2018-11-16 JP JP2018215387A patent/JP6728308B2/ja active Active
-
2019
- 2019-04-28 IL IL266268A patent/IL266268B/en active IP Right Grant
- 2019-05-17 CY CY20191100525T patent/CY1121638T1/el unknown
- 2019-12-30 US US16/729,852 patent/US11612151B2/en active Active
- 2019-12-30 US US16/729,798 patent/US11617357B2/en active Active
-
2020
- 2020-03-04 AU AU2020201596A patent/AU2020201596B2/en active Active
- 2020-07-01 JP JP2020113809A patent/JP7152447B2/ja active Active
-
2022
- 2022-08-24 AU AU2022221449A patent/AU2022221449A1/en not_active Abandoned
- 2022-09-29 JP JP2022156704A patent/JP7507823B2/ja active Active
-
2023
- 2023-02-15 US US18/110,276 patent/US12433266B2/en active Active
-
2024
- 2024-06-18 JP JP2024098071A patent/JP2024113207A/ja active Pending
-
2025
- 2025-04-17 AU AU2025202709A patent/AU2025202709A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015502177A5 (enExample) | ||
| JP2015505477A5 (enExample) | ||
| RU2014127339A (ru) | Мыши с гуманизированной легкой цепью | |
| US20240057572A1 (en) | Animal Models and Therapeutic Molecules | |
| JP2018138047A5 (enExample) | ||
| IL268675A (en) | Humanized rodents that express heavy chains that include VL complexes | |
| JP2014524243A5 (enExample) | ||
| JP2015519076A5 (enExample) | ||
| JP2015525071A5 (enExample) | ||
| HRP20170322T1 (hr) | Miševi koji stvaraju vl vezne proteine | |
| JP2014110814A5 (enExample) | ||
| HRP20191680T1 (hr) | Neljudske životinje koje izražavaju antitijela sa zajedničkim lakim lancem | |
| RU2019121863A (ru) | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения | |
| JP2020530760A5 (enExample) | ||
| HRP20160497T1 (hr) | Mišji hibridni laki lanac | |
| RU2014153673A (ru) | Гуманизированные не относящиеся к человеку животные с ограниченными локусами тяжелой цепи иммуноглобулина | |
| HRP20201403T1 (hr) | Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca | |
| JP2015509380A5 (enExample) | ||
| JP2019047806A5 (enExample) | ||
| JP2013535213A5 (enExample) | ||
| JP2020501516A5 (enExample) | ||
| JP2013532974A5 (enExample) | ||
| HRP20161551T4 (hr) | Miš sa zajedničkim lakim lancem | |
| HRP20230490T1 (hr) | Miševi koji izražavaju ograničeni repertoar lakog lanca imunoglobulina | |
| JP2014516518A5 (enExample) |