JP2009039107A5 - - Google Patents
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- Publication number
- JP2009039107A5 JP2009039107A5 JP2008184139A JP2008184139A JP2009039107A5 JP 2009039107 A5 JP2009039107 A5 JP 2009039107A5 JP 2008184139 A JP2008184139 A JP 2008184139A JP 2008184139 A JP2008184139 A JP 2008184139A JP 2009039107 A5 JP2009039107 A5 JP 2009039107A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- cancer
- antibody
- seq
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 46
- 206010028980 Neoplasm Diseases 0.000 claims 39
- 201000011510 cancer Diseases 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 101150073900 PTEN gene Proteins 0.000 claims 11
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 10
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 10
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 206010009944 Colon cancer Diseases 0.000 claims 8
- 206010014733 Endometrial cancer Diseases 0.000 claims 8
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 8
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 8
- 208000029742 colonic neoplasm Diseases 0.000 claims 8
- 201000010536 head and neck cancer Diseases 0.000 claims 8
- 208000014829 head and neck neoplasm Diseases 0.000 claims 8
- 201000005202 lung cancer Diseases 0.000 claims 8
- 208000020816 lung neoplasm Diseases 0.000 claims 8
- 108700028369 Alleles Proteins 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 6
- 238000009396 hybridization Methods 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 102000006382 Ribonucleases Human genes 0.000 claims 2
- 108010083644 Ribonucleases Proteins 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000829171 Hypocrea virens (strain Gv29-8 / FGSC 10586) Effector TSP1 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000037433 frameshift Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/791,115 US6262242B1 (en) | 1997-01-30 | 1997-01-30 | Tumor suppressor designated TS10Q23.3 |
| US08/791,115 | 1997-01-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53289798A Division JP2001511002A (ja) | 1997-01-30 | 1998-01-08 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010139230A Division JP5202583B2 (ja) | 1997-01-30 | 2010-06-18 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009039107A JP2009039107A (ja) | 2009-02-26 |
| JP2009039107A5 true JP2009039107A5 (enExample) | 2011-03-17 |
| JP4768783B2 JP4768783B2 (ja) | 2011-09-07 |
Family
ID=25152739
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53289798A Withdrawn JP2001511002A (ja) | 1997-01-30 | 1998-01-08 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
| JP2008184139A Expired - Lifetime JP4768783B2 (ja) | 1997-01-30 | 2008-07-15 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
| JP2010139230A Expired - Lifetime JP5202583B2 (ja) | 1997-01-30 | 2010-06-18 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
| JP2013006918A Withdrawn JP2013128485A (ja) | 1997-01-30 | 2013-01-18 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
| JP2014040353A Withdrawn JP2014155493A (ja) | 1997-01-30 | 2014-03-03 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53289798A Withdrawn JP2001511002A (ja) | 1997-01-30 | 1998-01-08 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010139230A Expired - Lifetime JP5202583B2 (ja) | 1997-01-30 | 2010-06-18 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
| JP2013006918A Withdrawn JP2013128485A (ja) | 1997-01-30 | 2013-01-18 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
| JP2014040353A Withdrawn JP2014155493A (ja) | 1997-01-30 | 2014-03-03 | Ｔｓ１０ｑ２３．３と称する腫瘍抑制因子 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6262242B1 (enExample) |
| EP (2) | EP2366712A3 (enExample) |
| JP (5) | JP2001511002A (enExample) |
| AR (1) | AR011607A1 (enExample) |
| AT (1) | ATE499444T1 (enExample) |
| AU (1) | AU745296B2 (enExample) |
| CA (1) | CA2278849C (enExample) |
| DE (1) | DE69842141D1 (enExample) |
| DK (1) | DK0972024T4 (enExample) |
| ES (1) | ES2361044T5 (enExample) |
| IL (1) | IL131168A0 (enExample) |
| PT (1) | PT972024E (enExample) |
| WO (1) | WO1998033907A1 (enExample) |
| ZA (1) | ZA98756B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287854B1 (en) | 1996-10-22 | 2001-09-11 | Imperial Cancer Research Technology Limited | Diagnosis of susceptibility to cancer and treatment thereof |
| US6482795B1 (en) * | 1997-01-30 | 2002-11-19 | Myriad Genetics, Inc. | Tumor suppressor designated TS10q23.3 |
| CA2280097A1 (en) * | 1997-02-07 | 1998-08-13 | The Trustees Of Columbia University In The City Of New York | Use of the p-ten suppressor gene in diagnosis and treatment of cancer |
| US6225120B1 (en) | 1997-05-15 | 2001-05-01 | The General Hospital Corporation | Therapeutic and diagnostic tools for impaired glucose tolerance conditions |
| US6861256B2 (en) * | 1997-05-15 | 2005-03-01 | The General Hospital Corporation | Therapeutic and diagnostic tools for impaired glucose tolerance conditions |
| WO1999002704A2 (en) * | 1997-07-08 | 1999-01-21 | Cold Spring Harbor Laboratory | Dual specifically phosphatase and methods of use |
| ES2245039T3 (es) * | 1997-08-26 | 2005-12-16 | Board Of Regents, The University Of Texas System | Un supresor de tumor designado ts10qs3.3. |
| AU2002226028A1 (en) | 2000-11-14 | 2002-05-27 | Board Of Regents, Unversity Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
| AU2002359697A1 (en) * | 2001-12-20 | 2003-07-09 | Tularik Inc. | Identification of an amplified gene and target for drug intervention |
| US7981618B2 (en) * | 2003-11-05 | 2011-07-19 | Board Of Regents Of The University Of Texas System | Diagnostic and therapeutic methods and compositions involving PTEN and breast cancer |
| BRPI0711011A2 (pt) | 2006-05-18 | 2011-08-23 | Molecular Profiling Inst Inc | método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença |
| US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| BRPI0921043A2 (pt) * | 2008-11-12 | 2018-08-07 | Caris Life Sciences Luxembourg Holdings | métodos e sistemas para usar exossomas para determinar fenótipos |
| AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| KR20130043104A (ko) | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| WO2012040387A1 (en) | 2010-09-24 | 2012-03-29 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
| BR112014013544A8 (pt) | 2011-12-30 | 2017-06-13 | Abbott Molecular Inc | materiais e métodos para diagnose, prognose e avaliação do tratamento terapêutico/profilático de câncer da próstata |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| EP0273085A1 (en) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| AU622104B2 (en) | 1987-03-11 | 1992-04-02 | Sangtec Molecular Diagnostics Ab | Method of assaying of nucleic acids, a reagent combination and kit therefore |
| FR2616841A1 (fr) | 1987-06-17 | 1988-12-23 | Rauner Hans | Perfectionnements au systeme de bloquage en position ouverte a levier de serrage pivotant, pour fiches et paumelles de portes et de fenetres |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| JP2846018B2 (ja) | 1988-01-21 | 1999-01-13 | ジェネンテク，インコーポレイテッド | 核酸配列の増幅および検出 |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US4932207A (en) | 1988-12-28 | 1990-06-12 | Sundstrand Corporation | Segmented seal plate for a turbine engine |
| US5279721A (en) | 1993-04-22 | 1994-01-18 | Peter Schmid | Apparatus and method for an automated electrophoresis system |
| CN1203633A (zh) | 1995-10-23 | 1998-12-30 | 帝国癌症研究技术有限公司 | 对癌症的易感性诊断及其治疗 |
| ES2245039T3 (es) * | 1997-08-26 | 2005-12-16 | Board Of Regents, The University Of Texas System | Un supresor de tumor designado ts10qs3.3. |
| US8312249B1 (en) | 2008-10-10 | 2012-11-13 | Apple Inc. | Dynamic trampoline and structured code generation in a signed code environment |
| FR2957821B1 (fr) | 2010-03-24 | 2014-08-29 | Inst Francais Du Petrole | Nouvelle zone de regeneration du catalyseur divisee en secteurs pour unites catalytiques regeneratives |
-
1997
- 1997-01-30 US US08/791,115 patent/US6262242B1/en not_active Expired - Lifetime
-
1998
- 1998-01-08 AU AU60189/98A patent/AU745296B2/en not_active Expired
- 1998-01-08 EP EP10180064A patent/EP2366712A3/en not_active Withdrawn
- 1998-01-08 CA CA2278849A patent/CA2278849C/en not_active Expired - Lifetime
- 1998-01-08 DK DK98903409.5T patent/DK0972024T4/da active
- 1998-01-08 WO PCT/US1998/000353 patent/WO1998033907A1/en not_active Ceased
- 1998-01-08 EP EP98903409.5A patent/EP0972024B2/en not_active Expired - Lifetime
- 1998-01-08 PT PT98903409T patent/PT972024E/pt unknown
- 1998-01-08 JP JP53289798A patent/JP2001511002A/ja not_active Withdrawn
- 1998-01-08 AT AT98903409T patent/ATE499444T1/de active
- 1998-01-08 DE DE69842141T patent/DE69842141D1/de not_active Expired - Lifetime
- 1998-01-08 IL IL13116898A patent/IL131168A0/xx unknown
- 1998-01-08 ES ES98903409.5T patent/ES2361044T5/es not_active Expired - Lifetime
- 1998-01-29 ZA ZA98756A patent/ZA98756B/xx unknown
- 1998-01-30 AR ARP980100442A patent/AR011607A1/es not_active Application Discontinuation
-
2008
- 2008-07-15 JP JP2008184139A patent/JP4768783B2/ja not_active Expired - Lifetime
-
2010
- 2010-06-18 JP JP2010139230A patent/JP5202583B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-18 JP JP2013006918A patent/JP2013128485A/ja not_active Withdrawn
-
2014
- 2014-03-03 JP JP2014040353A patent/JP2014155493A/ja not_active Withdrawn
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