JP2017532952A5 - - Google Patents
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- JP2017532952A5 JP2017532952A5 JP2017510871A JP2017510871A JP2017532952A5 JP 2017532952 A5 JP2017532952 A5 JP 2017532952A5 JP 2017510871 A JP2017510871 A JP 2017510871A JP 2017510871 A JP2017510871 A JP 2017510871A JP 2017532952 A5 JP2017532952 A5 JP 2017532952A5
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- 239000003795 chemical substances by application Substances 0.000 claims description 115
- 239000000203 mixture Substances 0.000 claims description 43
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 33
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 33
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 29
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 29
- 210000004027 cell Anatomy 0.000 claims description 24
- 239000012634 fragment Substances 0.000 claims description 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 229920001184 polypeptide Polymers 0.000 claims description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 19
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 18
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims description 18
- 235000018102 proteins Nutrition 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 102100038078 CD276 antigen Human genes 0.000 claims description 10
- 241000282326 Felis catus Species 0.000 claims description 10
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims description 10
- 241000282553 Macaca Species 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 208000025174 PANDAS Diseases 0.000 claims description 10
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 claims description 10
- 240000004718 Panda Species 0.000 claims description 10
- 235000016496 Panda oleosa Nutrition 0.000 claims description 10
- 241000282405 Pongo abelii Species 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 10
- 241001515942 marmosets Species 0.000 claims description 10
- 241000283073 Equus caballus Species 0.000 claims description 9
- 241000282414 Homo sapiens Species 0.000 claims description 9
- 241000282620 Hylobates sp. Species 0.000 claims description 9
- 241000406668 Loxodonta cyclotis Species 0.000 claims description 9
- 241000282577 Pan troglodytes Species 0.000 claims description 9
- 241000282898 Sus scrofa Species 0.000 claims description 9
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 9
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 9
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004473 Threonine Substances 0.000 claims description 4
- 235000001014 amino acid Nutrition 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 230000010782 T cell mediated cytotoxicity Effects 0.000 claims description 2
- 230000006052 T cell proliferation Effects 0.000 claims description 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 238000011467 adoptive cell therapy Methods 0.000 claims description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 2
- 230000003915 cell function Effects 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 239000000562 conjugate Substances 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 230000006870 function Effects 0.000 claims description 2
- 239000012216 imaging agent Substances 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 229940051026 immunotoxin Drugs 0.000 claims description 2
- 230000002637 immunotoxin Effects 0.000 claims description 2
- 239000002596 immunotoxin Substances 0.000 claims description 2
- 231100000608 immunotoxin Toxicity 0.000 claims description 2
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 210000000822 natural killer cell Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000011363 radioimmunotherapy Methods 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 241000282472 Canis lupus familiaris Species 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 241000283086 Equidae Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241000282596 Hylobatidae Species 0.000 claims 1
- 241000282579 Pan Species 0.000 claims 1
- 241000283080 Proboscidea <mammal> Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 238000000034 method Methods 0.000 description 43
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 6
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 6
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 description 6
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 description 6
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 241000009328 Perro Species 0.000 description 4
- 230000002463 transducing effect Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462042457P | 2014-08-27 | 2014-08-27 | |
| US62/042,457 | 2014-08-27 | ||
| PCT/US2015/047013 WO2016033225A2 (en) | 2014-08-27 | 2015-08-26 | Antibodies, compositions, and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532952A JP2017532952A (ja) | 2017-11-09 |
| JP2017532952A5 true JP2017532952A5 (enExample) | 2018-09-27 |
| JP6925264B2 JP6925264B2 (ja) | 2021-08-25 |
Family
ID=55400815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510871A Active JP6925264B2 (ja) | 2014-08-27 | 2015-08-26 | 抗体、組成物および使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10316093B2 (enExample) |
| EP (1) | EP3186277B1 (enExample) |
| JP (1) | JP6925264B2 (enExample) |
| KR (1) | KR102485788B1 (enExample) |
| CN (1) | CN106715469B (enExample) |
| AU (1) | AU2015306621B2 (enExample) |
| BR (1) | BR112017003582B1 (enExample) |
| CA (1) | CA2959356C (enExample) |
| EA (1) | EA038798B1 (enExample) |
| ES (1) | ES2838750T3 (enExample) |
| WO (1) | WO2016033225A2 (enExample) |
| ZA (1) | ZA201701168B (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9963509B2 (en) * | 2014-12-23 | 2018-05-08 | Full Spectrum Genetics, Inc. | Anti-B7H3 binding compounds and uses thereof |
| US10865245B2 (en) | 2014-12-23 | 2020-12-15 | Full Spectrum Genetics, Inc. | Anti-B7H3 binding compounds and uses thereof |
| EP3313522A1 (de) * | 2015-06-23 | 2018-05-02 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit anti-b7h3-antikörpern |
| US12128102B2 (en) | 2016-03-08 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Constrained conditionally activated binding proteins |
| CA3026588A1 (en) * | 2016-07-01 | 2018-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitory immune receptor inhibition methods and compositions |
| JP2020505034A (ja) | 2017-01-20 | 2020-02-20 | ジュノ セラピューティクス ゲーエムベーハー | 細胞表面コンジュゲートならびに関連する細胞組成物および方法 |
| WO2018161872A1 (zh) * | 2017-03-06 | 2018-09-13 | 江苏恒瑞医药股份有限公司 | 抗b7-h3抗体、其抗原结合片段及其医药用途 |
| WO2018177393A1 (zh) | 2017-03-31 | 2018-10-04 | 江苏恒瑞医药股份有限公司 | B7-h3抗体、其抗原结合片段及其医药用途 |
| CN110770255B (zh) | 2017-04-11 | 2025-07-01 | 因荷布瑞克斯生物科学公司 | 具有受限cd3结合的多特异性多肽构建体及其使用方法 |
| CN110799542A (zh) * | 2017-05-12 | 2020-02-14 | 纪念斯隆-凯特琳癌症中心 | 抗-b7h3抗体用于治疗中枢神经系统癌症的用途 |
| WO2019024911A1 (zh) * | 2017-08-04 | 2019-02-07 | 江苏恒瑞医药股份有限公司 | B7h3抗体-药物偶联物及其医药用途 |
| CN111491655A (zh) | 2017-08-07 | 2020-08-04 | 加利福尼亚大学董事会 | 用于生成安全细胞治疗剂的平台 |
| CA3073227A1 (en) | 2017-08-17 | 2019-02-21 | Michael D. Miller | Firearm assembly system and method |
| IL317013A (en) * | 2017-09-08 | 2025-01-01 | Takeda Pharmaceuticals Co | Binding proteins are activated under limited conditions |
| EP3700938A1 (en) * | 2017-10-26 | 2020-09-02 | ImmuneOnco Biopharmaceuticals (Shanghai) Co., Ltd. | Novel recombinant fusion proteins, preparation and use thereof |
| EP3703734A1 (en) | 2017-10-31 | 2020-09-09 | Pantarhei Bioscience B.V. | Immunotherapeutic methods for treating and/or preventing lung cancer |
| CN109939231A (zh) * | 2017-12-21 | 2019-06-28 | 张曼 | 关于cd3×b7h3双特异性抗体定向杀伤膀胱癌细胞t24的应用 |
| CN109939126A (zh) * | 2017-12-21 | 2019-06-28 | 张曼 | Cd3×b7h3双特异抗体定向杀伤耐阿霉素膀胱癌细胞pumc-91/adm的应用 |
| JP7471224B2 (ja) * | 2018-01-15 | 2024-04-19 | シュティッヒティング・サンコン・ブロードフォールジーニング | Ｈ因子増強抗体及びその使用 |
| CA3264983A1 (en) * | 2018-01-15 | 2025-10-31 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against pd-1 |
| SG11202009804RA (en) | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| WO2019225787A1 (ko) | 2018-05-24 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-b7-h3 항체 및 그 용도 |
| JP2021528393A (ja) | 2018-06-15 | 2021-10-21 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 後細胞シグナル伝達因子の調節による免疫活性の上昇 |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| WO2020023553A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| US12274759B2 (en) | 2018-08-23 | 2025-04-15 | Regents Of The University Of Minnesota | Affibody proteins specific for B7-H3 (CD276) |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| TW202028246A (zh) * | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | B7h3單域抗體及其治療性組合物 |
| KR102662915B1 (ko) * | 2018-11-22 | 2024-05-03 | 쑤저우 카노바 바이오파마슈티컬 컴퍼니 리미티드 | 항-b7-h3 항체 |
| EP4592313A3 (en) * | 2019-03-05 | 2025-11-19 | Takeda Pharmaceutical Company Limited | Constrained conditionally activated binding proteins |
| CN109929039A (zh) * | 2019-03-28 | 2019-06-25 | 郑州大学第一附属医院 | 基于cd276抗体的嵌合抗原受体、慢病毒表达载体及其应用 |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| JP7137696B2 (ja) | 2019-05-14 | 2022-09-14 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を予防するための方法および組成物 |
| US20220235134A1 (en) * | 2019-05-28 | 2022-07-28 | Single Cell Technology, Inc. | Anti-b7-h3 antibodies |
| WO2021003075A1 (en) | 2019-07-03 | 2021-01-07 | Crystal Bioscience Inc. | Anti-b7-h3 antibody and methods of use thereof |
| KR102732027B1 (ko) * | 2019-07-09 | 2024-11-20 | 주식회사 와이바이오로직스 | B7-h3(cd276)에 특이적으로 결합하는 항체 및 그의 용도 |
| TWI851771B (zh) | 2019-07-17 | 2024-08-11 | 美商雙子治療子公司 | 因子ｈ增強抗體及其用途 |
| WO2021037319A1 (en) | 2019-08-30 | 2021-03-04 | Y-Mabs Therapeutics, Inc. | Immunohistochemical assessment of b7-h3 expression |
| CN110642948B (zh) * | 2019-10-09 | 2021-06-29 | 达石药业(广东)有限公司 | B7-h3纳米抗体、其制备方法及用途 |
| US20230014398A1 (en) * | 2019-11-18 | 2023-01-19 | Board Of Regents, The University Of Texas System | Anti-b7-h3 monoclonal antibody and methods of use thereof |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| CN115380047A (zh) | 2020-01-29 | 2022-11-22 | 印希比股份有限公司 | Cd28单结构域抗体及其多价和多特异性构建体 |
| WO2021213601A1 (en) * | 2020-04-24 | 2021-10-28 | Y-Mabs Therapeutics, Inc. | B7h3 antibodies with chelators |
| WO2021244721A1 (en) | 2020-06-04 | 2021-12-09 | Y-Mabs Therapeutics, Inc. | Anti-b7h3 antibodies for the treatment of cancer |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| WO2022006179A1 (en) | 2020-06-29 | 2022-01-06 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| CN112961241B (zh) * | 2020-06-30 | 2022-04-22 | 广州百暨基因科技有限公司 | 抗b7h3抗体及其应用 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| WO2022135467A1 (zh) * | 2020-12-23 | 2022-06-30 | 信达生物制药(苏州)有限公司 | 抗b7-h3抗体及其用途 |
| JP2024508081A (ja) | 2021-02-09 | 2024-02-22 | メディリンク セラピューティクス（スーチョウ）カンパニー，リミティド | 生物活性物質コンジュゲート、その調製方法及びその使用 |
| EP4313109A1 (en) | 2021-03-31 | 2024-02-07 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| CA3224374A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| CA3232067A1 (en) * | 2021-09-18 | 2023-03-23 | Skyline Therapeutics Limited | Aav for the gene therapy of wet-amd |
| US20250230244A1 (en) * | 2021-10-05 | 2025-07-17 | Board Of Regents, The University Of Texas System | Methods and compositions comprising b7-h3 binding polypetides |
| CN118591563A (zh) * | 2022-01-14 | 2024-09-03 | 盛禾(中国)生物制药有限公司 | 一种结合b7h3和nkp30的双特异性抗体及其应用 |
| WO2023155808A1 (zh) | 2022-02-16 | 2023-08-24 | 苏州宜联生物医药有限公司 | 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途 |
| JP2025509832A (ja) | 2022-03-15 | 2025-04-11 | コンピュジェン リミテッド | Ｉｌ－１８ｂｐアンタゴニスト抗体、並びに癌の治療での単剤療法及び併用療法におけるそれらの使用 |
| CN116836281A (zh) * | 2022-03-25 | 2023-10-03 | 英诺湖医药(杭州)有限公司 | B7h3抗体及包含其的双功能抗体 |
| IL316510A (en) * | 2022-05-18 | 2024-12-01 | Wuxi Biologics Ireland Ltd | Anti-B7H3 antibody and its uses |
| EP4527415A1 (en) | 2022-05-18 | 2025-03-26 | Medilink Therapeutics (Suzhou) Co., Ltd. | Antibody-drug conjugate containing protein degradation agent bioactive compound, method for preparing same, and use thereof |
| CN119768434A (zh) * | 2022-08-19 | 2025-04-04 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体及其应用 |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| CN115819608A (zh) * | 2022-10-08 | 2023-03-21 | 盛禾(中国)生物制药有限公司 | 一种纯化融合蛋白的方法 |
| CN115845047A (zh) * | 2022-11-07 | 2023-03-28 | 盛禾(中国)生物制药有限公司 | 一种异源二聚体蛋白质组合物 |
| WO2024106939A1 (ko) * | 2022-11-15 | 2024-05-23 | 주식회사 셀랩메드 | B7-h3에 특이적으로 결합하는 항체 |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
| WO2025129565A1 (zh) * | 2023-12-21 | 2025-06-26 | 西湖实验室(生命科学和生物医学浙江省实验室) | 一种cd276迷你结合蛋白及其突变体及应用 |
| WO2025245264A1 (en) | 2024-05-21 | 2025-11-27 | Briapro Therapeutics Corp. | Anti-b7-h3 antibodies and methods of use thereof |
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| US8501471B2 (en) | 2000-10-18 | 2013-08-06 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US7666424B2 (en) | 2001-10-17 | 2010-02-23 | Sloan-Kettering Institute For Cancer Research | Methods of preparing and using single chain anti-tumor antibodies |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| KR20100014527A (ko) * | 2007-03-22 | 2010-02-10 | 슬로안-케테링인스티튜트퍼캔서리서치 | 단일클론항체 8ｈ9의 용도 |
| BR112012022210B1 (pt) * | 2010-03-04 | 2021-08-17 | Macrogenics, Inc | Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado |
| JP6029581B2 (ja) | 2010-06-19 | 2016-11-24 | メモリアル スローン−ケタリング キャンサー センター | 抗ｇｄ２抗体 |
| US9963509B2 (en) * | 2014-12-23 | 2018-05-08 | Full Spectrum Genetics, Inc. | Anti-B7H3 binding compounds and uses thereof |
-
2015
- 2015-08-26 CN CN201580052144.4A patent/CN106715469B/zh active Active
- 2015-08-26 AU AU2015306621A patent/AU2015306621B2/en active Active
- 2015-08-26 EA EA201790465A patent/EA038798B1/ru unknown
- 2015-08-26 EP EP15835755.8A patent/EP3186277B1/en active Active
- 2015-08-26 KR KR1020177007808A patent/KR102485788B1/ko active Active
- 2015-08-26 ES ES15835755T patent/ES2838750T3/es active Active
- 2015-08-26 WO PCT/US2015/047013 patent/WO2016033225A2/en not_active Ceased
- 2015-08-26 US US15/505,872 patent/US10316093B2/en active Active
- 2015-08-26 CA CA2959356A patent/CA2959356C/en active Active
- 2015-08-26 BR BR112017003582-0A patent/BR112017003582B1/pt active IP Right Grant
- 2015-08-26 JP JP2017510871A patent/JP6925264B2/ja active Active
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2017
- 2017-02-16 ZA ZA2017/01168A patent/ZA201701168B/en unknown
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