JP2014518615A5 - - Google Patents

Info

Publication number

JP2014518615A5

JP2014518615A5 JP2014506600A JP2014506600A JP2014518615A5 JP 2014518615 A5 JP2014518615 A5 JP 2014518615A5 JP 2014506600 A JP2014506600 A JP 2014506600A JP 2014506600 A JP2014506600 A JP 2014506600A JP 2014518615 A5 JP2014518615 A5 JP 2014518615A5

Authority

JP

Japan

Prior art keywords

seq

psma

amino acid

acid sequence

binding

Prior art date

2012-04-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 45
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 45
• 108090000765 processed proteins & peptides Proteins 0.000 claims 27
• 229920001184 polypeptide Polymers 0.000 claims 26
• 102000004196 processed proteins & peptides Human genes 0.000 claims 26
• 125000003275 alpha amino acid group Chemical group 0.000 claims 23
• 210000004027 cell Anatomy 0.000 claims 4
• 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 3
• 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 3
• 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 3
• 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 3
• 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 3
• 102100022964 Immunoglobulin kappa variable 3-20 Human genes 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 2
• 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
• 108060003951 Immunoglobulin Proteins 0.000 claims 2
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 2
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 2
• 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 108091008874 T cell receptors Proteins 0.000 claims 2
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
• 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 208000029742 colonic neoplasm Diseases 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 102000018358 immunoglobulin Human genes 0.000 claims 2
• 239000002523 lectin Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
• 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
• 208000030808 Clear cell renal carcinoma Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
• 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 206010073251 clear cell renal cell carcinoma Diseases 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 206010017758 gastric cancer Diseases 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 201000011330 nonpapillary renal cell carcinoma Diseases 0.000 claims 1
• 230000002018 overexpression Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 208000017497 prostate disease Diseases 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 201000011549 stomach cancer Diseases 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1