JP2010110329A5 - - Google Patents
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- Publication number
- JP2010110329A5 JP2010110329A5 JP2010000787A JP2010000787A JP2010110329A5 JP 2010110329 A5 JP2010110329 A5 JP 2010110329A5 JP 2010000787 A JP2010000787 A JP 2010000787A JP 2010000787 A JP2010000787 A JP 2010000787A JP 2010110329 A5 JP2010110329 A5 JP 2010110329A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- cell
- antibody
- sarcoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39020302P | 2002-06-19 | 2002-06-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516175A Division JP4488512B2 (ja) | 2002-06-19 | 2003-06-19 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011012411A Division JP5372973B2 (ja) | 2002-06-19 | 2011-01-24 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010110329A JP2010110329A (ja) | 2010-05-20 |
| JP2010110329A5 true JP2010110329A5 (enExample) | 2011-03-10 |
Family
ID=30000526
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516175A Expired - Lifetime JP4488512B2 (ja) | 2002-06-19 | 2003-06-19 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
| JP2010000787A Pending JP2010110329A (ja) | 2002-06-19 | 2010-01-05 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
| JP2011012411A Expired - Lifetime JP5372973B2 (ja) | 2002-06-19 | 2011-01-24 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516175A Expired - Lifetime JP4488512B2 (ja) | 2002-06-19 | 2003-06-19 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011012411A Expired - Lifetime JP5372973B2 (ja) | 2002-06-19 | 2011-01-24 | 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7527969B2 (enExample) |
| EP (2) | EP2277917A3 (enExample) |
| JP (3) | JP4488512B2 (enExample) |
| AT (1) | ATE488530T1 (enExample) |
| AU (1) | AU2003243749B2 (enExample) |
| CA (1) | CA2490399C (enExample) |
| DE (1) | DE60335022D1 (enExample) |
| DK (1) | DK1565489T3 (enExample) |
| ES (1) | ES2356444T3 (enExample) |
| MX (1) | MXPA04012664A (enExample) |
| PT (1) | PT1565489E (enExample) |
| WO (1) | WO2004001381A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE488530T1 (de) | 2002-06-19 | 2010-12-15 | Raven Biotechnologies Inc | Internalisierende antikörper spezifisch für das raag10 zelloberflächenziel |
| ES2381557T3 (es) | 2004-08-03 | 2012-05-29 | Innate Pharma | Métodos terapéuticos y de diagnóstico y composiciones para determinar 4IG-B7-H3 y su receptor homólogo en las células NK |
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| EP1846032A4 (en) * | 2005-01-31 | 2009-01-28 | Raven Biotechnologies Inc | LUCA2 AND THEREO BINDING ANTIBODIES |
| JP5328155B2 (ja) | 2005-02-02 | 2013-10-30 | マクロジェニックス ウエスト， インコーポレイテッド | Ａｄａｍ−９モジュレータ |
| US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| EP2094307A4 (en) * | 2006-11-08 | 2015-08-26 | Macrogenics West Inc | TES7 AND THEREO BINDING ANTIBODIES |
| AU2007317753B2 (en) * | 2006-11-09 | 2013-11-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Differential gene expression in physiological and pathological angiogenesis |
| WO2008091908A2 (en) | 2007-01-22 | 2008-07-31 | Raven Biotechnologies | Human cancer stem cells |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | 日東電工股份有限公司 | Cancer cells and tumor-related fibroblasts |
| CN106349390B (zh) | 2008-04-02 | 2019-12-10 | 宏观基因有限公司 | Bcr-复合体-特异性抗体和其使用方法 |
| JP5734201B2 (ja) | 2008-12-19 | 2015-06-17 | マクロジェニクス，インコーポレーテッド | 共有結合型ダイアボディ及びその使用 |
| EP2464661B1 (en) | 2009-08-13 | 2018-01-17 | The Johns Hopkins University | Methods of modulating immune function with anti-b7-h7cr antibodies |
| DK2542256T3 (da) | 2010-03-04 | 2019-08-26 | Macrogenics Inc | Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| ES2667100T3 (es) | 2010-08-02 | 2018-05-09 | Macrogenics, Inc. | Diacuerpos covalentes y sus usos |
| JP5950428B2 (ja) | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
| US8642951B2 (en) | 2011-05-04 | 2014-02-04 | Agilent Technologies, Inc. | Device, system, and method for reflecting ions |
| US9376495B2 (en) | 2011-05-21 | 2016-06-28 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use in extending serum half-life |
| US20140315975A1 (en) | 2011-06-21 | 2014-10-23 | Nitto Denko Corporation | Apoptosis-inducing agent |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| JP6076076B2 (ja) | 2012-12-21 | 2017-02-08 | 日東電工株式会社 | 組織再生促進剤 |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| SG11201606714TA (en) | 2014-02-14 | 2016-09-29 | Andrew S Chi | Improved methods for the treatment of vascularizing cancers |
| JP6602034B2 (ja) | 2014-04-02 | 2019-11-06 | 日東電工株式会社 | 標的化分子およびその使用 |
| CA2943733C (en) | 2014-04-07 | 2022-03-01 | Nitto Denko Corporation | Polymer-based hydrotropes for hydrophobic drug delivery |
| JP6727765B2 (ja) | 2014-06-17 | 2020-07-22 | 日東電工株式会社 | アポトーシス誘導剤 |
| UA128469C2 (uk) * | 2015-10-08 | 2024-07-24 | Макродженікс, Інк. | Спосіб лікування в7-н3-експресуючого раку |
| CN108367069B (zh) | 2015-12-14 | 2022-08-23 | 宏观基因有限公司 | 对于pd-1和ctla-4具有免疫反应性的双特异性分子及其使用方法 |
| CN109069633A (zh) | 2016-04-15 | 2018-12-21 | 宏观基因有限公司 | 新颖的b7-h3-结合分子、其抗体药物缀合物及其使用方法 |
| MX2018014950A (es) | 2016-06-07 | 2019-04-25 | Macrogenics Inc | Terapia de combinacion. |
| RS61828B1 (sr) * | 2016-06-08 | 2021-06-30 | Abbvie Inc | Anti-b7-h3 antitela i antitelske konjugacije lekova |
| BR112019017628A2 (pt) | 2017-02-24 | 2020-07-07 | Macrogenics, Inc. | molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição |
| EP3638306A4 (en) * | 2017-06-15 | 2020-07-01 | Development Center for Biotechnology | ANTIBODY DRUG CONJUGATES CONTAINING ANTI-GLOBO H ANTIBODIES AND USES THEREOF |
| US11795226B2 (en) | 2017-12-12 | 2023-10-24 | Macrogenics, Inc. | Bispecific CD16-binding molecules and their use in the treatment of disease |
| CN111787949A (zh) | 2018-02-15 | 2020-10-16 | 宏观基因有限公司 | 变体cd3-结合结构域及其在用于治疗疾病的组合疗法中的用途 |
| JP7745556B2 (ja) | 2020-02-21 | 2025-09-29 | マクロジェニクス，インコーポレーテッド | Ｃｄ１３７結合分子及びその使用 |
| US12245355B2 (en) | 2021-02-19 | 2025-03-04 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
| EP4373505A1 (en) | 2021-07-19 | 2024-05-29 | Regeneron Pharmaceuticals, Inc. | Combination of checkpoint inhibitors and an oncolytic virus for treating cancer |
| US20250152643A1 (en) | 2022-02-17 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Combinations of checkpoint inhibitors and oncolytic virus for treating cancer |
Family Cites Families (46)
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|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5552391A (en) | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
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| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
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| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
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| US5532159A (en) | 1994-04-01 | 1996-07-02 | The Ohio State University | Monoclonal antibody to canine placental oncofetal protein for detecting cancer |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| ES2312205T3 (es) | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
| WO2000068266A1 (en) | 1999-05-11 | 2000-11-16 | Eli Lilly And Company | Amyloid precursor protein protease and related nucleic acid compounds |
| EP1514933A1 (en) | 1999-07-08 | 2005-03-16 | Research Association for Biotechnology | Secretory protein or membrane protein |
| ES2539411T3 (es) * | 1999-08-23 | 2015-06-30 | Dana-Farber Cancer Institute, Inc. | PD-1, receptor para la B7-4 y su utilización |
| WO2001014577A1 (en) | 1999-08-24 | 2001-03-01 | Smithkline Beecham Corporation | Molecular cloning of a galanin like 7tm receptor (axor40) |
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| US6429303B1 (en) | 1999-09-03 | 2002-08-06 | Curagen Corporation | Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same |
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| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
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| WO2001089567A1 (en) * | 2000-05-22 | 2001-11-29 | Idec Pharmaceuticals Corporation | Identification of unique binding interactions between certain antibodies and the human b7.1 and b7.2 co-stimulatory antigens |
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| EP1892251A3 (en) | 2000-06-06 | 2008-12-31 | Brystol-Myers Squibb Company | B7-related nucleic acids and polypeptides and their uses for immunomodulation |
| US6965018B2 (en) | 2000-06-06 | 2005-11-15 | Bristol-Myers Squibb Company | Antibodies directed to B7-related polypeptide, BSL-2 |
| US6635750B1 (en) | 2000-07-20 | 2003-10-21 | Millennium Pharmaceuticals, Inc. | B7-H2 nucleic acids, members of the B7 family |
| WO2002010187A1 (en) | 2000-07-27 | 2002-02-07 | Mayo Foundation For Medical Education And Research | B7-h3 and b7-h4, novel immunoregulatory molecules |
| WO2002022683A1 (fr) | 2000-09-12 | 2002-03-21 | Kirin Beer Kabushiki Kaisha | Nouvelle membrane a paroi cellulaire dendritique et son utilisation |
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| WO2002032375A2 (en) | 2000-10-18 | 2002-04-25 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8h9 |
| WO2002094864A2 (en) | 2001-05-25 | 2002-11-28 | Genset S.A. | Human cdnas and proteins and uses thereof |
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| CA2475356A1 (en) | 2002-02-12 | 2003-08-21 | Raven Biotechnologies, Inc. | Human fetal bladder-derived epithelial cells |
| US20040162236A1 (en) | 2002-04-01 | 2004-08-19 | John Alsobrook | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| ATE488530T1 (de) * | 2002-06-19 | 2010-12-15 | Raven Biotechnologies Inc | Internalisierende antikörper spezifisch für das raag10 zelloberflächenziel |
| EP1534331B1 (en) | 2002-06-21 | 2014-10-29 | Johns Hopkins University School of Medicine | Membrane associated tumor endothelium markers |
-
2003
- 2003-06-19 AT AT03761281T patent/ATE488530T1/de active
- 2003-06-19 EP EP10180500A patent/EP2277917A3/en not_active Withdrawn
- 2003-06-19 PT PT03761281T patent/PT1565489E/pt unknown
- 2003-06-19 DK DK03761281.9T patent/DK1565489T3/da active
- 2003-06-19 WO PCT/US2003/019819 patent/WO2004001381A2/en not_active Ceased
- 2003-06-19 MX MXPA04012664A patent/MXPA04012664A/es active IP Right Grant
- 2003-06-19 AU AU2003243749A patent/AU2003243749B2/en not_active Expired
- 2003-06-19 DE DE60335022T patent/DE60335022D1/de not_active Expired - Lifetime
- 2003-06-19 CA CA2490399A patent/CA2490399C/en not_active Expired - Lifetime
- 2003-06-19 JP JP2004516175A patent/JP4488512B2/ja not_active Expired - Lifetime
- 2003-06-19 US US10/600,802 patent/US7527969B2/en not_active Expired - Lifetime
- 2003-06-19 ES ES03761281T patent/ES2356444T3/es not_active Expired - Lifetime
- 2003-06-19 EP EP03761281A patent/EP1565489B1/en not_active Expired - Lifetime
-
2009
- 2009-03-27 US US12/413,483 patent/US8779098B2/en not_active Expired - Fee Related
-
2010
- 2010-01-05 JP JP2010000787A patent/JP2010110329A/ja active Pending
-
2011
- 2011-01-24 JP JP2011012411A patent/JP5372973B2/ja not_active Expired - Lifetime
-
2014
- 2014-06-03 US US14/294,935 patent/US9574007B2/en not_active Expired - Fee Related