JP2019107018A5 - - Google Patents
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- JP2019107018A5 JP2019107018A5 JP2019036646A JP2019036646A JP2019107018A5 JP 2019107018 A5 JP2019107018 A5 JP 2019107018A5 JP 2019036646 A JP2019036646 A JP 2019036646A JP 2019036646 A JP2019036646 A JP 2019036646A JP 2019107018 A5 JP2019107018 A5 JP 2019107018A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 34
- 239000012634 fragment Substances 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 3
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000043321 human CTLA4 Human genes 0.000 claims 3
- 230000008629 immune suppression Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 101710135378 pH 6 antigen Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410377352.9 | 2014-08-01 | ||
| CN201410377352.9A CN105296433B (zh) | 2014-08-01 | 2014-08-01 | 一种ctla4抗体、其药物组合物及其用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525666A Division JP6514774B2 (ja) | 2014-08-01 | 2015-07-31 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019107018A JP2019107018A (ja) | 2019-07-04 |
| JP2019107018A5 true JP2019107018A5 (enExample) | 2019-09-19 |
| JP6783886B2 JP6783886B2 (ja) | 2020-11-11 |
Family
ID=55194268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525666A Active JP6514774B2 (ja) | 2014-08-01 | 2015-07-31 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
| JP2019036646A Active JP6783886B2 (ja) | 2014-08-01 | 2019-02-28 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525666A Active JP6514774B2 (ja) | 2014-08-01 | 2015-07-31 | 抗ｃｔｌａ４モノクローナル抗体またはその抗原結合断片、医薬組成物および使用 |
Country Status (39)
Families Citing this family (65)
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| CN105296433B (zh) * | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
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| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
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