AR108452A1 - Moléculas de unión a antígeno que comprenden un trímero ligando de la familia de fnt y una fracción de unión a tenascina - Google Patents

Moléculas de unión a antígeno que comprenden un trímero ligando de la familia de fnt y una fracción de unión a tenascina

Info

Publication number
AR108452A1
AR108452A1 ARP170101252A ARP170101252A AR108452A1 AR 108452 A1 AR108452 A1 AR 108452A1 AR P170101252 A ARP170101252 A AR P170101252A AR P170101252 A ARP170101252 A AR P170101252A AR 108452 A1 AR108452 A1 AR 108452A1
Authority
AR
Argentina
Prior art keywords
cdr
amino acid
acid sequence
sequence seq
antigen
Prior art date
Application number
ARP170101252A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR108452A1 publication Critical patent/AR108452A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La solicitud se refiere a moléculas de unión a antígeno que contienen trímero ligando de la familia de FNT, que comprenden: (a) por lo menos una fracción de unión a antígeno capaz de unión específica a la tenascina C (TnC) y (b) un primer y un segundo polipéptidos que se unen entre sí mediante un enlace disulfuro, en el que las moléculas de unión a antígeno se caracterizan porque el primer polipéptido comprende dos ectodominios de un elemento de la familia de ligandos de FNT o dos fragmentos del mismo que se encuentran conectados entre sí por un conector peptídico y porque el segundo polipéptido comprende únicamente un ectodominio de dicho elemento de la familia de ligandos de FNT o un fragmento del mismo. La solicitud se refiere además a métodos de producción de dichas moléculas y a métodos de utilización de las mismas. Reivindicación 11: Molécula de unión a antígeno que contiene trímero ligando de la familia del FNT según cualquiera de las reivindicaciones 1 a 10, en la que la fracción capaz de unión específica a TnC comprende un dominio VH que comprende: (i) CDR-H1 que comprende la secuencia de aminoácidos SEQ ID Nº 67, (ii) CDR-H2 que comprende la secuencia de aminoácidos SEQ ID Nº 68, e (iii) CDR-H3 que comprende la secuencia de aminoácidos SEQ ID Nº 69, y un dominio VL que comprende (iv) CDR-L1 que comprende la secuencia de aminoácidos SEQ ID Nº 55, (ii) CDR-L2 que comprende la secuencia de aminoácidos SEQ ID Nº 56, y (vi) CDR-L3 que comprende la secuencia de aminoácidos SEQ ID Nº 57. Reivindicación 12: Molécula de unión a antígeno que contiene trímero ligando de la familia del FNT según cualquiera de las reivindicaciones 1 a 10, en la que la fracción capaz de unión específica a TnC comprende un dominio VH que comprende: (i) CDR-H1 que comprende la secuencia de aminoácidos SEQ ID Nº 70, (ii) CDR-H2 que comprende la secuencia de aminoácidos SEQ ID Nº 71, e (iii) CDR-H3 que comprende la secuencia de aminoácidos SEQ ID Nº 72, y un dominio VL que comprende (iv) CDR-L1 que comprende la secuencia de aminoácidos SEQ ID Nº 58, (ii) CDR-L2 que comprende la secuencia de aminoácidos SEQ ID Nº 59, y (vi) CDR-L3 que comprende la secuencia de aminoácidos SEQ ID Nº 60.
ARP170101252A 2016-05-11 2017-05-11 Moléculas de unión a antígeno que comprenden un trímero ligando de la familia de fnt y una fracción de unión a tenascina AR108452A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16169244 2016-05-11

Publications (1)

Publication Number Publication Date
AR108452A1 true AR108452A1 (es) 2018-08-22

Family

ID=56026655

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101252A AR108452A1 (es) 2016-05-11 2017-05-11 Moléculas de unión a antígeno que comprenden un trímero ligando de la familia de fnt y una fracción de unión a tenascina

Country Status (7)

Country Link
US (1) US11149083B2 (es)
EP (1) EP3455254B1 (es)
JP (1) JP7285076B2 (es)
CN (1) CN109071652B (es)
AR (1) AR108452A1 (es)
TW (1) TW201805310A (es)
WO (1) WO2017194442A1 (es)

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CR20200459A (es) 2018-04-13 2020-11-11 Hoffmann La Roche Moléculas de unión a antígeno dirigidas a her2 que comprendan 4-1bbl
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Also Published As

Publication number Publication date
EP3455254A1 (en) 2019-03-20
US20190248877A1 (en) 2019-08-15
US11149083B2 (en) 2021-10-19
CN109071652A (zh) 2018-12-21
CN109071652B (zh) 2022-09-23
JP7285076B2 (ja) 2023-06-01
TW201805310A (zh) 2018-02-16
EP3455254B1 (en) 2021-07-07
WO2017194442A1 (en) 2017-11-16
JP2019523216A (ja) 2019-08-22

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