JP2010533498A5 - - Google Patents
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- Publication number
- JP2010533498A5 JP2010533498A5 JP2010517161A JP2010517161A JP2010533498A5 JP 2010533498 A5 JP2010533498 A5 JP 2010533498A5 JP 2010517161 A JP2010517161 A JP 2010517161A JP 2010517161 A JP2010517161 A JP 2010517161A JP 2010533498 A5 JP2010533498 A5 JP 2010533498A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims 4
- 102000048373 human GPC3 Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000010956 Glypican Human genes 0.000 claims 2
- 108050001154 Glypican Proteins 0.000 claims 2
- 108050007237 Glypican-3 Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95984507P | 2007-07-17 | 2007-07-17 | |
| US60/959,845 | 2007-07-17 | ||
| PCT/US2008/070344 WO2009012394A1 (en) | 2007-07-17 | 2008-07-17 | Monoclonal antibodies against glypican-3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014137921A Division JP2014236734A (ja) | 2007-07-17 | 2014-07-03 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533498A JP2010533498A (ja) | 2010-10-28 |
| JP2010533498A5 true JP2010533498A5 (enExample) | 2011-07-21 |
| JP5868593B2 JP5868593B2 (ja) | 2016-02-24 |
Family
ID=39874207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517161A Expired - Fee Related JP5868593B2 (ja) | 2007-07-17 | 2008-07-17 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
| JP2014137921A Pending JP2014236734A (ja) | 2007-07-17 | 2014-07-03 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014137921A Pending JP2014236734A (ja) | 2007-07-17 | 2014-07-03 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8680247B2 (enExample) |
| EP (1) | EP2178921B1 (enExample) |
| JP (2) | JP5868593B2 (enExample) |
| KR (2) | KR101527342B1 (enExample) |
| CN (1) | CN101815726B (enExample) |
| AU (1) | AU2008275985B2 (enExample) |
| CY (1) | CY1117236T1 (enExample) |
| DK (1) | DK2178921T3 (enExample) |
| ES (1) | ES2562790T3 (enExample) |
| HR (1) | HRP20160270T1 (enExample) |
| HU (1) | HUE028737T2 (enExample) |
| ME (1) | ME02345B (enExample) |
| MX (1) | MX2010000537A (enExample) |
| PL (1) | PL2178921T3 (enExample) |
| PT (1) | PT2178921E (enExample) |
| RS (1) | RS54624B1 (enExample) |
| SI (1) | SI2178921T1 (enExample) |
| WO (1) | WO2009012394A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2603408C (en) | 2005-03-31 | 2018-08-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CN101815726B (zh) | 2007-07-17 | 2013-04-03 | 米德列斯公司 | 针对磷脂酰肌醇蛋白聚糖-3的单克隆抗体 |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| CA2700986A1 (en) * | 2007-09-28 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican-3 antibody having improved kinetics in plasma |
| CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
| US8404811B2 (en) | 2009-05-08 | 2013-03-26 | Genentech, Inc. | Humanized anti-EGFL7 antibodies and methods using same |
| US9260492B2 (en) | 2010-11-15 | 2016-02-16 | Pieris Ag | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3) |
| SG190726A1 (en) | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Cytotoxicity-inducing therapeutic agent |
| JP6001456B2 (ja) * | 2010-12-28 | 2016-10-05 | 中外製薬株式会社 | 動物細胞の培養方法 |
| US9206257B2 (en) | 2011-04-19 | 2015-12-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| WO2013070468A1 (en) | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| CN104520331B (zh) * | 2012-06-01 | 2018-09-07 | 美国政府(由卫生和人类服务部的部长所代表) | 磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途 |
| CN103833852A (zh) * | 2012-11-23 | 2014-06-04 | 上海市肿瘤研究所 | 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体 |
| AU2014216539B2 (en) | 2013-02-14 | 2017-03-23 | Bristol-Myers Squibb Company | Tubulysin compounds, methods of making and use |
| SG11201601047SA (en) | 2013-08-14 | 2016-03-30 | Univ Rice William M | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents |
| WO2015046467A1 (ja) | 2013-09-27 | 2015-04-02 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| WO2016036973A1 (en) | 2014-09-04 | 2016-03-10 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| MX386942B (es) | 2014-11-21 | 2025-03-19 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas. |
| CN104829704B (zh) * | 2014-12-15 | 2016-08-17 | 河北省科学院生物研究所 | 一种磷脂酰肌醇蛋白聚糖gpc3蛋白片段及其应用和制备的杂交瘤细胞株 |
| ES2783624T3 (es) | 2015-01-14 | 2020-09-17 | Bristol Myers Squibb Co | Dímeros de benzodiacepina, conjugados de los mismos y métodos de preparación y uso |
| JP6676058B2 (ja) | 2015-01-14 | 2020-04-08 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法 |
| US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| CN105037540A (zh) * | 2015-05-13 | 2015-11-11 | 北京比洋生物技术有限公司 | 抗磷脂酰肌醇蛋白聚糖3全人源抗体 |
| RU2756318C2 (ru) | 2015-05-18 | 2021-09-29 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) |
| JP6947642B2 (ja) | 2015-05-18 | 2021-10-13 | ピエリス ファーマシューティカルズ ゲーエムベーハー | 抗がん性融合ポリペプチド |
| CN113881694A (zh) * | 2015-06-24 | 2022-01-04 | 学校法人庆应义塾 | 抗磷脂酰肌醇蛋白聚糖-1-免疫抗原受体 |
| CN111018986B (zh) | 2015-08-03 | 2023-07-18 | 科济生物医药（上海）有限公司 | 抗磷脂酰肌醇蛋白多糖-3的抗体及其应用 |
| KR101796688B1 (ko) | 2015-10-29 | 2017-12-01 | 재단법인 목암생명과학연구소 | 신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물 |
| AU2016377371A1 (en) | 2015-12-21 | 2018-08-09 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| CN105717303A (zh) * | 2016-01-29 | 2016-06-29 | 山东康力医疗器械科技有限公司 | 一种用荧光免疫层析法检测磷酯酰肌醇蛋白聚糖3的方法及其试剂盒 |
| TW201735947A (zh) | 2016-03-14 | 2017-10-16 | Chugai Pharmaceutical Co Ltd | 用於癌之治療的細胞傷害誘導治療劑 |
| US20170326249A1 (en) * | 2016-05-10 | 2017-11-16 | Bristol-Myers Squibb Company | Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses |
| WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
| CN106084041A (zh) * | 2016-06-24 | 2016-11-09 | 安徽未名细胞治疗有限公司 | 一种全人源抗GPC3的全分子IgG抗体及其应用 |
| US20190262397A1 (en) | 2016-07-26 | 2019-08-29 | Tessa Therapeutics Pte. Ltd. | Chimeric antigen receptor |
| EP3500574B1 (en) | 2016-08-19 | 2021-11-24 | Bristol-Myers Squibb Company | Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use |
| WO2018075842A1 (en) | 2016-10-20 | 2018-04-26 | Bristol-Myers Squibb Company | Condensed benzodiazepine derivatives and conjugates made therefrom |
| WO2018200586A1 (en) | 2017-04-26 | 2018-11-01 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
| JP7762498B2 (ja) | 2017-05-25 | 2025-10-30 | ブリストル－マイヤーズ スクイブ カンパニー | 修飾重鎖定常領域を含む抗体 |
| CN109988240B (zh) * | 2017-12-29 | 2022-06-28 | 安源医药科技（上海）有限公司 | 抗gpc-3抗体及其用途 |
| MX2020012674A (es) | 2018-05-29 | 2021-02-09 | Bristol Myers Squibb Co | Porciones autoinmolantes modificadas para usarse en profarmacos y conjugados y metodos de uso y fabricacion. |
| BR112021007175A2 (pt) | 2018-10-23 | 2021-08-10 | Dragonfly Therapeutics, Inc. | proteínas fundidas a fc heterodimérico |
| WO2020112781A1 (en) | 2018-11-28 | 2020-06-04 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| DK3886914T3 (da) | 2018-11-30 | 2023-07-03 | Bristol Myers Squibb Co | Antistof omfattende en glutaminholdig letkæde-c-terminal forlængelse, konjugater deraf og fremgangsmåder samt anvendelser |
| US12478686B2 (en) | 2018-12-12 | 2025-11-25 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
| CN113891897B (zh) * | 2019-03-21 | 2025-03-25 | 新加坡科技研究局 | 组合物 |
| JP7644777B2 (ja) | 2020-04-22 | 2025-03-12 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ヘテロ二量体Ｆｃ融合タンパク質のための製剤、投薬量レジメン、及び製造工程 |
| AU2021267893A1 (en) * | 2020-05-07 | 2022-11-03 | Phanes Therapeutics, Inc. | Anti-tumor associated antigen antibodies and uses thereof |
| KR20230123495A (ko) * | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | 글리피칸-3 및 t세포 수용체를 표적으로 하는 면역글로불린단일 가변 도메인을 포함하는 폴리펩티드 |
| IL307927A (en) * | 2021-04-23 | 2023-12-01 | Shanghai Henlius Biotech Inc | Anti-gpc3 antibodies and methods of use |
| CN113354737B (zh) * | 2021-07-20 | 2022-11-18 | 广州爱思迈生物医药科技有限公司 | 一种磷脂酰肌醇蛋白聚糖3抗体及其应用 |
| AU2022331350A1 (en) * | 2021-08-19 | 2024-03-14 | Adicet Therapeutics, Inc. | Methods for detection of membrane bound glypican-3 |
| WO2023061505A1 (en) * | 2021-10-15 | 2023-04-20 | Concept To Medicine Biotech Co., Ltd. | Anti-glypican 3 antibodies |
| JP2025535713A (ja) | 2022-10-07 | 2025-10-28 | アンブレツクス・インコーポレイテツド | 薬物リンカー及びその抗体コンジュゲート |
| TW202432596A (zh) * | 2022-11-01 | 2024-08-16 | 大陸商上海齊魯製藥研究中心有限公司 | 針對磷脂醯肌醇蛋白聚醣3的雙特異性抗體及其應用 |
| UY40783A (es) | 2023-06-12 | 2024-12-31 | Amgen Inc | Proteínas de unión a agonistas del receptor beta de linfotoxina |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3426001B2 (ja) | 1993-09-16 | 2003-07-14 | 東芝機械株式会社 | ステージ内蔵型雰囲気室装置 |
| DE69637481T2 (de) * | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| ATE483801T1 (de) | 2001-06-22 | 2010-10-15 | Chugai Pharmaceutical Co Ltd | Zellproliferationshemmer, die anti-glypican 3 antikörper enthalten |
| AU2002338020A1 (en) * | 2002-09-04 | 2004-03-29 | Chugai Seiyaku Kabushiki Kaisha | Antibody against blood-solubilized n-terminal peptide in gpc3 |
| WO2004023145A1 (ja) | 2002-09-04 | 2004-03-18 | Perseus Proteomics Inc. | Ｇｐｃ3の検出による癌の診断方法 |
| WO2004022595A1 (ja) | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | MRL/lprマウスを用いた抗体の作製 |
| US7303914B2 (en) | 2003-01-30 | 2007-12-04 | Hongyang Wang | Monoclonal antibody against human hepatoma and use thereof |
| JP4501859B2 (ja) | 2003-06-27 | 2010-07-14 | 日本電気株式会社 | 薄膜トランジスタ、薄膜トランジスタ基板、電子機器及び多結晶半導体薄膜の製造方法 |
| CN1842540B (zh) * | 2004-07-09 | 2012-07-04 | 中外制药株式会社 | 抗-磷脂酰肌醇蛋白聚糖3抗体 |
| EP1800693B1 (en) | 2004-08-24 | 2013-07-17 | Chugai Seiyaku Kabushiki Kaisha | Adjuvant therapy with the use of anti-glypican 3 antibody |
| UA93488C2 (uk) | 2004-10-26 | 2011-02-25 | Чугаі Сейяку Кабусікі Кайся | Композиція анти-гліпікан 3-антитіл, що мають модифікований цукровий ланцюг |
| ATE503770T1 (de) * | 2005-03-14 | 2011-04-15 | Us Gov Health & Human Serv | Humane monoklonale antikörper gegen hendra- und nipah-viren |
| EA019344B1 (ru) * | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| US7744800B2 (en) * | 2006-01-06 | 2010-06-29 | Molded Fiber Glass Companies | Method and apparatus for controlling the stacking height of stackable products during compression molding off stops |
| ES2678060T3 (es) * | 2006-12-01 | 2018-08-08 | E. R. Squibb & Sons, L.L.C. | Anticuerpos, en particular, anticuerpos humanos, que se unen a CD22 y usos de los mismos |
| CN101815726B (zh) * | 2007-07-17 | 2013-04-03 | 米德列斯公司 | 针对磷脂酰肌醇蛋白聚糖-3的单克隆抗体 |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
-
2008
- 2008-07-17 CN CN2008801031669A patent/CN101815726B/zh not_active Expired - Fee Related
- 2008-07-17 SI SI200831584A patent/SI2178921T1/sl unknown
- 2008-07-17 KR KR1020157007446A patent/KR101527342B1/ko not_active Expired - Fee Related
- 2008-07-17 ME MEP-2016-86A patent/ME02345B/me unknown
- 2008-07-17 MX MX2010000537A patent/MX2010000537A/es active IP Right Grant
- 2008-07-17 PL PL08796249T patent/PL2178921T3/pl unknown
- 2008-07-17 AU AU2008275985A patent/AU2008275985B2/en not_active Ceased
- 2008-07-17 DK DK08796249.4T patent/DK2178921T3/en active
- 2008-07-17 KR KR1020107003345A patent/KR101570252B1/ko not_active Expired - Fee Related
- 2008-07-17 EP EP08796249.4A patent/EP2178921B1/en active Active
- 2008-07-17 RS RS20160157A patent/RS54624B1/sr unknown
- 2008-07-17 WO PCT/US2008/070344 patent/WO2009012394A1/en not_active Ceased
- 2008-07-17 HR HRP20160270TT patent/HRP20160270T1/hr unknown
- 2008-07-17 HU HUE08796249A patent/HUE028737T2/en unknown
- 2008-07-17 PT PT87962494T patent/PT2178921E/pt unknown
- 2008-07-17 US US12/668,965 patent/US8680247B2/en active Active
- 2008-07-17 ES ES08796249.4T patent/ES2562790T3/es active Active
- 2008-07-17 JP JP2010517161A patent/JP5868593B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-10 US US14/176,790 patent/US9217033B2/en active Active
- 2014-07-03 JP JP2014137921A patent/JP2014236734A/ja active Pending
-
2016
- 2016-03-01 CY CY20161100174T patent/CY1117236T1/el unknown
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