JP2015502177A5 - - Google Patents
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- JP2015502177A5 JP2015502177A5 JP2014549157A JP2014549157A JP2015502177A5 JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5 JP 2014549157 A JP2014549157 A JP 2014549157A JP 2014549157 A JP2014549157 A JP 2014549157A JP 2015502177 A5 JP2015502177 A5 JP 2015502177A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human animal
- gene segments
- item
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578097P | 2011-12-20 | 2011-12-20 | |
| US61/578,097 | 2011-12-20 | ||
| PCT/US2012/069981 WO2013096142A1 (en) | 2011-12-20 | 2012-12-17 | Humanized light chain mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Division JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502177A JP2015502177A (ja) | 2015-01-22 |
| JP2015502177A5 true JP2015502177A5 (enExample) | 2016-02-12 |
| JP6327750B2 JP6327750B2 (ja) | 2018-05-23 |
Family
ID=47501484
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014549157A Active JP6327750B2 (ja) | 2011-12-20 | 2012-12-17 | ヒト化軽鎖マウス |
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016240915A Withdrawn JP2017046722A (ja) | 2011-12-20 | 2016-12-13 | ヒト化軽鎖マウス |
| JP2018215387A Active JP6728308B2 (ja) | 2011-12-20 | 2018-11-16 | ヒト化軽鎖マウス |
| JP2020113809A Active JP7152447B2 (ja) | 2011-12-20 | 2020-07-01 | ヒト化軽鎖マウス |
| JP2022156704A Active JP7507823B2 (ja) | 2011-12-20 | 2022-09-29 | ヒト化軽鎖マウス |
| JP2024098071A Pending JP2024113207A (ja) | 2011-12-20 | 2024-06-18 | ヒト化軽鎖マウス |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9706759B2 (enExample) |
| EP (3) | EP4696716A3 (enExample) |
| JP (6) | JP6327750B2 (enExample) |
| KR (5) | KR102156139B1 (enExample) |
| CN (1) | CN104159444B (enExample) |
| AU (6) | AU2012323987B2 (enExample) |
| BR (2) | BR112014015238B1 (enExample) |
| CA (1) | CA2859408C (enExample) |
| CY (1) | CY1121638T1 (enExample) |
| DK (2) | DK2793567T3 (enExample) |
| ES (2) | ES3057292T3 (enExample) |
| FI (1) | FI3527070T3 (enExample) |
| HR (2) | HRP20260031T1 (enExample) |
| HU (1) | HUE044266T2 (enExample) |
| IL (3) | IL233153B (enExample) |
| IN (1) | IN2014DN06094A (enExample) |
| LT (2) | LT3527070T (enExample) |
| ME (1) | ME03477B (enExample) |
| MX (3) | MX378871B (enExample) |
| MY (1) | MY173936A (enExample) |
| PL (2) | PL3527070T3 (enExample) |
| PT (2) | PT2793567T (enExample) |
| RS (2) | RS67678B1 (enExample) |
| RU (2) | RU2761639C2 (enExample) |
| SG (3) | SG10201605675WA (enExample) |
| SI (2) | SI2793567T1 (enExample) |
| SM (2) | SMT201900296T1 (enExample) |
| TR (1) | TR201903439T4 (enExample) |
| WO (1) | WO2013096142A1 (enExample) |
Families Citing this family (76)
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| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| SMT201700023T1 (it) | 2010-08-02 | 2017-03-08 | Regeneron Pharma | Topi che producono proteine leganti vl |
| ME02106B (me) | 2011-02-25 | 2015-10-20 | Regeneron Pharma | Miševi sa adam6 |
| HUE047278T2 (hu) | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| EP2758534B1 (en) | 2011-09-19 | 2020-04-29 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| SG11201401181YA (en) * | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US20180295821A1 (en) * | 2011-12-02 | 2018-10-18 | Kymab Limited | Transgenic Animals |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| SG10201605675WA (en) | 2011-12-20 | 2016-09-29 | Regeneron Pharma | Humanized light chain mice |
| EP3597038B1 (en) * | 2012-02-01 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Humanized rodents that express heavy chains containing vl domains |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| ME03551B (me) * | 2012-06-12 | 2020-07-20 | Regeneron Pharma | Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca |
| MY178882A (en) | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
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| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
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| CN113831407B (zh) | 2016-05-20 | 2024-06-11 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
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| BR112020023145A2 (pt) | 2018-05-17 | 2021-02-02 | Regeneron Pharmaceuticals, Inc. | anticorpo anti-cd63 ou fragmento de ligação ao antígeno do mesmo, molécula de ligação ao antígeno biespecífica, proteína terapêutica de múltiplos domínios, polinucleotídeo composição farmacêutica, e, composto |
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| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
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