JP2020500523A5 - - Google Patents
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- JP2020500523A5 JP2020500523A5 JP2019528909A JP2019528909A JP2020500523A5 JP 2020500523 A5 JP2020500523 A5 JP 2020500523A5 JP 2019528909 A JP2019528909 A JP 2019528909A JP 2019528909 A JP2019528909 A JP 2019528909A JP 2020500523 A5 JP2020500523 A5 JP 2020500523A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- sequence
- acid sequence
- antigen recognition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 62
- 239000000427 antigen Substances 0.000 claims 37
- 108091007433 antigens Proteins 0.000 claims 37
- 102000036639 antigens Human genes 0.000 claims 37
- 108091008874 T cell receptors Proteins 0.000 claims 31
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 31
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 20
- 210000004027 cell Anatomy 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000013598 vector Substances 0.000 claims 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 206010004593 Bile duct cancer Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 2
- 101001005728 Homo sapiens Melanoma-associated antigen 1 Proteins 0.000 claims 2
- 102100025050 Melanoma-associated antigen 1 Human genes 0.000 claims 2
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 2
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 210000000232 gallbladder Anatomy 0.000 claims 2
- 201000010175 gallbladder cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022006308A JP2022068152A (ja) | 2016-12-08 | 2022-01-19 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
| JP2024114654A JP2024153696A (ja) | 2016-12-08 | 2024-07-18 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662431588P | 2016-12-08 | 2016-12-08 | |
| DE102016123847.3 | 2016-12-08 | ||
| DE102016123847.3A DE102016123847B3 (de) | 2016-12-08 | 2016-12-08 | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
| US62/431,588 | 2016-12-08 | ||
| PCT/EP2017/081800 WO2018104438A1 (en) | 2016-12-08 | 2017-12-07 | Novel t cell receptors and immune therapy using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006308A Division JP2022068152A (ja) | 2016-12-08 | 2022-01-19 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500523A JP2020500523A (ja) | 2020-01-16 |
| JP2020500523A5 true JP2020500523A5 (enExample) | 2020-07-30 |
| JP7016543B2 JP7016543B2 (ja) | 2022-02-07 |
Family
ID=60990744
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528909A Active JP7016543B2 (ja) | 2016-12-08 | 2017-12-07 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
| JP2022006308A Pending JP2022068152A (ja) | 2016-12-08 | 2022-01-19 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
| JP2024114654A Withdrawn JP2024153696A (ja) | 2016-12-08 | 2024-07-18 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022006308A Pending JP2022068152A (ja) | 2016-12-08 | 2022-01-19 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
| JP2024114654A Withdrawn JP2024153696A (ja) | 2016-12-08 | 2024-07-18 | 新規ｔ細胞受容体およびそれを用いた免疫療法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10702609B2 (enExample) |
| EP (1) | EP4032544A3 (enExample) |
| JP (3) | JP7016543B2 (enExample) |
| KR (3) | KR20220038511A (enExample) |
| AU (1) | AU2024227729A1 (enExample) |
| CL (2) | CL2019001535A1 (enExample) |
| CO (1) | CO2019006914A2 (enExample) |
| CY (1) | CY1124997T1 (enExample) |
| DK (1) | DK3551221T3 (enExample) |
| ES (1) | ES2916092T3 (enExample) |
| HR (1) | HRP20220131T8 (enExample) |
| HU (1) | HUE058957T2 (enExample) |
| IL (1) | IL267129A (enExample) |
| LT (1) | LT3551221T (enExample) |
| MD (1) | MD3551221T2 (enExample) |
| MX (1) | MX2022015821A (enExample) |
| MY (1) | MY192819A (enExample) |
| NZ (1) | NZ754365A (enExample) |
| PH (1) | PH12019501241A1 (enExample) |
| PL (1) | PL3551221T3 (enExample) |
| PT (1) | PT3551221T (enExample) |
| RS (1) | RS62865B1 (enExample) |
| SI (1) | SI3551221T1 (enExample) |
| TW (1) | TWI803910B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012104843A1 (en) | 2011-02-06 | 2012-08-09 | Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science | Affinity maturated t cell receptors and use thereof |
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| GB201520570D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| DE102016123847B3 (de) * | 2016-12-08 | 2018-04-05 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
| PT3551221T (pt) * | 2016-12-08 | 2022-01-18 | Immatics Biotechnologies Gmbh | Novos recetores de células t e imunoterapia empregando os mesmos |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| PH12021552979A1 (en) | 2019-05-27 | 2023-10-09 | Immatics Us Inc | Viral vectors and their use in adoptive cellular therapy |
| IL295891A (en) | 2020-02-24 | 2022-10-01 | Immatics Us Inc | Methods for propagating t cells for the treatment of cancer and related malignancies |
| US20220056411A1 (en) | 2020-08-21 | 2022-02-24 | Immatics US, Inc. | Methods for isolating cd8+ selected t cells |
| DE102021100038A1 (de) | 2020-12-31 | 2022-06-30 | Immatics US, Inc. | Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung |
| WO2022147029A2 (en) | 2020-12-31 | 2022-07-07 | Immatics US, Inc. | Cd8 polypeptides, compositions, and methods of using thereof |
| TW202332765A (zh) | 2021-09-20 | 2023-08-16 | 美商英麥提克斯股份有限公司 | 用於ｔ細胞療法之ｔ細胞群體的單核球耗盡 |
| US20240390423A1 (en) * | 2021-10-29 | 2024-11-28 | Yafei Hou | T cell receptor recognizing s37f mutation in ctnnb1 and its application |
| US20230142468A1 (en) | 2021-11-08 | 2023-05-11 | Immatics US, Inc. | Methods for generating cell spheroids |
| CA3247927A1 (en) | 2022-01-14 | 2023-07-20 | Tune Therapeutics, Inc. | Compositions, systems and methods for programming T-lymphocyte phenotypes by targeted gene repression |
| WO2023137471A1 (en) | 2022-01-14 | 2023-07-20 | Tune Therapeutics, Inc. | Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation |
| EP4514834A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof |
| EP4514821A1 (en) | 2022-04-28 | 2025-03-05 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
| AU2023262596A1 (en) | 2022-04-28 | 2024-12-05 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| WO2023215825A1 (en) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Methods for improving t cell efficacy |
| CN120239746A (zh) | 2022-09-19 | 2025-07-01 | 图恩疗法股份有限公司 | 用于调节t细胞功能的组合物、系统和方法 |
| WO2025029840A1 (en) | 2023-07-31 | 2025-02-06 | Tune Therapeutics, Inc. | Compositions and methods for multiplexed activation and repression of t cell gene expression |
| WO2025029835A1 (en) | 2023-07-31 | 2025-02-06 | Tune Therapeutics, Inc. | Compositions and methods for modulating il-2 gene expression |
| WO2025096649A1 (en) | 2023-11-01 | 2025-05-08 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
| CN117624340B (zh) * | 2024-01-23 | 2024-04-30 | 北京臻知医学科技有限责任公司 | 识别人乙型肝炎病毒（hbv）抗原的t细胞受体（tcr）及其用途 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US20020150891A1 (en) | 1994-09-19 | 2002-10-17 | Leroy E. Hood | Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US20020197266A1 (en) | 2000-02-08 | 2002-12-26 | Waldemar Debinski | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| CA2743669C (en) * | 2008-11-24 | 2018-10-16 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | High affinity t cell receptor and use thereof |
| PT2619223T (pt) | 2010-09-21 | 2019-07-11 | Us Health | Recetores de células t anti-ssx-2 e materiais e métodos de utilização relacionados |
| EP3392270B1 (en) | 2011-09-15 | 2020-08-26 | The United States of America, as Represented by the Secretary Department of Health and Human Services | T cell receptors recognizing hla-a1- or hla-cw7-restricted mage |
| US10377808B2 (en) | 2013-01-29 | 2019-08-13 | Max-Delbrück-Centrum Für Molekulare Medizin (Mdc) Berlin-Buch | High avidity antigen recognizing constructs |
| WO2014160030A2 (en) | 2013-03-13 | 2014-10-02 | Health Research, Inc. | Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen |
| CN105431524B (zh) | 2013-06-10 | 2020-04-21 | 达娜-法勃肿瘤研究所公司 | 用于降低肿瘤细胞的免疫抑制的方法和组合物 |
| US10202640B2 (en) * | 2014-05-07 | 2019-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing |
| WO2016011210A2 (en) | 2014-07-15 | 2016-01-21 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| CN107002043A (zh) | 2014-10-31 | 2017-08-01 | 贝勒医学院 | 靶向肿瘤而非t细胞的存活素特异性t细胞受体 |
| US20220280564A1 (en) | 2014-11-21 | 2022-09-08 | Immatics US, Inc. | Methods for expanding t cells for the treatment of cancer and related malignancies |
| CN105316362B (zh) | 2015-08-19 | 2020-03-17 | 暨南大学 | 一种Dual-RMCE介导的TCR基因置换系统及其方法 |
| AU2017205637B2 (en) | 2016-01-06 | 2023-01-05 | Health Research, Inc. | Compositions and libraries comprising recombinant T-cell receptors and methods of using recombinant T-cell receptors |
| KR20180111870A (ko) | 2016-02-25 | 2018-10-11 | 셀 메디카 스위처란트 아게 | Pd-l1에 대한 결합 성분 |
| GB201604492D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| CN106749620B (zh) | 2016-03-29 | 2020-09-25 | 广东香雪精准医疗技术有限公司 | 识别mage-a1抗原短肽的t细胞受体 |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN109715669B (zh) * | 2016-06-17 | 2023-01-24 | 基因医疗免疫疗法股份有限公司 | T细胞受体及其用途 |
| DE102016123847B3 (de) * | 2016-12-08 | 2018-04-05 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| PT3551221T (pt) * | 2016-12-08 | 2022-01-18 | Immatics Biotechnologies Gmbh | Novos recetores de células t e imunoterapia empregando os mesmos |
| US11702459B2 (en) | 2017-03-07 | 2023-07-18 | Universität Basel | MR1 restricted T cell receptors for cancer immunotherapy |
| JP7037577B2 (ja) * | 2017-03-15 | 2022-03-16 | フレッド ハッチンソン キャンサー リサーチ センター | 高親和性ｍａｇｅ－ａ１特異的ｔｃｒ及びその使用 |
| CR20240302A (es) | 2017-09-29 | 2024-11-07 | Us Health | Receptores de células t que reconocen p53 mutado (divisional exp. 2020-0170) |
| KR102809909B1 (ko) * | 2017-09-29 | 2025-05-22 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | P53 암-특이적 돌연변이에 대한 항원 특이성을 갖는 t 세포를 단리하는 방법 |
| US11464800B2 (en) | 2018-02-09 | 2022-10-11 | Immatics US, Inc. | Methods for manufacturing T cells |
| DE102018108612A1 (de) | 2018-03-21 | 2019-09-26 | Immatics US, Inc. | Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen |
| GB201804724D0 (en) | 2018-03-23 | 2018-05-09 | Univ Oslo Hf | Method of diagnosing cceliac disease |
| CA3097399A1 (en) | 2018-04-19 | 2019-10-24 | The Board Of Regents, The University Of Texas System | T cell receptors with mage-b2 specificity and uses thereof |
| EA202091977A1 (ru) | 2018-05-28 | 2021-02-09 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения |
| EP3850005A1 (en) | 2018-09-12 | 2021-07-21 | Universität Basel | Mr1 restricted t cell receptors for cancer immunotherapy |
| EA202191107A1 (ru) | 2018-10-23 | 2021-09-17 | Ридженерон Фармасьютикалз, Инк. | T-клеточные рецепторы ny-eso-1 и способы их применения |
| GB201817821D0 (en) | 2018-10-31 | 2018-12-19 | Ospedale San Raffaele Srl | TCR and peptides |
| CN114026116A (zh) | 2019-02-20 | 2022-02-08 | 弗雷德哈钦森癌症研究中心 | Ras新抗原特异性结合蛋白及其用途 |
| KR102930963B1 (ko) | 2019-03-01 | 2026-02-25 | 시애틀 프로젝트 코포레이션 | T 세포 수용체의 선택 |
| CN113795585B (zh) | 2019-03-04 | 2026-03-06 | 大学健康网络 | T细胞受体及其使用方法 |
| MX2021010840A (es) | 2019-03-08 | 2022-01-19 | Obsidian Therapeutics Inc | Composiciones de anhidrasa carbónica 2 (ca2) humana y métodos de regulación ajustable. |
| BR112021017703A8 (pt) | 2019-03-11 | 2023-04-18 | Hutchinson Fred Cancer Res | Receptores de células t wt1 de alta avidez e usos dos mesmos |
| US20200297768A1 (en) | 2019-03-19 | 2020-09-24 | Immatics US, Inc. | Cd28 t cell cultures, compositions, and methods of using thereof |
| US20200318068A1 (en) | 2019-04-04 | 2020-10-08 | Immatics US, Inc. | Use of retinoic acid in t-cell manufacturing |
| WO2020227091A1 (en) | 2019-05-03 | 2020-11-12 | Gigamune, Inc. | Engineered cells expressing anti-tumor t cell receptors and methods of use thereof |
| PH12021552979A1 (en) | 2019-05-27 | 2023-10-09 | Immatics Us Inc | Viral vectors and their use in adoptive cellular therapy |
| CN114303060A (zh) | 2019-06-06 | 2022-04-08 | 伊玛提克斯生物技术有限公司 | 使用序列相似肽进行反向选择分选 |
| US20210032370A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
| US12480958B2 (en) | 2019-08-13 | 2025-11-25 | Immatics Biotechnologies Gmbh | Method for the characterization of peptide:MHC binding polypeptides |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| US20220056411A1 (en) | 2020-08-21 | 2022-02-24 | Immatics US, Inc. | Methods for isolating cd8+ selected t cells |
| US12234473B2 (en) | 2020-12-31 | 2025-02-25 | Immatics US, Inc. | CD8 polypeptides, compositions, and methods of using thereof |
-
2017
- 2017-12-07 PT PT178296091T patent/PT3551221T/pt unknown
- 2017-12-07 DK DK17829609.1T patent/DK3551221T3/da active
- 2017-12-07 MD MDE20191170T patent/MD3551221T2/ro not_active IP Right Cessation
- 2017-12-07 HU HUE17829609A patent/HUE058957T2/hu unknown
- 2017-12-07 KR KR1020227008109A patent/KR20220038511A/ko not_active Abandoned
- 2017-12-07 MY MYPI2019002714A patent/MY192819A/en unknown
- 2017-12-07 SI SI201731045T patent/SI3551221T1/sl unknown
- 2017-12-07 KR KR1020247000927A patent/KR20240007775A/ko not_active Ceased
- 2017-12-07 EP EP21207265.6A patent/EP4032544A3/en active Pending
- 2017-12-07 JP JP2019528909A patent/JP7016543B2/ja active Active
- 2017-12-07 ES ES17829609T patent/ES2916092T3/es active Active
- 2017-12-07 LT LTEPPCT/EP2017/081800T patent/LT3551221T/lt unknown
- 2017-12-07 KR KR1020217026811A patent/KR102375218B1/ko active Active
- 2017-12-07 RS RS20220094A patent/RS62865B1/sr unknown
- 2017-12-07 PL PL17829609T patent/PL3551221T3/pl unknown
- 2017-12-07 NZ NZ754365A patent/NZ754365A/en not_active IP Right Cessation
- 2017-12-07 HR HRP20220131TT patent/HRP20220131T8/hr unknown
- 2017-12-08 TW TW110126570A patent/TWI803910B/zh not_active IP Right Cessation
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2019
- 2019-05-03 US US16/403,003 patent/US10702609B2/en active Active
- 2019-06-04 PH PH12019501241A patent/PH12019501241A1/en unknown
- 2019-06-05 CL CL2019001535A patent/CL2019001535A1/es unknown
- 2019-06-05 IL IL26712919A patent/IL267129A/en unknown
- 2019-06-07 MX MX2022015821A patent/MX2022015821A/es unknown
- 2019-06-27 CO CONC2019/0006914A patent/CO2019006914A2/es unknown
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2020
- 2020-03-23 US US16/826,946 patent/US11998607B2/en active Active
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2021
- 2021-11-12 CL CL2021002997A patent/CL2021002997A1/es unknown
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2022
- 2022-01-19 JP JP2022006308A patent/JP2022068152A/ja active Pending
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2024
- 2024-04-23 US US18/642,871 patent/US20240285779A1/en active Pending
- 2024-07-18 JP JP2024114654A patent/JP2024153696A/ja not_active Withdrawn
- 2024-10-29 AU AU2024227729A patent/AU2024227729A1/en not_active Abandoned
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