NO2905338T3 - - Google Patents
Info
- Publication number
- NO2905338T3 NO2905338T3 NO14198318A NO14198318A NO2905338T3 NO 2905338 T3 NO2905338 T3 NO 2905338T3 NO 14198318 A NO14198318 A NO 14198318A NO 14198318 A NO14198318 A NO 14198318A NO 2905338 T3 NO2905338 T3 NO 2905338T3
- Authority
- NO
- Norway
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35731410P | 2010-06-22 | 2010-06-22 | |
US35731710P | 2010-06-22 | 2010-06-22 | |
EP11728508.0A EP2480675B1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing a light chain with human lambda variable and mouse constant regions |
Publications (1)
Publication Number | Publication Date |
---|---|
NO2905338T3 true NO2905338T3 (no) | 2017-12-30 |
Family
ID=44509861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO14198318A NO2905338T3 (no) | 2010-06-22 | 2011-06-22 |
Country Status (31)
Country | Link |
---|---|
US (21) | US9012717B2 (no) |
EP (7) | EP2568049B1 (no) |
JP (15) | JP5988969B2 (no) |
KR (16) | KR101945352B1 (no) |
CN (4) | CN103068993B (no) |
AU (1) | AU2011271046B2 (no) |
BR (3) | BR112012032991B1 (no) |
CA (2) | CA2804311C (no) |
CY (5) | CY1117537T1 (no) |
DK (5) | DK2905338T3 (no) |
ES (5) | ES2576928T3 (no) |
HK (4) | HK1168384A1 (no) |
HR (5) | HRP20160497T1 (no) |
HU (5) | HUE029692T2 (no) |
IL (11) | IL300712A (no) |
LT (4) | LT2905338T (no) |
ME (5) | ME02442B (no) |
MX (6) | MX2012015298A (no) |
MY (6) | MY157477A (no) |
NO (1) | NO2905338T3 (no) |
NZ (6) | NZ605758A (no) |
PL (5) | PL2905338T3 (no) |
PT (5) | PT2480675T (no) |
RS (5) | RS55042B1 (no) |
RU (3) | RU2601297C2 (no) |
SG (4) | SG10201504568YA (no) |
SI (5) | SI2905338T1 (no) |
SM (3) | SMT201600213B (no) |
TR (1) | TR201905992T4 (no) |
WO (2) | WO2011163314A1 (no) |
ZA (5) | ZA201300063B (no) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
NZ592308A (en) * | 2008-09-30 | 2012-11-30 | Ablexis Llc | Non-human mammals for the production of chimeric antibodies |
MX2011007660A (es) | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
PL3241435T3 (pl) * | 2009-07-08 | 2021-12-13 | Kymab Limited | Modele zwierzęce i cząsteczki terapeutyczne |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
RU2724663C2 (ru) | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
EP3251503B1 (en) | 2010-03-31 | 2024-03-20 | Ablexis, LLC | Genetic engineering of mice for the production of chimeric antibodies |
RS55042B1 (sr) * | 2010-06-22 | 2016-12-30 | Regeneron Pharma | Miševi koji ispoljavaju laki lanac hibridnog imunoglobulina sa promenljivim regionom čoveka |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
JP6482757B2 (ja) | 2010-07-26 | 2019-03-13 | トリアンニ インコーポレイテッドTrianni,Inc. | トランスジェニック動物および使用方法 |
JP6146913B2 (ja) | 2010-08-02 | 2017-06-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Vlドメインを含む結合タンパク質を作製するマウス |
RU2664232C2 (ru) | 2011-08-05 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной универсальной легкой цепью |
EP2758534B1 (en) | 2011-09-19 | 2020-04-29 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
ES2612935T3 (es) | 2011-09-19 | 2017-05-19 | Kymab Limited | Anticuerpos, dominios variables y cadenas adaptados para su uso en seres humanos |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
DK2793567T3 (en) | 2011-12-20 | 2019-04-15 | Regeneron Pharma | Humanized light chain mice |
MY173376A (en) | 2012-03-16 | 2020-01-21 | Regeneron Pharma | Mice that produce antigen?binding proteins with ph?dependent binding characteristics |
BR112014022855A2 (pt) | 2012-03-16 | 2017-07-18 | Regeneron Pharma | animal não humano geneticamente modificado, mamífero geneticamente modificado, e, método para fabricar um animal não humano |
CA2865643A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
WO2013144567A1 (en) | 2012-03-28 | 2013-10-03 | Kymab Limited | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
GB2502127A (en) * | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
KR101764800B1 (ko) | 2013-02-20 | 2017-08-04 | 리제너론 파마슈티칼스 인코포레이티드 | 변형된 면역글로불린 중쇄 서열을 갖는 비인간 동물 |
HUE044003T2 (hu) * | 2013-03-13 | 2019-09-30 | Regeneron Pharma | Korlátozott immunglobulin könnyûlánc-repertoárt expresszáló egerek |
US9980470B2 (en) | 2013-03-14 | 2018-05-29 | Erasmus University Medical Center | Antibody production |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US11707056B2 (en) * | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
RS59003B1 (sr) * | 2013-09-18 | 2019-08-30 | Regeneron Pharma | Antitela sa histidinom modifikovanim lakim lancem i genetski modifikovane nehumane životinje koje ih generišu |
ES2859373T3 (es) | 2013-10-01 | 2021-10-01 | Kymab Ltd | Modelos animales y moléculas terapéuticas |
WO2015103999A1 (en) * | 2014-01-10 | 2015-07-16 | Hung Alfur Fu-Hsin | Transgenic animals capable of producing humanized ige at much higher levels than mouse ige |
RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
US20150266976A1 (en) * | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
EP3151921B1 (en) | 2014-06-06 | 2019-08-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
CN107072184A (zh) | 2014-09-19 | 2017-08-18 | 瑞泽恩制药公司 | 嵌合抗原受体 |
AU2015327819B2 (en) | 2014-10-03 | 2021-07-01 | Massachusetts Institute Of Technology | Antibodies that bind ebola glycoprotein and uses thereof |
TWI758928B (zh) | 2014-11-21 | 2022-03-21 | 美商必治妥美雅史谷比公司 | 抗cd73抗體及其用途 |
PL3233912T3 (pl) | 2014-12-19 | 2021-12-27 | Regenesance B.V. | Przeciwciała, które wiążą ludzkie c6 oraz ich zastosowania |
CA2971732A1 (en) | 2014-12-23 | 2016-06-30 | Bristol-Myers Squibb Company | Antibodies to tigit |
WO2016124709A1 (de) | 2015-02-05 | 2016-08-11 | Basf Se | Solarkraftwerk mit einem ersten wärmeträgerkreislauf und einem zweiten wärmeträgerkreislauf |
WO2016149678A1 (en) * | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
LT3303396T (lt) | 2015-05-29 | 2023-01-10 | Bristol-Myers Squibb Company | Antikūnai prieš ox40 ir jų panaudojimo būdai |
EA201890162A1 (ru) | 2015-06-29 | 2018-07-31 | Бристол-Маерс Сквибб Компани | Антитела к cd40 с повышенной агонистической активностью |
CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
AU2016356780A1 (en) | 2015-11-19 | 2018-06-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
WO2017136734A1 (en) | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
MX2018010672A (es) | 2016-03-04 | 2019-05-27 | Univ Rockefeller | Anticuerpos para cumulo de diferenciación 40 (cd40) con actividad agonista mejorada. |
US20190284293A1 (en) | 2016-03-04 | 2019-09-19 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
KR102417687B1 (ko) | 2016-05-09 | 2022-07-07 | 브리스톨-마이어스 스큅 컴퍼니 | Tl1a 항체 및 그의 용도 |
NZ747857A (en) | 2016-05-20 | 2023-01-27 | Regeneron Pharma | Methods for breaking immunological tolerance using multiple guide rnas |
HUE061619T2 (hu) | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
WO2017214089A1 (en) * | 2016-06-06 | 2017-12-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing antibodies with human lambda light chains |
US20170372142A1 (en) * | 2016-06-27 | 2017-12-28 | Facebook, Inc. | Systems and methods for identifying matching content |
CN117683135A (zh) | 2016-07-14 | 2024-03-12 | 百时美施贵宝公司 | 针对tim3的抗体及其用途 |
US10981976B2 (en) | 2016-08-31 | 2021-04-20 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof |
CR20210094A (es) | 2016-10-13 | 2021-03-31 | Massachusetts Inst Technology | ANTICUERPOS QUE SE UNEN A LA PROTEÍNA DE ENVOLTURA DEL VIRUS ZIKA Y USOS DE LOS MISMOS (Divisional 2019-0193) |
IL308197A (en) * | 2016-11-04 | 2024-01-01 | Regeneron Pharma | Non-human animals with a transgenic locus of the lambda-type light chain of immunoglobulins |
SG11201906947SA (en) | 2017-02-17 | 2019-08-27 | Bristol Myers Squibb Co | Antibodies to alpha-synuclein and uses thereof |
TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
SI3720279T1 (sl) | 2017-12-05 | 2022-11-30 | Regeneron Pharmaceuticals, Inc. | Miši, ki imajo spremenjeno lahko verigo imunoglobulina lambda in njihova uporaba |
KR20200108870A (ko) | 2018-01-12 | 2020-09-21 | 브리스톨-마이어스 스큅 컴퍼니 | Tim3에 대한 항체 및 그의 용도 |
CN111886256A (zh) | 2018-03-23 | 2020-11-03 | 百时美施贵宝公司 | 抗mica和/或micb抗体及其用途 |
CA3093995A1 (en) | 2018-03-24 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
US11576984B2 (en) | 2018-03-26 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with humanized immunoglobulin heavy chain constant region genes and method of using |
US11337409B2 (en) | 2018-06-08 | 2022-05-24 | Crystal Bioscience Inc. | Transgenic animal for producing diversified antibodies that have the same light chain I |
IL305557A (en) | 2018-06-14 | 2023-10-01 | Regeneron Pharma | Non-human animals with transgenic DH–DH rearrangement capacity, and their uses |
EP3872506A4 (en) | 2018-10-26 | 2023-01-11 | Vehicle Energy Japan Inc. | BATTERY MONITORING DEVICE |
TW202033555A (zh) | 2018-11-16 | 2020-09-16 | 美商必治妥美雅史谷比公司 | 抗nkg2a抗體及其用途 |
PE20212305A1 (es) | 2019-01-22 | 2021-12-10 | Bristol Myers Squibb Co | Anticuerpos contra subunidad alfa il-7r y usos de estos |
WO2020172505A1 (en) | 2019-02-22 | 2020-08-27 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
KR20220016880A (ko) * | 2019-06-05 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 카파 유전자좌에서 발현된 제한적 람다 경쇄 레퍼토리를 갖는 비-인간 동물 및 이의 용도 |
EP3993623A1 (en) * | 2019-07-01 | 2022-05-11 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
IL293330A (en) | 2019-12-02 | 2022-07-01 | Regeneron Pharma | mhc ii peptide protein structures and uses thereof |
US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
JP2023541216A (ja) * | 2020-06-25 | 2023-09-29 | ヒューマブ カンパニー リミテッド | ヘテロ接合型トランスジェニック動物 |
KR20230066386A (ko) | 2020-09-11 | 2023-05-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항원 특이적 항체의 확인 및 제조 |
US20240065239A1 (en) | 2020-12-16 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
CA3197426A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
AU2021410655A1 (en) | 2020-12-23 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
DE69233367T2 (de) | 1991-04-10 | 2005-05-25 | The Scripps Research Institute, La Jolla | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
IL109168A0 (en) * | 1993-04-01 | 1994-06-24 | Univ Columbia | A retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs |
US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
CA2722378C (en) * | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
GB9823930D0 (en) * | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
CN101498731A (zh) * | 2000-05-18 | 2009-08-05 | 日本烟草产业株式会社 | 抗协同刺激信号转导分子ailim的人单克隆抗体及其药物用途 |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
IL155977A0 (en) * | 2000-11-30 | 2003-12-23 | Medarex Inc | Transgenic transchromosomal rodents for making human antibodies |
GB0031284D0 (en) * | 2000-12-21 | 2001-01-31 | Ks Biomedix Ltd | High affinity antibodies |
EP1632571B1 (en) * | 2001-05-11 | 2012-11-28 | Kyowa Hakko Kirin Co., Ltd. | Human artificial chromosome containing human antibody Lambda light chain and non-human animal containing the human artificial chromosome capable of genetic transmission |
GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
EP1461442B1 (en) * | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
US20030217171A1 (en) | 2002-05-17 | 2003-11-20 | Von Stuermer Wolfgang R. | Self-replicating and self-installing software apparatus |
CA2532117C (en) | 2003-07-15 | 2012-07-10 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
CN1605628A (zh) * | 2003-09-03 | 2005-04-13 | 中国疾病预防控制中心病毒病预防控制所 | Cho细胞生产的人源抗甲肝病毒基因工程抗体 |
ZA200701656B (en) * | 2004-08-05 | 2008-09-25 | Genentech Inc | Humanized anti-cment antagonists |
DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
ES2359567T3 (es) * | 2004-12-29 | 2011-05-24 | Yuhan Corporation | Anticuerpo humanizado específico para el factor de necrosis tumoral-alfa. |
WO2007117410A2 (en) | 2006-03-31 | 2007-10-18 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
US8084024B2 (en) * | 2006-08-22 | 2011-12-27 | G2 Inflammation Pty Ltd | Method for producing antibodies |
LT2769992T (lt) | 2006-10-02 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių |
US7864492B2 (en) | 2006-10-31 | 2011-01-04 | Siemens Industry, Inc. | Systems and methods for arc fault detection |
DE102007045897A1 (de) | 2007-09-26 | 2009-04-09 | Carl Zeiss Microimaging Gmbh | Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe |
WO2009129247A2 (en) * | 2008-04-14 | 2009-10-22 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
EP2288623B1 (en) * | 2008-05-23 | 2013-07-10 | Ablexis, LLC | Method of generating single vl domain antibodies in transgenic animals |
NZ592308A (en) | 2008-09-30 | 2012-11-30 | Ablexis Llc | Non-human mammals for the production of chimeric antibodies |
MX2011007660A (es) * | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
PL3241435T3 (pl) * | 2009-07-08 | 2021-12-13 | Kymab Limited | Modele zwierzęce i cząsteczki terapeutyczne |
RU2724663C2 (ru) * | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
RS55042B1 (sr) | 2010-06-22 | 2016-12-30 | Regeneron Pharma | Miševi koji ispoljavaju laki lanac hibridnog imunoglobulina sa promenljivim regionom čoveka |
-
2011
- 2011-06-22 RS RS20160548A patent/RS55042B1/sr unknown
- 2011-06-22 MY MYPI2012005501A patent/MY157477A/en unknown
- 2011-06-22 CN CN201180038411.4A patent/CN103068993B/zh active Active
- 2011-06-22 SG SG10201504568YA patent/SG10201504568YA/en unknown
- 2011-06-22 TR TR2019/05992T patent/TR201905992T4/tr unknown
- 2011-06-22 WO PCT/US2011/041370 patent/WO2011163314A1/en active Application Filing
- 2011-06-22 KR KR1020137001586A patent/KR101945352B1/ko active IP Right Grant
- 2011-06-22 PL PL14198318T patent/PL2905338T3/pl unknown
- 2011-06-22 LT LTEP14198318.9T patent/LT2905338T/lt unknown
- 2011-06-22 HU HUE11728508A patent/HUE029692T2/en unknown
- 2011-06-22 KR KR1020197017074A patent/KR102059909B1/ko active Application Filing
- 2011-06-22 EP EP12195716.1A patent/EP2568049B1/en active Active
- 2011-06-22 MY MYPI2016000694A patent/MY195214A/en unknown
- 2011-06-22 KR KR1020197002903A patent/KR102001430B1/ko active IP Right Grant
- 2011-06-22 PT PT117285080T patent/PT2480675T/pt unknown
- 2011-06-22 EP EP17162880.3A patent/EP3205726A1/en active Pending
- 2011-06-22 KR KR1020217034867A patent/KR102506001B1/ko active IP Right Grant
- 2011-06-22 NO NO14198318A patent/NO2905338T3/no unknown
- 2011-06-22 WO PCT/US2011/041366 patent/WO2011163311A1/en active Application Filing
- 2011-06-22 CA CA2804311A patent/CA2804311C/en active Active
- 2011-06-22 MY MYPI2016000459A patent/MY194456A/en unknown
- 2011-06-22 LT LTEP16154526.4T patent/LT3034608T/lt unknown
- 2011-06-22 MX MX2012015298A patent/MX2012015298A/es active IP Right Grant
- 2011-06-22 RS RS20160483A patent/RS54891B1/sr unknown
- 2011-06-22 NZ NZ605758A patent/NZ605758A/en unknown
- 2011-06-22 BR BR112012032991-0A patent/BR112012032991B1/pt active IP Right Grant
- 2011-06-22 SI SI201131325T patent/SI2905338T1/sl unknown
- 2011-06-22 HU HUE12195716A patent/HUE030285T2/en unknown
- 2011-06-22 MY MYPI2016000695A patent/MY195212A/en unknown
- 2011-06-22 US US13/166,171 patent/US9012717B2/en active Active
- 2011-06-22 PL PL11728508T patent/PL2480675T3/pl unknown
- 2011-06-22 CA CA2803864A patent/CA2803864C/en active Active
- 2011-06-22 MX MX2015009162A patent/MX347322B/es unknown
- 2011-06-22 PL PL11728509.8T patent/PL2480676T3/pl unknown
- 2011-06-22 EP EP11728509.8A patent/EP2480676B1/en active Active
- 2011-06-22 RU RU2013102595/10A patent/RU2601297C2/ru active
- 2011-06-22 ES ES12195716.1T patent/ES2576928T3/es active Active
- 2011-06-22 KR KR1020207036106A patent/KR102320944B1/ko active IP Right Grant
- 2011-06-22 DK DK14198318.9T patent/DK2905338T3/da active
- 2011-06-22 PT PT121957161T patent/PT2568049T/pt unknown
- 2011-06-22 PT PT141983189T patent/PT2905338T/pt unknown
- 2011-06-22 PT PT16154526T patent/PT3034608T/pt unknown
- 2011-06-22 NZ NZ627119A patent/NZ627119A/en unknown
- 2011-06-22 ES ES16154526T patent/ES2721749T3/es active Active
- 2011-06-22 PT PT117285098T patent/PT2480676E/pt unknown
- 2011-06-22 DK DK11728508.0T patent/DK2480675T3/en active
- 2011-06-22 SI SI201130889A patent/SI2568049T1/sl unknown
- 2011-06-22 SI SI201130810A patent/SI2480676T1/sl unknown
- 2011-06-22 LT LTEP12195716.1T patent/LT2568049T/lt unknown
- 2011-06-22 SG SG2012093258A patent/SG186390A1/en unknown
- 2011-06-22 ES ES14198318.9T patent/ES2646052T3/es active Active
- 2011-06-22 HU HUE11728509A patent/HUE029691T2/en unknown
- 2011-06-22 EP EP11728508.0A patent/EP2480675B1/en active Active
- 2011-06-22 NZ NZ707198A patent/NZ707198A/en unknown
- 2011-06-22 SI SI201131716T patent/SI3034608T1/sl unknown
- 2011-06-22 DK DK16154526.4T patent/DK3034608T3/da active
- 2011-06-22 ME MEP-2016-119A patent/ME02442B/me unknown
- 2011-06-22 BR BR122020013427-5A patent/BR122020013427B1/pt active IP Right Grant
- 2011-06-22 EP EP14198318.9A patent/EP2905338B8/en active Active
- 2011-06-22 NZ NZ626979A patent/NZ626979A/en unknown
- 2011-06-22 ME MEP-2017-244A patent/ME02902B/me unknown
- 2011-06-22 KR KR1020217017823A patent/KR102462042B1/ko active IP Right Grant
- 2011-06-22 MX MX2015008806A patent/MX347318B/es unknown
- 2011-06-22 US US13/166,200 patent/US9035128B2/en active Active
- 2011-06-22 KR KR1020187036183A patent/KR101975884B1/ko active Application Filing
- 2011-06-22 AU AU2011271046A patent/AU2011271046B2/en active Active
- 2011-06-22 RU RU2016119423A patent/RU2724736C2/ru active
- 2011-06-22 SI SI201130867A patent/SI2480675T1/sl unknown
- 2011-06-22 NZ NZ707200A patent/NZ707200A/en unknown
- 2011-06-22 RS RS20171091A patent/RS56589B1/sr unknown
- 2011-06-22 PL PL16154526T patent/PL3034608T3/pl unknown
- 2011-06-22 KR KR1020197002870A patent/KR101991234B1/ko active IP Right Grant
- 2011-06-22 RU RU2013102596/10A patent/RU2590594C2/ru active
- 2011-06-22 ME MEP-2016-132A patent/ME02440B/me unknown
- 2011-06-22 SG SG2012093266A patent/SG186391A1/en unknown
- 2011-06-22 CN CN201410538631.9A patent/CN104342455B/zh active Active
- 2011-06-22 IL IL300712A patent/IL300712A/en unknown
- 2011-06-22 ME MEP-2016-87A patent/ME02444B/me unknown
- 2011-06-22 RS RS20190533A patent/RS58736B1/sr unknown
- 2011-06-22 MX MX2012015300A patent/MX336344B/es unknown
- 2011-06-22 DK DK12195716.1T patent/DK2568049T3/en active
- 2011-06-22 MX MX2015008807A patent/MX348942B/es unknown
- 2011-06-22 MY MYPI2016000693A patent/MY195217A/en unknown
- 2011-06-22 EP EP16154526.4A patent/EP3034608B1/en active Active
- 2011-06-22 CN CN201180038415.2A patent/CN103068994B/zh active Active
- 2011-06-22 PL PL12195716T patent/PL2568049T3/pl unknown
- 2011-06-22 KR KR1020217002982A patent/KR102266097B1/ko active IP Right Grant
- 2011-06-22 JP JP2013516714A patent/JP5988969B2/ja active Active
- 2011-06-22 HU HUE16154526A patent/HUE044001T2/hu unknown
- 2011-06-22 KR KR1020227037565A patent/KR20220150430A/ko active Application Filing
- 2011-06-22 BR BR112012033248A patent/BR112012033248A2/pt not_active Application Discontinuation
- 2011-06-22 EP EP18202954.6A patent/EP3456832A1/en active Pending
- 2011-06-22 ES ES11728509T patent/ES2570131T3/es active Active
- 2011-06-22 MY MYPI2012005500A patent/MY165287A/en unknown
- 2011-06-22 KR KR1020207015360A patent/KR102193823B1/ko active IP Right Grant
- 2011-06-22 ES ES11728508.0T patent/ES2575223T3/es active Active
- 2011-06-22 HU HUE14198318A patent/HUE036597T2/hu unknown
- 2011-06-22 ME MEP-2019-128A patent/ME03386B/me unknown
- 2011-06-22 KR KR1020197037332A patent/KR102211911B1/ko active Application Filing
- 2011-06-22 KR KR1020187036167A patent/KR101970944B1/ko active IP Right Grant
- 2011-06-22 CN CN201410535091.9A patent/CN104404050B/zh active Active
- 2011-06-22 KR KR1020137001582A patent/KR101934852B1/ko active IP Right Grant
- 2011-06-22 SG SG10201504324UA patent/SG10201504324UA/en unknown
- 2011-06-22 KR KR1020237006658A patent/KR20230036157A/ko active Application Filing
- 2011-06-22 DK DK11728509.8T patent/DK2480676T3/en active
- 2011-06-22 LT LTEP11728508.0T patent/LT2480675T/lt unknown
- 2011-06-22 RS RS20160496A patent/RS55037B1/sr unknown
- 2011-06-22 NZ NZ605751A patent/NZ605751A/en unknown
- 2011-06-22 JP JP2013516716A patent/JP6009441B2/ja active Active
- 2011-06-22 KR KR1020197012527A patent/KR102118565B1/ko active IP Right Grant
-
2012
- 2012-09-20 HK HK12109218.3A patent/HK1168384A1/zh unknown
- 2012-11-13 HK HK12111457.9A patent/HK1170766A1/zh unknown
- 2012-11-13 HK HK13110524.9A patent/HK1183321A1/zh unknown
- 2012-12-18 IL IL223720A patent/IL223720A/en active IP Right Grant
- 2012-12-18 IL IL223719A patent/IL223719A/en active IP Right Grant
- 2012-12-19 MX MX2022002117A patent/MX2022002117A/es unknown
-
2013
- 2013-01-03 ZA ZA2013/00063A patent/ZA201300063B/en unknown
- 2013-01-03 ZA ZA2013/00062A patent/ZA201300062B/en unknown
- 2013-07-18 US US13/945,573 patent/US9029628B2/en active Active
- 2013-07-18 US US13/945,582 patent/US9006511B2/en active Active
- 2013-12-18 US US14/132,412 patent/US9066502B2/en active Active
-
2014
- 2014-06-23 ZA ZA2014/04600A patent/ZA201404600B/en unknown
- 2014-06-23 ZA ZA2014/04601A patent/ZA201404601B/en unknown
- 2014-12-05 US US14/561,867 patent/US9394373B2/en active Active
-
2015
- 2015-03-03 US US14/636,784 patent/US9206261B2/en active Active
- 2015-03-04 US US14/638,424 patent/US9206262B2/en active Active
- 2015-03-04 US US14/638,429 patent/US9206263B2/en active Active
- 2015-05-18 US US14/715,145 patent/US9163092B2/en active Active
- 2015-05-18 US US14/715,147 patent/US9150662B2/en active Active
- 2015-07-15 US US14/800,263 patent/US9226484B2/en active Active
- 2015-07-15 US US14/800,257 patent/US9334333B2/en active Active
- 2015-09-07 ZA ZA2015/06598A patent/ZA201506598B/en unknown
- 2015-10-19 JP JP2015205439A patent/JP6073441B2/ja active Active
- 2015-10-19 JP JP2015205321A patent/JP6243384B2/ja active Active
- 2015-11-17 US US14/943,890 patent/US9540452B2/en active Active
- 2015-11-17 US US14/943,672 patent/US9399683B2/en active Active
-
2016
- 2016-03-06 IL IL244450A patent/IL244450A/en active IP Right Grant
- 2016-05-10 HR HRP20160497TT patent/HRP20160497T1/hr unknown
- 2016-05-20 CY CY20161100440T patent/CY1117537T1/el unknown
- 2016-06-28 CY CY20161100585T patent/CY1117692T1/el unknown
- 2016-07-05 SM SM201600213T patent/SMT201600213B/it unknown
- 2016-07-05 SM SM201600212T patent/SMT201600212B/it unknown
- 2016-07-06 HR HRP20160794TT patent/HRP20160794T1/hr unknown
- 2016-07-13 CY CY20161100670T patent/CY1118126T1/el unknown
- 2016-07-13 HR HRP20160865TT patent/HRP20160865T1/hr unknown
- 2016-07-13 SM SM201600229T patent/SMT201600229B/it unknown
- 2016-08-21 IL IL247386A patent/IL247386A/en active IP Right Grant
- 2016-10-19 JP JP2016204854A patent/JP2017006152A/ja not_active Withdrawn
- 2016-10-25 JP JP2016208582A patent/JP6341972B2/ja active Active
- 2016-12-20 HK HK16114463A patent/HK1226766A1/zh unknown
-
2017
- 2017-01-04 US US15/398,410 patent/US9850462B2/en active Active
- 2017-05-24 US US15/604,021 patent/US9844212B2/en active Active
- 2017-10-22 IL IL255179A patent/IL255179B/en active IP Right Grant
- 2017-10-24 CY CY20171101102T patent/CY1119478T1/el unknown
- 2017-10-31 HR HRP20171666TT patent/HRP20171666T1/hr unknown
- 2017-11-13 US US15/810,900 patent/US10266803B2/en active Active
- 2017-11-20 JP JP2017222512A patent/JP6545773B2/ja active Active
-
2018
- 2018-06-12 IL IL259965A patent/IL259965B/en active IP Right Grant
- 2018-10-04 JP JP2018188847A patent/JP2018201528A/ja active Pending
- 2018-10-04 JP JP2018188846A patent/JP2018201527A/ja active Pending
- 2018-12-06 JP JP2018228851A patent/JP6963542B2/ja active Active
-
2019
- 2019-02-04 IL IL264634A patent/IL264634B/en active IP Right Grant
- 2019-02-06 US US16/269,477 patent/US20190153384A1/en not_active Abandoned
- 2019-03-11 US US16/298,308 patent/US20190203171A1/en not_active Abandoned
- 2019-04-30 CY CY20191100459T patent/CY1122877T1/el unknown
- 2019-04-30 HR HRP20190807TT patent/HRP20190807T1/hr unknown
- 2019-09-02 IL IL269078A patent/IL269078B/en active IP Right Grant
-
2020
- 2020-01-31 JP JP2020015538A patent/JP2020062061A/ja not_active Withdrawn
- 2020-02-12 US US16/788,532 patent/US20200239837A1/en not_active Abandoned
- 2020-06-05 JP JP2020098480A patent/JP7236409B2/ja active Active
-
2021
- 2021-01-25 JP JP2021009451A patent/JP2021061863A/ja not_active Withdrawn
- 2021-05-03 IL IL282872A patent/IL282872B/en unknown
-
2022
- 2022-03-07 JP JP2022034415A patent/JP2022066449A/ja active Pending
- 2022-03-13 IL IL291301A patent/IL291301B2/en unknown
-
2023
- 2023-08-03 JP JP2023127047A patent/JP2023133554A/ja active Pending