|
EP3056568B1
(en)
|
2006-03-31 |
2021-09-15 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
CN101874042B9
(zh)
|
2007-09-26 |
2019-01-01 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
|
CA2721052C
(en)
|
2008-04-11 |
2023-02-21 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
CN103052649B
(zh)
|
2010-07-29 |
2015-12-16 |
Xencor公司 |
具有修改的等电点的抗体
|
|
CN103328632A
(zh)
|
2010-11-30 |
2013-09-25 |
中外制药株式会社 |
与多分子的抗原重复结合的抗原结合分子
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
WO2014030750A1
(ja)
|
2012-08-24 |
2014-02-27 |
中外製薬株式会社 |
マウスFcγRII特異的Fc抗体
|
|
WO2014030728A1
(ja)
|
2012-08-24 |
2014-02-27 |
中外製薬株式会社 |
FcγRIIb特異的Fc領域改変体
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CN105051069B
(zh)
|
2013-01-14 |
2019-12-10 |
Xencor股份有限公司 |
新型异二聚体蛋白
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9738722B2
(en)
|
2013-01-15 |
2017-08-22 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
EP2970484B2
(en)
|
2013-03-15 |
2022-09-21 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
|
US10544187B2
(en)
|
2013-03-15 |
2020-01-28 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
EP2970508A4
(en)
*
|
2013-03-15 |
2016-12-14 |
Permeon Biologics Inc |
GENETICALLY MODIFIED LOADING ANTIBODIES OR ENHANCED ENHANCEMENT ENHANCEMENT TARGETING PROTEIN COMPOSITIONS AND METHODS OF USE
|
|
WO2014145806A2
(en)
|
2013-03-15 |
2014-09-18 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CN113621057A
(zh)
|
2013-04-02 |
2021-11-09 |
中外制药株式会社 |
Fc区变体
|
|
WO2015033223A2
(en)
*
|
2013-09-03 |
2015-03-12 |
Novimmune S.A. |
Readily isolated bispecific binding molecules with native format having mutated constant regions
|
|
MY176522A
(en)
*
|
2013-11-04 |
2020-08-13 |
Ichnos Sciences SA |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
|
EP3122781B1
(en)
|
2014-03-28 |
2020-01-01 |
Xencor, Inc. |
Bispecific antibodies that bind to cd38 and cd3
|
|
TWI706960B
(zh)
|
2014-09-26 |
2020-10-11 |
美商宏觀基因股份有限公司 |
能夠結合cd19和cd3的雙特異性雙抗體及其用途
|
|
JP6993228B2
(ja)
*
|
2014-11-19 |
2022-03-03 |
ジェネンテック， インコーポレイテッド |
抗トランスフェリン受容体／抗ｂａｃｅ１多重特異性抗体および使用方法
|
|
CN107108745B
(zh)
|
2014-11-19 |
2021-01-12 |
基因泰克公司 |
抗bace1的抗体和其用于神经疾病免疫疗法的用途
|
|
EP3223845B1
(en)
*
|
2014-11-26 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cd20
|
|
WO2016086186A2
(en)
*
|
2014-11-26 |
2016-06-02 |
Xencor, Inc. |
Heterodimeric antibodies including binding to cd8
|
|
AU2015353416C1
(en)
|
2014-11-26 |
2022-01-27 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and CD38
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
IL278014B2
(en)
|
2014-12-19 |
2023-10-01 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use
|
|
EP3237449A2
(en)
|
2014-12-22 |
2017-11-01 |
Xencor, Inc. |
Trispecific antibodies
|
|
SG10201907215QA
(en)
|
2015-02-05 |
2019-09-27 |
Chugai Pharmaceutical Co Ltd |
Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
CA2984134A1
(en)
*
|
2015-05-08 |
2016-11-17 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and tumor antigens
|
|
WO2017100372A1
(en)
|
2015-12-07 |
2017-06-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
|
KR102850929B1
(ko)
|
2015-12-09 |
2025-08-27 |
에프. 호프만-라 로슈 아게 |
항-약물 항체의 형성을 감소시키기 위한 ii형 항-cd20 항체
|
|
EP3394098A4
(en)
|
2015-12-25 |
2019-11-13 |
Chugai Seiyaku Kabushiki Kaisha |
ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE
|
|
EP3464365A1
(en)
|
2016-06-01 |
2019-04-10 |
Xencor, Inc. |
Bispecific antibodies that bind cd123 and cd3
|
|
EP3464370A1
(en)
|
2016-06-01 |
2019-04-10 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma
|
|
EP3252078A1
(en)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
|
|
AU2018276419A1
(en)
|
2016-06-02 |
2019-10-17 |
F. Hoffmann-La Roche Ag |
Type II anti-CD20 antibody and anti-CD20/CD3 bispecific antibody for treatment of cancer
|
|
WO2017218707A2
(en)
|
2016-06-14 |
2017-12-21 |
Xencor, Inc. |
Bispecific checkpoint inhibitor antibodies
|
|
US10316088B2
(en)
|
2016-06-28 |
2019-06-11 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
|
CN109689099B
(zh)
|
2016-08-05 |
2023-02-28 |
中外制药株式会社 |
用于预防或治疗il-8相关疾病的组合物
|
|
SG11201901712YA
(en)
*
|
2016-08-30 |
2019-03-28 |
Xencor Inc |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
WO2018045110A1
(en)
|
2016-08-30 |
2018-03-08 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
MA46534A
(fr)
|
2016-10-14 |
2019-08-21 |
Xencor Inc |
Protéines de fusion fc hétérodimères il15/il15r
|
|
PT3558339T
(pt)
|
2016-12-22 |
2024-03-15 |
Cue Biopharma Inc |
Polipeptídeos multiméricos moduladores de células t e métodos de utilização dos mesmos
|
|
US11851471B2
(en)
|
2017-01-09 |
2023-12-26 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
US11111305B2
(en)
|
2017-01-09 |
2021-09-07 |
Torch Therapeutics |
Method of using a bispecific antibody to conditionally inhibit a receptor signaling complex
|
|
EP3579848B1
(en)
|
2017-02-08 |
2024-10-30 |
Dragonfly Therapeutics, Inc. |
Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
|
|
US20210130471A1
(en)
*
|
2017-02-20 |
2021-05-06 |
Dragonfly Therapeutics, Inc. |
Proteins binding cd33, nkg2d and cd16
|
|
JP7685821B2
(ja)
|
2017-02-20 |
2025-05-30 |
ドラゴンフライ セラピューティクス， インコーポレイテッド |
Ｈｅｒ２、ＮＫＧ２ＤおよびＣＤ１６に結合するタンパク質
|
|
CA3054955A1
(en)
|
2017-03-15 |
2018-09-20 |
Cue Biopharma, Inc. |
Methods for modulating an immune response
|
|
KR20240165484A
(ko)
|
2017-04-11 |
2024-11-22 |
인히브릭스 바이오사이언스, 인크. |
제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 이를 이용한 방법
|
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
EP3409322A1
(en)
|
2017-06-01 |
2018-12-05 |
F. Hoffmann-La Roche AG |
Treatment method
|
|
WO2018223004A1
(en)
|
2017-06-01 |
2018-12-06 |
Xencor, Inc. |
Bispecific antibodies that bind cd20 and cd3
|
|
AU2018275109A1
(en)
|
2017-06-01 |
2020-01-02 |
Xencor, Inc. |
Bispecific antibodies that bind CD 123 CD3
|
|
UY37758A
(es)
|
2017-06-12 |
2019-01-31 |
Novartis Ag |
Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
|
|
WO2019006472A1
(en)
|
2017-06-30 |
2019-01-03 |
Xencor, Inc. |
TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
|
|
KR20210029298A
(ko)
*
|
2017-08-16 |
2021-03-15 |
드래곤플라이 쎄라퓨틱스, 인크. |
Nkg2d, cd16, 및 egfr, ccr4 또는 pd-l1에 결합하는 단백질
|
|
SG11201913968VA
(en)
*
|
2017-08-23 |
2020-01-30 |
Dragonfly Therapeutics Inc |
Proteins binding nkg2d, cd16 and a tumor-associated antigen
|
|
US11987609B2
(en)
|
2017-09-25 |
2024-05-21 |
Dingfu Biotarget Co., Ltd. |
Proteinaceous heterodimer and use thereof
|
|
AU2018366199A1
(en)
*
|
2017-11-08 |
2020-05-28 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
MA51291A
(fr)
|
2017-12-19 |
2020-10-28 |
Xencor Inc |
Protéines de fusion il-2 fc modifiées
|
|
BR112020015994A2
(pt)
|
2018-02-08 |
2020-12-15 |
Dragonfly Therapeutics, Inc. |
Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
|
|
MX2020008336A
(es)
|
2018-02-08 |
2020-09-21 |
Dragonfly Therapeutics Inc |
Dominios variables de anticuerpos que se dirigen al receptor nkg2d.
|
|
MA51747A
(fr)
|
2018-02-08 |
2020-12-16 |
Amgen Inc |
Formulation d'anticorps pharmaceutique à ph faible
|
|
JP7353576B2
(ja)
|
2018-02-20 |
2023-10-02 |
ドラゴンフライ セラピューティクス， インコーポレイテッド |
Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法
|
|
TWI887899B
(zh)
|
2018-03-15 |
2025-06-21 |
日商中外製藥股份有限公司 |
對茲卡病毒具有交叉反應性的抗登革病毒抗體之用途
|
|
CA3096052A1
(en)
|
2018-04-04 |
2019-10-10 |
Xencor, Inc. |
Heterodimeric antibodies that bind fibroblast activation protein
|
|
CN112204052A
(zh)
*
|
2018-04-05 |
2021-01-08 |
诺华股份有限公司 |
针对癌症的三特异性结合分子及其用途
|
|
EP3773913A1
(en)
*
|
2018-04-11 |
2021-02-17 |
Inhibrx, Inc. |
Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses
|
|
SG11202010159RA
(en)
|
2018-04-18 |
2020-11-27 |
Xencor Inc |
Il-15/il-15ra heterodimeric fc fusion proteins and uses thereof
|
|
MX2020010910A
(es)
|
2018-04-18 |
2021-02-09 |
Xencor Inc |
Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos.
|
|
US20190352362A1
(en)
|
2018-04-18 |
2019-11-21 |
Xencor, Inc. |
LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
|
|
CA3097741A1
(en)
|
2018-04-18 |
2019-10-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
WO2019210147A1
(en)
|
2018-04-27 |
2019-10-31 |
Xencor, Inc. |
Dosing of a bispecific antibody that bind cd123 and cd3
|
|
EA202091977A1
(ru)
*
|
2018-05-28 |
2021-02-09 |
Драгонфлай Терапьютикс, Инк. |
Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
|
|
AU2019276578A1
(en)
|
2018-06-01 |
2021-01-14 |
Compugen Ltd |
Anti-PVRIG/anti-TIGIT bispecific antibodies and methods of use
|
|
CN118459594A
(zh)
|
2018-06-01 |
2024-08-09 |
诺华股份有限公司 |
针对bcma的结合分子及其用途
|
|
WO2019232528A1
(en)
|
2018-06-01 |
2019-12-05 |
Xencor, Inc. |
Dosing of a bispecific antibody that bind cd123 and cd3
|
|
CN112566650A
(zh)
*
|
2018-06-21 |
2021-03-26 |
沙塔克实验室有限公司 |
异二聚体蛋白及其用途
|
|
WO2020018556A1
(en)
|
2018-07-16 |
2020-01-23 |
Amgen Inc. |
Method of treating multiple myeloma
|
|
US12195533B2
(en)
|
2018-07-24 |
2025-01-14 |
Inhibrx Biosciences, Inc. |
Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same
|
|
EA202190468A1
(ru)
|
2018-08-08 |
2021-07-06 |
Драгонфлай Терапьютикс, Инк. |
Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения
|
|
EA202091888A1
(ru)
*
|
2018-08-08 |
2020-10-23 |
Драгонфлай Терапьютикс, Инк. |
Вариабельные домены антител, нацеленные на рецептор nkg2d
|
|
SG11202101298XA
(en)
|
2018-08-08 |
2021-03-30 |
Dragonfly Therapeutics Inc |
Proteins binding nkg2d, cd16 and a tumor-associated antigen
|
|
CA3115096A1
(en)
|
2018-10-03 |
2020-04-09 |
Xencor, Inc. |
Il-12 heterodimeric fc-fusion proteins
|
|
JP2022512684A
(ja)
|
2018-10-11 |
2022-02-07 |
インヒブルクス インコーポレイテッド |
Ｂ７ｈ３シングルドメイン抗体およびその治療用組成物
|
|
TW202028245A
(zh)
|
2018-10-11 |
2020-08-01 |
美商英伊布里克斯公司 |
Dll3單域抗體及其治療性組合物
|
|
TWI863932B
(zh)
|
2018-10-11 |
2024-12-01 |
美商因荷布瑞克斯生物科學公司 |
5t4單域抗體及其治療性組合物
|
|
MA53862A
(fr)
|
2018-10-12 |
2022-01-19 |
Xencor Inc |
Protéines de fusion fc d'il-15/il-15ralpha ciblant pd-1 et utilisations dans des polythérapies faisant intervenir celles-ci
|
|
MX2021005823A
(es)
|
2018-11-30 |
2021-07-15 |
Jiangsu Hengrui Medicine Co |
Anticuerpo anti-cd40, fragmento de union a antigeno y uso farmaceutico del mismo.
|
|
TW202033218A
(zh)
*
|
2018-12-07 |
2020-09-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
多特異性蛋白分子
|
|
EP3897853A1
(en)
|
2018-12-20 |
2021-10-27 |
Xencor, Inc. |
Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
|
|
CN113811549A
(zh)
|
2019-02-21 |
2021-12-17 |
Xencor股份有限公司 |
非靶向和靶向性il-10 fc融合蛋白
|
|
BR112021016955A2
(pt)
|
2019-03-01 |
2021-11-23 |
Xencor Inc |
Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico
|
|
US20210079094A1
(en)
|
2019-03-29 |
2021-03-18 |
Xencor, Inc. |
Dosing of a bispecific antibody that binds pd1 and ctla4
|
|
KR20220017909A
(ko)
*
|
2019-05-09 |
2022-02-14 |
메뤼스 엔.페. |
단백질 다량체화를 위한 변이체 도메인 및 그의 분리
|
|
WO2020236655A1
(en)
|
2019-05-17 |
2020-11-26 |
Xencor, Inc. |
Il-7-fc-fusi0n proteins
|
|
JP7762570B2
(ja)
|
2019-05-20 |
2025-10-30 |
サイチューン ファーマ |
癌又は感染性疾患を処置するためのＩＬ－２／ＩＬ－１５Ｒβγアゴニスト投薬レジメン
|
|
EP3972993A1
(en)
|
2019-05-21 |
2022-03-30 |
Novartis AG |
Variant cd58 domains and uses thereof
|
|
US20220396631A1
(en)
|
2019-05-21 |
2022-12-15 |
Lu HUANG |
Trispecific binding molecules against bcma and uses thereof
|
|
JP7489407B2
(ja)
|
2019-05-21 |
2024-05-23 |
ノバルティス アーゲー |
Ｃｄ１９結合分子及びその使用
|
|
MX2021014476A
(es)
*
|
2019-05-29 |
2022-02-11 |
Cue Biopharma Inc |
Polipeptidos multimericos moduladores de linfocitos t y metodos de uso de estos.
|
|
EP3976644A4
(en)
|
2019-05-31 |
2022-12-14 |
The Johns Hopkins University |
BI-SPECIFIC LIAISONS
|
|
EP3976649A4
(en)
*
|
2019-05-31 |
2022-12-14 |
The Johns Hopkins University |
B-SPECIFIC IL-6Ra/IL-8R BINDING AGENTS TO BLOCK MIGRATION OF CANCER CELLS
|
|
CN114008082A
(zh)
*
|
2019-06-24 |
2022-02-01 |
南京金斯瑞生物科技有限公司 |
单克隆抗体-细胞因子融合蛋白二聚体及其应用
|
|
WO2021026387A2
(en)
|
2019-08-06 |
2021-02-11 |
Xencor, Inc. |
HETERODIMERIC IgG-LIKE BISPECIFIC ANTIBODIES
|
|
CN115916233A
(zh)
|
2019-10-03 |
2023-04-04 |
Xencor股份有限公司 |
靶向IL-12异源二聚体Fc融合蛋白
|
|
TW202128757A
(zh)
|
2019-10-11 |
2021-08-01 |
美商建南德克公司 |
具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
|
|
TW202136287A
(zh)
|
2019-12-17 |
2021-10-01 |
法商Ｏｓｅ免疫治療公司 |
包含il-7變體之雙官能分子
|
|
MX2022009101A
(es)
*
|
2020-01-23 |
2022-10-07 |
Adagene Ag |
Proteinas heterodimericas con mutaciones fc.
|
|
IL294879A
(en)
|
2020-01-29 |
2022-09-01 |
Inhibrx Inc |
Cd28 single domain antibodies and multivalent and multispecific constructs thereof
|
|
TW202146452A
(zh)
|
2020-02-28 |
2021-12-16 |
瑞士商諾華公司 |
結合ｃｄ１２３和ｃｄ３之雙特異性抗體的給藥
|
|
US11365239B2
(en)
|
2020-03-20 |
2022-06-21 |
Tsb Therapeutics (Beijing) Co., Ltd. |
Anti-SARS-COV-2 antibodies and uses thereof
|
|
WO2021195513A1
(en)
|
2020-03-27 |
2021-09-30 |
Novartis Ag |
Bispecific combination therapy for treating proliferative diseases and autoimmune disorders
|
|
AR122018A1
(es)
|
2020-05-06 |
2022-08-03 |
Dragonfly Therapeutics Inc |
Proteínas que se unen a nkg2d, cd16 y clec12a
|
|
AU2021272291A1
(en)
|
2020-05-11 |
2023-02-02 |
Janssen Biotech, Inc. |
Methods for treating multiple myeloma
|
|
WO2021231376A2
(en)
|
2020-05-12 |
2021-11-18 |
Cue Biopharma, Inc. |
Multimeric t-cell modulatory polypeptides and methods of use thereof
|
|
WO2021231969A1
(en)
|
2020-05-14 |
2021-11-18 |
Xencor, Inc. |
Heterodimeric antibodies that bind msln and cd3
|
|
US11919956B2
(en)
|
2020-05-14 |
2024-03-05 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
|
|
AU2021302126B2
(en)
*
|
2020-06-30 |
2025-09-11 |
Harbour Biomed (Shanghai), Co., Ltd. |
Binding protein having h2l2 and hcab structures
|
|
KR20220014531A
(ko)
*
|
2020-07-29 |
2022-02-07 |
(주)메디톡스 |
헤테로이량체 Ｆｃ 융합 단백질, 및 관련 조성물, 용도 및 방법
|
|
AU2021329378A1
(en)
|
2020-08-19 |
2023-03-23 |
Xencor, Inc. |
Anti-CD28 compositions
|
|
JP2023541366A
(ja)
|
2020-09-09 |
2023-10-02 |
キュー バイオファーマ， インコーポレイテッド |
１型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法
|
|
WO2022061240A1
(en)
*
|
2020-09-21 |
2022-03-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Heteromultimeric proteins for reducing ige-dependent allergic effector cell activation
|
|
KR20230086765A
(ko)
|
2020-10-13 |
2023-06-15 |
얀센 바이오테크 인코포레이티드 |
분화 클러스터 iv 및/또는 viii을 조절하기 위한 바이오-조작된 t 세포 매개 면역, 물질 및 기타 방법
|
|
US20220135684A1
(en)
|
2020-10-14 |
2022-05-05 |
Xencor, Inc. |
Bispecific antibodies that bind pd-l1 and cd28
|
|
US20250197519A1
(en)
|
2020-10-23 |
2025-06-19 |
Xencor, Inc. |
Anti-cd20 antibodies and therapeutic uses thereof
|
|
JP2023550685A
(ja)
|
2020-10-26 |
2023-12-05 |
サイチューン ファーマ |
扁平上皮癌を治療するためのＩＬ－２／ＩＬ－１５Ｒβγアゴニスト
|
|
US20230398185A1
(en)
|
2020-10-26 |
2023-12-14 |
Cytune Pharma |
Il-2/il-15r-beta-gamma agonist for treating non-melanoma skin cancer
|
|
WO2022099090A1
(en)
|
2020-11-06 |
2022-05-12 |
Xencor, Inc. |
Heterodimeric antibodies that bind tgfbrii
|
|
AU2021374083A1
(en)
|
2020-11-06 |
2023-06-01 |
Novartis Ag |
Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
|
|
EP4240765A2
(en)
*
|
2020-11-06 |
2023-09-13 |
Novartis AG |
Antibody fc variants
|
|
US20240025993A1
(en)
|
2020-11-06 |
2024-01-25 |
Novartis Ag |
Cd19 binding molecules and uses thereof
|
|
MX2023005565A
(es)
*
|
2020-11-11 |
2024-02-23 |
Hq Han |
Antagonistas bifuncionales de activina/tgf-beta y rankl y usos de los mismos.
|
|
WO2022129512A1
(en)
|
2020-12-17 |
2022-06-23 |
Ose Immunotherapeutics |
Bifunctional anti-pd1/il-7 molecules
|
|
US20220227867A1
(en)
|
2020-12-24 |
2022-07-21 |
Xencor, Inc. |
ICOS TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND ICOS ANTIGEN BINDING DOMAINS
|
|
CN117222663A
(zh)
|
2021-03-03 |
2023-12-12 |
蜻蜓疗法股份有限公司 |
使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法
|
|
CA3212665A1
(en)
|
2021-03-09 |
2022-09-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cldn6
|
|
KR20230154311A
(ko)
|
2021-03-10 |
2023-11-07 |
젠코어 인코포레이티드 |
Cd3 및 gpc3에 결합하는 이종이량체 항체
|
|
EP4320156A1
(en)
|
2021-04-09 |
2024-02-14 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
IL307419A
(en)
|
2021-04-09 |
2023-12-01 |
Ose Immunotherapeutics |
A new scaffold for bifunctional molecules with improved properties
|
|
US20240383998A1
(en)
*
|
2021-04-20 |
2024-11-21 |
Korea University Research And Business Foundation |
Asymmetric antibody with improved cytotoxicity against cancer cells
|
|
CN115925967A
(zh)
|
2021-04-22 |
2023-04-07 |
广东菲鹏制药股份有限公司 |
双特异性多功能融合多肽
|
|
TW202244059A
(zh)
|
2021-04-30 |
2022-11-16 |
瑞士商赫孚孟拉羅股份公司 |
用抗ｃｄ２０／抗ｃｄ３雙特異性抗體進行治療之給藥
|
|
EP4330282A1
(en)
|
2021-04-30 |
2024-03-06 |
F. Hoffmann-La Roche AG |
Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
|
|
WO2022266219A1
(en)
|
2021-06-15 |
2022-12-22 |
Xencor, Inc. |
Heterodimeric antibodies that bind claudin18.2 and cd3
|
|
CA3219360A1
(en)
|
2021-06-22 |
2022-12-29 |
Novartis Ag |
Bispecific antibodies for use in treatment of hidradenitis suppurativa
|
|
KR20240024242A
(ko)
*
|
2021-06-23 |
2024-02-23 |
싸이튠 파마 |
인터루킨-15 기반 면역 사이토카인
|
|
EP4362984A1
(en)
|
2021-07-02 |
2024-05-08 |
Yale University |
Compositions and methods for treating cancers
|
|
WO2023010021A1
(en)
|
2021-07-27 |
2023-02-02 |
Xencor, Inc. |
Il-18-fc fusion proteins
|
|
EP4384204A1
(en)
|
2021-08-13 |
2024-06-19 |
Cytune Pharma |
Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
|
|
CN118139638A
(zh)
*
|
2021-08-25 |
2024-06-04 |
拜格拉夫55公司 |
靶向免疫抑制b细胞的抗体
|
|
US20240392000A1
(en)
*
|
2021-08-25 |
2024-11-28 |
Biograph 55, Inc. |
Methods of treating cancers associated with immunosuppressive b cells
|
|
WO2023034864A1
(en)
|
2021-08-31 |
2023-03-09 |
Yale University |
Compositions and methods for treating cancers
|
|
EP4408889A1
(en)
|
2021-09-27 |
2024-08-07 |
Xencor, Inc. |
B-cell maturation antigen (bcma) binding domain compositions
|
|
KR20240099376A
(ko)
|
2021-11-03 |
2024-06-28 |
얀센 바이오테크 인코포레이티드 |
암 치료 및 bcmaxcd3 이중특이성 항체의 효능을 향상시키는 방법
|
|
WO2023081915A1
(en)
|
2021-11-08 |
2023-05-11 |
Xencor, Inc. |
Il-8 as a predictive biomarker and methods of use thereof for the treatment of cancer
|
|
WO2023110918A1
(en)
|
2021-12-14 |
2023-06-22 |
Cdr-Life Ag |
Dual mhc-targeting t cell engager
|
|
CA3252619A1
(en)
|
2022-02-23 |
2023-08-31 |
Xencor, Inc. |
Anti-CD28 and anti-PSMA antibodies
|
|
EP4496631A1
(en)
|
2022-03-23 |
2025-01-29 |
F. Hoffmann-La Roche AG |
Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
|
|
US20240025968A1
(en)
|
2022-04-07 |
2024-01-25 |
Xencor, Inc. |
LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS
|
|
TW202404637A
(zh)
|
2022-04-13 |
2024-02-01 |
瑞士商赫孚孟拉羅股份公司 |
抗ｃｄ２０／抗ｃｄ３雙特異性抗體之醫藥組成物及使用方法
|
|
JP2025512391A
(ja)
|
2022-04-13 |
2025-04-17 |
ゼンコア インコーポレイテッド |
Ｐｄ－ｌ１、ｐｄ－ｌ２及び／またはｃｄ２８と結合する抗体
|
|
IL316174A
(en)
|
2022-04-26 |
2024-12-01 |
Novartis Ag |
Multiple specific antibodies targeting IL-13 and IL-18
|
|
CA3259886A1
(en)
|
2022-07-01 |
2024-01-04 |
Aarhus Universitet |
IGE-FCERI RELOCATION ARRANGEMENTS
|
|
JP2025525886A
(ja)
|
2022-08-02 |
2025-08-07 |
オーエスイー・イミュノセラピューティクス |
Ｃｄ２８に対する多機能性分子
|
|
US12161673B2
(en)
|
2022-09-14 |
2024-12-10 |
Cdr-Life Ag |
MAGE-A4 peptide dual T cell engagers
|
|
WO2024088987A1
(en)
|
2022-10-26 |
2024-05-02 |
F. Hoffmann-La Roche Ag |
Combination therapy for the treatment of cancer
|
|
US20240166705A1
(en)
|
2022-11-07 |
2024-05-23 |
Xencor, Inc. |
Il18-fc fusion proteins
|
|
WO2024102645A1
(en)
|
2022-11-07 |
2024-05-16 |
Xencor, Inc. |
Combination treatment with a bispecific antibody that binds ctla4 and pd1 for prostate cancer
|
|
WO2024102948A1
(en)
|
2022-11-11 |
2024-05-16 |
Celgene Corporation |
Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
|
|
TW202440636A
(zh)
|
2023-03-21 |
2024-10-16 |
美商傳記５５有限公司 |
Ｃｄ１９／ｃｄ３８多特異性抗體
|
|
WO2024215989A1
(en)
|
2023-04-14 |
2024-10-17 |
Sotio Biotech Inc. |
ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS
|
|
WO2025038668A1
(en)
|
2023-08-14 |
2025-02-20 |
Voro Therapeutics, Inc. |
Therapeutic binding agents that conditionally promote myeloid cell activity against target cells and uses thereof
|
|
TW202525853A
(zh)
|
2023-08-28 |
2025-07-01 |
美商山可爾股份有限公司 |
抗ｃｄ２０ｘ抗ｃｄ２８組合療法
|
|
WO2025068957A1
(en)
|
2023-09-29 |
2025-04-03 |
Novartis Ag |
Bispecific antibodies for use in lowering the risk of cardiovascular disease events in subjects known to be a carrier of clonal expansion of hematopoietic cell lines with somatic mutations
|
|
WO2025075057A1
(ja)
*
|
2023-10-02 |
2025-04-10 |
国立大学法人 熊本大学 |
ポリペプチドの会合体形成抑制方法
|
|
WO2025085447A1
(en)
|
2023-10-17 |
2025-04-24 |
Xencor, Inc. |
Pd-1 targeted il18-fc fusion proteins
|
|
WO2025157132A1
(en)
|
2024-01-23 |
2025-07-31 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Multispecific antibodies targeting cd3, cd19 and cd20 and uses thereof
|
|
WO2025183172A1
(ja)
*
|
2024-02-28 |
2025-09-04 |
旭化成株式会社 |
等電点が改変されたドメインを有する抗体
|
|
WO2025210181A1
(en)
|
2024-04-04 |
2025-10-09 |
Cdr-Life Ag |
Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide
|
|
US20250333514A1
(en)
|
2024-04-11 |
2025-10-30 |
Cdr-Life Ag |
Antigen binding proteins targeting an hla-restricted prame peptide
|
|
WO2025240670A2
(en)
|
2024-05-15 |
2025-11-20 |
Abalytics Oncology, Inc. |
Anti-pd-1 antibodies and related binding molecules and methods and uses thereof
|
|
WO2025242836A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders
|
|
WO2025242835A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of cancer
|
|
US20250361311A1
(en)
|
2024-05-24 |
2025-11-27 |
Xencor, Inc. |
Anti-tnf-like ligand 1a (tl1a) antibodies
|
|
WO2025255349A1
(en)
|
2024-06-06 |
2025-12-11 |
Bristol-Myers Squibb Company |
Multispecific anti-cd40 / anti-fap antibodies and uses thereof
|
|
WO2025255405A1
(en)
|
2024-06-06 |
2025-12-11 |
Bristol-Myers Squibb Company |
Anti-fap antibodies and uses thereof
|