ES2666301T3 - Métodos y reactivos para crear anticuerpos monoclonales - Google Patents
Métodos y reactivos para crear anticuerpos monoclonales Download PDFInfo
- Publication number
- ES2666301T3 ES2666301T3 ES12711501.2T ES12711501T ES2666301T3 ES 2666301 T3 ES2666301 T3 ES 2666301T3 ES 12711501 T ES12711501 T ES 12711501T ES 2666301 T3 ES2666301 T3 ES 2666301T3
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- 238000000034 method Methods 0.000 title abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract description 34
- 150000007523 nucleic acids Chemical group 0.000 abstract description 29
- 239000000427 antigen Substances 0.000 abstract description 19
- 102000036639 antigens Human genes 0.000 abstract description 19
- 108091007433 antigens Proteins 0.000 abstract description 19
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 14
- 125000003275 alpha amino acid group Chemical group 0.000 abstract description 10
- 102000012745 Immunoglobulin Subunits Human genes 0.000 abstract description 9
- 108010079585 Immunoglobulin Subunits Proteins 0.000 abstract description 9
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 9
- 108060003951 Immunoglobulin Proteins 0.000 abstract description 8
- 102000018358 immunoglobulin Human genes 0.000 abstract description 8
- 238000001819 mass spectrum Methods 0.000 abstract description 6
- 241000894007 species Species 0.000 abstract description 5
- 102000007079 Peptide Fragments Human genes 0.000 abstract description 4
- 108010033276 Peptide Fragments Proteins 0.000 abstract description 4
- 229940072221 immunoglobulins Drugs 0.000 abstract description 3
- 230000003595 spectral effect Effects 0.000 abstract description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 abstract 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 description 10
- 108020004707 nucleic acids Proteins 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 235000002198 Annona diversifolia Nutrition 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 241000238586 Cirripedia Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- -1 Glu-C Proteins 0.000 description 1
- 108010027044 HIV Core Protein p24 Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000283953 Lagomorpha Species 0.000 description 1
- 241000282842 Lama glama Species 0.000 description 1
- 101001018085 Lysobacter enzymogenes Lysyl endopeptidase Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
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- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450922P | 2011-03-09 | 2011-03-09 | |
| US201161450922P | 2011-03-09 | ||
| US201161560006P | 2011-11-15 | 2011-11-15 | |
| US201161560006P | 2011-11-15 | ||
| US201161566876P | 2011-12-05 | 2011-12-05 | |
| US201161566876P | 2011-12-05 | ||
| US201261594729P | 2012-02-03 | 2012-02-03 | |
| US201261594729P | 2012-02-03 | ||
| PCT/US2012/028501 WO2012122484A1 (en) | 2011-03-09 | 2012-03-09 | Methods and reagents for creating monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2666301T3 true ES2666301T3 (es) | 2018-05-03 |
Family
ID=45922811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12711501.2T Active ES2666301T3 (es) | 2011-03-09 | 2012-03-09 | Métodos y reactivos para crear anticuerpos monoclonales |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9920110B2 (enExample) |
| EP (2) | EP3345922A1 (enExample) |
| JP (3) | JP6211931B2 (enExample) |
| KR (3) | KR101938343B1 (enExample) |
| CN (2) | CN108220297A (enExample) |
| AU (3) | AU2012225310B2 (enExample) |
| CA (1) | CA2829606C (enExample) |
| DK (1) | DK2683736T3 (enExample) |
| ES (1) | ES2666301T3 (enExample) |
| HK (1) | HK1256304A1 (enExample) |
| HU (1) | HUE037095T2 (enExample) |
| WO (1) | WO2012122484A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and a method for producing monoclonal antibodies |
| EP2783214A2 (en) | 2011-11-23 | 2014-10-01 | The Board of Regents of The University of Texas System | Proteomic identification of antibodies |
| ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
| PT2831276T (pt) | 2012-05-08 | 2016-07-26 | Adaptive Biotechnologies Corp | Composições e método para medição e calibração do viés de amplificação em reações pcr multiplex |
| EP2861760B1 (en) | 2012-06-15 | 2020-01-01 | The Board of Regents of The University of Texas System | High throughput sequencing of multiple transcripts of a single cell |
| SG11201506991VA (en) * | 2013-03-15 | 2015-10-29 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| PL3023777T3 (pl) * | 2013-09-09 | 2018-04-30 | Shimadzu Corporation | Sposób otrzymywania fragmentów peptydowych, zestaw do otrzymywania fragmentów peptydowych przeznaczony do stosowania w nim i sposób analizy |
| GB201316644D0 (en) * | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3399052A3 (en) * | 2014-06-25 | 2018-12-26 | The Rockefeller University | Compositions and methods for rapid production of versatile nanobody repertoires |
| CN105277638A (zh) * | 2014-07-22 | 2016-01-27 | 沈鹤霄 | 一种单克隆抗体IgG质谱测序方法 |
| EP3715455A1 (en) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CN104560979B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠bcr重链文库的多重pcr引物和方法 |
| CN104560980B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠BCR轻链Lamda文库的多重PCR引物和方法 |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| CN107533032A (zh) | 2015-03-06 | 2018-01-02 | 英国质谱公司 | 用于从块状组织直接映射的原位电离质谱测定成像平台 |
| GB2555921B (en) | 2015-03-06 | 2021-09-15 | Micromass Ltd | Endoscopic tissue identification tool |
| CA2981085A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Spectrometric analysis |
| EP3265820B1 (en) | 2015-03-06 | 2023-12-13 | Micromass UK Limited | Spectrometric analysis of microbes |
| EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| CN112964625B (zh) | 2015-03-06 | 2024-06-07 | 英国质谱公司 | 细胞群体分析 |
| US10026599B2 (en) * | 2015-03-06 | 2018-07-17 | Micromass Uk Limited | Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples |
| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
| US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
| CA3006044A1 (en) * | 2015-09-09 | 2017-03-16 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with cerebro-craniofacial health |
| WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
| CN106047857B (zh) * | 2016-06-01 | 2020-04-03 | 苏州金唯智生物科技有限公司 | 一种发掘特异性功能抗体的方法 |
| CN107525934A (zh) * | 2016-06-21 | 2017-12-29 | 张效龙 | 一种测定血液中抗体氨基酸序列的方法 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| JP7473339B2 (ja) * | 2017-03-07 | 2024-04-23 | エフ． ホフマン－ラ ロシュ アーゲー | 代替の抗原特異的抗体変異体を発見するための方法 |
| AU2018303254B2 (en) * | 2017-07-21 | 2025-05-29 | Novimmune Sa | Generating multispecific antibody mixtures and methods of uses thereof |
| CN109425662A (zh) * | 2017-08-23 | 2019-03-05 | 深圳华大基因研究院 | 一种鉴定蛋白的方法及系统 |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN111902720B (zh) | 2018-03-21 | 2025-02-07 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| JP2020514681A (ja) * | 2018-03-29 | 2020-05-21 | 深▲セン▼▲達▼▲闥▼科技控股有限公司Ｃｌｏｕｄｍｉｎｄｓ （Ｓｈｅｎｚｈｅｎ） Ｈｏｌｄｉｎｇｓ Ｃｏ．， Ｌｔｄ． | 物質検出方法、装置、電子機器、およびコンピュータ可読記憶媒体 |
| CN108530533B (zh) * | 2018-04-13 | 2020-09-04 | 吉林大学 | 猪瘟病毒单克隆抗体hk24及医用用途 |
| WO2020123268A1 (en) * | 2018-12-11 | 2020-06-18 | Merck Sharp & Dohme Corp. | Method for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of b-cell and hybridoma libraries |
| CN114008713A (zh) * | 2019-06-07 | 2022-02-01 | 中外制药株式会社 | 信息处理系统、信息处理方法、程序、以及制备抗原结合分子或蛋白质的方法 |
| CN110452296A (zh) * | 2019-07-16 | 2019-11-15 | 福州精锐生物技术有限公司 | 一种兔单克隆抗体制备方法 |
| MX2022003244A (es) * | 2019-09-16 | 2022-04-26 | Regeneron Pharma | Metodos de lc-ms para la isotipificacion y cuantificacion de anticuerpos. |
| EP4074725A4 (en) * | 2019-12-09 | 2024-02-28 | Optolane Technologies Inc. | SWITCH BINDER, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION, ASSAY KIT, AND METHOD FOR DOSING ANTIGEN AND ANTIBODY, EACH USING THE SAME |
| WO2021222546A1 (en) * | 2020-05-01 | 2021-11-04 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compositions and methods for identifying nanobodies and nanobody affinities |
| CA3214755A1 (en) * | 2021-04-09 | 2022-10-13 | Natalie CASTELLANA | Method for antibody identification from protein mixtures |
| IT202100019334A1 (it) * | 2021-07-21 | 2023-01-21 | Univ Degli Studi Di Pavia | Metodo per l’identificazione dell’intera sequenza della regione variabile delle catene pesanti e leggere di immunoglobuline |
| CN115894687B (zh) * | 2022-03-31 | 2024-06-07 | 台州恩泽医疗中心(集团) | 一种抗hla-g1，-g2，-g5及hla-g6异构体分子的单克隆抗体及其用途 |
| CN116779037B (zh) * | 2022-07-27 | 2025-08-05 | 北京理工大学 | 一种基于从头测序和同源标签图论的抗体序列鉴定方法 |
| CN117849159B (zh) * | 2024-01-09 | 2025-01-07 | 融智生物科技（青岛）有限公司 | M蛋白的检测方法、电子设备及存储介质 |
| CN120214310B (zh) * | 2025-05-20 | 2025-08-19 | 中国农业大学 | 一种禽白血病抗原检测试剂盒及其制备方法 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2137354T3 (es) | 1993-01-12 | 1999-12-16 | Biogen Inc | Moleculas de anticuerpo anti-vla4 recombinante. |
| US6436908B1 (en) | 1995-05-30 | 2002-08-20 | Duke University | Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
| WO1999018792A1 (en) | 1997-10-10 | 1999-04-22 | Johns Hopkins University | Gene delivery compositions and methods |
| CA2330673C (en) | 1998-05-01 | 2009-05-26 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and dna molecules |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US7300753B2 (en) | 1998-09-04 | 2007-11-27 | John Rush | Immunoaffinity isolation of modified peptides from complex mixtures |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| DE60239962D1 (de) | 2001-08-14 | 2011-06-16 | Harvard College | Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie |
| EP1458736A4 (en) * | 2001-12-14 | 2005-09-14 | Lilly Co Eli | RECOMBINANT RINDER THROMBIN |
| GB0130267D0 (en) | 2001-12-19 | 2002-02-06 | Neutec Pharma Plc | Focussed antibody technology |
| CA2526120A1 (en) | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| AU2005211790B2 (en) | 2004-02-09 | 2010-03-11 | Northeastern University | Monoclonal antibody based biomarker discovery and development platform |
| AU2005216549A1 (en) | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
| US20070161001A1 (en) | 2004-03-04 | 2007-07-12 | Dena Leshkowitz | Quantifying and profiling antibody and t cell receptor gene expression |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| HRP20110948T1 (hr) * | 2005-06-10 | 2012-01-31 | Ares Trading S.A. | Postupak za pročišćavanje il-18 vezujućeg proteina |
| AU2007254005B2 (en) | 2006-02-10 | 2012-11-29 | Genentech, Inc. | Anti-FGF19 antibodies and methods using same |
| GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
| CA2657223A1 (en) * | 2006-07-07 | 2008-01-10 | Pall Corporation | Use of denaturing agents during affinity capture |
| JP2010515020A (ja) | 2006-12-21 | 2010-05-06 | ノバルティス アーゲー | 抗体定量法 |
| CN101675075B (zh) | 2007-03-01 | 2014-06-18 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| BRPI0808673A2 (pt) * | 2007-03-06 | 2014-08-12 | Symphogen As | Anticorpos recombinantes para tratamento de infecções com vírus sinciciais respiratórios. |
| EP2125894B1 (en) | 2007-03-22 | 2018-12-19 | Biogen MA Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
| SI2602323T1 (en) | 2007-06-01 | 2018-05-31 | Open Monoclonal Technology, Inc. | Compositions and procedures for inhibiting endogenous immunoglobin gene and the formation of transgenic human idiopathic antibodies |
| US7887801B2 (en) | 2007-07-13 | 2011-02-15 | Topotarget Germany Ag | Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins |
| NZ585500A (en) * | 2007-11-12 | 2012-06-29 | Theraclone Sciences Inc | Antibodies which bind to an epitope in the extracellular domain of the matrix 2 ectodomain polypeptide of an influenza virus |
| AU2008328370A1 (en) | 2007-11-22 | 2009-05-28 | Symphogen A/S | A method for characterization of a recombinant polyclonal protein |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| WO2010002911A2 (en) | 2008-06-30 | 2010-01-07 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Methods and materials for monitoring myeloma using quantitative mass spetrometry |
| KR102362774B1 (ko) | 2008-09-30 | 2022-02-15 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 인간 이외의 포유동물 |
| CN112690250B (zh) | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| HUE029424T2 (en) | 2009-01-15 | 2017-02-28 | Adaptive Biotechnologies Corp | Adaptive immunity profiling and a method for producing monoclonal antibodies |
| US20110313138A1 (en) | 2009-02-25 | 2011-12-22 | Ucb Pharma, S.A. | Method for Producing Proteins |
| DK2792236T4 (da) | 2009-07-08 | 2023-05-15 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| US20110045534A1 (en) | 2009-08-20 | 2011-02-24 | Cell Signaling Technology, Inc. | Nucleic Acid Cassette For Producing Recombinant Antibodies |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| KR102004106B1 (ko) | 2010-03-31 | 2019-07-25 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| US9234240B2 (en) | 2010-05-07 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| AU2011256290B2 (en) | 2010-05-17 | 2014-06-12 | The Board Of Regents Of The University Of Texas System | Rapid isolation of monoclonal antibodies from animals |
| AU2011266843C9 (en) | 2010-06-17 | 2018-03-01 | Kymab Limited | Animal models and therapeutic molecules |
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2012
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- 2012-03-09 EP EP17196465.3A patent/EP3345922A1/en not_active Withdrawn
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- 2012-03-09 KR KR1020197026655A patent/KR20190107761A/ko not_active Ceased
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2017
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| JP2019195335A (ja) | 2019-11-14 |
| KR101938343B1 (ko) | 2019-01-14 |
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| HUE037095T2 (hu) | 2018-08-28 |
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| DK2683736T3 (en) | 2018-04-23 |
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| EP2683736B1 (en) | 2018-01-17 |
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| CN108220297A (zh) | 2018-06-29 |
| US9920110B2 (en) | 2018-03-20 |
| CA2829606C (en) | 2020-06-02 |
| WO2012122484A1 (en) | 2012-09-13 |
| KR20140010436A (ko) | 2014-01-24 |
| CN103842379A (zh) | 2014-06-04 |
| EP2683736A1 (en) | 2014-01-15 |
| US20190002532A1 (en) | 2019-01-03 |
| JP6211931B2 (ja) | 2017-10-11 |
| AU2012225310B2 (en) | 2017-08-03 |
| AU2019216660A1 (en) | 2019-09-05 |
| AU2017245395A2 (en) | 2017-11-23 |
| JP6557709B2 (ja) | 2019-08-07 |
| AU2017245395A1 (en) | 2017-11-02 |
| JP2018027090A (ja) | 2018-02-22 |
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