CY1122419T1 - Εξανθρωπισμενοι ποντικοι οι οποιοι εκφραζουν βαριες αλυσιδες που περιεχουν τομεις vl - Google Patents
Εξανθρωπισμενοι ποντικοι οι οποιοι εκφραζουν βαριες αλυσιδες που περιεχουν τομεις vlInfo
- Publication number
- CY1122419T1 CY1122419T1 CY20191101302T CY191101302T CY1122419T1 CY 1122419 T1 CY1122419 T1 CY 1122419T1 CY 20191101302 T CY20191101302 T CY 20191101302T CY 191101302 T CY191101302 T CY 191101302T CY 1122419 T1 CY1122419 T1 CY 1122419T1
- Authority
- CY
- Cyprus
- Prior art keywords
- heavy chain
- human
- light chain
- human immunoglobulin
- dehumanized
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24046—Adamalysin (3.4.24.46)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Abstract
Παρέχονται ζώα πλην του ανθρώπου, μη ανθρώπινοι ιστοί, κύτταρα και γενετικό υλικό που περιλαμβάνουν μια τροποποίηση μιας ενδογενούς μη ανθρώπινης αλληλουχίας βαριάς αλυσίδας της ανοσοσφαιρίνης και που περιλαμβάνουν δράση ADAM6 που είναι λειτουργική σε ένα τρωκτικό (π.χ. έναν ποντικό), όπου τα ζώα πλην του ανθρώπου αναδιατάσσουν ανθρώπινα γονιδιακά τμήματα ελαφριάς αλυσίδας της ανοσοσφαιρίνης στο πλαίσιο σταθερών περιοχών βαριάς αλυσίδας και εκφράζουν μόρια ομοιάζοντα με ανοσοσφαιρίνη που περιλαμβάνουν ανθρώπινους μεταβλητούς τομείς ελαφριάς αλυσίδας της ανοσοσφαιρίνης συντετηγμένους με σταθερούς τομείς βαριάς αλυσίδας που είναι συγγενείς με ανθρώπινους μεταβλητούς τομείς ελαφριάς αλυσίδας της ανοσοσφαιρίνης συντετηγμένους με σταθερούς τομείς ελαφριάς αλυσίδας.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261593463P | 2012-02-01 | 2012-02-01 | |
US201261677538P | 2012-07-31 | 2012-07-31 | |
PCT/US2013/024295 WO2013116609A1 (en) | 2012-02-01 | 2013-02-01 | Humanized rodents that express heavy chains containing vl domains |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122419T1 true CY1122419T1 (el) | 2021-01-27 |
Family
ID=47714588
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101302T CY1122419T1 (el) | 2012-02-01 | 2019-12-10 | Εξανθρωπισμενοι ποντικοι οι οποιοι εκφραζουν βαριες αλυσιδες που περιεχουν τομεις vl |
CY20211100659T CY1124361T1 (el) | 2012-02-01 | 2021-07-20 | Εξανθρωπισμενα τρωκτικα που εκφραζουν βαριες αλυσιδες που περιεχουν τομεις vl |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100659T CY1124361T1 (el) | 2012-02-01 | 2021-07-20 | Εξανθρωπισμενα τρωκτικα που εκφραζουν βαριες αλυσιδες που περιεχουν τομεις vl |
Country Status (26)
Country | Link |
---|---|
US (3) | US20130212719A1 (el) |
EP (3) | EP3912465A1 (el) |
JP (6) | JP2015505477A (el) |
KR (2) | KR20140123983A (el) |
CN (2) | CN106117364B (el) |
AU (3) | AU2013204758B2 (el) |
BR (1) | BR112014018843B1 (el) |
CA (1) | CA2863175A1 (el) |
CY (2) | CY1122419T1 (el) |
DK (2) | DK2809150T3 (el) |
ES (2) | ES2753774T3 (el) |
HK (1) | HK1202771A1 (el) |
HR (2) | HRP20192218T1 (el) |
HU (2) | HUE055610T2 (el) |
IL (3) | IL233827A0 (el) |
LT (2) | LT2809150T (el) |
ME (1) | ME03611B (el) |
MX (2) | MX2020003491A (el) |
NZ (3) | NZ627977A (el) |
PL (2) | PL2809150T3 (el) |
PT (2) | PT3597038T (el) |
RS (2) | RS59699B1 (el) |
RU (2) | RU2664185C2 (el) |
SG (3) | SG10201913428QA (el) |
SI (2) | SI2809150T1 (el) |
WO (1) | WO2013116609A1 (el) |
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ES2436044T3 (es) * | 2008-05-23 | 2013-12-26 | Ablexis, Llc | Procedimiento de generación de anticuerpos de dominio VL individual en animales transgénicos |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
ES2965212T3 (es) | 2009-07-08 | 2024-04-11 | Kymab Ltd | Modelos de animales y moléculas terapéuticas |
NZ707327A (en) | 2010-08-02 | 2017-01-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
CA2846322A1 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
MX356429B (es) | 2011-12-20 | 2018-05-29 | Regeneron Pharma | Ratones con cadena ligera humanizada. |
DK2809150T3 (da) * | 2012-02-01 | 2019-12-09 | Regeneron Pharma | Humaniserede mus, der udtrykker tungkæder indeholdende VL-domæner |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
LT3597037T (lt) | 2012-06-12 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Humanizuoti gyvūnai, išskyrus žmones, su apribotu imunoglobulino sunkiosios grandinės lokusu |
RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
JP7133902B2 (ja) | 2013-10-01 | 2022-09-09 | カイマブ・リミテッド | 動物モデル及び治療用分子 |
JP2017510273A (ja) | 2014-03-21 | 2017-04-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 異なる結合特性を示すvl抗原結合タンパク質 |
KR20210088756A (ko) | 2014-03-21 | 2021-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
AU2016232715A1 (en) * | 2015-03-19 | 2017-09-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
ES2959608T3 (es) * | 2015-04-03 | 2024-02-27 | Dana Farber Cancer Inst Inc | Composición y métodos de edición del genoma de células B |
KR20240016444A (ko) | 2016-05-20 | 2024-02-06 | 리제너론 파마슈티칼스 인코포레이티드 | 다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법 |
CN110719732B (zh) * | 2017-03-30 | 2022-11-18 | 犹他州立大学 | 表达蜘蛛丝的转基因蚕 |
HUE060608T2 (hu) * | 2017-12-05 | 2023-03-28 | Regeneron Pharma | Genetikailag módosított immunglobulin lambda könnyûlánccal rendelkezõ egerek és azok alkalmazása |
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SG11202012084WA (en) * | 2018-06-14 | 2021-01-28 | Regeneron Pharma | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
EP4262373A1 (en) | 2020-12-16 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
CN114645042A (zh) * | 2020-12-18 | 2022-06-21 | 中国食品药品检定研究院 | 一种构建具有表达荧光素酶和红色荧光蛋白的重组巨噬细胞的转基因小鼠的方法 |
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BRPI0917352A2 (pt) * | 2008-08-29 | 2017-08-22 | Symphogen As | Métodos para produção de uma biblioteca de pares cognatos que compreende sequências ligadas que codificam regiões variáveis e para gerar um vetor que codifica um anticorpo quimérico com regiões de seres humanos constantes e regiões variáveis não humanas, biblioteca de vetores, e método para produção de uma biblioteca de sequências de imunoglobulina derivadas de aves |
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DK2809150T3 (da) * | 2012-02-01 | 2019-12-09 | Regeneron Pharma | Humaniserede mus, der udtrykker tungkæder indeholdende VL-domæner |
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2013
- 2013-02-01 DK DK13704329T patent/DK2809150T3/da active
- 2013-02-01 PL PL13704329T patent/PL2809150T3/pl unknown
- 2013-02-01 DK DK19191081.9T patent/DK3597038T3/da active
- 2013-02-01 RU RU2014133653A patent/RU2664185C2/ru active
- 2013-02-01 ES ES13704329T patent/ES2753774T3/es active Active
- 2013-02-01 WO PCT/US2013/024295 patent/WO2013116609A1/en active Application Filing
- 2013-02-01 CN CN201610371631.3A patent/CN106117364B/zh active Active
- 2013-02-01 JP JP2014555736A patent/JP2015505477A/ja not_active Withdrawn
- 2013-02-01 NZ NZ627977A patent/NZ627977A/en active IP Right Revival
- 2013-02-01 MX MX2020003491A patent/MX2020003491A/es unknown
- 2013-02-01 CN CN201380017544.2A patent/CN104202971B/zh active Active
- 2013-02-01 RU RU2018122695A patent/RU2770016C2/ru active
- 2013-02-01 SI SI201331592T patent/SI2809150T1/sl unknown
- 2013-02-01 EP EP21167681.2A patent/EP3912465A1/en active Pending
- 2013-02-01 EP EP13704329.5A patent/EP2809150B1/en active Active
- 2013-02-01 SG SG10201913428QA patent/SG10201913428QA/en unknown
- 2013-02-01 SG SG10201606256TA patent/SG10201606256TA/en unknown
- 2013-02-01 HU HUE19191081A patent/HUE055610T2/hu unknown
- 2013-02-01 AU AU2013204758A patent/AU2013204758B2/en active Active
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