SI3720279T1 - Miši, ki imajo spremenjeno lahko verigo imunoglobulina lambda in njihova uporaba - Google Patents

Miši, ki imajo spremenjeno lahko verigo imunoglobulina lambda in njihova uporaba

Info

Publication number
SI3720279T1
SI3720279T1 SI201830769T SI201830769T SI3720279T1 SI 3720279 T1 SI3720279 T1 SI 3720279T1 SI 201830769 T SI201830769 T SI 201830769T SI 201830769 T SI201830769 T SI 201830769T SI 3720279 T1 SI3720279 T1 SI 3720279T1
Authority
SI
Slovenia
Prior art keywords
mice
light chain
lambda light
engineered immunoglobulin
immunoglobulin lambda
Prior art date
Application number
SI201830769T
Other languages
English (en)
Inventor
Andrew J. Murphy
Lynn Macdonald
Chunguang Guo
John Mcwhirter
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of SI3720279T1 publication Critical patent/SI3720279T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI201830769T 2017-12-05 2018-12-04 Miši, ki imajo spremenjeno lahko verigo imunoglobulina lambda in njihova uporaba SI3720279T1 (sl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762594944P 2017-12-05 2017-12-05
US201762594946P 2017-12-05 2017-12-05
US201762609241P 2017-12-21 2017-12-21
US201762609251P 2017-12-21 2017-12-21
EP18821945.5A EP3720279B1 (en) 2017-12-05 2018-12-04 Mice having an engineered immunoglobulin lambda light chain and uses thereof
PCT/US2018/063841 WO2019113065A1 (en) 2017-12-05 2018-12-04 Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof

Publications (1)

Publication Number Publication Date
SI3720279T1 true SI3720279T1 (sl) 2022-11-30

Family

ID=64734263

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201830769T SI3720279T1 (sl) 2017-12-05 2018-12-04 Miši, ki imajo spremenjeno lahko verigo imunoglobulina lambda in njihova uporaba

Country Status (22)

Country Link
US (3) US11051498B2 (sl)
EP (2) EP4140297A1 (sl)
JP (2) JP7430636B2 (sl)
KR (1) KR20200093570A (sl)
CN (2) CN116058333A (sl)
AU (1) AU2018381316A1 (sl)
BR (1) BR112020011184A2 (sl)
CA (1) CA3084049A1 (sl)
DK (1) DK3720279T3 (sl)
ES (1) ES2928995T3 (sl)
HR (1) HRP20221459T1 (sl)
HU (1) HUE060608T2 (sl)
IL (1) IL274797A (sl)
LT (1) LT3720279T (sl)
MX (1) MX2020005830A (sl)
PL (1) PL3720279T3 (sl)
PT (1) PT3720279T (sl)
RS (1) RS63772B1 (sl)
SG (1) SG11202003044SA (sl)
SI (1) SI3720279T1 (sl)
TW (1) TWI827567B (sl)
WO (1) WO2019113065A1 (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
WO2017095939A1 (en) 2015-12-03 2017-06-08 Trianni, Inc. Enhanced immunoglobulin diversity
LT3720279T (lt) 2017-12-05 2022-10-25 Regeneron Pharmaceuticals, Inc. Pelės, turinčios sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas
DK3629720T3 (da) 2018-06-14 2022-03-07 Regeneron Pharma Ikke-humane dyr, der er i stand til at omarrangere DH-DH i immunoglobulin-tungkæde-kodningssekvenser
KR20210129083A (ko) 2019-02-22 2021-10-27 리제너론 파마슈티칼스 인코포레이티드 유전적으로 변형된 나트륨 채널을 갖는 설치류 및 이의 사용 방법
JP2022538885A (ja) * 2019-07-01 2022-09-06 トリアニ・インコーポレイテッド トランスジェニック哺乳動物およびその使用法
WO2022056276A1 (en) 2020-09-11 2022-03-17 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
WO2022132943A1 (en) 2020-12-16 2022-06-23 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors
KR20230125236A (ko) 2020-12-23 2023-08-29 리제너론 파마슈티칼스 인코포레이티드 앵커 변형된 항체를 암호화하는 핵산 및 이의 사용
MX2023007583A (es) 2020-12-23 2023-07-07 Regeneron Pharma Metodos para obtener anticuerpos que se unen a proteinas transmembranarias y celulas que los producen.
CN114763558B (zh) * 2021-01-14 2024-02-20 上海泰槿生物技术有限公司 重组基因组、非人哺乳动物细胞及其产生方法和用途
JP2024512702A (ja) * 2021-03-31 2024-03-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｔｃｒβレパートリーの改善された多様性を伴うヒト化細胞免疫系の構成要素を含む、遺伝的に改変されたマウス

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
AU669124B2 (en) * 1991-09-18 1996-05-30 Kyowa Hakko Kirin Co., Ltd. Process for producing humanized chimera antibody
US5670356A (en) 1994-12-12 1997-09-23 Promega Corporation Modified luciferase
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
KR20080059467A (ko) * 1996-12-03 2008-06-27 아브게닉스, 인크. 복수의 ｖｈ 및 ｖｋ 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체
GB9823930D0 (en) 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
EA013564B1 (ru) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
ES2645563T3 (es) 2001-11-30 2017-12-05 Amgen Fremont Inc. Animales transgénicos que portan genes de cadena ligera de Ig humana
MY147468A (en) 2006-06-02 2012-12-14 Regeneron Pharma High affinity antibodies to human il-6 receptor
CA2696934A1 (en) * 2007-09-12 2010-02-16 Probiodrug Ag Transgenic mice
DK2147594T3 (da) * 2008-06-27 2014-02-10 Merus B V Antistofproducerende ikke-humane pattedyr
DK2346994T3 (da) 2008-09-30 2022-02-28 Ablexis Llc Knock-in-mus til fremstilling af kimære antistoffer
NO2792236T3 (sl) 2009-07-08 2018-04-14
US9445581B2 (en) * 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
KR102506001B1 (ko) 2010-06-22 2023-03-07 리제너론 파아마슈티컬스, 인크. 하이브리드 경쇄 마우스
ES2946169T3 (es) 2011-02-25 2023-07-13 Regeneron Pharma Ratones ADAM6
DK3216871T3 (da) 2011-10-17 2022-02-21 Regeneron Pharma Mus med indskrænket tung immunoglobulinkæde
US9253965B2 (en) * 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
CN104159444B (zh) 2011-12-20 2017-09-01 瑞泽恩制药公司 人源化的轻链小鼠
AU2013204758B2 (en) * 2012-02-01 2015-07-23 Regeneron Pharmaceuticals, Inc. Humanized rodents that express heavy chains containing VL domains
MX364449B (es) * 2012-06-12 2019-04-26 Regeneron Pharma Animales no humanos humanizados con loci de cadena pesada de inmunoglobulina restringidos.
ES2904803T3 (es) 2013-02-20 2022-04-06 Regeneron Pharma Modificación genética de ratas
ES2888250T3 (es) 2013-04-16 2022-01-03 Regeneron Pharma Modificación direccionada del genoma de rata
SG10201802295XA (en) * 2013-10-01 2018-04-27 Kymab Ltd Animal Models and Therapeutic Molecules
CN106715694B (zh) 2014-06-23 2020-10-20 瑞泽恩制药公司 核酸酶介导的dna组装
PL3221457T3 (pl) 2014-11-21 2019-09-30 Regeneron Pharmaceuticals, Inc. Sposoby i kompozycje do celowanej modyfikacji genetycznej z zastosowaniem sparowanych przewodników RNA
CN107208113A (zh) 2014-12-19 2017-09-26 瑞泽恩制药公司 用于通过单步多重靶向进行靶向遗传修饰的方法和组合物
EP3462853B1 (en) 2016-06-03 2023-03-01 Regeneron Pharmaceuticals, Inc. Rodents expressing exogenous terminal deoxynucleotidyltransferase
LT3720279T (lt) 2017-12-05 2022-10-25 Regeneron Pharmaceuticals, Inc. Pelės, turinčios sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas

Also Published As

Publication number Publication date
CA3084049A1 (en) 2019-06-13
CN111432635B (zh) 2022-10-21
RU2020118699A3 (sl) 2022-04-07
DK3720279T3 (da) 2022-10-24
EP4140297A1 (en) 2023-03-01
WO2019113065A1 (en) 2019-06-13
RU2020118699A (ru) 2022-01-10
RS63772B1 (sr) 2022-12-30
CN111432635A (zh) 2020-07-17
JP2021505141A (ja) 2021-02-18
AU2018381316A1 (en) 2020-04-23
EP3720279A1 (en) 2020-10-14
SG11202003044SA (en) 2020-04-29
TWI827567B (zh) 2024-01-01
LT3720279T (lt) 2022-10-25
PT3720279T (pt) 2022-10-06
HRP20221459T1 (hr) 2023-01-20
US20190223418A1 (en) 2019-07-25
HUE060608T2 (hu) 2023-03-28
US11051498B2 (en) 2021-07-06
JP7430636B2 (ja) 2024-02-13
KR20200093570A (ko) 2020-08-05
JP2024036440A (ja) 2024-03-15
BR112020011184A2 (pt) 2020-11-17
ES2928995T3 (es) 2022-11-24
IL274797A (en) 2020-07-30
TW201938019A (zh) 2019-10-01
US20210292439A1 (en) 2021-09-23
PL3720279T3 (pl) 2023-01-16
US20210345591A1 (en) 2021-11-11
EP3720279B1 (en) 2022-09-21
MX2020005830A (es) 2020-08-20
CN116058333A (zh) 2023-05-05

Similar Documents

Publication Publication Date Title
SI3720279T1 (sl) Miši, ki imajo spremenjeno lahko verigo imunoglobulina lambda in njihova uporaba
IL260937A (en) Fabs antibodies one by one and their uses
IL276950A (en) Anti-CD73 antibodies and uses thereof
KR102162129B9 (ko) 항-갈렉틴-9 항체 및 이의 용도
IL266282A (en) Non-human animals with a transgenic immunoglobulin light chain locus
IL282968A (en) Anti-NKG2A antibodies and their use
HK1257174A1 (zh) 包含κ和λ輕鏈的抗原結合多肽構建體及其用途
SG11202106483WA (en) Antibodies that neutralize hepatitis b virus and uses thereof
IL281297A (en) Anti-NPR1 antibodies and uses thereof
IL277330A (en) Anti-IL-27 antibodies and uses thereof
IL275826A (en) Anti-mct1 antibodies and their uses
IL280321A (en) Antibodies against CXCR2 and their uses
DE112018004458A5 (de) Leuchtstoffmischung, konversionselement und optoelektronisches bauelement
IL283875A (en) Anti-il-27 antibodies and uses thereof
IL281202A (en) Anti-TNFRSF9 antibodies and uses thereof
IL277075A (en) Anti-PHF-tau antibodies and uses thereof
IL276548A (en) Binding antibodies - BCMA and their uses
IL283890A (en) Anti-periostin antibodies and their uses
IL279790A (en) Anti-L1CAM antibodies and uses thereof
TH1501005360A (th) หนูเมาส์ซึ่งแสดงออกเรเพอร์ทอร์ที่จำกัดของสายเบาของอิมมูโนโกลบูลิน