MX2015012539A - Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. - Google Patents
Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina.Info
- Publication number
- MX2015012539A MX2015012539A MX2015012539A MX2015012539A MX2015012539A MX 2015012539 A MX2015012539 A MX 2015012539A MX 2015012539 A MX2015012539 A MX 2015012539A MX 2015012539 A MX2015012539 A MX 2015012539A MX 2015012539 A MX2015012539 A MX 2015012539A
- Authority
- MX
- Mexico
- Prior art keywords
- light chain
- chain variable
- immunoglobulin light
- mice expressing
- mice
- Prior art date
Links
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 title abstract 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 title abstract 3
- 241000699670 Mus sp. Species 0.000 title abstract 3
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se proporciona un ratón genéticamente modificado, en donde el ratón expresa un repertorio de cadena ligera de inmunoglobulina caracterizado por un número limitado de dominios variables de cadena ligera. Se proporcionan ratones que presentan una elección de dos segmentos genéticos variables de cadena ligera humanos, de tal manera que las cadenas ligeras de inmunoglobulina expresada por el ratón comprenden uno de los dos segmentos genéticos variables de cadena ligera humanos. Se proporcionan métodos para la elaboración de anticuerpos biespecíficos que tienen cadenas ligeras universales utilizando ratones, como se describe en la presente, incluyendo regiones variables de cadena ligera humanas. Se proporcionan métodos para la elaboración de regiones variables humanas adecuadas para utilizarse en proteínas de enlace multiespecíficas, por ejemplo, anticuerpos biespecíficos, y células huésped.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
| PCT/US2014/026040 WO2014160202A1 (en) | 2013-03-13 | 2014-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015012539A true MX2015012539A (es) | 2016-06-28 |
| MX357308B MX357308B (es) | 2018-07-04 |
Family
ID=50483561
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010837A MX2020010837A (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
| MX2015012539A MX357308B (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010837A MX2020010837A (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
Country Status (26)
| Country | Link |
|---|---|
| EP (3) | EP3501272B1 (es) |
| JP (4) | JP6529957B2 (es) |
| KR (2) | KR102424756B1 (es) |
| CN (2) | CN108611369B (es) |
| AU (3) | AU2014244020B2 (es) |
| BR (1) | BR112015022034B1 (es) |
| CA (1) | CA2903698C (es) |
| CY (1) | CY1121545T1 (es) |
| DK (2) | DK2967013T3 (es) |
| ES (2) | ES2712207T3 (es) |
| FI (1) | FI3501272T3 (es) |
| HK (1) | HK1218493A1 (es) |
| HR (2) | HRP20230490T1 (es) |
| HU (2) | HUE044003T2 (es) |
| IL (2) | IL240563B (es) |
| LT (2) | LT2967013T (es) |
| MX (2) | MX2020010837A (es) |
| PL (2) | PL2967013T3 (es) |
| PT (2) | PT2967013T (es) |
| RS (2) | RS64185B1 (es) |
| RU (1) | RU2689664C2 (es) |
| SG (2) | SG11201506278RA (es) |
| SI (2) | SI2967013T1 (es) |
| TR (1) | TR201901668T4 (es) |
| WO (1) | WO2014160202A1 (es) |
| ZA (2) | ZA201505835B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3095871T1 (sl) | 2010-02-08 | 2019-06-28 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| RS61946B1 (sr) | 2011-08-05 | 2021-07-30 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lakca |
| EP3216871B1 (en) | 2011-10-17 | 2021-12-22 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
| EP3597037B1 (en) | 2012-06-12 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| DK2840892T3 (en) * | 2013-02-20 | 2018-07-23 | Regeneron Pharma | Non-human animals with modified heavy chain immunoglobulin sequences |
| US10881085B2 (en) | 2014-03-21 | 2021-01-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| MX2018008701A (es) | 2016-01-13 | 2019-06-06 | Regeneron Pharma | Roedores que tienen una region de diversidad de cadena pesada modificada geneticamente. |
| WO2019067682A1 (en) * | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | BISPECIFIC ANTIGEN-BINDING MOLECULES BINDING TO TARGET STAPHYLOCOCCUS ANTIGEN AND COMPONENT COMPONENT, AND USES THEREOF |
| SI3629720T1 (sl) | 2018-06-14 | 2022-04-29 | Regeneron Pharmaceuticals, Inc. | Nehumane živali zmožne prerazporeditve DH-DH v kodirnih zaporedjih težke verige imunoglobulina |
| US20220090125A1 (en) * | 2018-12-21 | 2022-03-24 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| CN117099741A (zh) | 2019-02-18 | 2023-11-24 | 百奥赛图(北京)医药科技股份有限公司 | 具有人源化免疫球蛋白基因座的经遗传修饰的非人动物 |
| CN113473850A (zh) | 2019-02-22 | 2021-10-01 | 瑞泽恩制药公司 | 具有遗传修饰的钠通道的啮齿动物及其使用方法 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| WO2021244522A1 (en) | 2020-06-02 | 2021-12-09 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| BR112023011689A2 (pt) | 2020-12-23 | 2023-10-31 | Regeneron Pharma | Método para obter uma célula produtora de anticorpos, anticorpo, e, célula hospedeira de mamífero |
| US20220195014A1 (en) | 2020-12-23 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| DK2767161T3 (en) | 2004-10-19 | 2018-05-07 | Regeneron Pharma | Method of generating an animal homozygous for genetic modification |
| WO2007117410A2 (en) * | 2006-03-31 | 2007-10-18 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| MX2008014804A (es) | 2006-06-02 | 2009-01-27 | Regeneron Pharma | Anticuerpos de afinidad elevada a receptor de il-6 humano. |
| ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| AU2009263082C1 (en) * | 2008-06-27 | 2018-11-01 | Merus N.V. | Antibody producing non-human mammals |
| AU2009329365B2 (en) * | 2008-12-18 | 2016-01-14 | Roger Kingdon Craig | Non-human transgenic animals expressing humanised antibodies and use thereof |
| CN102471378B (zh) | 2009-06-26 | 2014-04-02 | 瑞泽恩制药公司 | 容易地分离的具有天然免疫球蛋白形式的双特异性抗体 |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| SI3095871T1 (sl) * | 2010-02-08 | 2019-06-28 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| IL300712A (en) * | 2010-06-22 | 2023-04-01 | Regeneron Pharma | Mice with light chain to human |
| DK2601298T3 (en) * | 2010-08-02 | 2017-02-27 | Regeneron Pharma | Mice generating binding proteins comprising VL domains |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| RS61946B1 (sr) * | 2011-08-05 | 2021-07-30 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lakca |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
-
2014
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active IP Right Grant
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 MX MX2020010837A patent/MX2020010837A/es unknown
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en active Application Filing
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active IP Right Grant
- 2014-03-13 DK DK18210518.9T patent/DK3501272T3/da active
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 EP EP23151398.7A patent/EP4218409A3/en active Pending
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
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2015
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
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2016
- 2016-06-06 HK HK16106453.9A patent/HK1218493A1/zh unknown
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2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
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2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-04-16 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
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2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
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2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
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2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |