JP2010533498A5 - - Google Patents
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- Publication number
- JP2010533498A5 JP2010533498A5 JP2010517161A JP2010517161A JP2010533498A5 JP 2010533498 A5 JP2010533498 A5 JP 2010533498A5 JP 2010517161 A JP2010517161 A JP 2010517161A JP 2010517161 A JP2010517161 A JP 2010517161A JP 2010533498 A5 JP2010533498 A5 JP 2010533498A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims 4
- 102000048373 human GPC3 Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000010956 Glypican Human genes 0.000 claims 2
- 108050001154 Glypican Proteins 0.000 claims 2
- 108050007237 Glypican-3 Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95984507P | 2007-07-17 | 2007-07-17 | |
| US60/959,845 | 2007-07-17 | ||
| PCT/US2008/070344 WO2009012394A1 (en) | 2007-07-17 | 2008-07-17 | Monoclonal antibodies against glypican-3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014137921A Division JP2014236734A (ja) | 2007-07-17 | 2014-07-03 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533498A JP2010533498A (ja) | 2010-10-28 |
| JP2010533498A5 true JP2010533498A5 (enExample) | 2011-07-21 |
| JP5868593B2 JP5868593B2 (ja) | 2016-02-24 |
Family
ID=39874207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517161A Expired - Fee Related JP5868593B2 (ja) | 2007-07-17 | 2008-07-17 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
| JP2014137921A Pending JP2014236734A (ja) | 2007-07-17 | 2014-07-03 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014137921A Pending JP2014236734A (ja) | 2007-07-17 | 2014-07-03 | Ｇｌｙｐｉｃａｎ−３に対するモノクローナル抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8680247B2 (enExample) |
| EP (1) | EP2178921B1 (enExample) |
| JP (2) | JP5868593B2 (enExample) |
| KR (2) | KR101527342B1 (enExample) |
| CN (1) | CN101815726B (enExample) |
| AU (1) | AU2008275985B2 (enExample) |
| CY (1) | CY1117236T1 (enExample) |
| DK (1) | DK2178921T3 (enExample) |
| ES (1) | ES2562790T3 (enExample) |
| HR (1) | HRP20160270T1 (enExample) |
| HU (1) | HUE028737T2 (enExample) |
| ME (1) | ME02345B (enExample) |
| MX (1) | MX2010000537A (enExample) |
| PL (1) | PL2178921T3 (enExample) |
| PT (1) | PT2178921E (enExample) |
| RS (1) | RS54624B1 (enExample) |
| SI (1) | SI2178921T1 (enExample) |
| WO (1) | WO2009012394A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101374454B1 (ko) | 2005-03-31 | 2014-03-17 | 추가이 세이야쿠 가부시키가이샤 | 회합제어에 의한 폴리펩티드 제조방법 |
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| AU2008275985B2 (en) * | 2007-07-17 | 2013-09-19 | E. R. Squibb & Sons, L.L.C. | Monoclonal antibodies against Glypican-3 |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| KR20150126724A (ko) * | 2007-09-28 | 2015-11-12 | 추가이 세이야쿠 가부시키가이샤 | 혈장 중 반응속도가 개선된 항-글리피칸-3 항체 |
| CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
| RU2011149798A (ru) * | 2009-05-08 | 2013-06-20 | Дженентек, Инк. | Гуманизированные анти-egfl7-антитела и способы их применения |
| CA2817779C (en) | 2010-11-15 | 2019-02-19 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
| TWI736437B (zh) | 2010-11-30 | 2021-08-11 | 日商中外製藥股份有限公司 | 細胞傷害誘導治療劑 |
| MY163081A (en) * | 2010-12-28 | 2017-08-15 | Chugai Pharmaceutical Co Ltd | Animal cell culturing method |
| US9206257B2 (en) | 2011-04-19 | 2015-12-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| WO2013070468A1 (en) | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| CN104520331B (zh) * | 2012-06-01 | 2018-09-07 | 美国政府(由卫生和人类服务部的部长所代表) | 磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途 |
| CN103833852A (zh) * | 2012-11-23 | 2014-06-04 | 上海市肿瘤研究所 | 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体 |
| DK2956173T3 (en) | 2013-02-14 | 2017-07-17 | Bristol Myers Squibb Co | TUBULYSIS RELATIONSHIPS, METHODS OF PRODUCING AND USING THEREOF |
| JP6474404B2 (ja) | 2013-08-14 | 2019-02-27 | ウィリアム マーシュ ライス ユニバーシティＷｉｌｌｉａｍ Ｍａｒｓｈ Ｒｉｃｅ Ｕｎｉｖｅｒｓｉｔｙ | ウンシアラマイシン誘導体、合成方法、および抗腫瘍薬としてのそれらの使用 |
| CA2925256C (en) | 2013-09-27 | 2023-08-15 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
| US10093746B2 (en) | 2014-09-04 | 2018-10-09 | The Trustees Of The University Of Pennsylvania | Glypican-3 antibody and uses thereof |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| ES2826566T3 (es) | 2014-11-21 | 2021-05-18 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas |
| CN104829704B (zh) * | 2014-12-15 | 2016-08-17 | 河北省科学院生物研究所 | 一种磷脂酰肌醇蛋白聚糖gpc3蛋白片段及其应用和制备的杂交瘤细胞株 |
| CN107231804B (zh) | 2015-01-14 | 2019-11-26 | 百时美施贵宝公司 | 亚杂芳基桥连苯并二氮杂*二聚体、其缀合物及制备和使用方法 |
| TW201632531A (zh) | 2015-01-14 | 2016-09-16 | 必治妥美雅史谷比公司 | 苯二氮呯二聚物，其結合物及製造與使用方法 |
| JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| CN105037540A (zh) * | 2015-05-13 | 2015-11-11 | 北京比洋生物技术有限公司 | 抗磷脂酰肌醇蛋白聚糖3全人源抗体 |
| EP3298029A1 (en) | 2015-05-18 | 2018-03-28 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
| DK3298030T5 (en) | 2015-05-18 | 2024-10-07 | Pieris Pharmaceuticals Gmbh | Anti-cancerfusionspolypeptid |
| US11370845B2 (en) * | 2015-06-24 | 2022-06-28 | Keio University | Anti-glypican-1-immunizing antigen receptor |
| AU2016304060B2 (en) * | 2015-08-03 | 2022-09-29 | Crage Medical Co., Limited | Antibody against glypican-3 and application thereof |
| KR101796688B1 (ko) * | 2015-10-29 | 2017-12-01 | 재단법인 목암생명과학연구소 | 신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물 |
| EP3394096A1 (en) | 2015-12-21 | 2018-10-31 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| CN105717303A (zh) * | 2016-01-29 | 2016-06-29 | 山东康力医疗器械科技有限公司 | 一种用荧光免疫层析法检测磷酯酰肌醇蛋白聚糖3的方法及其试剂盒 |
| EP3431102A4 (en) | 2016-03-14 | 2019-09-25 | Chugai Seiyaku Kabushiki Kaisha | CELL DAMAGING THERAPEUTIC MEDICAMENT FOR USE IN CANCER THERAPY |
| US20170326249A1 (en) * | 2016-05-10 | 2017-11-16 | Bristol-Myers Squibb Company | Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses |
| WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
| CN106084041A (zh) * | 2016-06-24 | 2016-11-09 | 安徽未名细胞治疗有限公司 | 一种全人源抗GPC3的全分子IgG抗体及其应用 |
| CN110035768A (zh) | 2016-07-26 | 2019-07-19 | 泰莎治疗私人有限公司 | 嵌合抗原受体 |
| WO2018035391A1 (en) | 2016-08-19 | 2018-02-22 | Bristol-Myers Squibb Company | Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use |
| US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
| EP3615574B1 (en) | 2017-04-26 | 2026-06-24 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
| MX2019013132A (es) | 2017-05-25 | 2020-01-27 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas. |
| CN109988240B (zh) * | 2017-12-29 | 2022-06-28 | 安源医药科技（上海）有限公司 | 抗gpc-3抗体及其用途 |
| JP7458997B2 (ja) | 2018-05-29 | 2024-04-01 | ブリストル－マイヤーズ スクイブ カンパニー | プロドラッグおよび複合体に使用する修飾自己切断部分ならびにその使用方法および製造方法 |
| KR20210080460A (ko) | 2018-10-23 | 2021-06-30 | 드래곤플라이 쎄라퓨틱스, 인크. | 이종이량체성 Fc-융합된 단백질 |
| JP2022513653A (ja) | 2018-11-28 | 2022-02-09 | ブリストル－マイヤーズ スクイブ カンパニー | 修飾された重鎖定常領域を含む抗体 |
| DK3886914T3 (da) | 2018-11-30 | 2023-07-03 | Bristol Myers Squibb Co | Antistof omfattende en glutaminholdig letkæde-c-terminal forlængelse, konjugater deraf og fremgangsmåder samt anvendelser |
| WO2020123425A2 (en) | 2018-12-12 | 2020-06-18 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
| CN113891897B (zh) * | 2019-03-21 | 2025-03-25 | 新加坡科技研究局 | 组合物 |
| CN112390886B (zh) * | 2019-08-16 | 2022-08-16 | 原启生物科技(上海)有限责任公司 | 一种分离的抗原结合蛋白及其用途 |
| AU2021260960A1 (en) | 2020-04-22 | 2022-11-24 | Dragonfly Therapeutics, Inc. | Formulation, dosage regimen, and manufacturing process for heterodimeric Fc-fused proteins |
| MX2022013920A (es) * | 2020-05-07 | 2022-11-30 | Phanes Therapeutics Inc | Anticuerpos anti-antigeno asociado con tumor y usos de los mismos. |
| CA3205422A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
| AU2022263126A1 (en) * | 2021-04-23 | 2023-11-02 | Shanghai Henlius Biotech, Inc. | Anti-gpc3 antibodies and methods of use |
| CN113354737B (zh) * | 2021-07-20 | 2022-11-18 | 广州爱思迈生物医药科技有限公司 | 一种磷脂酰肌醇蛋白聚糖3抗体及其应用 |
| WO2023023354A2 (en) * | 2021-08-19 | 2023-02-23 | Adicet Therapeutics, Inc. | Methods for detection of membrane bound glypican-3 |
| CN118488970A (zh) * | 2021-10-15 | 2024-08-13 | 乐普创一生物科技（上海）有限公司 | 抗磷脂酰肌醇蛋白聚糖3抗体 |
| CN120344270A (zh) | 2022-10-07 | 2025-07-18 | Ambrx 公司 | 药物接头及其抗体缀合物 |
| TW202432596A (zh) * | 2022-11-01 | 2024-08-16 | 大陸商上海齊魯製藥研究中心有限公司 | 針對磷脂醯肌醇蛋白聚醣3的雙特異性抗體及其應用 |
| CN121399157A (zh) | 2023-06-12 | 2026-01-23 | 美国安进公司 | 淋巴毒素β受体激动剂结合蛋白 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3426001B2 (ja) | 1993-09-16 | 2003-07-14 | 東芝機械株式会社 | ステージ内蔵型雰囲気室装置 |
| CA2219361C (en) * | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP1411118B1 (en) | 2001-06-22 | 2008-09-03 | Chugai Seiyaku Kabushiki Kaisha | Cell proliferation inhibitors containing anti-glypican-3 antibody |
| WO2004022597A1 (ja) | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3の血中可溶化ｎ端ﾍﾟﾌﾟﾁﾄﾞに対する抗体 |
| AU2002330482A1 (en) | 2002-09-04 | 2004-03-29 | Perseus Proteomics Inc. | Method of diagnosing cancer by detecting gpc3 |
| AU2002328429A1 (en) | 2002-09-04 | 2004-03-29 | Chugai Seiyaku Kabushiki Kaisha | CONSTRUCTION OF ANTIBODY USING MRL/lpr MOUSE |
| US7303914B2 (en) | 2003-01-30 | 2007-12-04 | Hongyang Wang | Monoclonal antibody against human hepatoma and use thereof |
| CN100555588C (zh) | 2003-06-27 | 2009-10-28 | 日本电气株式会社 | 薄膜晶体管、薄膜晶体管基板、电子设备及多晶半导体薄膜的制造方法 |
| AU2005256113B2 (en) | 2004-07-09 | 2011-02-10 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican 3 antibody |
| KR101300546B1 (ko) | 2004-08-24 | 2013-09-02 | 추가이 세이야쿠 가부시키가이샤 | 항 글리피칸 3 항체를 이용한 어쥬번트 요법 |
| KR101296931B1 (ko) | 2004-10-26 | 2013-08-14 | 추가이 세이야쿠 가부시키가이샤 | 변형된 당쇄를 갖는 항-글리피칸 3 항체 |
| AU2005333155B2 (en) * | 2005-03-14 | 2011-11-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies against Hendra and Nipah viruses |
| KR101704734B1 (ko) * | 2005-07-01 | 2017-02-09 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| US7744800B2 (en) | 2006-01-06 | 2010-06-29 | Molded Fiber Glass Companies | Method and apparatus for controlling the stacking height of stackable products during compression molding off stops |
| SG177168A1 (en) * | 2006-12-01 | 2012-01-30 | Medarex Inc | Human antibodies that bind cd22 and uses thereof |
| AU2008275985B2 (en) * | 2007-07-17 | 2013-09-19 | E. R. Squibb & Sons, L.L.C. | Monoclonal antibodies against Glypican-3 |
| US8852599B2 (en) * | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
-
2008
- 2008-07-17 AU AU2008275985A patent/AU2008275985B2/en not_active Ceased
- 2008-07-17 HR HRP20160270TT patent/HRP20160270T1/hr unknown
- 2008-07-17 EP EP08796249.4A patent/EP2178921B1/en active Active
- 2008-07-17 PT PT87962494T patent/PT2178921E/pt unknown
- 2008-07-17 ME MEP-2016-86A patent/ME02345B/me unknown
- 2008-07-17 US US12/668,965 patent/US8680247B2/en active Active
- 2008-07-17 MX MX2010000537A patent/MX2010000537A/es active IP Right Grant
- 2008-07-17 SI SI200831584A patent/SI2178921T1/sl unknown
- 2008-07-17 RS RS20160157A patent/RS54624B1/sr unknown
- 2008-07-17 ES ES08796249.4T patent/ES2562790T3/es active Active
- 2008-07-17 JP JP2010517161A patent/JP5868593B2/ja not_active Expired - Fee Related
- 2008-07-17 WO PCT/US2008/070344 patent/WO2009012394A1/en not_active Ceased
- 2008-07-17 CN CN2008801031669A patent/CN101815726B/zh not_active Expired - Fee Related
- 2008-07-17 KR KR1020157007446A patent/KR101527342B1/ko not_active Expired - Fee Related
- 2008-07-17 KR KR1020107003345A patent/KR101570252B1/ko not_active Expired - Fee Related
- 2008-07-17 DK DK08796249.4T patent/DK2178921T3/en active
- 2008-07-17 PL PL08796249T patent/PL2178921T3/pl unknown
- 2008-07-17 HU HUE08796249A patent/HUE028737T2/en unknown
-
2014
- 2014-02-10 US US14/176,790 patent/US9217033B2/en active Active
- 2014-07-03 JP JP2014137921A patent/JP2014236734A/ja active Pending
-
2016
- 2016-03-01 CY CY20161100174T patent/CY1117236T1/el unknown
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