JP2012525128A5 - - Google Patents
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- JP2012525128A5 JP2012525128A5 JP2012507695A JP2012507695A JP2012525128A5 JP 2012525128 A5 JP2012525128 A5 JP 2012525128A5 JP 2012507695 A JP2012507695 A JP 2012507695A JP 2012507695 A JP2012507695 A JP 2012507695A JP 2012525128 A5 JP2012525128 A5 JP 2012525128A5
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- Prior art keywords
- antibody
- seq
- igf
- antigen
- binding fragment
- Prior art date
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- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 12
- 239000000556 agonist Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 6
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 6
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 6
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 6
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102000004472 Myostatin Human genes 0.000 claims 5
- 108010056852 Myostatin Proteins 0.000 claims 5
- 208000023178 Musculoskeletal disease Diseases 0.000 claims 4
- 102000016970 Follistatin Human genes 0.000 claims 3
- 108010014612 Follistatin Proteins 0.000 claims 3
- 101000685982 Homo sapiens NAD(+) hydrolase SARM1 Proteins 0.000 claims 3
- 102100023356 NAD(+) hydrolase SARM1 Human genes 0.000 claims 3
- 230000002779 inactivation Effects 0.000 claims 3
- 208000017445 musculoskeletal system disease Diseases 0.000 claims 3
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 3
- 102000012004 Ghrelin Human genes 0.000 claims 2
- 101800001586 Ghrelin Proteins 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 206010049565 Muscle fatigue Diseases 0.000 claims 1
- 229940124748 beta 2 agonist Drugs 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- UJADSHNYKLSXNU-UHFFFAOYSA-N n-(4-tert-butyl-3-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Chemical compound N12N=CN=C2N=C(C)C=C1NC1=CC=C(C(C)(C)C)C(F)=C1 UJADSHNYKLSXNU-UHFFFAOYSA-N 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17300409P | 2009-04-27 | 2009-04-27 | |
| US61/173,004 | 2009-04-27 | ||
| US30613710P | 2010-02-19 | 2010-02-19 | |
| US61/306,137 | 2010-02-19 | ||
| PCT/EP2010/055458 WO2010125003A1 (en) | 2009-04-27 | 2010-04-23 | Compositions and methods for increasing muscle growth |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014070238A Division JP2014158480A (ja) | 2009-04-27 | 2014-03-28 | 筋肉増殖を増加させるための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525128A JP2012525128A (ja) | 2012-10-22 |
| JP2012525128A5 true JP2012525128A5 (enExample) | 2014-05-08 |
| JP5766179B2 JP5766179B2 (ja) | 2015-08-19 |
Family
ID=42306628
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507695A Active JP5766179B2 (ja) | 2009-04-27 | 2010-04-23 | 筋肉増殖を増加させるための組成物および方法 |
| JP2014070238A Withdrawn JP2014158480A (ja) | 2009-04-27 | 2014-03-28 | 筋肉増殖を増加させるための組成物および方法 |
| JP2016129498A Pending JP2017014207A (ja) | 2009-04-27 | 2016-06-30 | 筋肉増殖を増加させるための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014070238A Withdrawn JP2014158480A (ja) | 2009-04-27 | 2014-03-28 | 筋肉増殖を増加させるための組成物および方法 |
| JP2016129498A Pending JP2017014207A (ja) | 2009-04-27 | 2016-06-30 | 筋肉増殖を増加させるための組成物および方法 |
Country Status (41)
Families Citing this family (102)
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