JP2019076109A5 - - Google Patents
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- Publication number
- JP2019076109A5 JP2019076109A5 JP2019006738A JP2019006738A JP2019076109A5 JP 2019076109 A5 JP2019076109 A5 JP 2019076109A5 JP 2019006738 A JP2019006738 A JP 2019006738A JP 2019006738 A JP2019006738 A JP 2019006738A JP 2019076109 A5 JP2019076109 A5 JP 2019076109A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- gene segment
- mouse
- human immunoglobulin
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 112
- 241000699666 Mus <mouse, genus> Species 0.000 claims 51
- 108060003951 Immunoglobulin Proteins 0.000 claims 48
- 102000018358 immunoglobulin Human genes 0.000 claims 48
- 238000000034 method Methods 0.000 claims 28
- 210000004602 germ cell Anatomy 0.000 claims 19
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 15
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 15
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 12
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 12
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 10
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 5
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 5
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 5
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 5
- 101100060131 Mus musculus Cdk5rap2 gene Proteins 0.000 claims 4
- 229940072221 immunoglobulins Drugs 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 3
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 3
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 3
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000699670 Mus sp. Species 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 101150084750 1 gene Proteins 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
| US13/798,455 | 2013-03-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502035A Division JP6529957B2 (ja) | 2013-03-13 | 2014-03-13 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148806A Division JP7010902B2 (ja) | 2013-03-13 | 2019-08-14 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019076109A JP2019076109A (ja) | 2019-05-23 |
| JP2019076109A5 true JP2019076109A5 (enExample) | 2019-07-04 |
| JP6790136B2 JP6790136B2 (ja) | 2020-11-25 |
Family
ID=50483561
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502035A Active JP6529957B2 (ja) | 2013-03-13 | 2014-03-13 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019006738A Active JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019148806A Active JP7010902B2 (ja) | 2013-03-13 | 2019-08-14 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2020128111A Pending JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502035A Active JP6529957B2 (ja) | 2013-03-13 | 2014-03-13 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148806A Active JP7010902B2 (ja) | 2013-03-13 | 2019-08-14 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2020128111A Pending JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Country Status (26)
| Country | Link |
|---|---|
| EP (4) | EP2967013B1 (enExample) |
| JP (4) | JP6529957B2 (enExample) |
| KR (2) | KR102295842B1 (enExample) |
| CN (2) | CN108611369B (enExample) |
| AU (3) | AU2014244020B2 (enExample) |
| BR (1) | BR112015022034B1 (enExample) |
| CA (1) | CA2903698C (enExample) |
| CY (1) | CY1121545T1 (enExample) |
| DK (2) | DK3501272T5 (enExample) |
| ES (3) | ES2712207T3 (enExample) |
| FI (1) | FI3501272T3 (enExample) |
| HR (2) | HRP20190706T1 (enExample) |
| HU (2) | HUE044003T2 (enExample) |
| IL (2) | IL240563B (enExample) |
| LT (2) | LT3501272T (enExample) |
| MX (3) | MX357308B (enExample) |
| PL (2) | PL3501272T3 (enExample) |
| PT (2) | PT3501272T (enExample) |
| RS (2) | RS58669B1 (enExample) |
| RU (1) | RU2689664C2 (enExample) |
| SG (2) | SG11201506278RA (enExample) |
| SI (2) | SI2967013T1 (enExample) |
| SM (2) | SMT202300112T1 (enExample) |
| TR (1) | TR201901668T4 (enExample) |
| WO (1) | WO2014160202A1 (enExample) |
| ZA (2) | ZA201505835B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT201900372T1 (it) | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| HUE068728T2 (hu) | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| PL3216871T3 (pl) | 2011-10-17 | 2022-03-21 | Regeneron Pharmaceuticals, Inc. | Ograniczony łańcuch ciężki immonoglobuliny pochodzącej od myszy |
| EP2858487B1 (en) | 2012-06-12 | 2019-10-23 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| RS57582B1 (sr) * | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| IL260526B2 (en) | 2016-01-13 | 2023-10-01 | Regeneron Pharma | Rodents having an engineered heavy chain diversity region |
| WO2019067682A1 (en) * | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | BISPECIFIC ANTIGEN-BINDING MOLECULES BINDING TO TARGET STAPHYLOCOCCUS ANTIGEN AND COMPONENT COMPONENT, AND USES THEREOF |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| US12467062B2 (en) | 2018-12-21 | 2025-11-11 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| AU2020226445B2 (en) | 2019-02-18 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| EP3927153A1 (en) | 2019-02-22 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| AU2021283564B2 (en) | 2020-06-02 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| JP7758739B2 (ja) | 2020-12-23 | 2025-10-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンカー改変型抗体をコードする核酸およびその使用 |
| AU2021409906A1 (en) | 2020-12-23 | 2023-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
| TW202430641A (zh) * | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| EP2505058A1 (en) * | 2006-03-31 | 2012-10-03 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| ITMI20071522A1 (it) * | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| RU2559524C2 (ru) * | 2008-06-27 | 2015-08-10 | Мерюс Б.В. | Продуцирующие антитела млекопитающие, не являющиеся человеком |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| MX368932B (es) | 2009-06-26 | 2019-10-22 | Regeneron Pharma | Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original. |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| SMT201900372T1 (it) * | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SI2480676T1 (sl) * | 2010-06-22 | 2016-10-28 | Regeneron Pharmaceuticals, Inc. | Hibridna mišja lahka veriga |
| RU2612903C2 (ru) * | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| HUE068728T2 (hu) * | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
-
2014
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active Active
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active Active
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 SM SM20230112T patent/SMT202300112T1/it unknown
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 EP EP24223729.5A patent/EP4545567A3/en active Pending
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en not_active Ceased
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 MX MX2018008279A patent/MX377146B/es unknown
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 DK DK18210518.9T patent/DK3501272T5/da active
- 2014-03-13 EP EP23151398.7A patent/EP4218409B1/en active Active
- 2014-03-13 MX MX2020010837A patent/MX391010B/es unknown
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
- 2014-03-13 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2014-03-13 SM SM20190196T patent/SMT201900196T1/it unknown
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 ES ES23151398T patent/ES3013063T3/es active Active
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2015
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
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2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
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2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
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2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
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2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
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2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783A1/en active Pending
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