HK1202771A1 - Humanized rodents that express heavy chains containing vl domains vl - Google Patents

Humanized rodents that express heavy chains containing vl domains vl

Info

Publication number
HK1202771A1
HK1202771A1 HK15103518.0A HK15103518A HK1202771A1 HK 1202771 A1 HK1202771 A1 HK 1202771A1 HK 15103518 A HK15103518 A HK 15103518A HK 1202771 A1 HK1202771 A1 HK 1202771A1
Authority
HK
Hong Kong
Prior art keywords
domains
heavy chains
chains containing
express heavy
humanized rodents
Prior art date
Application number
HK15103518.0A
Other languages
English (en)
Chinese (zh)
Inventor
‧麥克唐納
‧古雷爾
‧梅格爾
‧史蒂文斯
‧莫菲
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1202771A1 publication Critical patent/HK1202771A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24046—Adamalysin (3.4.24.46)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Housing For Livestock And Birds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15103518.0A 2012-02-01 2015-04-10 Humanized rodents that express heavy chains containing vl domains vl HK1202771A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261593463P 2012-02-01 2012-02-01
US201261677538P 2012-07-31 2012-07-31
PCT/US2013/024295 WO2013116609A1 (en) 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains

Publications (1)

Publication Number Publication Date
HK1202771A1 true HK1202771A1 (en) 2015-10-09

Family

ID=47714588

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103518.0A HK1202771A1 (en) 2012-02-01 2015-04-10 Humanized rodents that express heavy chains containing vl domains vl

Country Status (26)

Country Link
US (3) US20130212719A1 (xx)
EP (3) EP2809150B1 (xx)
JP (6) JP2015505477A (xx)
KR (2) KR20190006029A (xx)
CN (2) CN104202971B (xx)
AU (3) AU2013204758B2 (xx)
BR (1) BR112014018843B1 (xx)
CA (1) CA2863175A1 (xx)
CY (2) CY1122419T1 (xx)
DK (2) DK2809150T3 (xx)
ES (2) ES2753774T3 (xx)
HK (1) HK1202771A1 (xx)
HR (2) HRP20192218T1 (xx)
HU (2) HUE046744T2 (xx)
IL (3) IL233827A0 (xx)
LT (2) LT2809150T (xx)
ME (1) ME03611B (xx)
MX (2) MX2020003491A (xx)
NZ (3) NZ719228A (xx)
PL (2) PL3597038T3 (xx)
PT (2) PT3597038T (xx)
RS (2) RS62023B1 (xx)
RU (2) RU2770016C2 (xx)
SG (3) SG10201606256TA (xx)
SI (2) SI3597038T1 (xx)
WO (1) WO2013116609A1 (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2288623T3 (pl) * 2008-05-23 2014-01-31 Ablexis Llc Sposób wytwarzania przeciwciał z pojedynczą domeną VL w zwierzętach transgenicznych
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
HUE055817T2 (hu) 2009-07-08 2021-12-28 Kymab Ltd Állatmodellek és terápiás molekulák
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
SG187673A1 (en) * 2010-08-02 2013-03-28 Regeneron Pharma Mice that make binding proteins comprising vl domains
SG10201606158TA (en) 2011-08-05 2016-09-29 Regeneron Pharma Humanized universal light chain mice
DK2757875T3 (en) 2011-09-19 2018-01-08 Kymab Ltd MANIPULATION OF IMMUNOGLOBULIN GENE DIVERSITY AND MULTI-ANTIBODY THERAPEUTICS
EP2761008A1 (en) 2011-09-26 2014-08-06 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
GB201122047D0 (en) * 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
SG10201913164YA (en) 2011-12-20 2020-03-30 Regeneron Pharma Humanized light chain mice
CN104202971B (zh) * 2012-02-01 2016-07-06 瑞泽恩制药公司 表达包含vl结构域的重链的人源化啮齿动物的制备方法
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
LT2858487T (lt) 2012-06-12 2019-12-27 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, kurie yra humanizuoti ir turi redukuotą imunoglobulino sunkiosios grandinės lokusą
KR20160025033A (ko) 2013-02-20 2016-03-07 리제너론 파마슈티칼스 인코포레이티드 변형된 면역글로불린 중쇄 서열을 갖는 비인간 동물
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
DE112014004537T5 (de) 2013-10-01 2016-07-21 Kymab Limited Tiermodelle und therapeutische Moleküle
EP3119811B1 (en) 2014-03-21 2019-10-30 Regeneron Pharmaceuticals, Inc. Vl antigen binding proteins exhibiting distinct binding characteristics
KR20210088756A (ko) 2014-03-21 2021-07-14 리제너론 파마슈티칼스 인코포레이티드 단일 도메인 결합 단백질을 생산하는 비-인간 동물
AU2016232715A1 (en) * 2015-03-19 2017-09-28 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
EP3277823B1 (en) * 2015-04-03 2023-09-13 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
KR102661748B1 (ko) 2016-05-20 2024-05-31 리제너론 파마슈티칼스 인코포레이티드 다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법
CN110719732B (zh) * 2017-03-30 2022-11-18 犹他州立大学 表达蜘蛛丝的转基因蚕
LT3720279T (lt) * 2017-12-05 2022-10-25 Regeneron Pharmaceuticals, Inc. Pelės, turinčios sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas
US20210051929A1 (en) * 2018-03-24 2021-02-25 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
AU2019287727B2 (en) * 2018-06-14 2022-12-01 Regeneron Pharmaceuticals, Inc. Non-human animals capable of DH-DH rearrangement in the immunoglobulin heavy chain coding sequences
AU2021342159A1 (en) 2020-09-11 2023-03-02 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
IL303626A (en) 2020-12-16 2023-08-01 Regeneron Pharma Mice expressing human FC alpha receptors
CN114645042A (zh) * 2020-12-18 2022-06-21 中国食品药品检定研究院 一种构建具有表达荧光素酶和红色荧光蛋白的重组巨噬细胞的转基因小鼠的方法
CN114196626A (zh) * 2022-02-16 2022-03-18 北京国卫生物科技有限公司 脐带间充质干细胞及其分离培养扩增方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
US7129084B2 (en) * 2000-08-03 2006-10-31 Therapeutic Human Polyclonals, Inc. Production of humanized antibodies in transgenic animals
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
CN101016543A (zh) * 2000-11-17 2007-08-15 罗切斯特大学 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的多核苷酸的方法
US7473557B2 (en) 2001-06-06 2009-01-06 Regeneron Pharmaceuticals, Inc. Method for targeting transcriptionally active loci
WO2003081993A2 (en) * 2002-03-22 2003-10-09 Origen Therapeutics Transgenic aves producing human polyclonal antibodies
WO2005007696A2 (en) * 2003-07-15 2005-01-27 Therapeutic Human Polyclonals, Inc. Humanized immunoglobulin loci
US7294754B2 (en) 2004-10-19 2007-11-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
US20060117398A1 (en) * 2004-10-22 2006-06-01 Roland Buelow Suppression of endogenous immunoglobulin expression
WO2007117410A2 (en) * 2006-03-31 2007-10-18 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
ES2378407T3 (es) * 2006-09-01 2012-04-12 Therapeutic Human Polyclonals, Inc. Aumento de la expresión de inmunoglobulina humana o humanizada en animales transgénicos no humanos
CN101970491A (zh) * 2007-08-30 2011-02-09 沃尔特及伊莱萨霍尔医学研究院 树突状细胞标记物及其用途
TWI563002B (en) * 2007-09-26 2016-12-21 Chugai Pharmaceutical Co Ltd Antibody constant region mutant
US7659842B2 (en) 2007-10-24 2010-02-09 Infineon Technologies Ag Quantization error reduction in PWM full-MASH converters
PL2288623T3 (pl) * 2008-05-23 2014-01-31 Ablexis Llc Sposób wytwarzania przeciwciał z pojedynczą domeną VL w zwierzętach transgenicznych
CN112481300A (zh) * 2008-06-27 2021-03-12 莫鲁斯股份有限公司 产生抗体的非人哺乳动物
US20100069262A1 (en) * 2008-08-29 2010-03-18 Symphogen A/S Method for Cloning Avian-Derived Antibodies
WO2010091182A2 (en) * 2009-02-04 2010-08-12 Molecular Innovations Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin, and antibodies used therein
US20120204278A1 (en) * 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
HUE055817T2 (hu) * 2009-07-08 2021-12-28 Kymab Ltd Állatmodellek és terápiás molekulák
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
EP2582230A1 (en) * 2010-06-17 2013-04-24 Kymab Limited Animal models and therapeutic molecules
SG187673A1 (en) * 2010-08-02 2013-03-28 Regeneron Pharma Mice that make binding proteins comprising vl domains
EP2738258B2 (en) * 2011-02-25 2023-02-01 Regeneron Pharmaceuticals, Inc. ADAM6 mice
SG10201606158TA (en) * 2011-08-05 2016-09-29 Regeneron Pharma Humanized universal light chain mice
SG10201913164YA (en) * 2011-12-20 2020-03-30 Regeneron Pharma Humanized light chain mice
CN104202971B (zh) * 2012-02-01 2016-07-06 瑞泽恩制药公司 表达包含vl结构域的重链的人源化啮齿动物的制备方法
LT2858487T (lt) * 2012-06-12 2019-12-27 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, kurie yra humanizuoti ir turi redukuotą imunoglobulino sunkiosios grandinės lokusą
LT3766343T (lt) * 2016-11-04 2022-06-10 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, turintys sukonstruotą imunoglobulino lambda lengvosios grandinės lokusą

Also Published As

Publication number Publication date
CN106117364B (zh) 2021-08-31
CN104202971B (zh) 2016-07-06
KR20140123983A (ko) 2014-10-23
IL261280B (en) 2019-08-29
JP2019170395A (ja) 2019-10-10
AU2017251848B2 (en) 2020-02-20
MX2019002517A (es) 2019-06-17
US20130212719A1 (en) 2013-08-15
AU2013204758B2 (en) 2015-07-23
IL268675B (en) 2020-11-30
IL268675A (en) 2019-10-31
RU2018122695A3 (xx) 2021-10-06
DK3597038T3 (da) 2021-06-28
SI3597038T1 (sl) 2021-07-30
IL261280A (en) 2018-10-31
ES2870703T3 (es) 2021-10-27
US20210368751A1 (en) 2021-12-02
RU2770016C2 (ru) 2022-04-14
EP2809150A1 (en) 2014-12-10
JP6698718B2 (ja) 2020-05-27
JP2018075041A (ja) 2018-05-17
NZ719228A (en) 2022-08-26
SI2809150T1 (sl) 2019-11-29
AU2015246154B2 (en) 2017-11-23
EP3597038A1 (en) 2020-01-22
SG11201404477YA (en) 2014-08-28
AU2013204758A1 (en) 2013-08-15
SG10201606256TA (en) 2016-09-29
EP2809150B1 (en) 2019-09-18
CN104202971A (zh) 2014-12-10
IL233827A0 (en) 2014-09-30
HUE055610T2 (hu) 2021-12-28
KR20190006029A (ko) 2019-01-16
NZ734504A (en) 2022-10-28
PL2809150T3 (pl) 2020-04-30
RU2018122695A (ru) 2019-03-06
JP7187615B2 (ja) 2022-12-12
BR112014018843A2 (pt) 2017-07-04
ES2753774T3 (es) 2020-04-14
MX2020003491A (es) 2022-10-25
LT3597038T (lt) 2021-05-25
RU2014133653A (ru) 2016-03-20
RS59699B1 (sr) 2020-01-31
DK2809150T3 (da) 2019-12-09
CA2863175A1 (en) 2013-08-08
BR112014018843B1 (pt) 2024-02-20
CN106117364A (zh) 2016-11-16
SG10201913428QA (en) 2020-03-30
JP6942757B2 (ja) 2021-09-29
JP2015505477A (ja) 2015-02-23
JP2021137030A (ja) 2021-09-16
AU2017251848A1 (en) 2017-11-16
HRP20210987T1 (hr) 2021-09-17
RU2664185C2 (ru) 2018-08-15
BR112014018843A8 (pt) 2019-01-29
HRP20192218T1 (hr) 2020-03-06
RS62023B1 (sr) 2021-07-30
LT2809150T (lt) 2019-10-25
US20170094955A1 (en) 2017-04-06
AU2015246154A1 (en) 2015-11-12
PL3597038T3 (pl) 2021-11-08
PT2809150T (pt) 2019-12-09
EP3597038B1 (en) 2021-04-21
EP3912465A1 (en) 2021-11-24
NZ627977A (en) 2016-06-24
HUE046744T2 (hu) 2020-03-30
JP2023168590A (ja) 2023-11-24
CY1122419T1 (el) 2021-01-27
ME03611B (me) 2020-07-20
CY1124361T1 (el) 2022-07-22
WO2013116609A1 (en) 2013-08-08
JP2023014242A (ja) 2023-01-26
PT3597038T (pt) 2021-05-10

Similar Documents

Publication Publication Date Title
IL268675B (en) Humanized rodents expressing heavy chains comprising vl complexes
IL268674A (en) Rodents with humanized IL-7
HK1217958A1 (zh) 四價雙特異性抗體
SG11201406726PA (en) Anti-baff-anti-il-17 bispecific antibodies
PL3058134T3 (pl) Pozakomórkowe polimery z granulowanego osadu ściekowego jako środki zaklejające
HK1205145A1 (en) Improved antibody light chains
ZA201306526B (en) Roll-open closure
GB201321568D0 (en) Chain stopper
AU342768S (en) Latch for lunchbox