JP2019522490A5 - - Google Patents
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- JP2019522490A5 JP2019522490A5 JP2019518145A JP2019518145A JP2019522490A5 JP 2019522490 A5 JP2019522490 A5 JP 2019522490A5 JP 2019518145 A JP2019518145 A JP 2019518145A JP 2019518145 A JP2019518145 A JP 2019518145A JP 2019522490 A5 JP2019522490 A5 JP 2019522490A5
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- JP
- Japan
- Prior art keywords
- seq
- specific binding
- binding member
- domain
- antibody molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000009870 specific binding Effects 0.000 claims 20
- 230000027455 binding Effects 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022051878A JP7394162B2 (ja) | 2016-06-20 | 2022-03-28 | Ｌａｇ－３結合要素 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662352470P | 2016-06-20 | 2016-06-20 | |
| US62/352,470 | 2016-06-20 | ||
| PCT/EP2017/065052 WO2017220555A1 (en) | 2016-06-20 | 2017-06-20 | Lag -3 binding members |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022051878A Division JP7394162B2 (ja) | 2016-06-20 | 2022-03-28 | Ｌａｇ－３結合要素 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522490A JP2019522490A (ja) | 2019-08-15 |
| JP2019522490A5 true JP2019522490A5 (enExample) | 2020-07-27 |
| JP7085708B2 JP7085708B2 (ja) | 2022-06-17 |
Family
ID=59269995
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518145A Active JP7085708B2 (ja) | 2016-06-20 | 2017-06-20 | Ｌａｇ－３結合要素 |
| JP2022051878A Active JP7394162B2 (ja) | 2016-06-20 | 2022-03-28 | Ｌａｇ－３結合要素 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022051878A Active JP7394162B2 (ja) | 2016-06-20 | 2022-03-28 | Ｌａｇ－３結合要素 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11214618B2 (enExample) |
| EP (1) | EP3472206B1 (enExample) |
| JP (2) | JP7085708B2 (enExample) |
| KR (1) | KR20190022632A (enExample) |
| CN (1) | CN109311993B (enExample) |
| AU (1) | AU2017281157B2 (enExample) |
| BR (1) | BR112018076525A2 (enExample) |
| CA (1) | CA3027302A1 (enExample) |
| ES (1) | ES3010640T3 (enExample) |
| IL (1) | IL263715A (enExample) |
| MX (1) | MX2018016344A (enExample) |
| RU (1) | RU2018142573A (enExample) |
| SG (1) | SG11201811184UA (enExample) |
| TW (1) | TW201831513A (enExample) |
| WO (1) | WO2017220555A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7085709B2 (ja) | 2016-06-20 | 2022-06-17 | エフ－スター セラピューティクス リミテッド | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
| SG11201811184UA (en) * | 2016-06-20 | 2019-01-30 | F Star Beta Ltd | Lag -3 binding members |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| KR20230133934A (ko) | 2016-10-11 | 2023-09-19 | 아게누스 인코포레이티드 | 항-lag-3 항체 및 이의 사용 방법 |
| CA3052532A1 (en) | 2017-04-05 | 2018-10-11 | F. Hoffmann-La Roche Ag | Bispecific antibodies specifically binding to pd1 and lag3 |
| JP2020522495A (ja) | 2017-05-30 | 2020-07-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 抗ｌａｇ−３抗体、ｐｄ−１経路阻害剤および免疫療法剤の組み合わせを含む組成物 |
| JP7301002B2 (ja) | 2017-05-30 | 2023-06-30 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｌａｇ－３抗体または抗ｌａｇ－３抗体および抗ｐｄ－１もしくは抗ｐｄ－ｌ１抗体を含む組成物 |
| WO2018222718A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
| CA3086098A1 (en) | 2017-12-19 | 2019-06-27 | F-Star Beta Limited | Fc binding fragments comprising a pd-l1 antigen-binding site |
| CN112584862A (zh) * | 2018-05-17 | 2021-03-30 | 伊米若梅有限公司 | Ch3结构域表位标签 |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| AU2019301206B2 (en) | 2018-07-12 | 2025-10-30 | Invox Pharma Limited | Antibody molecules that bind CD137 and OX40 |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| BR112021000394A2 (pt) | 2018-07-12 | 2021-04-06 | F-Star Beta Limited | Moléculas de anticorpo que se ligam a pd-l1 e cd137 |
| AU2019309849A1 (en) | 2018-07-26 | 2021-03-18 | Bristol-Myers Squibb Company | LAG-3 combination therapy for the treatment of cancer |
| WO2020081928A1 (en) | 2018-10-19 | 2020-04-23 | Bristol-Myers Squibb Company | Combination therapy for melanoma |
| JP2022534982A (ja) | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| WO2020243570A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| US20220363760A1 (en) | 2019-05-30 | 2022-11-17 | Bristol-Myers Squibb Company | Multi-tumor gene signature for suitability to immuno-oncology therapy |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| WO2021055994A1 (en) | 2019-09-22 | 2021-03-25 | Bristol-Myers Squibb Company | Quantitative spatial profiling for lag-3 antagonist therapy |
| WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| EP4054723A1 (en) | 2019-11-08 | 2022-09-14 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for melanoma |
| WO2021146749A1 (en) | 2020-01-13 | 2021-07-22 | The University Of Chicago | Toll-like receptor agonist formulations and methods of use |
| WO2021158938A1 (en) | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Il-10 and uses thereof |
| CN116234568A (zh) | 2020-07-07 | 2023-06-06 | 生物技术公司 | 用于hpv阳性癌症的治疗性rna |
| MX2023002332A (es) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | Terapia con antagonistas del gen 3 de activacion de linfocitos (lag-3) para carcinoma hepatocelular. |
| IL300916A (en) | 2020-08-31 | 2023-04-01 | Bristol Myers Squibb Co | Cell localization signature and immunotherapy |
| CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| AU2021416156A1 (en) | 2020-12-28 | 2023-06-22 | Bristol-Myers Squibb Company | Methods of treating tumors |
| PT4267105T (pt) | 2020-12-28 | 2025-04-30 | Bristol Myers Squibb Co | Composições de anticorpos e métodos de utilização das mesmas |
| EP4284950A4 (en) | 2021-01-29 | 2024-12-25 | Board of Regents, The University of Texas System | METHODS OF TREATMENT OF CANCER USING KINASE INHIBITORS |
| CN117858719A (zh) | 2021-03-29 | 2024-04-09 | 朱诺治疗学股份有限公司 | 使用检查点抑制剂疗法和car t细胞疗法的组合进行给药和治疗的方法 |
| EP4319755A4 (en) | 2021-04-08 | 2025-03-26 | Board of Regents, The University of Texas System | Compounds and methods for theranostic targeting of parp activity |
| US20240285740A1 (en) | 2021-05-12 | 2024-08-29 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating cancer |
| WO2023285552A1 (en) | 2021-07-13 | 2023-01-19 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
| EP4410835A4 (en) * | 2021-09-29 | 2025-09-24 | Akeso Biopharma Inc | ANTI-LAG3 ANTIBODY, PHARMACEUTICAL COMPOSITION AND USE |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| WO2023077090A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
| AU2023213937A1 (en) | 2022-01-26 | 2024-07-18 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
| KR20240153583A (ko) | 2022-02-25 | 2024-10-23 | 브리스톨-마이어스 스큅 컴퍼니 | 결장직장암종에 대한 병용 요법 |
| WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
| CN119156403A (zh) | 2022-03-08 | 2024-12-17 | 阿伦蒂斯治疗股份公司 | 抗紧密连接蛋白-1抗体增加t细胞可用性的用途 |
| US20250206775A1 (en) | 2022-03-18 | 2025-06-26 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| AU2023281061A1 (en) | 2022-06-02 | 2024-12-05 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| CN114807054B (zh) * | 2022-06-24 | 2022-09-13 | 北京索莱宝科技有限公司 | 小鼠抗人IgG单抗杂交瘤细胞株、抗体、抗体组合物及试剂盒 |
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| JP2026501506A (ja) | 2022-12-14 | 2026-01-16 | アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ | Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法 |
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| US20260217828A1 (en) | 2023-01-31 | 2026-07-30 | University Of Rochester | Immune checkpoint blockade therapy for treating staphylococcus aureus infections |
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| US20260144885A1 (en) | 2024-11-22 | 2026-05-28 | Bristol-Myers Squibb Company | Anti-lrrc15 antibodies and uses thereof |
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2017
- 2017-06-20 SG SG11201811184UA patent/SG11201811184UA/en unknown
- 2017-06-20 US US16/311,596 patent/US11214618B2/en active Active
- 2017-06-20 MX MX2018016344A patent/MX2018016344A/es unknown
- 2017-06-20 EP EP17734668.1A patent/EP3472206B1/en active Active
- 2017-06-20 WO PCT/EP2017/065052 patent/WO2017220555A1/en not_active Ceased
- 2017-06-20 CA CA3027302A patent/CA3027302A1/en active Pending
- 2017-06-20 CN CN201780038556.1A patent/CN109311993B/zh active Active
- 2017-06-20 JP JP2019518145A patent/JP7085708B2/ja active Active
- 2017-06-20 RU RU2018142573A patent/RU2018142573A/ru not_active Application Discontinuation
- 2017-06-20 AU AU2017281157A patent/AU2017281157B2/en not_active Expired - Fee Related
- 2017-06-20 KR KR1020197001120A patent/KR20190022632A/ko not_active Withdrawn
- 2017-06-20 BR BR112018076525-2A patent/BR112018076525A2/pt not_active Application Discontinuation
- 2017-06-20 TW TW106120621A patent/TW201831513A/zh unknown
- 2017-06-20 ES ES17734668T patent/ES3010640T3/es active Active
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2018
- 2018-12-16 IL IL263715A patent/IL263715A/en unknown
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2021
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- 2022-03-28 JP JP2022051878A patent/JP7394162B2/ja active Active
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