HK1256304A1 - Methods and reagents for creating monoclonal antibodies - Google Patents
Methods and reagents for creating monoclonal antibodies Download PDFInfo
- Publication number
- HK1256304A1 HK1256304A1 HK18115369.1A HK18115369A HK1256304A1 HK 1256304 A1 HK1256304 A1 HK 1256304A1 HK 18115369 A HK18115369 A HK 18115369A HK 1256304 A1 HK1256304 A1 HK 1256304A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nucleic acid
- antigen
- acid sequences
- immunoglobulin
- seq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450922P | 2011-03-09 | 2011-03-09 | |
| US201161450922P | 2011-03-09 | ||
| US201161560006P | 2011-11-15 | 2011-11-15 | |
| US201161560006P | 2011-11-15 | ||
| US201161566876P | 2011-12-05 | 2011-12-05 | |
| US201161566876P | 2011-12-05 | ||
| US201261594729P | 2012-02-03 | 2012-02-03 | |
| US201261594729P | 2012-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1256304A1 true HK1256304A1 (en) | 2019-09-20 |
Family
ID=45922811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18115369.1A HK1256304A1 (en) | 2011-03-09 | 2018-11-30 | Methods and reagents for creating monoclonal antibodies |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9920110B2 (enExample) |
| EP (2) | EP3345922A1 (enExample) |
| JP (3) | JP6211931B2 (enExample) |
| KR (3) | KR20190006083A (enExample) |
| CN (2) | CN103842379A (enExample) |
| AU (3) | AU2012225310B2 (enExample) |
| CA (1) | CA2829606C (enExample) |
| DK (1) | DK2683736T3 (enExample) |
| ES (1) | ES2666301T3 (enExample) |
| HK (1) | HK1256304A1 (enExample) |
| HU (1) | HUE037095T2 (enExample) |
| WO (1) | WO2012122484A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685898B2 (en) | 2009-01-15 | 2014-04-01 | Imdaptive, Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| EP2783214A2 (en) | 2011-11-23 | 2014-10-01 | The Board of Regents of The University of Texas System | Proteomic identification of antibodies |
| US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
| MX354329B (es) | 2012-05-08 | 2018-02-27 | Adaptive Biotechnologies Corp | Composiciones y metodos para medir y calibrar el error de amplificacion en reacciones de pcr multiple. |
| CN104619862B (zh) | 2012-06-15 | 2017-10-31 | 得克萨斯系统大学董事会 | 单细胞的多转录物的高通量测序 |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| SG10201707394PA (en) * | 2013-03-15 | 2017-10-30 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| JP5924455B2 (ja) * | 2013-09-09 | 2016-05-25 | 株式会社島津製作所 | ペプチド断片の調製方法およびそれに用いられるペプチド断片調製用キット、ならびに分析方法 |
| GB201316644D0 (en) * | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| WO2015200626A1 (en) * | 2014-06-25 | 2015-12-30 | The Rockefeller University | Compositions and methods for rapid production of versatile nanobody repertoires |
| CN105277638A (zh) * | 2014-07-22 | 2016-01-27 | 沈鹤霄 | 一种单克隆抗体IgG质谱测序方法 |
| ES2784343T3 (es) | 2014-10-29 | 2020-09-24 | Adaptive Biotechnologies Corp | Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CN104560980B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠BCR轻链Lamda文库的多重PCR引物和方法 |
| CN104560979B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠bcr重链文库的多重pcr引物和方法 |
| US11047008B2 (en) | 2015-02-24 | 2021-06-29 | Adaptive Biotechnologies Corporation | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
| GB2555921B (en) | 2015-03-06 | 2021-09-15 | Micromass Ltd | Endoscopic tissue identification tool |
| GB2553918B (en) | 2015-03-06 | 2022-10-12 | Micromass Ltd | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| CA2981085A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Spectrometric analysis |
| CN110057901B (zh) * | 2015-03-06 | 2022-07-01 | 英国质谱公司 | 拭子和活检样品的快速蒸发电离质谱和解吸电喷雾电离质谱分析 |
| CN108700590B (zh) | 2015-03-06 | 2021-03-02 | 英国质谱公司 | 细胞群体分析 |
| US11282688B2 (en) | 2015-03-06 | 2022-03-22 | Micromass Uk Limited | Spectrometric analysis of microbes |
| CA2978042A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| WO2017044885A1 (en) * | 2015-09-09 | 2017-03-16 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with cerebro-craniofacial health |
| US11454611B2 (en) | 2016-04-14 | 2022-09-27 | Micromass Uk Limited | Spectrometric analysis of plants |
| CN106047857B (zh) * | 2016-06-01 | 2020-04-03 | 苏州金唯智生物科技有限公司 | 一种发掘特异性功能抗体的方法 |
| CN107525934A (zh) * | 2016-06-21 | 2017-12-29 | 张效龙 | 一种测定血液中抗体氨基酸序列的方法 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CN110382696B (zh) * | 2017-03-07 | 2024-04-19 | 豪夫迈·罗氏有限公司 | 发现替代性抗原特异性抗体变体的方法 |
| AU2018303254B2 (en) * | 2017-07-21 | 2025-05-29 | Novimmune Sa | Generating multispecific antibody mixtures and methods of uses thereof |
| CN109425662A (zh) * | 2017-08-23 | 2019-03-05 | 深圳华大基因研究院 | 一种鉴定蛋白的方法及系统 |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN119881293A (zh) | 2018-03-21 | 2025-04-25 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| JP2020514681A (ja) * | 2018-03-29 | 2020-05-21 | 深▲セン▼▲達▼▲闥▼科技控股有限公司Cloudminds (Shenzhen) Holdings Co., Ltd. | 物質検出方法、装置、電子機器、およびコンピュータ可読記憶媒体 |
| CN108530533B (zh) * | 2018-04-13 | 2020-09-04 | 吉林大学 | 猪瘟病毒单克隆抗体hk24及医用用途 |
| EP3894867A4 (en) * | 2018-12-11 | 2022-09-28 | Merck Sharp & Dohme Corp. | PROCEDURE FOR IDENTIFICATION OF HIGH-AFFINITY MONOCLONAL ANTIBODIES OF HEAVY AND LIGHT CHAIN FROM HIGH-THROUGHPUT SCREENS OF B-CELL AND HYBRIDOME LIBRARIES |
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| CN115175919A (zh) * | 2019-12-09 | 2022-10-11 | 光行科技株式会社 | 转换结合剂、其制备方法、和各自使用该转换结合剂的药物组合物、测定试剂盒、以及抗原和抗体测定方法 |
| JP7765090B2 (ja) * | 2020-05-01 | 2025-11-06 | ユニバーシティ オブ ピッツバーグ -オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | ナノボディ及びナノボディ親和性を同定するための組成物及び方法 |
| EP4320148A4 (en) * | 2021-04-09 | 2025-05-14 | Abterra Biosciences, Inc. | METHOD FOR IDENTIFYING ANTIBODIES FROM PROTEIN MIXTURES |
| IT202100019334A1 (it) * | 2021-07-21 | 2023-01-21 | Univ Degli Studi Di Pavia | Metodo per l’identificazione dell’intera sequenza della regione variabile delle catene pesanti e leggere di immunoglobuline |
| CN115894687B (zh) * | 2022-03-31 | 2024-06-07 | 台州恩泽医疗中心(集团) | 一种抗hla-g1,-g2,-g5及hla-g6异构体分子的单克隆抗体及其用途 |
| CN116779037B (zh) * | 2022-07-27 | 2025-08-05 | 北京理工大学 | 一种基于从头测序和同源标签图论的抗体序列鉴定方法 |
| CN117849159B (zh) * | 2024-01-09 | 2025-01-07 | 融智生物科技(青岛)有限公司 | M蛋白的检测方法、电子设备及存储介质 |
| CN120214310B (zh) * | 2025-05-20 | 2025-08-19 | 中国农业大学 | 一种禽白血病抗原检测试剂盒及其制备方法 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CA2050918A1 (en) | 1990-01-12 | 1991-07-13 | Raju Kucherlapati | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| JPH07503132A (ja) | 1991-12-17 | 1995-04-06 | ジェンファーム インターナショナル,インコーポレイティド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| AU688751B2 (en) | 1993-01-12 | 1998-03-19 | Biogen Idec Ma Inc. | Recombinant anti-VLA4 antibody molecules |
| US6436908B1 (en) | 1995-05-30 | 2002-08-20 | Duke University | Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5750341A (en) | 1995-04-17 | 1998-05-12 | Lynx Therapeutics, Inc. | DNA sequencing by parallel oligonucleotide extensions |
| WO1999018792A1 (en) | 1997-10-10 | 1999-04-22 | Johns Hopkins University | Gene delivery compositions and methods |
| EP1082458A1 (en) | 1998-05-01 | 2001-03-14 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and dna molecules |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US7300753B2 (en) | 1998-09-04 | 2007-11-27 | John Rush | Immunoaffinity isolation of modified peptides from complex mixtures |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| DE60239962D1 (de) | 2001-08-14 | 2011-06-16 | Harvard College | Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie |
| EP1458736A4 (en) * | 2001-12-14 | 2005-09-14 | Lilly Co Eli | RECOMBINANT RINDER THROMBIN |
| GB0130267D0 (en) | 2001-12-19 | 2002-02-06 | Neutec Pharma Plc | Focussed antibody technology |
| US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
| CA2526120A1 (en) | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| WO2005077106A2 (en) | 2004-02-09 | 2005-08-25 | Northeastern University | Monoclonal antibody based biomarker discovery and development platform |
| CA2557841A1 (en) | 2004-02-27 | 2005-09-09 | President And Fellows Of Harvard College | Polony fluorescent in situ sequencing beads |
| US20070161001A1 (en) | 2004-03-04 | 2007-07-12 | Dena Leshkowitz | Quantifying and profiling antibody and t cell receptor gene expression |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| SI1891088T1 (sl) * | 2005-06-10 | 2012-02-29 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
| AR059432A1 (es) | 2006-02-10 | 2008-04-09 | Genentech Inc | Anticuerpos anti-fgf19 y metodos que usan estos |
| GB0612928D0 (en) | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
| CA2657223A1 (en) * | 2006-07-07 | 2008-01-10 | Pall Corporation | Use of denaturing agents during affinity capture |
| JP2010515020A (ja) | 2006-12-21 | 2010-05-06 | ノバルティス アーゲー | 抗体定量法 |
| EP2132229B1 (en) | 2007-03-01 | 2016-05-11 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| KR20090127341A (ko) | 2007-03-06 | 2009-12-10 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 항체 |
| PL2125894T3 (pl) | 2007-03-22 | 2019-08-30 | Biogen Ma Inc. | Białka wiążące, w tym przeciwciała, pochodne przeciwciał i fragmenty przeciwciał, które swoiście wiążą się z CD154 i ich zastosowania |
| EP2336329B8 (en) | 2007-06-01 | 2012-11-21 | Omt, Inc. | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenis human idiotype antibodies |
| US7887801B2 (en) | 2007-07-13 | 2011-02-15 | Topotarget Germany Ag | Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins |
| JP4932940B2 (ja) * | 2007-11-12 | 2012-05-16 | セラクローン サイエンシーズ, インコーポレイテッド | インフルエンザの治療および診断のための組成物および方法 |
| CA2702322A1 (en) | 2007-11-22 | 2009-05-28 | Symphogen A/S | A method for characterization of a recombinant polyclonal protein |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| WO2010002911A2 (en) | 2008-06-30 | 2010-01-07 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Methods and materials for monitoring myeloma using quantitative mass spetrometry |
| LT2346994T (lt) | 2008-09-30 | 2022-03-10 | Ablexis, Llc | Knock-in pelė, skirta chimerinių antikūnų gamybai |
| MX2011007660A (es) | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
| US8685898B2 (en) | 2009-01-15 | 2014-04-01 | Imdaptive, Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| TR201818431T4 (tr) | 2009-02-25 | 2019-01-21 | Ucb Biopharma Sprl | Antikorlar Üretmek İçin Usul |
| PT2564695E (pt) | 2009-07-08 | 2015-06-03 | Kymab Ltd | Modelos animais e moléculas terapêuticas |
| US20110045534A1 (en) | 2009-08-20 | 2011-02-24 | Cell Signaling Technology, Inc. | Nucleic Acid Cassette For Producing Recombinant Antibodies |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| ES2984483T3 (es) | 2010-03-31 | 2024-10-29 | Ablexis Llc | Ingeniería genética de ratones para la producción de anticuerpos quiméricos |
| US9234240B2 (en) | 2010-05-07 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| CA2799746C (en) | 2010-05-17 | 2020-11-24 | Sai Reddy | Rapid isolation of monoclonal antibodies from animals |
| CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
-
2012
- 2012-03-09 EP EP17196465.3A patent/EP3345922A1/en not_active Withdrawn
- 2012-03-09 CN CN201280021326.1A patent/CN103842379A/zh active Pending
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- 2012-03-09 DK DK12711501.2T patent/DK2683736T3/en active
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- 2012-03-09 KR KR1020197000660A patent/KR20190006083A/ko not_active Ceased
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2018
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| KR20140010436A (ko) | 2014-01-24 |
| EP3345922A1 (en) | 2018-07-11 |
| EP2683736B1 (en) | 2018-01-17 |
| AU2012225310B2 (en) | 2017-08-03 |
| DK2683736T3 (en) | 2018-04-23 |
| AU2019216660A1 (en) | 2019-09-05 |
| AU2012225310A1 (en) | 2013-09-26 |
| EP2683736A1 (en) | 2014-01-15 |
| JP2014509853A (ja) | 2014-04-24 |
| CN103842379A (zh) | 2014-06-04 |
| AU2017245395B2 (en) | 2019-05-16 |
| AU2017245395A1 (en) | 2017-11-02 |
| KR20190006083A (ko) | 2019-01-16 |
| AU2017245395A2 (en) | 2017-11-23 |
| US20120308555A1 (en) | 2012-12-06 |
| JP6557709B2 (ja) | 2019-08-07 |
| HUE037095T2 (hu) | 2018-08-28 |
| WO2012122484A1 (en) | 2012-09-13 |
| KR101938343B1 (ko) | 2019-01-14 |
| CN108220297A (zh) | 2018-06-29 |
| ES2666301T3 (es) | 2018-05-03 |
| KR20190107761A (ko) | 2019-09-20 |
| JP6211931B2 (ja) | 2017-10-11 |
| JP2019195335A (ja) | 2019-11-14 |
| CA2829606A1 (en) | 2012-09-13 |
| US20190002532A1 (en) | 2019-01-03 |
| JP2018027090A (ja) | 2018-02-22 |
| CA2829606C (en) | 2020-06-02 |
| US9920110B2 (en) | 2018-03-20 |
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