SG11201805941WA - Tgfbeta 2 antibodies - Google Patents

Tgfbeta 2 antibodies

Info

Publication number
SG11201805941WA
SG11201805941WA SG11201805941WA SG11201805941WA SG11201805941WA SG 11201805941W A SG11201805941W A SG 11201805941WA SG 11201805941W A SG11201805941W A SG 11201805941WA SG 11201805941W A SG11201805941W A SG 11201805941WA SG 11201805941W A SG11201805941W A SG 11201805941WA
Authority
SG
Singapore
Prior art keywords
novartis
international
tgf
massachusetts
antibodies
Prior art date
Application number
SG11201805941WA
Inventor
Chikwendu Ibebunjo
Carsten Jacobi
Angelika Meyer
Eveline Schaadt
Anne-Ulrike Trendelenburg
Mitina Olga Vladimirovna
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58191507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201805941W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201805941WA publication Critical patent/SG11201805941WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

met G.o1 1 iOa Yo966 .150 con& Imp . o MOR13434 • • 4Ent fate A •,,r.Z.11,9436. • (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/141208 Al 24 August 2017 (24.08.2017) WIPO I PCT (51) International Patent Classification: C07K 16/22 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/IB2017/050917 (22) International Filing Date: 17 February 2017 (17.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/296,282 17 February 2016 (17.02.2016) US (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4053 Basel (CH). (72) Inventors: IBEBUNJO, Chikwendu; Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139 (US). JACOBI, Carsten; Novartis Pharma AG, Postfach, Novartis Insti- tutes for Biomed. Research, 4002 Basel (CH). MEYER, Angelika; Novartis Pharma AG, Postfach, Novartis Insti- tutes for Biomed. Research, 4002 Basel (CH). SCHAADT, Eveline; MORPHOSYS AG, Lena-Christ-Strasse 48, 82152 Planegg (DE). TRENDELENBURG, Anne-Ul- rike; Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139 (US). VLADIMIROVNA MITINA, Olga; Morphosys AG, Lena-Christ-Strasse 48, 82152 Planegg (DE). (74) Agent: NOVARTIS AG; Lichtstrasse 35, 4053 (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: — with international search report (Art. 21(3)) [Continued on next page] = (54) Title: TGFBETA 2 ANTIBODIES Figure 3: Biologic activity and isoform-specificity by RGA activity (MOR13436) RGA:t9FDP40y t TGF4 it9A.PFOR:nti'GF-az 111111111111110111011111111111010111110 01011111011101011111110111111111110111111 W O 20 17 / 141208 Al o MOiR 1 S43 e CAT 15re g WS.V.2231 1 0.0691 0.0 -ipg 1 01196 Iii RsAloromap TGF-p! RIGA TaF-01 (57) : This invention is in the field of anti-transforming growth factor beta 2 (TGF-132) antibodies. In particular, the inven - tion provides human monoclonal antibodies that bind the human TGF-132 isoform preferentially over the human TGF-131 or TGF-133 isoforms. WO 2017/141208 Al 1#110HO1101DION01013010111101101011HOMOVOIMIE — with sequence listing part of description (Rule 5.2(a))
SG11201805941WA 2016-02-17 2017-02-17 Tgfbeta 2 antibodies SG11201805941WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662296282P 2016-02-17 2016-02-17
PCT/IB2017/050917 WO2017141208A1 (en) 2016-02-17 2017-02-17 Tgfbeta 2 antibodies

Publications (1)

Publication Number Publication Date
SG11201805941WA true SG11201805941WA (en) 2018-09-27

Family

ID=58191507

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201805941WA SG11201805941WA (en) 2016-02-17 2017-02-17 Tgfbeta 2 antibodies

Country Status (21)

Country Link
US (1) US11180546B2 (en)
EP (1) EP3416982A1 (en)
JP (1) JP2019511911A (en)
KR (1) KR20180107151A (en)
CN (1) CN108699142A (en)
AU (1) AU2017219254B2 (en)
BR (1) BR112018015690A2 (en)
CA (1) CA3012294A1 (en)
CL (1) CL2018001941A1 (en)
CO (1) CO2018008590A2 (en)
CU (1) CU20180088A7 (en)
EA (1) EA201891724A1 (en)
EC (1) ECSP18064646A (en)
HK (1) HK1257455A1 (en)
IL (1) IL261065A (en)
MA (1) MA44236A (en)
MX (1) MX2018010021A (en)
PH (1) PH12018501525A1 (en)
RU (1) RU2018131123A (en)
SG (1) SG11201805941WA (en)
WO (1) WO2017141208A1 (en)

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US11919948B2 (en) 2020-03-19 2024-03-05 Genentech, Inc. Isoform-selective anti-TGFβ antibodies and methods of use
CA3208365A1 (en) 2021-02-15 2022-08-18 Chantal KUHN Cell therapy compositions and methods for modulating tgf-b signaling
CN112940119B (en) * 2021-04-26 2022-05-20 北京芳渟阳生生物科技有限公司 Monoclonal antibody and combined application thereof and mesenchymal stem cell exosome
WO2023201310A1 (en) 2022-04-13 2023-10-19 HCW Biologics, Inc. Multi-chain chimeric polypeptide for use in the treatment of circardian clock gene disorder
WO2023201311A1 (en) 2022-04-13 2023-10-19 HCW Biologics, Inc. Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder

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Also Published As

Publication number Publication date
KR20180107151A (en) 2018-10-01
PH12018501525A1 (en) 2019-03-18
EP3416982A1 (en) 2018-12-26
CU20180088A7 (en) 2019-05-03
CA3012294A1 (en) 2017-08-24
WO2017141208A1 (en) 2017-08-24
AU2017219254A1 (en) 2018-08-02
CO2018008590A2 (en) 2018-08-21
JP2019511911A (en) 2019-05-09
IL261065A (en) 2018-10-31
MA44236A (en) 2018-12-26
RU2018131123A (en) 2020-03-17
HK1257455A1 (en) 2019-10-18
ECSP18064646A (en) 2018-09-30
BR112018015690A2 (en) 2018-12-26
AU2017219254B2 (en) 2019-12-12
CN108699142A (en) 2018-10-23
MX2018010021A (en) 2018-11-09
US20190092846A1 (en) 2019-03-28
EA201891724A1 (en) 2019-01-31
RU2018131123A3 (en) 2020-07-09
US11180546B2 (en) 2021-11-23
CL2018001941A1 (en) 2018-09-07

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