JP2012525128A5 - - Google Patents
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- JP2012525128A5 JP2012525128A5 JP2012507695A JP2012507695A JP2012525128A5 JP 2012525128 A5 JP2012525128 A5 JP 2012525128A5 JP 2012507695 A JP2012507695 A JP 2012507695A JP 2012507695 A JP2012507695 A JP 2012507695A JP 2012525128 A5 JP2012525128 A5 JP 2012525128A5
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- Prior art keywords
- antibody
- seq
- igf
- antigen
- binding fragment
- Prior art date
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- 102000004965 antibodies Human genes 0.000 claims 18
- 108090001123 antibodies Proteins 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 12
- 102000038129 antigens Human genes 0.000 claims 12
- 108091007172 antigens Proteins 0.000 claims 12
- 239000000556 agonist Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 229920000023 polynucleotide Polymers 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 101710024843 ACVR2B Proteins 0.000 claims 6
- 102400000022 Insulin-Like Growth Factor II Human genes 0.000 claims 6
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 6
- 102000004218 Insulin-like growth factor I Human genes 0.000 claims 6
- 108090000723 Insulin-like growth factor I Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102000004472 Myostatin Human genes 0.000 claims 5
- 108010056852 Myostatin Proteins 0.000 claims 5
- 206010048592 Musculoskeletal disease Diseases 0.000 claims 4
- 102000016970 Follistatin Human genes 0.000 claims 3
- 108010014612 Follistatin Proteins 0.000 claims 3
- 102100014130 SARM1 Human genes 0.000 claims 3
- 101700082124 SARM1 Proteins 0.000 claims 3
- 230000002779 inactivation Effects 0.000 claims 3
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 3
- 101700010630 GHRL Proteins 0.000 claims 2
- 102000012004 Ghrelin Human genes 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- BGHSOEHUOOAYMY-JTZMCQEISA-N ghrelin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)C1=CC=CC=C1 BGHSOEHUOOAYMY-JTZMCQEISA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 206010049565 Muscle fatigue Diseases 0.000 claims 1
- UJADSHNYKLSXNU-UHFFFAOYSA-N N-(4-tert-butyl-3-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Chemical compound N12N=CN=C2N=C(C)C=C1NC1=CC=C(C(C)(C)C)C(F)=C1 UJADSHNYKLSXNU-UHFFFAOYSA-N 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
Claims (23)
- 配列番号：９のアミノ酸配列を含む重鎖可変領域ＣＤＲ１；
配列番号：２３のアミノ酸配列を含む重鎖可変領域ＣＤＲ２；
配列番号：３７のアミノ酸配列を含む重鎖可変領域ＣＤＲ３；
配列番号：５１のアミノ酸配列を含む軽鎖可変領域ＣＤＲ１；
配列番号：６５のアミノ酸配列を含む軽鎖可変領域ＣＤＲ２；および
配列番号：７９のアミノ酸配列を含む軽鎖可変領域ＣＤＲ３を含む、
抗ＡｃｔＲＩＩＢ抗体またはそれらの抗原結合断片。 - 配列番号：９３の可変軽鎖配列および配列番号：１０７の可変重鎖配列
を含む、ＡｃｔＲＩＩＢ結合抗体またはそれらの抗原結合断片。 - （ａ）配列番号：１４６の重鎖配列および配列番号：１４１の軽鎖配列；または
（ｂ）配列番号：１５６の重鎖配列および配列番号：１５１の軽鎖配列
を含む、ＡｃｔＲＩＩＢ結合抗体またはそれらの抗原結合断片。 - 前記抗体が、ＩｇＧ１アイソタイプである、請求項１〜３のいずれかに記載の抗ＡｃｔＲＩＩＢ抗体またはそれらの抗原結合断片。
- Ｆｃ領域の変異を介して改変されたエフェクター機能を有する、請求項１〜４のいずれかに記載の抗ＡｃｔＲＩＩＢ抗体。
- 請求項１〜５のいずれかに記載の抗体またはそれらの抗原結合断片をコードする単離されたポリヌクレオチド配列。
- 配列番号：１２１、１３５、１４１、１４６、１５１、１５６、１６１、１６６、１７１、または１７６の１つまたはそれ以上を含む、請求項６に記載の単離されたポリヌクレオチド配列。
- １つまたはそれ以上の請求項６または請求項７に記載の単離されたポリヌクレオチド配列を含むクローニングまたは発現ベクター。
- 請求項８に記載の１つまたはそれ以上のベクターを含む、単離された宿主細胞。
- 請求項１−５のいずれかに記載の抗体またはそれらの抗原結合断片の生産のための方法であって、請求項９に記載の宿主細胞を培養し、該抗体またはそれらの抗原結合断片を単離することを含む方法。
- 請求項１−５のいずれかに記載の抗体またはそれらの抗原結合断片または請求項６または請求項７に記載のポリヌクレオチド配列を含む医薬組成物。
- 薬学的に許容される希釈剤または担体をさらに含む、請求項１１に記載の医薬組成物。
- １つまたはそれ以上のさらなる活性剤をさらに含む、請求項１１または１２に記載の医薬組成物。
- 前記さらなる活性剤がＩＧＦ−１、ＩＧＦ−２またはＩＧＦ−１もしくはＩＧＦ−２の変異体、抗ミオスタチン抗体、ミオスタチンプロペプチド、ＡｃｔＲＩＩＢに結合するが、それを活性化しないミオスタチンデコイタンパク質、ベータ２アゴニスト、Ｇｈｒｅｌｉｎアゴニスト、ＳＡＲＭ、ＧＨアゴニスト／模擬物またはフォリスタチンから選択される請求項１３に記載の医薬組成物。
- 医薬として使用するための、請求項１−５のいずれかに記載の抗体またはそれらの抗原結合断片、請求項６または請求項７に記載のポリヌクレオチド配列、または請求項１１−１４のいずれかに記載の医薬組成物。
- 筋骨格疾患または障害の処置のための医薬の製造における、請求項１−５のいずれかに記載の抗体またはそれらの抗原結合断片、請求項６または請求項７に記載のポリヌクレオチド配列、または請求項１１−１４のいずれかに記載の医薬組成物の使用。
- 筋骨格疾患または障害の処置における使用のための、請求項１−５のいずれかに記載の抗体またはそれらの抗原結合断片、請求項６または請求項７に記載のポリヌクレオチド配列、または請求項１１−１４のいずれかに記載の医薬組成物。
- 前記筋骨格疾患または障害が、筋萎縮である、請求項１６または１７に記載の使用。
- 処置される患者が、ＩＧＦ−１、ＩＧＦ−２またはＩＧＦ−１もしくはＩＧＦ−２の変異体、抗ミオスタチン抗体、ミオスタチンプロペプチド、ＡｃｔＲＩＩＢに結合するが、それを活性化しないミオスタチンデコイタンパク質、ベータ２アゴニスト、Ｇｈｒｅｌｉｎアゴニスト、ＳＡＲＭ、ＧＨアゴニスト／模擬物またはフォリスタチンで以前に処置されている、請求項１８に記載の使用。
- 処置される患者が、ＩＧＦ−１、ＩＧＦ−２またはＩＧＦ−１もしくはＩＧＦ−２の変異体、抗ミオスタチン抗体、ミオスタチンプロペプチド、ＡｃｔＲＩＩＢに結合するが、それを活性化しないミオスタチンデコイタンパク質、ベータ２アゴニスト、Ｇｈｒｅｌｉｎアゴニスト、ＳＡＲＭ、ＧＨアゴニスト／模擬物またはフォリスタチンでの処置に対して以前に屈折性であった、請求項１８に記載の使用。
- 処置される患者が、高齢者であるか、無重力状態で過ごしているか、または不活化の期間を経験している、請求項１８に記載の使用。
- 強化された不活化の期間または無重力状態の時間の前に、有効用量の請求項１−５のいずれかの抗体またはそれらの抗原結合断片を投与することを含む、強化された不活化または無重力状態の時間の筋肉疲労効果を改善する方法。
- ｐＢＷ５２４（ＤＳＭ２２８７）によってコードされるＡｃｔＲＩＩＢ抗体。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17300409P | 2009-04-27 | 2009-04-27 | |
| US61/173,004 | 2009-04-27 | ||
| US30613710P | 2010-02-19 | 2010-02-19 | |
| US61/306,137 | 2010-02-19 | ||
| PCT/EP2010/055458 WO2010125003A1 (en) | 2009-04-27 | 2010-04-23 | Compositions and methods for increasing muscle growth |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014070238A Division JP2014158480A (ja) | 2009-04-27 | 2014-03-28 | 筋肉増殖を増加させるための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525128A JP2012525128A (ja) | 2012-10-22 |
| JP2012525128A5 true JP2012525128A5 (ja) | 2014-05-08 |
| JP5766179B2 JP5766179B2 (ja) | 2015-08-19 |
Family
ID=42306628
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507695A Active JP5766179B2 (ja) | 2009-04-27 | 2010-04-23 | 筋肉増殖を増加させるための組成物および方法 |
| JP2014070238A Withdrawn JP2014158480A (ja) | 2009-04-27 | 2014-03-28 | 筋肉増殖を増加させるための組成物および方法 |
| JP2016129498A Pending JP2017014207A (ja) | 2009-04-27 | 2016-06-30 | 筋肉増殖を増加させるための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014070238A Withdrawn JP2014158480A (ja) | 2009-04-27 | 2014-03-28 | 筋肉増殖を増加させるための組成物および方法 |
| JP2016129498A Pending JP2017014207A (ja) | 2009-04-27 | 2016-06-30 | 筋肉増殖を増加させるための組成物および方法 |
Country Status (41)
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