JP2016512034A5 - - Google Patents
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- Publication number
- JP2016512034A5 JP2016512034A5 JP2016502035A JP2016502035A JP2016512034A5 JP 2016512034 A5 JP2016512034 A5 JP 2016512034A5 JP 2016502035 A JP2016502035 A JP 2016502035A JP 2016502035 A JP2016502035 A JP 2016502035A JP 2016512034 A5 JP2016512034 A5 JP 2016512034A5
- Authority
- JP
- Japan
- Prior art keywords
- human immunoglobulin
- human
- heavy chain
- mouse
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 | 2013-03-13 | ||
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
| PCT/US2014/026040 WO2014160202A1 (en) | 2013-03-13 | 2014-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006738A Division JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512034A JP2016512034A (ja) | 2016-04-25 |
| JP2016512034A5 true JP2016512034A5 (enExample) | 2017-06-01 |
| JP6529957B2 JP6529957B2 (ja) | 2019-06-12 |
Family
ID=50483561
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502035A Active JP6529957B2 (ja) | 2013-03-13 | 2014-03-13 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019006738A Active JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019148806A Active JP7010902B2 (ja) | 2013-03-13 | 2019-08-14 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2020128111A Pending JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006738A Active JP6790136B2 (ja) | 2013-03-13 | 2019-01-18 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2019148806A Active JP7010902B2 (ja) | 2013-03-13 | 2019-08-14 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
| JP2020128111A Pending JP2020182490A (ja) | 2013-03-13 | 2020-07-29 | 限られた免疫グロブリン軽鎖レパートリーを発現するマウス |
Country Status (26)
| Country | Link |
|---|---|
| EP (4) | EP2967013B1 (enExample) |
| JP (4) | JP6529957B2 (enExample) |
| KR (2) | KR102295842B1 (enExample) |
| CN (2) | CN105188357B (enExample) |
| AU (3) | AU2014244020B2 (enExample) |
| BR (1) | BR112015022034B1 (enExample) |
| CA (1) | CA2903698C (enExample) |
| CY (1) | CY1121545T1 (enExample) |
| DK (2) | DK2967013T3 (enExample) |
| ES (3) | ES3013063T3 (enExample) |
| FI (1) | FI3501272T3 (enExample) |
| HR (2) | HRP20230490T1 (enExample) |
| HU (2) | HUE061977T2 (enExample) |
| IL (2) | IL240563B (enExample) |
| LT (2) | LT2967013T (enExample) |
| MX (3) | MX357308B (enExample) |
| PL (2) | PL3501272T3 (enExample) |
| PT (2) | PT2967013T (enExample) |
| RS (2) | RS58669B1 (enExample) |
| RU (1) | RU2689664C2 (enExample) |
| SG (2) | SG11201506278RA (enExample) |
| SI (2) | SI2967013T1 (enExample) |
| SM (2) | SMT202300112T1 (enExample) |
| TR (1) | TR201901668T4 (enExample) |
| WO (1) | WO2014160202A1 (enExample) |
| ZA (2) | ZA201505835B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG183149A1 (en) | 2010-02-08 | 2012-09-27 | Regeneron Pharma | Common light chain mouse |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
| EP4074833A1 (en) | 2011-10-17 | 2022-10-19 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
| NZ703689A (en) | 2012-06-12 | 2016-05-27 | Regeneron Pharma | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| RS57582B1 (sr) * | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| AU2015230938C1 (en) | 2014-03-21 | 2021-10-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| US20190037816A1 (en) | 2016-01-13 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| BR112020004977A2 (pt) * | 2017-09-29 | 2020-10-06 | Regeneron Pharmaceuticals, Inc. | moléculas de ligação de antígenos biespecíficas que ligam antígeno alvo de staphyocococcus e componente de complemento e usos dos mesmos |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| EP3897117A1 (en) * | 2018-12-21 | 2021-10-27 | Compass Therapeutics LLC | Transgenic mouse expressing common human light chain |
| WO2020169022A1 (en) | 2019-02-18 | 2020-08-27 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animals with humanized immunoglobulin locus |
| BR112021016173A2 (pt) | 2019-02-22 | 2021-11-03 | Regeneron Pharma | Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| CN115667532A (zh) | 2020-06-02 | 2023-01-31 | 百奥赛图(北京)医药科技股份有限公司 | 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物 |
| CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| MX2023007401A (es) | 2020-12-23 | 2023-07-06 | Regeneron Pharma | Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos. |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
| TW202615661A (zh) * | 2023-01-18 | 2026-04-16 | 美商基利科學股份有限公司 | 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途 |
| US20260022395A1 (en) * | 2024-07-16 | 2026-01-22 | Gilead Sciences, Inc. | Human immunoglobulin common light chain transgene constructs and uses thereof |
| CN121628915A (zh) * | 2024-08-29 | 2026-03-10 | 上海泰槿生物技术有限公司 | 产生限制的免疫球蛋白轻链库的细胞、动物和方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| JP5514539B2 (ja) * | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| ATE537190T1 (de) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | Hochaffine antikörper gegen den humanen il-6- rezeptor |
| ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| EP3456191A1 (en) * | 2008-06-27 | 2019-03-20 | Merus N.V. | Antibody producing non-human mammals |
| KR101711222B1 (ko) * | 2008-12-18 | 2017-02-28 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용 |
| TWI507525B (zh) | 2009-06-26 | 2015-11-11 | Regeneron Pharma | 具天然免疫球蛋白形式之易分離的雙專一性抗體 |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SG183149A1 (en) * | 2010-02-08 | 2012-09-27 | Regeneron Pharma | Common light chain mouse |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| MY195217A (en) * | 2010-06-22 | 2023-01-11 | Regeneron Pharma | MICE Expressing An Immunoglobulin Hybrid Light Chain |
| EP2601298B1 (en) * | 2010-08-02 | 2016-11-30 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| ES2872081T3 (es) * | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
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2014
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 ES ES23151398T patent/ES3013063T3/es active Active
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active Active
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 MX MX2018008279A patent/MX377146B/es unknown
- 2014-03-13 MX MX2020010837A patent/MX391010B/es unknown
- 2014-03-13 EP EP24223729.5A patent/EP4545567A3/en active Pending
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 DK DK18210518.9T patent/DK3501272T5/da active
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active Active
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en not_active Ceased
- 2014-03-13 SM SM20230112T patent/SMT202300112T1/it unknown
- 2014-03-13 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 SM SM20190196T patent/SMT201900196T1/it unknown
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 EP EP23151398.7A patent/EP4218409B1/en active Active
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2015
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
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2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
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2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
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2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
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2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
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2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783B2/en active Active
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