MX357308B - Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. - Google Patents
Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina.Info
- Publication number
- MX357308B MX357308B MX2015012539A MX2015012539A MX357308B MX 357308 B MX357308 B MX 357308B MX 2015012539 A MX2015012539 A MX 2015012539A MX 2015012539 A MX2015012539 A MX 2015012539A MX 357308 B MX357308 B MX 357308B
- Authority
- MX
- Mexico
- Prior art keywords
- light chain
- chain variable
- immunoglobulin light
- mice expressing
- mice
- Prior art date
Links
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 title abstract 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 title abstract 3
- 241000699670 Mus sp. Species 0.000 title abstract 3
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un ratón genéticamente modificado, en donde el ratón expresa un repertorio de cadena ligera de inmunoglobulina caracterizado por un número limitado de dominios variables de cadena ligera. Se proporcionan ratones que presentan una elección de dos segmentos genéticos variables de cadena ligera humanos, de tal manera que las cadenas ligeras de inmunoglobulina expresada por el ratón comprenden uno de los dos segmentos genéticos variables de cadena ligera humanos. Se proporcionan métodos para la elaboración de anticuerpos biespecíficos que tienen cadenas ligeras universales utilizando ratones, como se describe en la presente, incluyendo regiones variables de cadena ligera humanas. Se proporcionan métodos para la elaboración de regiones variables humanas adecuadas para utilizarse en proteínas de enlace multiespecíficas, por ejemplo, anticuerpos biespecíficos, y células huésped.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
| PCT/US2014/026040 WO2014160202A1 (en) | 2013-03-13 | 2014-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015012539A MX2015012539A (es) | 2016-06-28 |
| MX357308B true MX357308B (es) | 2018-07-04 |
Family
ID=50483561
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012539A MX357308B (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
| MX2020010837A MX2020010837A (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010837A MX2020010837A (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
Country Status (26)
| Country | Link |
|---|---|
| EP (3) | EP3501272B1 (es) |
| JP (4) | JP6529957B2 (es) |
| KR (2) | KR102424756B1 (es) |
| CN (2) | CN105188357B (es) |
| AU (3) | AU2014244020B2 (es) |
| BR (1) | BR112015022034B1 (es) |
| CA (1) | CA2903698C (es) |
| CY (1) | CY1121545T1 (es) |
| DK (2) | DK3501272T5 (es) |
| ES (2) | ES2942413T3 (es) |
| FI (1) | FI3501272T3 (es) |
| HK (1) | HK1218493A1 (es) |
| HR (2) | HRP20230490T1 (es) |
| HU (2) | HUE061977T2 (es) |
| IL (2) | IL240563B (es) |
| LT (2) | LT2967013T (es) |
| MX (2) | MX357308B (es) |
| PL (2) | PL2967013T3 (es) |
| PT (2) | PT2967013T (es) |
| RS (2) | RS58669B1 (es) |
| RU (1) | RU2689664C2 (es) |
| SG (2) | SG11201506278RA (es) |
| SI (2) | SI2967013T1 (es) |
| TR (1) | TR201901668T4 (es) |
| WO (1) | WO2014160202A1 (es) |
| ZA (2) | ZA201505835B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| RU2724663C2 (ru) | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
| MY172718A (en) | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
| SG10202010120XA (en) | 2011-10-17 | 2020-11-27 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| KR102436654B1 (ko) | 2012-06-12 | 2022-08-26 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 |
| LT2840892T (lt) * | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
| KR102601491B1 (ko) | 2014-03-21 | 2023-11-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| CA3011359A1 (en) | 2016-01-13 | 2017-07-20 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| BR112020004977A2 (pt) * | 2017-09-29 | 2020-10-06 | Regeneron Pharmaceuticals, Inc. | moléculas de ligação de antígenos biespecíficas que ligam antígeno alvo de staphyocococcus e componente de complemento e usos dos mesmos |
| IL305557A (en) | 2018-06-14 | 2023-10-01 | Regeneron Pharma | Non-human animals with transgenic DH–DH rearrangement capacity, and their uses |
| US20220090125A1 (en) * | 2018-12-21 | 2022-03-24 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| BR112021016173A2 (pt) | 2019-02-22 | 2021-11-03 | Regeneron Pharma | Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| EP4158034A4 (en) | 2020-06-02 | 2024-07-03 | Biocytogen Pharmaceuticals Beijing Co Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMALS HAVING A LIGHT-CHAIN IMMUNOGLOBULIN LOCUS |
| BR112023011689A2 (pt) | 2020-12-23 | 2023-10-31 | Regeneron Pharma | Método para obter uma célula produtora de anticorpos, anticorpo, e, célula hospedeira de mamífero |
| US20240317849A1 (en) | 2020-12-23 | 2024-09-26 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
| US20240263190A1 (en) * | 2023-01-18 | 2024-08-08 | Gilead Sciences, Inc. | Human immunoglobulin binary light chain transgene constructs and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| EP2505058A1 (en) * | 2006-03-31 | 2012-10-03 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| PL2041177T3 (pl) | 2006-06-02 | 2012-09-28 | Regeneron Pharma | Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6 |
| ITMI20071522A1 (it) * | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| ES2906344T3 (es) * | 2008-06-27 | 2022-04-18 | Merus Nv | Animal murino transgénico productor de anticuerpos |
| RU2011129459A (ru) * | 2008-12-18 | 2013-01-27 | Эрасмус Юниверсити Медикал Сентр Роттердам | Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение |
| EP3916011A1 (en) | 2009-06-26 | 2021-12-01 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| RU2724663C2 (ru) * | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| JP6009441B2 (ja) * | 2010-06-22 | 2016-10-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ハイブリッド軽鎖マウス |
| NZ606824A (en) * | 2010-08-02 | 2015-05-29 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| MY172718A (en) * | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
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2014
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 DK DK18210518.9T patent/DK3501272T5/da active
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 MX MX2020010837A patent/MX2020010837A/es unknown
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 EP EP23151398.7A patent/EP4218409A3/en active Pending
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en active Application Filing
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active IP Right Grant
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active IP Right Grant
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
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2015
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
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2016
- 2016-06-06 HK HK16106453.9A patent/HK1218493A1/zh unknown
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2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
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2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-04-16 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
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2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
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2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
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2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783A1/en active Pending
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