JP2017532952A5 - - Google Patents

Download PDF

Info

Publication number
JP2017532952A5
JP2017532952A5 JP2017510871A JP2017510871A JP2017532952A5 JP 2017532952 A5 JP2017532952 A5 JP 2017532952A5 JP 2017510871 A JP2017510871 A JP 2017510871A JP 2017510871 A JP2017510871 A JP 2017510871A JP 2017532952 A5 JP2017532952 A5 JP 2017532952A5
Authority
JP
Japan
Prior art keywords
composition
seq
antibody
antibody agent
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017510871A
Other languages
English (en)
Japanese (ja)
Other versions
JP6925264B2 (ja
JP2017532952A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/047013 external-priority patent/WO2016033225A2/en
Publication of JP2017532952A publication Critical patent/JP2017532952A/ja
Publication of JP2017532952A5 publication Critical patent/JP2017532952A5/ja
Application granted granted Critical
Publication of JP6925264B2 publication Critical patent/JP6925264B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017510871A 2014-08-27 2015-08-26 抗体、組成物および使用 Active JP6925264B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462042457P 2014-08-27 2014-08-27
US62/042,457 2014-08-27
PCT/US2015/047013 WO2016033225A2 (en) 2014-08-27 2015-08-26 Antibodies, compositions, and uses

Publications (3)

Publication Number Publication Date
JP2017532952A JP2017532952A (ja) 2017-11-09
JP2017532952A5 true JP2017532952A5 (enExample) 2018-09-27
JP6925264B2 JP6925264B2 (ja) 2021-08-25

Family

ID=55400815

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017510871A Active JP6925264B2 (ja) 2014-08-27 2015-08-26 抗体、組成物および使用

Country Status (12)

Country Link
US (1) US10316093B2 (enExample)
EP (1) EP3186277B1 (enExample)
JP (1) JP6925264B2 (enExample)
KR (1) KR102485788B1 (enExample)
CN (1) CN106715469B (enExample)
AU (1) AU2015306621B2 (enExample)
BR (1) BR112017003582B1 (enExample)
CA (1) CA2959356C (enExample)
EA (1) EA038798B1 (enExample)
ES (1) ES2838750T3 (enExample)
WO (1) WO2016033225A2 (enExample)
ZA (1) ZA201701168B (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10865245B2 (en) 2014-12-23 2020-12-15 Full Spectrum Genetics, Inc. Anti-B7H3 binding compounds and uses thereof
WO2016106004A1 (en) * 2014-12-23 2016-06-30 Full Spectrum Genetics, Inc. Novel anti-b7h3 binding compounds and uses thereof
US11071788B2 (en) * 2015-06-23 2021-07-27 Bayer Pharma Aktiengesellschaft Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
US12128102B2 (en) 2016-03-08 2024-10-29 Takeda Pharmaceutical Company Limited Constrained conditionally activated binding proteins
US20190300606A1 (en) * 2016-07-01 2019-10-03 The Board Of Trustees Of The Leland Stanford Junior University Inhibitory Immune Receptor Inhibition Methods and Compositions
CA3050085A1 (en) 2017-01-20 2018-07-26 Juno Therapeutics Gmbh Cell surface conjugates and related cell compositions and methods
CN109843927B (zh) * 2017-03-06 2022-06-21 江苏恒瑞医药股份有限公司 抗b7-h3抗体、其抗原结合片段及其医药用途
UA125593C2 (uk) 2017-03-31 2022-04-27 Джянгсу Хенгруй Медісін Ко., Лтд. Антитіло в7-н3, його антигензв'язуючий фрагмент та його медичне застосування
WO2018191438A1 (en) 2017-04-11 2018-10-18 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
EA201992683A1 (ru) * 2017-05-12 2020-04-23 Мемориал Слоан-Кеттеринг Кэнсер Сентер Применение антител против b7h3 для лечения злокачественных опухолей в центральной нервной системе
CN109963591B (zh) * 2017-08-04 2023-04-04 江苏恒瑞医药股份有限公司 B7h3抗体-药物偶联物及其医药用途
WO2019032628A1 (en) 2017-08-07 2019-02-14 The Regents Of The University Of California GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS
CA3073227A1 (en) 2017-08-17 2019-02-21 Michael D. Miller Firearm assembly system and method
WO2019051102A2 (en) 2017-09-08 2019-03-14 Maverick Therapeutics, Inc. Constrained conditionally activated binding proteins
EP3700938A1 (en) * 2017-10-26 2020-09-02 ImmuneOnco Biopharmaceuticals (Shanghai) Co., Ltd. Novel recombinant fusion proteins, preparation and use thereof
WO2019086507A1 (en) 2017-10-31 2019-05-09 Pantarhei Bioscience B.V. Immunotherapeutic methods for treating and/or preventing lung cancer
CN109939231A (zh) * 2017-12-21 2019-06-28 张曼 关于cd3×b7h3双特异性抗体定向杀伤膀胱癌细胞t24的应用
CN109939126A (zh) * 2017-12-21 2019-06-28 张曼 Cd3×b7h3双特异抗体定向杀伤耐阿霉素膀胱癌细胞pumc-91/adm的应用
KR102839330B1 (ko) 2018-01-15 2025-07-30 난징 레전드 바이오테크 씨오., 엘티디. Pd-1에 대한 단일-도메인 항체 및 이의 변이체
CN111868083B (zh) 2018-01-15 2025-02-11 桑昆血液供给基金会 因子h增强抗体及其用途
IL277863B2 (en) 2018-04-11 2026-02-01 Inhibrx Inc Multispecific polypeptide constructs with forced CD3 binding and related methods and uses
WO2019225787A1 (ko) * 2018-05-24 2019-11-28 에이비엘바이오 주식회사 항-b7-h3 항체 및 그 용도
MA52889A (fr) 2018-06-15 2021-04-21 Flagship Pioneering Innovations V Inc Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
CA3105891A1 (en) 2018-07-24 2020-01-30 Inhibrx, Inc. Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
WO2020041626A1 (en) * 2018-08-23 2020-02-27 The Board Of Trustees Of The Leland Stanford Junior University Affibody proteins specific for b7-h3 (cd276)
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CA3115082A1 (en) * 2018-10-11 2020-04-16 Inhibrx, Inc. B7h3 single domain antibodies and therapeutic compositions thereof
AU2018449846B2 (en) * 2018-11-22 2023-12-14 Beijing Kanova Biopharmaceutical Co., Ltd. An anti-B7-H3 antibody
WO2020181140A1 (en) 2019-03-05 2020-09-10 Maverick Therapeutics, Inc. Constrained conditionally activated binding proteins
CN109929039A (zh) * 2019-03-28 2019-06-25 郑州大学第一附属医院 基于cd276抗体的嵌合抗原受体、慢病毒表达载体及其应用
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
BR112021022682A2 (pt) 2019-05-14 2022-02-22 Provention Bio Inc Métodos e composições para prevenir diabetes do tipo 1
WO2020238926A1 (en) * 2019-05-28 2020-12-03 Single Cell Technology, Inc. Anti-b7-h3 antibodies
JP2022537672A (ja) * 2019-07-03 2022-08-29 クリスタル バイオサイエンス インコーポレイテッド 抗b7-h3抗体およびその使用方法
KR102732027B1 (ko) * 2019-07-09 2024-11-20 주식회사 와이바이오로직스 B7-h3(cd276)에 특이적으로 결합하는 항체 및 그의 용도
US11820814B2 (en) 2019-07-17 2023-11-21 Gemini Therapeutics Sub, Inc. Factor H potentiating antibodies and uses thereof
WO2021037319A1 (en) 2019-08-30 2021-03-04 Y-Mabs Therapeutics, Inc. Immunohistochemical assessment of b7-h3 expression
CN110642948B (zh) * 2019-10-09 2021-06-29 达石药业(广东)有限公司 B7-h3纳米抗体、其制备方法及用途
CN114929748A (zh) * 2019-11-18 2022-08-19 得克萨斯州大学系统董事会 抗b7-h3单克隆抗体及其使用方法
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
IL294879A (en) 2020-01-29 2022-09-01 Inhibrx Inc Monodomain antibodies of cd28 and their multivalent and multispecific constructs
EP4138931A1 (en) * 2020-04-24 2023-03-01 Y-Mabs Therapeutics, Inc. B7h3 antibodies with chelators
US20230312721A1 (en) * 2020-06-04 2023-10-05 Y-Mabs Therapeutics, Inc. Anti-B7H3 Antibodies for the Treatment of Cancer
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
EP4172323A1 (en) 2020-06-29 2023-05-03 Flagship Pioneering Innovations V, Inc. Viruses engineered to promote thanotransmission and their use in treating cancer
CN112851812B (zh) 2020-06-30 2021-09-14 广州百暨基因科技有限公司 抗b7h3抗体及其应用
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス,インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
JP2024500512A (ja) * 2020-12-23 2024-01-09 イノベント バイオロジクス(シンガポール)プライベート リミティド 抗b7-h3抗体およびその使用
CN119504997A (zh) 2021-02-09 2025-02-25 苏州宜联生物医药有限公司 生物活性物偶联物及其制备方法和用途
US20220325287A1 (en) 2021-03-31 2022-10-13 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
WO2022251253A1 (en) 2021-05-24 2022-12-01 Provention Bio, Inc. Methods for treating type 1 diabetes
KR20240026507A (ko) 2021-06-29 2024-02-28 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도
EP4401836A1 (en) * 2021-09-18 2024-07-24 Skyline Therapeutics Limited Aav for the gene therapy of wet-amd
WO2023060137A2 (en) * 2021-10-05 2023-04-13 Board Of Regents, The University Of Texas System Methods and compositions comprising b7-h3 binding polypeptides
US20250092140A1 (en) * 2022-01-14 2025-03-20 Shenghe (China) Biopharmaceutical Co., Ltd. Bispecific antibody binding to b7h3 and nkp30, and application thereof
WO2023155808A1 (zh) 2022-02-16 2023-08-24 苏州宜联生物医药有限公司 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途
AU2023236289A1 (en) 2022-03-15 2024-08-15 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
CN116836281A (zh) * 2022-03-25 2023-10-03 英诺湖医药(杭州)有限公司 B7h3抗体及包含其的双功能抗体
WO2023221975A1 (zh) 2022-05-18 2023-11-23 苏州宜联生物医药有限公司 包含蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途
AU2023273853A1 (en) * 2022-05-18 2024-10-24 WuXi Biologics Ireland Limited Anti-b7h3 antibody and uses thereof
US20260055188A1 (en) * 2022-08-19 2026-02-26 Shenghe (China) Biopharmaceutical Co., Ltd. Bispecific antibody and use thereof
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
CN115819608A (zh) * 2022-10-08 2023-03-21 盛禾(中国)生物制药有限公司 一种纯化融合蛋白的方法
CN115845047A (zh) * 2022-11-07 2023-03-28 盛禾(中国)生物制药有限公司 一种异源二聚体蛋白质组合物
WO2024106939A1 (ko) * 2022-11-15 2024-05-23 주식회사 셀랩메드 B7-h3에 특이적으로 결합하는 항체
US20240269251A1 (en) 2023-01-09 2024-08-15 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Il—18bp拮抗抗體及其於癌症治療之單一療法及組合療法的用途
WO2025129565A1 (zh) * 2023-12-21 2025-06-26 西湖实验室(生命科学和生物医学浙江省实验室) 一种cd276迷你结合蛋白及其突变体及应用
WO2025245264A1 (en) * 2024-05-21 2025-11-27 Briapro Therapeutics Corp. Anti-b7-h3 antibodies and methods of use thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4938948A (en) 1985-10-07 1990-07-03 Cetus Corporation Method for imaging breast tumors using labeled monoclonal anti-human breast cancer antibodies
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
ES2146648T3 (es) 1993-03-09 2000-08-16 Genzyme Corp Procedimiento de aislamiento de proteinas de la leche.
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US8414892B2 (en) 2000-10-18 2013-04-09 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
US7666424B2 (en) 2001-10-17 2010-02-23 Sloan-Kettering Institute For Cancer Research Methods of preparing and using single chain anti-tumor antibodies
US7737258B2 (en) * 2000-10-18 2010-06-15 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
US8501471B2 (en) 2000-10-18 2013-08-06 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
EP2121008A4 (en) * 2007-03-22 2010-03-31 Sloan Kettering Inst Cancer USE OF MONOCLONAL ANTIBODY 8H9
PH12018501083A1 (en) * 2010-03-04 2019-02-18 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
ES2961381T3 (es) * 2010-06-19 2024-03-11 Memorial Sloan Kettering Cancer Center Anticuerpos anti-GD2
WO2016106004A1 (en) * 2014-12-23 2016-06-30 Full Spectrum Genetics, Inc. Novel anti-b7h3 binding compounds and uses thereof

Similar Documents

Publication Publication Date Title
Stumpp et al. Beyond Antibodies: The DARPin® Drug Platform: MT Stumpp et al.
JP2020525032A5 (enExample)
AU2020363041B2 (en) Antibodies against the poliovirus receptor (PVR) and uses thereof
JP2012525128A5 (enExample)
RU2016129113A (ru) Антитела к pd-1 собак
JP2018527919A5 (enExample)
CN114269782B (zh) 抗tigit抗体及其应用
JP2019513777A5 (enExample)
JP2012518425A5 (enExample)
JP2013502913A5 (enExample)
JP2014527814A5 (enExample)
CN114729031A (zh) 抗溶瘤病毒抗原抗体及其使用方法
JP2017537082A5 (enExample)
JP2022553922A5 (enExample)
JP6914283B2 (ja) ヒトのがんを治療するための特異的抗cd38抗体
CN119899267A (zh) 拮抗性pd-1、pd-l1和lag-3结合蛋白
JP2018502068A5 (enExample)
JP2025512953A (ja) T細胞結合タンパク質
IL323457A (en) CD19/CD38 multispecific antibodies
JP2025513593A5 (enExample)
AU2022219681A1 (en) Antibodies against cd112r and uses thereof
Pauthner et al. Antibody engineering & therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA
JP2016013104A (ja) 抗イヌcd20モノクローナル抗体又は抗体フラグメント、キット、診断方法、治療用組成物、治療方法、核酸、ベクター、キメラ抗原受容体及びt細胞
JP2025503533A5 (enExample)
CN114502781A (zh) 个人化癌症免疫治疗