RU2664185C2 - Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl - Google Patents

Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl Download PDF

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RU2664185C2
RU2664185C2 RU2014133653A RU2014133653A RU2664185C2 RU 2664185 C2 RU2664185 C2 RU 2664185C2 RU 2014133653 A RU2014133653 A RU 2014133653A RU 2014133653 A RU2014133653 A RU 2014133653A RU 2664185 C2 RU2664185 C2 RU 2664185C2
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human
mouse
gene segments
gene
adam6
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RU2014133653A
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RU2014133653A (ru
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Линн МАКДОНАЛЬД
Саган ГУРЕР
Каролина А. МЕАГХЕР
Шон СТИВЕНС
Эндрю Джей. МЕРФИ
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Регенерон Фармасьютикалз, Инк.
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K67/027New or modified breeds of vertebrates
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    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
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    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
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    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24046Adamalysin (3.4.24.46)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/15Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/10Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
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    • C12N2800/00Nucleic acids vectors
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Biophysics (AREA)
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  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Housing For Livestock And Birds (AREA)
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RU2014133653A 2012-02-01 2013-02-01 Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl RU2664185C2 (ru)

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Application Number Priority Date Filing Date Title
US201261593463P 2012-02-01 2012-02-01
US61/593,463 2012-02-01
US201261677538P 2012-07-31 2012-07-31
US61/677,538 2012-07-31
PCT/US2013/024295 WO2013116609A1 (en) 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains

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RU2018122695A Division RU2770016C2 (ru) 2012-02-01 2013-02-01 Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl

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RU2014133653A RU2014133653A (ru) 2016-03-20
RU2664185C2 true RU2664185C2 (ru) 2018-08-15

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RU2018122695A RU2770016C2 (ru) 2012-02-01 2013-02-01 Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl

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KR20140123983A (ko) 2014-10-23
CN104202971B (zh) 2016-07-06
AU2013204758B2 (en) 2015-07-23
ES2753774T3 (es) 2020-04-14
JP2015505477A (ja) 2015-02-23
AU2015246154A1 (en) 2015-11-12
EP2809150B1 (en) 2019-09-18
EP2809150A1 (en) 2014-12-10
DK2809150T3 (da) 2019-12-09
US20170094955A1 (en) 2017-04-06
AU2013204758A1 (en) 2013-08-15
IL268675B (en) 2020-11-30
NZ627977A (en) 2016-06-24
RU2014133653A (ru) 2016-03-20
WO2013116609A1 (en) 2013-08-08
CY1124361T1 (el) 2022-07-22
MX2020003491A (es) 2022-10-25
HUE055610T2 (hu) 2021-12-28
CY1122419T1 (el) 2021-01-27
EP3597038A1 (en) 2020-01-22
EP3912465A1 (en) 2021-11-24
PL3597038T3 (pl) 2021-11-08
LT3597038T (lt) 2021-05-25
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