JP2020511135A5 - - Google Patents
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- Publication number
- JP2020511135A5 JP2020511135A5 JP2019549581A JP2019549581A JP2020511135A5 JP 2020511135 A5 JP2020511135 A5 JP 2020511135A5 JP 2019549581 A JP2019549581 A JP 2019549581A JP 2019549581 A JP2019549581 A JP 2019549581A JP 2020511135 A5 JP2020511135 A5 JP 2020511135A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- nucleic acid
- encodes
- polynucleotides
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 31
- 108091033319 polynucleotide Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 22
- 239000002157 polynucleotide Substances 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 108020004705 Codon Proteins 0.000 claims 12
- 238000009826 distribution Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000002194 synthesizing effect Effects 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000002703 mutagenesis Methods 0.000 claims 4
- 231100000350 mutagenesis Toxicity 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000009828 non-uniform distribution Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 241000203069 Archaea Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023011285A JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471723P | 2017-03-15 | 2017-03-15 | |
| US62/471,723 | 2017-03-15 | ||
| US201762578326P | 2017-10-27 | 2017-10-27 | |
| US62/578,326 | 2017-10-27 | ||
| PCT/US2018/022487 WO2018170164A1 (en) | 2017-03-15 | 2018-03-14 | De novo synthesized combinatorial nucleic acid libraries |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023011285A Division JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511135A JP2020511135A (ja) | 2020-04-16 |
| JP2020511135A5 true JP2020511135A5 (enExample) | 2021-04-22 |
| JP7335165B2 JP7335165B2 (ja) | 2023-08-29 |
Family
ID=63523968
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549581A Active JP7335165B2 (ja) | 2017-03-15 | 2018-03-14 | デノボ合成されたコンビナトリアル核酸ライブラリー |
| JP2023011285A Active JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023011285A Active JP7696937B2 (ja) | 2017-03-15 | 2023-01-27 | デノボ合成されたコンビナトリアル核酸ライブラリー |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20180282721A1 (enExample) |
| EP (1) | EP3596258A4 (enExample) |
| JP (2) | JP7335165B2 (enExample) |
| KR (2) | KR102607157B1 (enExample) |
| CN (2) | CN117888207A (enExample) |
| AU (2) | AU2018234624B2 (enExample) |
| CA (1) | CA3056386A1 (enExample) |
| GB (1) | GB2575576A (enExample) |
| IL (1) | IL269288A (enExample) |
| SG (1) | SG11201908489XA (enExample) |
| WO (1) | WO2018170164A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9409139B2 (en) | 2013-08-05 | 2016-08-09 | Twist Bioscience Corporation | De novo synthesized gene libraries |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| AU2016324296A1 (en) | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
| CA3034769A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| CN110248724B (zh) | 2016-09-21 | 2022-11-18 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| CN110366613A (zh) | 2016-12-16 | 2019-10-22 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
| AU2018234624B2 (en) * | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| KR102637566B1 (ko) | 2017-10-20 | 2024-02-16 | 트위스트 바이오사이언스 코포레이션 | 폴리뉴클레오타이드 합성을 위한 가열된 나노웰 |
| CN112041438B (zh) | 2018-01-04 | 2025-05-23 | 特韦斯特生物科学公司 | 基于dna的数字信息存储 |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| CA3124980A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| KR20210143766A (ko) * | 2019-02-26 | 2021-11-29 | 트위스트 바이오사이언스 코포레이션 | Glp1 수용체에 대한 변이체 핵산 라이브러리 |
| CN113785057A (zh) | 2019-02-26 | 2021-12-10 | 特韦斯特生物科学公司 | 用于抗体优化的变异核酸文库 |
| JP2022550497A (ja) | 2019-06-21 | 2022-12-02 | ツイスト バイオサイエンス コーポレーション | バーコードに基づいた核酸配列アセンブリ |
| CA3155629A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for crth2 |
| AU2020355027A1 (en) * | 2019-09-23 | 2022-04-21 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| CA3177029A1 (en) | 2020-04-27 | 2021-11-04 | Aaron Sato | Variant nucleic acid libraries for coronavirus |
| US12391762B2 (en) | 2020-08-26 | 2025-08-19 | Twist Bioscience Corporation | Methods and compositions relating to GLP1R variants |
| WO2022047076A1 (en) * | 2020-08-28 | 2022-03-03 | Twist Bioscience Corporation | Devices and methods for synthesis |
| US11970697B2 (en) | 2020-10-19 | 2024-04-30 | Twist Bioscience Corporation | Methods of synthesizing oligonucleotides using tethered nucleotides |
| EP4281112A4 (en) | 2021-01-21 | 2025-01-15 | Twist Bioscience Corporation | METHODS AND COMPOSITIONS RELATING TO ADENOSINE RECEPTORS |
| US12258406B2 (en) | 2021-03-24 | 2025-03-25 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| WO2022271884A2 (en) | 2021-06-22 | 2022-12-29 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| AU2022390457A1 (en) | 2021-11-18 | 2024-06-20 | Twist Bioscience Corporation | Dickkopf-1 variant antibodies and methods of use |
| WO2023130123A2 (en) | 2022-01-03 | 2023-07-06 | Twist Bioscience Corporation | Bispecific sars-cov-2 antibodies and methods of use |
| US20230325641A1 (en) * | 2022-04-07 | 2023-10-12 | Winbond Electronics Corp. | Light source optimization apparatus and light source optimization method |
| CN114694757B (zh) * | 2022-04-20 | 2025-04-18 | 中南民族大学 | Rna序列编码潜力预测方法及系统 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681702A (en) * | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| US20030130827A1 (en) * | 2001-08-10 | 2003-07-10 | Joerg Bentzien | Protein design automation for protein libraries |
| US20080287320A1 (en) | 2006-10-04 | 2008-11-20 | Codon Devices | Libraries and their design and assembly |
| JP2010520748A (ja) * | 2007-02-20 | 2010-06-17 | アナプティスバイオ インコーポレイティッド | 体細胞超変異系 |
| US8401798B2 (en) * | 2008-06-06 | 2013-03-19 | Dna Twopointo, Inc. | Systems and methods for constructing frequency lookup tables for expression systems |
| US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
| JP6590694B2 (ja) * | 2012-08-31 | 2019-10-16 | ザ スクリプス リサーチ インスティテュート | 真核生物細胞の調節因子に関する方法及び組成物 |
| US9409139B2 (en) * | 2013-08-05 | 2016-08-09 | Twist Bioscience Corporation | De novo synthesized gene libraries |
| AU2016324296A1 (en) * | 2015-09-18 | 2018-04-12 | Twist Bioscience Corporation | Oligonucleic acid variant libraries and synthesis thereof |
| AU2018234624B2 (en) | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
-
2018
- 2018-03-14 AU AU2018234624A patent/AU2018234624B2/en active Active
- 2018-03-14 SG SG11201908489X patent/SG11201908489XA/en unknown
- 2018-03-14 WO PCT/US2018/022487 patent/WO2018170164A1/en not_active Ceased
- 2018-03-14 KR KR1020197029959A patent/KR102607157B1/ko active Active
- 2018-03-14 JP JP2019549581A patent/JP7335165B2/ja active Active
- 2018-03-14 CN CN202410055914.1A patent/CN117888207A/zh active Pending
- 2018-03-14 US US15/921,479 patent/US20180282721A1/en not_active Abandoned
- 2018-03-14 GB GB1914881.6A patent/GB2575576A/en not_active Withdrawn
- 2018-03-14 CN CN201880032556.5A patent/CN110914486B/zh active Active
- 2018-03-14 EP EP18768130.9A patent/EP3596258A4/en active Pending
- 2018-03-14 CA CA3056386A patent/CA3056386A1/en active Pending
- 2018-03-14 KR KR1020237040300A patent/KR20230163591A/ko not_active Ceased
-
2019
- 2019-09-11 IL IL26928819A patent/IL269288A/en unknown
-
2023
- 2023-01-27 JP JP2023011285A patent/JP7696937B2/ja active Active
-
2024
- 2024-02-16 AU AU2024201012A patent/AU2024201012A1/en not_active Abandoned
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