AU2013257642B2 - Biparatopic binding polypeptides for CXCR2 and uses thereof - Google Patents

Biparatopic binding polypeptides for CXCR2 and uses thereof Download PDF

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Publication number
AU2013257642B2
AU2013257642B2 AU2013257642A AU2013257642A AU2013257642B2 AU 2013257642 B2 AU2013257642 B2 AU 2013257642B2 AU 2013257642 A AU2013257642 A AU 2013257642A AU 2013257642 A AU2013257642 A AU 2013257642A AU 2013257642 B2 AU2013257642 B2 AU 2013257642B2
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polypeptide
amino acid
cxcr2
seq
biparatopic
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AU2013257642A1 (en
Inventor
Judith Baumeister
Marie-Paule BOUCHE
Carlo Boutton
Michelle Bradley
Zarin Brown
Marie-Ange Buyse
Steven John Charlton
Karen Cromie
Bruno Dombrecht
Veerle Snoeck
Stephanie Staelens
Soren Steffensen
Gino Anselmus VAN HEEKE
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Ablynx NV
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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AU2013257642A 2012-05-09 2013-05-08 Biparatopic binding polypeptides for CXCR2 and uses thereof Active AU2013257642B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644582P 2012-05-09 2012-05-09
US61/644,582 2012-05-09
PCT/IB2013/053711 WO2013168108A2 (en) 2012-05-09 2013-05-08 Chemokine receptor binding polypeptides

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AU2013257642A1 AU2013257642A1 (en) 2014-10-30
AU2013257642B2 true AU2013257642B2 (en) 2016-09-15

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US (3) US9328174B2 (enExample)
EP (1) EP2847221B1 (enExample)
JP (1) JP6290861B2 (enExample)
KR (2) KR102198321B1 (enExample)
CN (1) CN104487456B (enExample)
AR (1) AR091000A1 (enExample)
AU (1) AU2013257642B2 (enExample)
BR (1) BR112014027697B1 (enExample)
CA (1) CA2871353C (enExample)
EA (1) EA031129B1 (enExample)
ES (1) ES2687654T3 (enExample)
MX (1) MX359258B (enExample)
TW (1) TWI619725B (enExample)
UY (1) UY34798A (enExample)
WO (1) WO2013168108A2 (enExample)

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US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
BR112018076260A2 (pt) 2016-06-20 2019-03-26 Kymab Limited anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
WO2018154391A1 (en) * 2017-02-27 2018-08-30 Monash University Cxcr2 antibodies and uses thereof
AU2018368731A1 (en) 2017-11-16 2020-05-14 Novartis Ag Combination therapies
CN107964045B (zh) * 2017-12-18 2021-04-23 南京医科大学 一种人鼠嵌合抗CXCR2全分子IgG及其应用
CN117050184A (zh) * 2017-12-28 2023-11-14 南京传奇生物科技有限公司 针对tigit的单域抗体和其变体
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
CA3108071A1 (en) 2018-08-01 2020-02-06 Cephalon, Inc. Anti-cxcr2 antibodies and uses thereof
WO2020128972A1 (en) 2018-12-20 2020-06-25 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
ES2982474T3 (es) 2019-02-15 2024-10-16 Novartis Ag Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
ES3032659T3 (en) 2019-02-15 2025-07-23 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
US20220332835A1 (en) * 2019-09-04 2022-10-20 Shanghaitech University Anti-cxcr2 antibodies and uses thereof
MX2022007759A (es) 2019-12-20 2022-07-19 Novartis Ag Combinacion del anticuerpo anti tim-3 mbg453 y anticuerpo anti tgf-beta nis793, con o sin decitabina o el anticuerpo anti pd-1 spartalizumab, para el tratamiento de mielofibrosis y sindrome mielodisplasico.
MX2022015852A (es) 2020-06-23 2023-01-24 Novartis Ag Regimen de dosificacion que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona.
EP4188549A1 (en) 2020-08-03 2023-06-07 Novartis AG Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
CN115058431B (zh) * 2021-05-13 2024-02-02 南华大学 mEOS纳米抗体及其制备方法和应用
AR125874A1 (es) 2021-05-18 2023-08-23 Novartis Ag Terapias de combinación
TW202440614A (zh) 2022-12-23 2024-10-16 比利時商艾伯霖克斯公司 基於蛋白質的接合載體
TW202448926A (zh) 2023-02-17 2024-12-16 比利時商艾伯霖克斯公司 結合新生兒fc受體之多肽
CN118994362B (zh) * 2024-08-06 2025-05-23 重庆医药高等专科学校 一种cxcr-2突变体及其制备方法和应用

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