JP6529957B2 - 限られた免疫グロブリン軽鎖レパートリーを発現するマウス - Google Patents

限られた免疫グロブリン軽鎖レパートリーを発現するマウス Download PDF

Info

Publication number
JP6529957B2
JP6529957B2 JP2016502035A JP2016502035A JP6529957B2 JP 6529957 B2 JP6529957 B2 JP 6529957B2 JP 2016502035 A JP2016502035 A JP 2016502035A JP 2016502035 A JP2016502035 A JP 2016502035A JP 6529957 B2 JP6529957 B2 JP 6529957B2
Authority
JP
Japan
Prior art keywords
human
mouse
light chain
heavy chain
human immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016502035A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016512034A (ja
JP2016512034A5 (enExample
Inventor
ロバート バブ，
ロバート バブ，
ジョン ミクウィルター，
ジョン ミクウィルター，
リン マクドナルド，
リン マクドナルド，
ショーン スティーブンズ，
ショーン スティーブンズ，
サミュエル デイビス，
サミュエル デイビス，
デイビッド アール． バックラー，
デイビッド アール． バックラー，
カロライナ エー． ミーガー，
カロライナ エー． ミーガー，
アンドリュー ジェイ． マーフィー，
アンドリュー ジェイ． マーフィー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/798,455 external-priority patent/US9796788B2/en
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of JP2016512034A publication Critical patent/JP2016512034A/ja
Publication of JP2016512034A5 publication Critical patent/JP2016512034A5/ja
Application granted granted Critical
Publication of JP6529957B2 publication Critical patent/JP6529957B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016502035A 2013-03-13 2014-03-13 限られた免疫グロブリン軽鎖レパートリーを発現するマウス Active JP6529957B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/798,455 2013-03-13
US13/798,455 US9796788B2 (en) 2010-02-08 2013-03-13 Mice expressing a limited immunoglobulin light chain repertoire
PCT/US2014/026040 WO2014160202A1 (en) 2013-03-13 2014-03-13 Mice expressing a limited immunoglobulin light chain repertoire

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019006738A Division JP6790136B2 (ja) 2013-03-13 2019-01-18 限られた免疫グロブリン軽鎖レパートリーを発現するマウス

Publications (3)

Publication Number Publication Date
JP2016512034A JP2016512034A (ja) 2016-04-25
JP2016512034A5 JP2016512034A5 (enExample) 2017-06-01
JP6529957B2 true JP6529957B2 (ja) 2019-06-12

Family

ID=50483561

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016502035A Active JP6529957B2 (ja) 2013-03-13 2014-03-13 限られた免疫グロブリン軽鎖レパートリーを発現するマウス
JP2019006738A Active JP6790136B2 (ja) 2013-03-13 2019-01-18 限られた免疫グロブリン軽鎖レパートリーを発現するマウス
JP2019148806A Active JP7010902B2 (ja) 2013-03-13 2019-08-14 限られた免疫グロブリン軽鎖レパートリーを発現するマウス
JP2020128111A Pending JP2020182490A (ja) 2013-03-13 2020-07-29 限られた免疫グロブリン軽鎖レパートリーを発現するマウス

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019006738A Active JP6790136B2 (ja) 2013-03-13 2019-01-18 限られた免疫グロブリン軽鎖レパートリーを発現するマウス
JP2019148806A Active JP7010902B2 (ja) 2013-03-13 2019-08-14 限られた免疫グロブリン軽鎖レパートリーを発現するマウス
JP2020128111A Pending JP2020182490A (ja) 2013-03-13 2020-07-29 限られた免疫グロブリン軽鎖レパートリーを発現するマウス

Country Status (26)

Country Link
EP (4) EP2967013B1 (enExample)
JP (4) JP6529957B2 (enExample)
KR (2) KR102295842B1 (enExample)
CN (2) CN105188357B (enExample)
AU (3) AU2014244020B2 (enExample)
BR (1) BR112015022034B1 (enExample)
CA (1) CA2903698C (enExample)
CY (1) CY1121545T1 (enExample)
DK (2) DK2967013T3 (enExample)
ES (3) ES3013063T3 (enExample)
FI (1) FI3501272T3 (enExample)
HR (2) HRP20230490T1 (enExample)
HU (2) HUE061977T2 (enExample)
IL (2) IL240563B (enExample)
LT (2) LT2967013T (enExample)
MX (3) MX357308B (enExample)
PL (2) PL3501272T3 (enExample)
PT (2) PT2967013T (enExample)
RS (2) RS58669B1 (enExample)
RU (1) RU2689664C2 (enExample)
SG (2) SG11201506278RA (enExample)
SI (2) SI2967013T1 (enExample)
SM (2) SMT202300112T1 (enExample)
TR (1) TR201901668T4 (enExample)
WO (1) WO2014160202A1 (enExample)
ZA (2) ZA201505835B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG183149A1 (en) 2010-02-08 2012-09-27 Regeneron Pharma Common light chain mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
ES2872081T3 (es) 2011-08-05 2021-11-02 Regeneron Pharma Ratones con cadena ligera universal humanizada
EP4074833A1 (en) 2011-10-17 2022-10-19 Regeneron Pharmaceuticals, Inc. Restricted immunoglobulin heavy chain mice
NZ703689A (en) 2012-06-12 2016-05-27 Regeneron Pharma Humanized non-human animals with restricted immunoglobulin heavy chain loci
RS57582B1 (sr) * 2013-02-20 2018-11-30 Regeneron Pharma Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca
AU2015230938C1 (en) 2014-03-21 2021-10-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
CN107438622A (zh) 2015-03-19 2017-12-05 瑞泽恩制药公司 选择结合抗原的轻链可变区的非人动物
US20190037816A1 (en) 2016-01-13 2019-02-07 Regeneron Pharmaceuticals, Inc. Rodents having an engineered heavy chain diversity region
BR112020004977A2 (pt) * 2017-09-29 2020-10-06 Regeneron Pharmaceuticals, Inc. moléculas de ligação de antígenos biespecíficas que ligam antígeno alvo de staphyocococcus e componente de complemento e usos dos mesmos
IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
EP3897117A1 (en) * 2018-12-21 2021-10-27 Compass Therapeutics LLC Transgenic mouse expressing common human light chain
WO2020169022A1 (en) 2019-02-18 2020-08-27 Beijing Biocytogen Co., Ltd Genetically modified non-human animals with humanized immunoglobulin locus
BR112021016173A2 (pt) 2019-02-22 2021-11-03 Regeneron Pharma Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
CN115667532A (zh) 2020-06-02 2023-01-31 百奥赛图(北京)医药科技股份有限公司 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物
CA3197426A1 (en) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same
MX2023007401A (es) 2020-12-23 2023-07-06 Regeneron Pharma Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos.
CN114736927A (zh) * 2022-05-19 2022-07-12 东北大学 一种单抗克隆与表达载体的构建及应用
TW202615661A (zh) * 2023-01-18 2026-04-16 美商基利科學股份有限公司 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途
US20260022395A1 (en) * 2024-07-16 2026-01-22 Gilead Sciences, Inc. Human immunoglobulin common light chain transgene constructs and uses thereof
CN121628915A (zh) * 2024-08-29 2026-03-10 上海泰槿生物技术有限公司 产生限制的免疫球蛋白轻链库的细胞、动物和方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041871B1 (en) * 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
MXPA06000562A (es) * 2003-07-15 2006-03-30 Therapeutic Human Polyclonals Loci de inmunoglobulina humanizada.
EP1802193B1 (en) 2004-10-19 2014-04-30 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
JP5514539B2 (ja) * 2006-03-31 2014-06-04 メダレックス・リミテッド・ライアビリティ・カンパニー ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物
ATE537190T1 (de) 2006-06-02 2011-12-15 Regeneron Pharma Hochaffine antikörper gegen den humanen il-6- rezeptor
ITMI20071522A1 (it) 2007-07-27 2009-01-28 Areta Internat S R L Vaccino idiotipico
EP3456191A1 (en) * 2008-06-27 2019-03-20 Merus N.V. Antibody producing non-human mammals
KR101711222B1 (ko) * 2008-12-18 2017-02-28 에라스무스 유니버시티 메디컬 센터 로테르담 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용
TWI507525B (zh) 2009-06-26 2015-11-11 Regeneron Pharma 具天然免疫球蛋白形式之易分離的雙專一性抗體
US20130045492A1 (en) * 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
SG183149A1 (en) * 2010-02-08 2012-09-27 Regeneron Pharma Common light chain mouse
US20120021409A1 (en) * 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
MY195217A (en) * 2010-06-22 2023-01-11 Regeneron Pharma MICE Expressing An Immunoglobulin Hybrid Light Chain
EP2601298B1 (en) * 2010-08-02 2016-11-30 Regeneron Pharmaceuticals, Inc. Mice that make binding proteins comprising vl domains
RU2460287C1 (ru) * 2011-03-29 2012-09-10 Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии
ES2872081T3 (es) * 2011-08-05 2021-11-02 Regeneron Pharma Ratones con cadena ligera universal humanizada
GB201122047D0 (en) * 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals

Also Published As

Publication number Publication date
EP4218409B1 (en) 2025-02-12
CN108611369B (zh) 2022-08-26
CA2903698C (en) 2023-02-28
JP2016512034A (ja) 2016-04-25
SMT201900196T1 (it) 2019-05-10
HK1218493A1 (en) 2017-02-24
KR20210107911A (ko) 2021-09-01
SI2967013T1 (sl) 2019-03-29
MX377146B (es) 2025-03-07
KR20150126871A (ko) 2015-11-13
RU2015143110A (ru) 2017-04-18
WO2014160202A1 (en) 2014-10-02
BR112015022034B1 (pt) 2023-02-28
PL3501272T3 (pl) 2023-07-03
EP3501272A1 (en) 2019-06-26
RS58669B1 (sr) 2019-06-28
RU2689664C2 (ru) 2019-05-28
IL240563B (en) 2021-03-25
KR102424756B1 (ko) 2022-07-25
IL280892B1 (en) 2023-01-01
JP2019076109A (ja) 2019-05-23
EP4218409C0 (en) 2025-02-12
SG10201801101QA (en) 2018-04-27
EP4545567A3 (en) 2025-08-13
HUE044003T2 (hu) 2019-09-30
TR201901668T4 (tr) 2019-02-21
IL280892A (en) 2021-04-29
AU2020203238A1 (en) 2020-06-11
DK2967013T3 (en) 2019-03-11
PT2967013T (pt) 2019-04-03
ES3013063T3 (en) 2025-04-10
MX2020010837A (es) 2022-03-28
CN105188357B (zh) 2018-04-24
AU2020203238B2 (en) 2023-04-13
IL280892B2 (en) 2023-05-01
MX2015012539A (es) 2016-06-28
CN108611369A (zh) 2018-10-02
DK3501272T3 (da) 2023-04-03
CN105188357A (zh) 2015-12-23
LT3501272T (lt) 2023-03-27
JP7010902B2 (ja) 2022-02-10
AU2014244020B2 (en) 2020-06-04
LT2967013T (lt) 2019-04-25
MX391010B (es) 2025-03-21
SG11201506278RA (en) 2015-09-29
KR102295842B1 (ko) 2021-08-31
ZA201505835B (en) 2019-09-25
BR112015022034A2 (pt) 2017-08-29
SI3501272T1 (sl) 2023-05-31
AU2023202783A1 (en) 2023-05-25
ES2712207T3 (es) 2019-05-09
AU2014244020A1 (en) 2015-09-24
JP2020182490A (ja) 2020-11-12
FI3501272T3 (fi) 2023-04-06
NZ711776A (en) 2021-09-24
ES2942413T3 (es) 2023-06-01
SMT202300112T1 (it) 2023-05-12
EP4545567A2 (en) 2025-04-30
EP4218409A2 (en) 2023-08-02
WO2014160202A4 (en) 2014-11-13
JP6790136B2 (ja) 2020-11-25
RU2019115237A (ru) 2019-06-11
EP4218409A3 (en) 2023-08-30
AU2023202783B2 (en) 2026-02-12
JP2019213549A (ja) 2019-12-19
EP3501272B1 (en) 2023-03-01
EP2967013A1 (en) 2016-01-20
DK3501272T5 (da) 2024-09-02
ZA201805369B (en) 2021-08-25
HUE061977T2 (hu) 2023-09-28
HRP20190706T1 (hr) 2019-10-18
HRP20230490T1 (hr) 2023-08-04
IL240563A0 (en) 2015-09-24
PL2967013T3 (pl) 2019-07-31
CY1121545T1 (el) 2020-05-29
RS64185B1 (sr) 2023-05-31
PT3501272T (pt) 2023-03-29
EP2967013B1 (en) 2019-01-16
MX357308B (es) 2018-07-04
CA2903698A1 (en) 2014-10-02

Similar Documents

Publication Publication Date Title
US12389888B2 (en) Mice expressing a limited immunoglobulin light chain repertoire
JP7010902B2 (ja) 限られた免疫グロブリン軽鎖レパートリーを発現するマウス
JP6522557B2 (ja) 共通の軽鎖を有する抗体を発現する非ヒト動物
US9969814B2 (en) Methods for making fully human bispecific antibodies using a common light chain
US20190090462A1 (en) Common light chain mouse
JP2018138047A (ja) 共通の軽鎖のマウス
JP2015509380A (ja) 共通の軽鎖のマウス
JP2016519568A (ja) 共通軽鎖のマウス
HK40126399A (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40097135B (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40097135A (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40010381A (en) Mice expressing a limited immunoglobulin light chain repertoire
HK40010381B (en) Mice expressing a limited immunoglobulin light chain repertoire
NZ711776B2 (en) Mice expressing a limited immunoglobulin light chain repertoire
HK1218493B (en) Mice expressing a limited immunoglobulin light chain repertoire

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170310

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180123

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180420

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180608

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181019

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190118

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190423

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190515

R150 Certificate of patent or registration of utility model

Ref document number: 6529957

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250