JP2008526256A5 - - Google Patents
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- Publication number
- JP2008526256A5 JP2008526256A5 JP2007551402A JP2007551402A JP2008526256A5 JP 2008526256 A5 JP2008526256 A5 JP 2008526256A5 JP 2007551402 A JP2007551402 A JP 2007551402A JP 2007551402 A JP2007551402 A JP 2007551402A JP 2008526256 A5 JP2008526256 A5 JP 2008526256A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- kid31
- antibody
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 48
- 210000004027 cell Anatomy 0.000 claims 37
- 201000011510 cancer Diseases 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 15
- 206010039491 Sarcoma Diseases 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 10
- 208000003174 Brain Neoplasms Diseases 0.000 claims 8
- 206010008342 Cervix carcinoma Diseases 0.000 claims 8
- 206010009944 Colon cancer Diseases 0.000 claims 8
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 8
- 201000010881 cervical cancer Diseases 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 206010005949 Bone cancer Diseases 0.000 claims 5
- 208000018084 Bone neoplasm Diseases 0.000 claims 5
- 208000005243 Chondrosarcoma Diseases 0.000 claims 5
- 206010024612 Lipoma Diseases 0.000 claims 5
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 230000003352 fibrogenic effect Effects 0.000 claims 5
- 230000003993 interaction Effects 0.000 claims 5
- 201000001441 melanoma Diseases 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 208000030507 AIDS Diseases 0.000 claims 4
- 208000003200 Adenoma Diseases 0.000 claims 4
- 206010001233 Adenoma benign Diseases 0.000 claims 4
- 208000037540 Alveolar soft tissue sarcoma Diseases 0.000 claims 4
- 208000008884 Aneurysmal Bone Cysts Diseases 0.000 claims 4
- 206010003571 Astrocytoma Diseases 0.000 claims 4
- 206010004593 Bile duct cancer Diseases 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 208000001843 Carotid Body Tumor Diseases 0.000 claims 4
- 208000037211 Carotid body tumour Diseases 0.000 claims 4
- 201000009047 Chordoma Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 206010014967 Ependymoma Diseases 0.000 claims 4
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 4
- 206010053717 Fibrous histiocytoma Diseases 0.000 claims 4
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 4
- 208000021309 Germ cell tumor Diseases 0.000 claims 4
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 4
- 208000000172 Medulloblastoma Diseases 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 4
- 206010068116 Metastatic uterine cancer Diseases 0.000 claims 4
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 4
- 206010029260 Neuroblastoma Diseases 0.000 claims 4
- 208000000035 Osteochondroma Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 4
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims 4
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 4
- 206010057644 Testis cancer Diseases 0.000 claims 4
- 208000000728 Thymus Neoplasms Diseases 0.000 claims 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 4
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 4
- 230000000890 antigenic effect Effects 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 208000001119 benign fibrous histiocytoma Diseases 0.000 claims 4
- 208000026900 bile duct neoplasm Diseases 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 208000011654 childhood malignant neoplasm Diseases 0.000 claims 4
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 4
- 208000009060 clear cell adenocarcinoma Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 210000000232 gallbladder Anatomy 0.000 claims 4
- 201000010175 gallbladder cancer Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 208000003884 gestational trophoblastic disease Diseases 0.000 claims 4
- 201000010536 head and neck cancer Diseases 0.000 claims 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims 4
- 208000014951 hematologic disease Diseases 0.000 claims 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 4
- 210000004153 islets of langerhan Anatomy 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 201000010260 leiomyoma Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 206010024627 liposarcoma Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 206010027191 meningioma Diseases 0.000 claims 4
- 230000009401 metastasis Effects 0.000 claims 4
- 230000001394 metastastic effect Effects 0.000 claims 4
- 208000037819 metastatic cancer Diseases 0.000 claims 4
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 201000011519 neuroendocrine tumor Diseases 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 210000000578 peripheral nerve Anatomy 0.000 claims 4
- 208000028591 pheochromocytoma Diseases 0.000 claims 4
- 208000010916 pituitary tumor Diseases 0.000 claims 4
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 4
- 201000000849 skin cancer Diseases 0.000 claims 4
- 201000011096 spinal cancer Diseases 0.000 claims 4
- 208000014618 spinal cord cancer Diseases 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 206010042863 synovial sarcoma Diseases 0.000 claims 4
- 201000003120 testicular cancer Diseases 0.000 claims 4
- 210000001685 thyroid gland Anatomy 0.000 claims 4
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 4
- 208000013076 thyroid tumor Diseases 0.000 claims 4
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 208000008383 Wilms tumor Diseases 0.000 claims 3
- 208000012080 benign lipomatous neoplasm Diseases 0.000 claims 3
- 230000002124 endocrine Effects 0.000 claims 3
- 208000022013 kidney Wilms tumor Diseases 0.000 claims 3
- 210000003292 kidney cell Anatomy 0.000 claims 3
- 201000009500 myxoid chondrosarcoma Diseases 0.000 claims 3
- 201000008026 nephroblastoma Diseases 0.000 claims 3
- 201000008968 osteosarcoma Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 201000002267 posterior uveal melanoma Diseases 0.000 claims 3
- 208000008732 thymoma Diseases 0.000 claims 3
- 208000025443 tumor of adipose tissue Diseases 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 208000013558 Developmental Bone disease Diseases 0.000 claims 2
- 206010058314 Dysplasia Diseases 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims 2
- 206010072610 Skeletal dysplasia Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 201000005252 lipomatous cancer Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 208000016065 neuroendocrine neoplasm Diseases 0.000 claims 2
- 208000008720 Bone Marrow Neoplasms Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000014787 Vitis vinifera Nutrition 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000008524 alveolar soft part sarcoma Diseases 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 201000006491 bone marrow cancer Diseases 0.000 claims 1
- 206010006007 bone sarcoma Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 201000010073 fibrogenesis imperfecta ossium Diseases 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 206010051747 multiple endocrine neoplasia Diseases 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64375705P | 2005-01-12 | 2005-01-12 | |
| PCT/US2006/001245 WO2006076584A2 (en) | 2005-01-12 | 2006-01-12 | Kid31 and antibodies that bind thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526256A JP2008526256A (ja) | 2008-07-24 |
| JP2008526256A5 true JP2008526256A5 (enExample) | 2009-02-26 |
Family
ID=36678229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551402A Pending JP2008526256A (ja) | 2005-01-12 | 2006-01-12 | Ｋｉｄ３１およびｋｉｄ３１に結合する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7687242B2 (enExample) |
| EP (1) | EP1846767B1 (enExample) |
| JP (1) | JP2008526256A (enExample) |
| CA (1) | CA2593786A1 (enExample) |
| WO (1) | WO2006076584A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9889197B2 (en) | 2005-04-15 | 2018-02-13 | Macrogenics, Inc. | Covalently-associated diabody complexes that possess charged coil domains and that are capable of enhanced binding to serum albumin |
| US8309354B2 (en) | 2007-01-22 | 2012-11-13 | Macrogenics West, Inc. | Human cancer stem cells |
| CA2720365C (en) | 2008-04-02 | 2019-01-15 | Macrogenics, Inc. | Bcr-complex-specific antibodies and methods of using same |
| CA2745460C (en) | 2008-12-19 | 2021-07-13 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| ME03447B (me) | 2010-03-04 | 2020-01-20 | Macrogenics Inc | Anтitela reakтivna sa b7-нз, njihovi imunološki akтivni fragmenтi i upotreba |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| US9376495B2 (en) | 2011-05-21 | 2016-06-28 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use in extending serum half-life |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| WO2015184207A1 (en) | 2014-05-29 | 2015-12-03 | Macrogenics, Inc. | Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof |
| IL287916B2 (en) | 2015-07-30 | 2023-09-01 | Macrogenics Inc | Molecules that bind pd-1 and methods of using them |
| SG11201804839WA (en) | 2015-12-14 | 2018-07-30 | Macrogenics Inc | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof |
| WO2017180813A1 (en) | 2016-04-15 | 2017-10-19 | Macrogenics, Inc. | Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
| KR102585848B1 (ko) | 2017-02-24 | 2023-10-11 | 마크로제닉스, 인크. | Cd137 및 종양 항원에 결합할 수 있는 이중특이적 결합 분자, 및 그것의 용도 |
| SG11202005557TA (en) | 2017-12-12 | 2020-07-29 | Macrogenics Inc | Bispecific cd 16-binding molecules and their use in the treatment of disease |
| MX2020008489A (es) | 2018-02-15 | 2020-09-25 | Macrogenics Inc | Dominios de union a cd3 variantes y su uso en terapias de combinacion para el tratamiento de enfermedades. |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862925A (en) | 1973-07-05 | 1975-01-28 | American Home Prod | Preparation of somatotropin release inhibiting factor and intermediates therefor |
| US3842067A (en) | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
| JPS5726506B2 (enExample) | 1974-03-08 | 1982-06-04 | ||
| US4105603A (en) | 1977-03-28 | 1978-08-08 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| USRE30548E (en) | 1979-08-31 | 1981-03-17 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5552391A (en) | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
| AU669124B2 (en) | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| US5532159A (en) | 1994-04-01 | 1996-07-02 | The Ohio State University | Monoclonal antibody to canine placental oncofetal protein for detecting cancer |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| US6406840B1 (en) | 1999-12-17 | 2002-06-18 | Biomosaic Systems, Inc. | Cell arrays and the uses thereof |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| WO2004074506A2 (en) * | 2003-02-13 | 2004-09-02 | Mergen Ltd | Polynucleotide sequences and corresponding encoded polypeptides of particular secreted and membrane-bound proteins overexpressed in certain cancers |
| JP4532493B2 (ja) | 2003-09-18 | 2010-08-25 | レイベン バイオテクノロジーズ，インコーポレイティド | 細胞培養培地 |
-
2006
- 2006-01-12 US US11/331,717 patent/US7687242B2/en not_active Expired - Fee Related
- 2006-01-12 JP JP2007551402A patent/JP2008526256A/ja active Pending
- 2006-01-12 CA CA002593786A patent/CA2593786A1/en not_active Abandoned
- 2006-01-12 WO PCT/US2006/001245 patent/WO2006076584A2/en not_active Ceased
- 2006-01-12 EP EP06718332A patent/EP1846767B1/en not_active Not-in-force
-
2010
- 2010-02-13 US US12/705,577 patent/US8313916B2/en not_active Expired - Fee Related
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