JP2014509853A5 - - Google Patents
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- JP2014509853A5 JP2014509853A5 JP2013557906A JP2013557906A JP2014509853A5 JP 2014509853 A5 JP2014509853 A5 JP 2014509853A5 JP 2013557906 A JP2013557906 A JP 2013557906A JP 2013557906 A JP2013557906 A JP 2013557906A JP 2014509853 A5 JP2014509853 A5 JP 2014509853A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- antigen
- acid sequence
- variable region
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108060003951 Immunoglobulin Proteins 0.000 claims 55
- 102000018358 immunoglobulin Human genes 0.000 claims 55
- 239000000427 antigen Substances 0.000 claims 44
- 108091007433 antigens Proteins 0.000 claims 44
- 102000036639 antigens Human genes 0.000 claims 44
- 238000000034 method Methods 0.000 claims 32
- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 150000007523 nucleic acids Chemical group 0.000 claims 24
- 241001465754 Metazoa Species 0.000 claims 21
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 18
- 102000007079 Peptide Fragments Human genes 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 108010033276 Peptide Fragments Proteins 0.000 claims 15
- 230000003595 spectral effect Effects 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 238000003556 assay Methods 0.000 claims 7
- 229940072221 immunoglobulins Drugs 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 238000001819 mass spectrum Methods 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000282414 Homo sapiens Species 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 3
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 3
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000007026 protein scission Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010039101 Rhinorrhoea Diseases 0.000 claims 1
- 101710120037 Toxin CcdB Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 210000003567 ascitic fluid Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 230000002055 immunohistochemical effect Effects 0.000 claims 1
- 238000001114 immunoprecipitation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 208000010753 nasal discharge Diseases 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 238000000730 protein immunoprecipitation Methods 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450922P | 2011-03-09 | 2011-03-09 | |
| US61/450,922 | 2011-03-09 | ||
| US201161560006P | 2011-11-15 | 2011-11-15 | |
| US61/560,006 | 2011-11-15 | ||
| US201161566876P | 2011-12-05 | 2011-12-05 | |
| US61/566,876 | 2011-12-05 | ||
| US201261594729P | 2012-02-03 | 2012-02-03 | |
| US61/594,729 | 2012-02-03 | ||
| PCT/US2012/028501 WO2012122484A1 (en) | 2011-03-09 | 2012-03-09 | Methods and reagents for creating monoclonal antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017175320A Division JP6557709B2 (ja) | 2011-03-09 | 2017-09-13 | モノクローナル抗体を作製するための方法および試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509853A JP2014509853A (ja) | 2014-04-24 |
| JP2014509853A5 true JP2014509853A5 (enExample) | 2015-04-09 |
| JP6211931B2 JP6211931B2 (ja) | 2017-10-11 |
Family
ID=45922811
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557906A Active JP6211931B2 (ja) | 2011-03-09 | 2012-03-09 | モノクローナル抗体を作製するための方法および試薬 |
| JP2017175320A Expired - Fee Related JP6557709B2 (ja) | 2011-03-09 | 2017-09-13 | モノクローナル抗体を作製するための方法および試薬 |
| JP2019128863A Pending JP2019195335A (ja) | 2011-03-09 | 2019-07-11 | モノクローナル抗体を作製するための方法および試薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017175320A Expired - Fee Related JP6557709B2 (ja) | 2011-03-09 | 2017-09-13 | モノクローナル抗体を作製するための方法および試薬 |
| JP2019128863A Pending JP2019195335A (ja) | 2011-03-09 | 2019-07-11 | モノクローナル抗体を作製するための方法および試薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9920110B2 (enExample) |
| EP (2) | EP3345922A1 (enExample) |
| JP (3) | JP6211931B2 (enExample) |
| KR (3) | KR20190006083A (enExample) |
| CN (2) | CN103842379A (enExample) |
| AU (3) | AU2012225310B2 (enExample) |
| CA (1) | CA2829606C (enExample) |
| DK (1) | DK2683736T3 (enExample) |
| ES (1) | ES2666301T3 (enExample) |
| HK (1) | HK1256304A1 (enExample) |
| HU (1) | HUE037095T2 (enExample) |
| WO (1) | WO2012122484A1 (enExample) |
Families Citing this family (53)
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| US8685898B2 (en) | 2009-01-15 | 2014-04-01 | Imdaptive, Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| EP2783214A2 (en) | 2011-11-23 | 2014-10-01 | The Board of Regents of The University of Texas System | Proteomic identification of antibodies |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| MX354329B (es) | 2012-05-08 | 2018-02-27 | Adaptive Biotechnologies Corp | Composiciones y metodos para medir y calibrar el error de amplificacion en reacciones de pcr multiple. |
| CN104619862B (zh) | 2012-06-15 | 2017-10-31 | 得克萨斯系统大学董事会 | 单细胞的多转录物的高通量测序 |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| SG10201707394PA (en) * | 2013-03-15 | 2017-10-30 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| JP5924455B2 (ja) * | 2013-09-09 | 2016-05-25 | 株式会社島津製作所 | ペプチド断片の調製方法およびそれに用いられるペプチド断片調製用キット、ならびに分析方法 |
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| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
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| CN105277638A (zh) * | 2014-07-22 | 2016-01-27 | 沈鹤霄 | 一种单克隆抗体IgG质谱测序方法 |
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| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CN104560980B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠BCR轻链Lamda文库的多重PCR引物和方法 |
| CN104560979B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠bcr重链文库的多重pcr引物和方法 |
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| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
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| CN110382696B (zh) * | 2017-03-07 | 2024-04-19 | 豪夫迈·罗氏有限公司 | 发现替代性抗原特异性抗体变体的方法 |
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| CN115894687B (zh) * | 2022-03-31 | 2024-06-07 | 台州恩泽医疗中心(集团) | 一种抗hla-g1，-g2，-g5及hla-g6异构体分子的单克隆抗体及其用途 |
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| KR20090127341A (ko) | 2007-03-06 | 2009-12-10 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 항체 |
| PL2125894T3 (pl) | 2007-03-22 | 2019-08-30 | Biogen Ma Inc. | Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania |
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-
2012
- 2012-03-09 EP EP17196465.3A patent/EP3345922A1/en not_active Withdrawn
- 2012-03-09 CN CN201280021326.1A patent/CN103842379A/zh active Pending
- 2012-03-09 JP JP2013557906A patent/JP6211931B2/ja active Active
- 2012-03-09 CA CA2829606A patent/CA2829606C/en active Active
- 2012-03-09 WO PCT/US2012/028501 patent/WO2012122484A1/en not_active Ceased
- 2012-03-09 DK DK12711501.2T patent/DK2683736T3/en active
- 2012-03-09 US US13/416,582 patent/US9920110B2/en active Active
- 2012-03-09 AU AU2012225310A patent/AU2012225310B2/en active Active
- 2012-03-09 EP EP12711501.2A patent/EP2683736B1/en active Active
- 2012-03-09 ES ES12711501.2T patent/ES2666301T3/es active Active
- 2012-03-09 CN CN201810154961.6A patent/CN108220297A/zh active Pending
- 2012-03-09 KR KR1020197000660A patent/KR20190006083A/ko not_active Ceased
- 2012-03-09 KR KR1020137026647A patent/KR101938343B1/ko active Active
- 2012-03-09 HU HUE12711501A patent/HUE037095T2/hu unknown
- 2012-03-09 KR KR1020197026655A patent/KR20190107761A/ko not_active Ceased
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2017
- 2017-09-13 JP JP2017175320A patent/JP6557709B2/ja not_active Expired - Fee Related
- 2017-10-12 AU AU2017245395A patent/AU2017245395B2/en active Active
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2018
- 2018-01-19 US US15/875,615 patent/US20190002532A1/en not_active Abandoned
- 2018-11-30 HK HK18115369.1A patent/HK1256304A1/en unknown
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2019
- 2019-07-11 JP JP2019128863A patent/JP2019195335A/ja active Pending
- 2019-08-14 AU AU2019216660A patent/AU2019216660A1/en not_active Abandoned
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