JP2003527832A5 - - Google Patents
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- Publication number
- JP2003527832A5 JP2003527832A5 JP2001528642A JP2001528642A JP2003527832A5 JP 2003527832 A5 JP2003527832 A5 JP 2003527832A5 JP 2001528642 A JP2001528642 A JP 2001528642A JP 2001528642 A JP2001528642 A JP 2001528642A JP 2003527832 A5 JP2003527832 A5 JP 2003527832A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- human
- antibody
- antibody chains
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 description 16
- 102000039446 nucleic acids Human genes 0.000 description 15
- 108020004707 nucleic acids Proteins 0.000 description 15
- 150000007523 nucleic acids Chemical class 0.000 description 15
- 230000009261 transgenic effect Effects 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 7
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 101000941289 Homo sapiens Hepatic triacylglycerol lipase Proteins 0.000 description 1
- 101001047912 Homo sapiens Hydroxymethylglutaryl-CoA lyase, mitochondrial Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000000521 hyperimmunizing effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15741599P | 1999-10-02 | 1999-10-02 | |
| US60/157,415 | 1999-10-02 | ||
| US09/453,234 US6794132B2 (en) | 1999-10-02 | 1999-12-01 | Human antibodies |
| US09/453,234 | 1999-12-01 | ||
| PCT/US2000/027237 WO2001025492A1 (en) | 1999-10-02 | 2000-10-02 | Human antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003527832A JP2003527832A (ja) | 2003-09-24 |
| JP2003527832A5 true JP2003527832A5 (enExample) | 2007-11-22 |
Family
ID=26854113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001528642A Pending JP2003527832A (ja) | 1999-10-02 | 2000-10-02 | ヒト抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6794132B2 (enExample) |
| EP (1) | EP1222314A4 (enExample) |
| JP (1) | JP2003527832A (enExample) |
| AU (1) | AU783276B2 (enExample) |
| CA (1) | CA2385709A1 (enExample) |
| WO (1) | WO2001025492A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US20070111259A1 (en) * | 1999-10-02 | 2007-05-17 | Medarex, Inc. | Human antibodies |
| US7135287B1 (en) * | 1999-10-02 | 2006-11-14 | Biosite, Inc. | Human antibodies |
| US6680209B1 (en) | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| KR100945108B1 (ko) * | 2001-06-13 | 2010-03-02 | 젠맵 에이/에스 | 표피 성장 인자 수용체 (egfr)에 대한 인간모노클로날 항체 |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| US20060073095A1 (en) * | 2001-08-22 | 2006-04-06 | Steven Kessler | Methods for screening antibody-producing cells on heterogeneous antigen substrates |
| US20030044849A1 (en) * | 2001-08-22 | 2003-03-06 | Steven Kessler | Methods for screening monoclonal antibodies on heterogeneous antigen substrates |
| US20030186374A1 (en) * | 2001-10-01 | 2003-10-02 | Hufton Simon E. | Multi-chain eukaryotic display vectors and uses thereof |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| US7094579B2 (en) | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
| NZ541050A (en) | 2002-12-16 | 2010-06-25 | Genmab As | Human monoclonal antibodies against interleukin 8 (IL-8) |
| WO2004074432A2 (en) | 2003-01-31 | 2004-09-02 | Celldex Therapeutics, Inc. | Antibody vaccine conjugates and uses therefor |
| US9259459B2 (en) | 2003-01-31 | 2016-02-16 | Celldex Therapeutics Inc. | Antibody vaccine conjugates and uses therefor |
| EP1625162A2 (en) * | 2003-05-06 | 2006-02-15 | Albert Einstein College Of Medicine Of Yeshiva University | Compositions and methods for treatment of cryptococcosis |
| US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| JP2007501011A (ja) * | 2003-08-01 | 2007-01-25 | ジェネンテック・インコーポレーテッド | 制限多様性配列を有する結合型ポリペプチド |
| AR045563A1 (es) * | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| AU2004272607B2 (en) * | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| AU2004309373A1 (en) * | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| EP1786463A4 (en) * | 2004-03-26 | 2009-05-20 | Human Genome Sciences Inc | ANTIBODY AGAINST NOGO RECEPTOR |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| JP4909988B2 (ja) * | 2005-04-20 | 2012-04-04 | アムジエン・フレモント・インコーポレイテツド | インターロイキン‐8に対する高親和性の完全ヒトモノクローナル抗体、およびそのような抗体のエピトープ |
| EP1877444A2 (en) * | 2005-04-26 | 2008-01-16 | Pfizer, Inc. | P-cadherin antibodies |
| EP2532677A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| WO2007064919A2 (en) * | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| EP2463305B1 (en) | 2006-01-12 | 2016-05-11 | Alexion Pharmaceuticals, Inc. | Antibodies to OX-2/CD200 and uses thereof |
| CA2647769C (en) | 2006-03-20 | 2015-05-26 | Japan Science And Technology Agency | Control of intracellular target molecule by ip3 receptor-binding protein |
| JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| NL1031818C2 (nl) * | 2006-05-15 | 2007-11-23 | Pfizer | P-Cadherineantilichamen. |
| SI2066351T1 (sl) | 2006-10-02 | 2016-02-29 | E.R. Squibb & Sons, L.L.C. | Humana protitelesa, ki vežejo cxcr4 in njihova uporaba |
| SG177168A1 (en) | 2006-12-01 | 2012-01-30 | Medarex Inc | Human antibodies that bind cd22 and uses thereof |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| US20100150950A1 (en) | 2006-12-14 | 2010-06-17 | Medarex, Inc. | Human antibodies that bind cd70 and uses thereof |
| US8470325B2 (en) * | 2007-02-15 | 2013-06-25 | Kagoshima University | Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody |
| JP5285437B2 (ja) * | 2007-02-15 | 2013-09-11 | 学校法人福岡大学 | 抗hmgb−1抗体を含む臓器移植拒絶抑制剤 |
| WO2008099920A1 (ja) * | 2007-02-15 | 2008-08-21 | Kyushu University, National University Corporation | 抗hmgb-1抗体を含む間質性肺疾患治療剤 |
| BRPI0809042B1 (pt) | 2007-03-22 | 2021-08-31 | Biogen Ma Inc. | Proteína de ligação a cd154 isolada, seu uso, e composição |
| US8236318B2 (en) | 2007-11-07 | 2012-08-07 | Celldex Therapeutics Inc. | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
| KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| PL2346994T3 (pl) | 2008-09-30 | 2022-04-19 | Ablexis, Llc | Myszy knock-in do wytwarzania chimerycznych przeciwciał |
| EP2364366B1 (en) | 2008-11-05 | 2014-01-08 | MorphoSys AG | Deconvolution method |
| JP6223659B2 (ja) | 2008-11-10 | 2017-11-01 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体関連障害を処置するための方法および組成物 |
| JP6012473B2 (ja) | 2010-01-11 | 2016-10-25 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 抗cd200抗体を用いたヒトの処置における免疫調節効果のバイオマーカー |
| PL3248462T3 (pl) | 2010-03-31 | 2024-07-08 | Ablexis, Llc | Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych |
| AU2011245117B2 (en) | 2010-04-30 | 2015-03-12 | Alexion Pharmaceuticals, Inc. | Anti-C5a antibodies and methods for using the antibodies |
| WO2011159959A2 (en) * | 2010-06-16 | 2011-12-22 | Cdi Laboratories | Methods and systems for generating, validating and using monoclonal antibodies |
| BR112012033119A2 (pt) | 2010-06-22 | 2016-10-25 | Univ Colorado Regents | anticorpos para o fragamento c3d do componente do complemento 3. |
| CA2804550C (en) * | 2010-07-09 | 2021-01-05 | Bionovion Holding B.V. | Agonistic antibody to cd27 |
| MX381912B (es) | 2010-07-16 | 2025-03-13 | Adimab Llc | Colecciones de anticuerpos. |
| US8440195B2 (en) * | 2010-11-12 | 2013-05-14 | National University Corporation Chiba University | Inhibition of CD69 for treatment of inflammatory conditions |
| TW201244737A (en) | 2011-02-03 | 2012-11-16 | Alexion Pharma Inc | Use of an anti-CD200 antibody for prolonging the survival of allografts |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| DK2694108T3 (en) | 2011-04-08 | 2018-08-20 | Univ Leicester | METHODS OF TREATING DISEASES ASSOCIATED WITH MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
| ES2821375T3 (es) * | 2011-06-13 | 2021-04-26 | Tla Targeted Immunotherapies Ab | Tratamiento de afecciones respiratorias |
| US9726666B2 (en) | 2011-06-13 | 2017-08-08 | Tla Targeted Immunotherapies Ab | Diagnosing and treating inflammatory diseases |
| HUE043001T2 (hu) | 2011-11-09 | 2019-07-29 | Bristol Myers Squibb Co | Hematológiai malignómák kezelése anti-CXCR4 antitesttel |
| KR101566539B1 (ko) * | 2012-06-08 | 2015-11-05 | 국립암센터 | 신규한 Th2 세포 전환용 에피토프 및 이의 용도 |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| EP2925878A1 (en) | 2012-11-28 | 2015-10-07 | Abwiz Bio Inc. | Preparation of gene-specific templates for the use in single primer amplification |
| WO2014093786A1 (en) * | 2012-12-14 | 2014-06-19 | Abbvie, Inc. | Methods for increasing the efficiency of hybridoma generation |
| KR101759687B1 (ko) * | 2013-01-25 | 2017-07-19 | 타이몬, 엘엘씨 | 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법 |
| CN105682683A (zh) | 2013-08-02 | 2016-06-15 | 阿杜罗生物科技控股有限公司 | 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激 |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| EP3882271A3 (en) | 2017-02-10 | 2022-01-05 | Eutilex Co., Ltd. | Ifn-gamma-inducible regulatory t cell convertible anti-cancer (irtca) antibody and uses thereof |
| WO2019140150A1 (en) | 2018-01-12 | 2019-07-18 | Bristol-Myers Squibb Company | Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer |
| US12570725B2 (en) | 2019-09-13 | 2026-03-10 | Duke University | ZIKA antibodies and their use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US5173418A (en) | 1985-05-10 | 1992-12-22 | Benzon Pharma, A/S | Production in Escherichia coli of extracellular Serratia spp. hydrolases |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5914241A (en) | 1993-01-19 | 1999-06-22 | Biosite Diagnostics, Inc. | Assays and kits for detecting analytes in the presence of cross-reacting substances |
| WO1994026787A1 (en) | 1993-05-07 | 1994-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for generating cell type specific phage antibody libraries |
| ES2201097T3 (es) | 1994-01-31 | 2004-03-16 | Trustees Of Boston University | Bibliotecas de anticuerpos policlonales. |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5766905A (en) | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
| DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| US6057098A (en) * | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| EP0985033A4 (en) | 1997-04-04 | 2005-07-13 | Biosite Inc | POLYVALENT AND POLYCLONAL LIBRARIES |
| EP0934953A2 (en) | 1997-12-03 | 1999-08-11 | Boehringer Mannheim Corporation | Complex specific antibodies, method of preparation and uses thereof |
| US5939807A (en) | 1997-12-16 | 1999-08-17 | Reliance Electric Industrial Company | Cap mounted drive for a brushless DC motor |
| US20020029391A1 (en) * | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
-
1999
- 1999-12-01 US US09/453,234 patent/US6794132B2/en not_active Expired - Fee Related
-
2000
- 2000-10-02 CA CA002385709A patent/CA2385709A1/en not_active Abandoned
- 2000-10-02 EP EP00968612A patent/EP1222314A4/en not_active Withdrawn
- 2000-10-02 WO PCT/US2000/027237 patent/WO2001025492A1/en not_active Ceased
- 2000-10-02 JP JP2001528642A patent/JP2003527832A/ja active Pending
- 2000-10-02 AU AU78496/00A patent/AU783276B2/en not_active Ceased
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