JP2018530331A5 - - Google Patents
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- Publication number
- JP2018530331A5 JP2018530331A5 JP2018517521A JP2018517521A JP2018530331A5 JP 2018530331 A5 JP2018530331 A5 JP 2018530331A5 JP 2018517521 A JP2018517521 A JP 2018517521A JP 2018517521 A JP2018517521 A JP 2018517521A JP 2018530331 A5 JP2018530331 A5 JP 2018530331A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- peptide chain
- chain
- receptor
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 47
- 239000000427 antigen Substances 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108020003175 receptors Proteins 0.000 claims 11
- 102000005962 receptors Human genes 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 230000011664 signaling Effects 0.000 claims 8
- 102000006306 Antigen Receptors Human genes 0.000 claims 6
- 108010083359 Antigen Receptors Proteins 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 3
- 230000002068 genetic effect Effects 0.000 claims 3
- 102100026964 M1-specific T cell receptor beta chain Human genes 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 1
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 1
- 102000012745 Immunoglobulin Subunits Human genes 0.000 claims 1
- 108010079585 Immunoglobulin Subunits Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/073156 | 2015-10-07 | ||
| PCT/EP2015/073156 WO2017059900A1 (en) | 2015-10-07 | 2015-10-07 | Antigen receptors and uses thereof |
| PCT/EP2016/073792 WO2017060300A1 (en) | 2015-10-07 | 2016-10-05 | Antigen receptors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530331A JP2018530331A (ja) | 2018-10-18 |
| JP2018530331A5 true JP2018530331A5 (enExample) | 2019-11-21 |
| JP6657393B2 JP6657393B2 (ja) | 2020-03-04 |
Family
ID=54288785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517521A Active JP6657393B2 (ja) | 2015-10-07 | 2016-10-05 | 抗原受容体及びその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20180282390A1 (enExample) |
| EP (2) | EP3617226A1 (enExample) |
| JP (1) | JP6657393B2 (enExample) |
| KR (1) | KR102084173B1 (enExample) |
| CN (2) | CN108137673B (enExample) |
| AU (1) | AU2016335217B2 (enExample) |
| BR (1) | BR112018006006A2 (enExample) |
| CA (1) | CA2998450C (enExample) |
| DK (1) | DK3359563T3 (enExample) |
| ES (1) | ES2748224T3 (enExample) |
| HU (1) | HUE046749T2 (enExample) |
| IL (1) | IL258079B (enExample) |
| MX (1) | MX378368B (enExample) |
| NZ (1) | NZ740474A (enExample) |
| PL (1) | PL3359563T3 (enExample) |
| PT (1) | PT3359563T (enExample) |
| SI (1) | SI3359563T1 (enExample) |
| WO (2) | WO2017059900A1 (enExample) |
| ZA (1) | ZA201801607B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018166589A1 (en) * | 2017-03-15 | 2018-09-20 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
| SG11202000027WA (en) | 2017-07-14 | 2020-02-27 | Immatics Biotechnologies Gmbh | Improved dual specificity polypeptide molecule |
| BR112020005676A2 (pt) * | 2017-09-22 | 2020-10-20 | WuXi Biologics Ireland Limited | novos complexos polipeptídicos biespecíficos |
| KR102820804B1 (ko) | 2017-09-22 | 2025-06-16 | 우시 바이올로직스 아일랜드 리미티드 | 신규한 이중특이적 cd3/cd19 폴리펩티드 복합체 |
| CN107827959B (zh) * | 2017-11-09 | 2018-10-30 | 杭州续缓生物科技有限公司 | 识别乙肝病毒(hbv)表面抗原s183-91表位的tcr及其用途 |
| CN113166246B (zh) * | 2018-12-28 | 2024-10-18 | 四川科伦博泰生物医药股份有限公司 | 一种抗体及其用途 |
| WO2020156405A1 (en) * | 2019-01-28 | 2020-08-06 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel bispecific cd3/cd20 polypeptide complexes |
| WO2021190580A1 (en) * | 2020-03-26 | 2021-09-30 | Wuxi Biologics (Shanghai) Co., Ltd. | Bispecific polypeptide complexes, compositions, and methods of preparation and use |
| MX2023012902A (es) | 2021-05-05 | 2023-11-08 | Immatics Biotechnologies Gmbh | Proteinas de union a antigenos que se unen especificamente a prame. |
| WO2023215725A1 (en) * | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2024062138A1 (en) | 2022-09-23 | 2024-03-28 | Mnemo Therapeutics | Immune cells comprising a modified suv39h1 gene |
| WO2025052001A1 (en) | 2023-09-07 | 2025-03-13 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| EP4520334A1 (en) | 2023-09-07 | 2025-03-12 | Mnemo Therapeutics | Methods and compositions for improving immune response |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| DE102006041455B4 (de) * | 2006-09-04 | 2011-07-28 | Johannes-Gutenberg-Universität Mainz, 55122 | Verfahren zur Herstellung einer einen stabilisierten funktionellen humanen Einzelketten-Antigen-erkennenden-TCR (scTCR) exprimierenden Zelllinie, damit hergestellt Zelllinie, stabilisierter TAA-spezifischer scTCR, deren Verwendungen und diese enthaltende pharmazeutische Zusammmensetzungen |
| DK2388266T3 (da) * | 2007-05-11 | 2014-05-26 | Altor Bioscience Corp | Fusionsmolekyler og IL-15-varianter |
| CA2807269A1 (en) * | 2010-08-24 | 2012-03-01 | Roche Glycart Ag | Activatable bispecific antibodies |
| EP2688909A2 (en) * | 2011-03-25 | 2014-01-29 | Glenmark Pharmaceuticals S.A. | Hetero-dimeric immunoglobulins |
| TWI622597B (zh) * | 2011-03-28 | 2018-05-01 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| AU2013221672B2 (en) * | 2012-02-13 | 2017-11-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| CN104769103B (zh) * | 2012-09-04 | 2018-06-08 | 塞勒克提斯公司 | 多链嵌合抗原受体和其用途 |
| WO2018166589A1 (en) * | 2017-03-15 | 2018-09-20 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
-
2015
- 2015-10-07 WO PCT/EP2015/073156 patent/WO2017059900A1/en not_active Ceased
-
2016
- 2016-10-05 KR KR1020187010044A patent/KR102084173B1/ko active Active
- 2016-10-05 WO PCT/EP2016/073792 patent/WO2017060300A1/en not_active Ceased
- 2016-10-05 PL PL16777681T patent/PL3359563T3/pl unknown
- 2016-10-05 BR BR112018006006-2A patent/BR112018006006A2/en not_active Application Discontinuation
- 2016-10-05 US US15/765,926 patent/US20180282390A1/en not_active Abandoned
- 2016-10-05 JP JP2018517521A patent/JP6657393B2/ja active Active
- 2016-10-05 CN CN201680058729.1A patent/CN108137673B/zh active Active
- 2016-10-05 CN CN202210717765.1A patent/CN115536752A/zh active Pending
- 2016-10-05 MX MX2018004121A patent/MX378368B/es unknown
- 2016-10-05 EP EP19187303.3A patent/EP3617226A1/en not_active Withdrawn
- 2016-10-05 AU AU2016335217A patent/AU2016335217B2/en active Active
- 2016-10-05 ES ES16777681T patent/ES2748224T3/es active Active
- 2016-10-05 SI SI201630392T patent/SI3359563T1/sl unknown
- 2016-10-05 DK DK16777681.4T patent/DK3359563T3/da active
- 2016-10-05 CA CA2998450A patent/CA2998450C/en active Active
- 2016-10-05 PT PT167776814T patent/PT3359563T/pt unknown
- 2016-10-05 EP EP16777681.4A patent/EP3359563B8/en active Active
- 2016-10-05 HU HUE16777681A patent/HUE046749T2/hu unknown
- 2016-10-05 NZ NZ740474A patent/NZ740474A/en unknown
-
2018
- 2018-03-08 ZA ZA2018/01607A patent/ZA201801607B/en unknown
- 2018-03-13 IL IL258079A patent/IL258079B/en unknown
-
2021
- 2021-09-18 US US17/478,906 patent/US20220033461A1/en not_active Abandoned
-
2022
- 2022-08-21 US US17/892,089 patent/US20230119334A1/en not_active Abandoned