MX2019002517A - Roedores humanizados que expresan cadenas pesadas que contienen dominios vl. - Google Patents

Roedores humanizados que expresan cadenas pesadas que contienen dominios vl.

Info

Publication number
MX2019002517A
MX2019002517A MX2019002517A MX2019002517A MX2019002517A MX 2019002517 A MX2019002517 A MX 2019002517A MX 2019002517 A MX2019002517 A MX 2019002517A MX 2019002517 A MX2019002517 A MX 2019002517A MX 2019002517 A MX2019002517 A MX 2019002517A
Authority
MX
Mexico
Prior art keywords
heavy chain
human
light chain
domains
chain containing
Prior art date
Application number
MX2019002517A
Other languages
English (en)
Inventor
J Murphy Andrew
Macdonald Lynn
Gurer Cagan
A Meagher Karolina
Stevens Sean
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2019002517A publication Critical patent/MX2019002517A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24046—Adamalysin (3.4.24.46)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Housing For Livestock And Birds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proveen animales, tejidos, células, y material genético no humanos que comprenden una modificación de una secuencia de inmunoglobulina de la cadena pesada no humana endógena y que comprende una actividad de ADAM6 funcional en un roedor (por ejemplo, un ratón), en los cuales los animales no humanos reacomodan los segmentos de gen de la cadena ligera de inmunoglobulina de humano en el contexto de regiones constantes de la cadena pesada y expresan moléculas tipo inmunoglobulina que comprenden dominios variables de la cadena ligera de inmunoglobulina de humano fusionados a dominios constantes de la cadena pesada que son cognados con dominios variables de la cadena ligera de inmunoglobulina de humano fusionados a dominios constantes de la cadena ligera.
MX2019002517A 2012-02-01 2014-07-31 Roedores humanizados que expresan cadenas pesadas que contienen dominios vl. MX2019002517A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261593463P 2012-02-01 2012-02-01
US201261677538P 2012-07-31 2012-07-31

Publications (1)

Publication Number Publication Date
MX2019002517A true MX2019002517A (es) 2019-06-17

Family

ID=47714588

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020003491A MX2020003491A (es) 2012-02-01 2013-02-01 Roedores humanizados que expresan cadenas pesadas que contienen dominios vl.
MX2019002517A MX2019002517A (es) 2012-02-01 2014-07-31 Roedores humanizados que expresan cadenas pesadas que contienen dominios vl.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020003491A MX2020003491A (es) 2012-02-01 2013-02-01 Roedores humanizados que expresan cadenas pesadas que contienen dominios vl.

Country Status (26)

Country Link
US (3) US20130212719A1 (es)
EP (3) EP2809150B1 (es)
JP (6) JP2015505477A (es)
KR (2) KR20190006029A (es)
CN (2) CN104202971B (es)
AU (3) AU2013204758B2 (es)
BR (1) BR112014018843B1 (es)
CA (1) CA2863175A1 (es)
CY (2) CY1122419T1 (es)
DK (2) DK2809150T3 (es)
ES (2) ES2753774T3 (es)
HK (1) HK1202771A1 (es)
HR (2) HRP20192218T1 (es)
HU (2) HUE055610T2 (es)
IL (3) IL233827A0 (es)
LT (2) LT2809150T (es)
ME (1) ME03611B (es)
MX (2) MX2020003491A (es)
NZ (3) NZ627977A (es)
PL (2) PL2809150T3 (es)
PT (2) PT3597038T (es)
RS (2) RS62023B1 (es)
RU (2) RU2770016C2 (es)
SG (3) SG10201913428QA (es)
SI (2) SI2809150T1 (es)
WO (1) WO2013116609A1 (es)

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HUE055610T2 (hu) 2021-12-28
LT3597038T (lt) 2021-05-25
JP2021137030A (ja) 2021-09-16
IL268675B (en) 2020-11-30
HK1202771A1 (en) 2015-10-09
IL261280A (en) 2018-10-31
BR112014018843A8 (pt) 2019-01-29
AU2017251848A1 (en) 2017-11-16
NZ627977A (en) 2016-06-24
US20210368751A1 (en) 2021-12-02
EP2809150A1 (en) 2014-12-10
IL268675A (en) 2019-10-31
ES2753774T3 (es) 2020-04-14
SG11201404477YA (en) 2014-08-28
SG10201606256TA (en) 2016-09-29
RU2664185C2 (ru) 2018-08-15
HUE046744T2 (hu) 2020-03-30
JP7187615B2 (ja) 2022-12-12
WO2013116609A1 (en) 2013-08-08
MX2020003491A (es) 2022-10-25
KR20190006029A (ko) 2019-01-16
AU2013204758A1 (en) 2013-08-15
LT2809150T (lt) 2019-10-25
US20130212719A1 (en) 2013-08-15
NZ719228A (en) 2022-08-26
PL3597038T3 (pl) 2021-11-08
EP3597038A1 (en) 2020-01-22
PT2809150T (pt) 2019-12-09
CN106117364A (zh) 2016-11-16
PT3597038T (pt) 2021-05-10
EP3597038B1 (en) 2021-04-21
CY1124361T1 (el) 2022-07-22
JP2019170395A (ja) 2019-10-10
CN106117364B (zh) 2021-08-31
JP6698718B2 (ja) 2020-05-27
JP2023014242A (ja) 2023-01-26
RS62023B1 (sr) 2021-07-30
JP2018075041A (ja) 2018-05-17
KR20140123983A (ko) 2014-10-23
BR112014018843B1 (pt) 2024-02-20
CN104202971B (zh) 2016-07-06
AU2017251848B2 (en) 2020-02-20
PL2809150T3 (pl) 2020-04-30
HRP20192218T1 (hr) 2020-03-06
CN104202971A (zh) 2014-12-10
AU2013204758B2 (en) 2015-07-23
RU2018122695A (ru) 2019-03-06
SI2809150T1 (sl) 2019-11-29
NZ734504A (en) 2022-10-28
RU2770016C2 (ru) 2022-04-14
IL233827A0 (en) 2014-09-30
EP2809150B1 (en) 2019-09-18
ME03611B (me) 2020-07-20
SI3597038T1 (sl) 2021-07-30
HRP20210987T1 (hr) 2021-09-17
US20170094955A1 (en) 2017-04-06
JP2015505477A (ja) 2015-02-23
IL261280B (en) 2019-08-29
CA2863175A1 (en) 2013-08-08
RU2014133653A (ru) 2016-03-20
AU2015246154A1 (en) 2015-11-12
BR112014018843A2 (pt) 2017-07-04
DK3597038T3 (da) 2021-06-28
RU2018122695A3 (es) 2021-10-06
ES2870703T3 (es) 2021-10-27
DK2809150T3 (da) 2019-12-09
SG10201913428QA (en) 2020-03-30
JP6942757B2 (ja) 2021-09-29
CY1122419T1 (el) 2021-01-27
JP2023168590A (ja) 2023-11-24
RS59699B1 (sr) 2020-01-31
EP3912465A1 (en) 2021-11-24
AU2015246154B2 (en) 2017-11-23

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