JP2010518820A5 - - Google Patents
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- JP2010518820A5 JP2010518820A5 JP2009549644A JP2009549644A JP2010518820A5 JP 2010518820 A5 JP2010518820 A5 JP 2010518820A5 JP 2009549644 A JP2009549644 A JP 2009549644A JP 2009549644 A JP2009549644 A JP 2009549644A JP 2010518820 A5 JP2010518820 A5 JP 2010518820A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- variable region
- chain variable
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 96
- 102000036639 antigens Human genes 0.000 claims description 96
- 108091007433 antigens Proteins 0.000 claims description 96
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 11
- 239000002773 nucleotide Substances 0.000 claims description 8
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 230000026731 phosphorylation Effects 0.000 claims description 8
- 238000006366 phosphorylation reaction Methods 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 210000004408 hybridoma Anatomy 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 6
- 101800001382 Betacellulin Proteins 0.000 claims description 5
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 5
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 5
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 5
- 150000003384 small molecules Chemical class 0.000 claims description 5
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 230000009261 transgenic effect Effects 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010073140 Clear cell sarcoma of soft tissue Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 102000056372 ErbB-3 Receptor Human genes 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 102000029749 Microtubule Human genes 0.000 claims description 2
- 108091022875 Microtubule Proteins 0.000 claims description 2
- 102400000058 Neuregulin-1 Human genes 0.000 claims description 2
- 108090000556 Neuregulin-1 Proteins 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 229940123573 Protein synthesis inhibitor Drugs 0.000 claims description 2
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 229940100198 alkylating agent Drugs 0.000 claims description 2
- 239000002168 alkylating agent Substances 0.000 claims description 2
- 230000000340 anti-metabolite Effects 0.000 claims description 2
- 229940100197 antimetabolite Drugs 0.000 claims description 2
- 239000002256 antimetabolite Substances 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 201000000292 clear cell sarcoma Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 239000003862 glucocorticoid Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 239000002955 immunomodulating agent Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 229940043355 kinase inhibitor Drugs 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 229940124302 mTOR inhibitor Drugs 0.000 claims description 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 210000004688 microtubule Anatomy 0.000 claims description 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 2
- 238000000159 protein binding assay Methods 0.000 claims description 2
- 239000000007 protein synthesis inhibitor Substances 0.000 claims description 2
- 201000010174 renal carcinoma Diseases 0.000 claims description 2
- 230000019491 signal transduction Effects 0.000 claims description 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims description 2
- 229940126585 therapeutic drug Drugs 0.000 claims description 2
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 2
- 102400001242 Betacellulin Human genes 0.000 claims 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical group C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 21
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 21
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 description 21
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 description 21
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 description 21
- 108091036078 conserved sequence Proteins 0.000 description 8
- 101100118545 Holotrichia diomphalia EGF-like gene Proteins 0.000 description 7
- 239000003446 ligand Substances 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 5
- 102100029837 Probetacellulin Human genes 0.000 description 3
- 108010080308 biregulin Proteins 0.000 description 3
- 102100038778 Amphiregulin Human genes 0.000 description 2
- 108010033760 Amphiregulin Proteins 0.000 description 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 2
- 101000871708 Homo sapiens Proheparin-binding EGF-like growth factor Proteins 0.000 description 2
- 101710098940 Pro-epidermal growth factor Proteins 0.000 description 2
- 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 description 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 description 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 description 2
- 238000006471 dimerization reaction Methods 0.000 description 2
- 210000004602 germ cell Anatomy 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 229940122815 Aromatase inhibitor Drugs 0.000 description 1
- 102100030323 Epigen Human genes 0.000 description 1
- 108010016906 Epigen Proteins 0.000 description 1
- 101800000155 Epiregulin Proteins 0.000 description 1
- 101001057612 Homo sapiens Dual specificity protein phosphatase 5 Proteins 0.000 description 1
- 102100025498 Proepiregulin Human genes 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 239000003886 aromatase inhibitor Substances 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- 102000043381 human DUSP5 Human genes 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90190407P | 2007-02-16 | 2007-02-16 | |
| US60/901,904 | 2007-02-16 | ||
| US979608P | 2008-01-02 | 2008-01-02 | |
| US61/009,796 | 2008-01-02 | ||
| PCT/US2008/002119 WO2008100624A2 (en) | 2007-02-16 | 2008-02-15 | Antibodies against erbb3 and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048517A Division JP2014113167A (ja) | 2007-02-16 | 2014-03-12 | Ｅｒｂｂ３に対する抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518820A JP2010518820A (ja) | 2010-06-03 |
| JP2010518820A5 true JP2010518820A5 (enExample) | 2012-03-15 |
| JP5564266B2 JP5564266B2 (ja) | 2014-07-30 |
Family
ID=39690706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549644A Active JP5564266B2 (ja) | 2007-02-16 | 2008-02-15 | Ｅｒｂｂ３に対する抗体およびその使用 |
| JP2014048517A Withdrawn JP2014113167A (ja) | 2007-02-16 | 2014-03-12 | Ｅｒｂｂ３に対する抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048517A Withdrawn JP2014113167A (ja) | 2007-02-16 | 2014-03-12 | Ｅｒｂｂ３に対する抗体およびその使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US7846440B2 (enExample) |
| EP (4) | EP2647388A1 (enExample) |
| JP (2) | JP5564266B2 (enExample) |
| KR (1) | KR101598229B1 (enExample) |
| CN (1) | CN101674846B (enExample) |
| AU (1) | AU2008216600B2 (enExample) |
| BR (1) | BRPI0808055A2 (enExample) |
| CA (1) | CA2678181C (enExample) |
| CO (1) | CO6231000A2 (enExample) |
| CR (1) | CR11029A (enExample) |
| CY (1) | CY1114632T1 (enExample) |
| DK (2) | DK2129396T3 (enExample) |
| EA (1) | EA020465B1 (enExample) |
| EC (1) | ECSP099637A (enExample) |
| ES (2) | ES2431940T3 (enExample) |
| HR (2) | HRP20131113T1 (enExample) |
| HU (1) | HUE033472T2 (enExample) |
| IL (1) | IL200373A (enExample) |
| MA (1) | MA31254B1 (enExample) |
| MX (1) | MX2009008656A (enExample) |
| NZ (1) | NZ579644A (enExample) |
| PL (2) | PL2129396T3 (enExample) |
| PT (2) | PT2716301T (enExample) |
| RS (1) | RS53042B (enExample) |
| SG (1) | SG178789A1 (enExample) |
| SI (2) | SI2129396T1 (enExample) |
| WO (1) | WO2008100624A2 (enExample) |
| ZA (1) | ZA200906360B (enExample) |
Families Citing this family (190)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
| CA2480099C (en) | 2002-03-26 | 2019-01-08 | Zensun (Shanghai) Sci-Tech. Ltd. | Erbb3 based methods and compositions for treating neoplasms |
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| US8505468B2 (en) * | 2002-11-19 | 2013-08-13 | Sharp Kabushiki Kaisha | Substrate accommodating tray |
| RU2424792C2 (ru) | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| EP2647388A1 (en) * | 2007-02-16 | 2013-10-09 | Merrimack Pharmaceuticals, Inc. | Antibodies Against ERBB3 and Uses Thereof |
| CA2680237C (en) | 2007-03-27 | 2018-11-06 | Sea Lane Biotechnologies, Llc | Constructs and libraries comprising antibody surrogate light chain sequences |
| WO2009036379A2 (en) | 2007-09-14 | 2009-03-19 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| AU2009241589B2 (en) | 2008-04-29 | 2013-10-10 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| NZ589434A (en) | 2008-06-03 | 2012-11-30 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| EP2297208A4 (en) | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| MX2010014574A (es) | 2008-07-08 | 2011-04-27 | Abbott Lab | Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas. |
| KR20110044905A (ko) * | 2008-08-15 | 2011-05-02 | 메리맥 파마슈티컬즈, 인크. | 치료제에 대한 세포의 반응을 예측하는 방법 및 시스템 |
| JP5624114B2 (ja) | 2009-03-20 | 2014-11-12 | ジェネンテック， インコーポレイテッド | 抗ｈｅｒ抗体 |
| AU2010230563A1 (en) | 2009-04-02 | 2011-09-22 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain Fab fragments |
| SI2417156T1 (sl) * | 2009-04-07 | 2015-06-30 | Roche Glycart Ag | Trivalentna, bispecifiäśna protitelesa |
| KR20110124369A (ko) * | 2009-04-07 | 2011-11-16 | 로슈 글리카트 아게 | 이중특이적 항ｅｒｂｂ3／항ｃｍｅｔ 항체 |
| MX2011010169A (es) * | 2009-04-07 | 2011-10-11 | Roche Glycart Ag | Anticuerpos biespecificos anti-erbb-1/anti-c-met. |
| CA2761681A1 (en) | 2009-05-13 | 2010-11-18 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| IN2012DN01518A (enExample) * | 2009-08-21 | 2015-06-05 | Merrimack Pharmaceuticals Inc | |
| BR112012004710A2 (pt) | 2009-09-01 | 2016-08-16 | Abbott Lab | imunoglobulinas de domínio variável duplo e uso das mesmas |
| AU2010296018B2 (en) | 2009-09-16 | 2016-05-05 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| CA2775573A1 (en) * | 2009-10-09 | 2011-04-14 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-her 3 antibodies |
| AU2010306774A1 (en) | 2009-10-14 | 2012-05-03 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents targeting IGF-1R and ErbB3 signalling and uses thereof |
| PH12012500691A1 (en) | 2009-10-15 | 2012-11-12 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| WO2011056124A1 (en) * | 2009-11-04 | 2011-05-12 | Affibody Ab | Her3 binding polypeptides |
| PL2719708T3 (pl) | 2009-11-13 | 2018-04-30 | Daiichi Sankyo Europe Gmbh | Materiał i sposoby leczenia lub zapobiegania chorobom związanym z HER-3 |
| WO2011060380A1 (en) * | 2009-11-14 | 2011-05-19 | The Regents Of The University Of California | Pik3ca mutation status and sash1 expression predicts synergy between lapatinib and an akt inhibitor in her2 positive breast cancer |
| JP5680671B2 (ja) * | 2009-12-22 | 2015-03-04 | ロシュ グリクアート アーゲー | 抗ｈｅｒ３抗体及びその使用 |
| ES2602971T3 (es) | 2010-03-02 | 2017-02-23 | Kyowa Hakko Kirin Co., Ltd. | Composición de anticuerpo modificado |
| US8895001B2 (en) | 2010-03-11 | 2014-11-25 | Merrimack Pharmaceuticals, Inc. | Use of ErbB3 inhibitors in the treatment of triple negative and basal-like breast cancers |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| CN102884085B (zh) | 2010-04-09 | 2016-08-03 | Aveo制药公司 | 抗erbb3抗体 |
| US20120010388A1 (en) * | 2010-04-16 | 2012-01-12 | Gottfried Himmler | LeY SPECIFIC BIOTHERAPEUTIC |
| KR20130060223A (ko) | 2010-05-04 | 2013-06-07 | 메리맥 파마슈티컬즈, 인크. | 상피세포 성장인자 수용체(ｅｇｆｒ)에 대한 항체 및 이의 용도 |
| CN102906118B (zh) | 2010-05-20 | 2017-07-28 | 埃博灵克斯股份有限公司 | 与her3相关的生物材料 |
| AU2011276285A1 (en) | 2010-07-06 | 2013-01-24 | Aveo Pharmaceuticals, Inc. | Anti-RON antibodies |
| CA2803900A1 (en) | 2010-07-09 | 2012-01-12 | Exelixis, Inc. | Combinations of kinase inhibitors for the treatment of cancer |
| AR082461A1 (es) | 2010-08-03 | 2012-12-12 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| WO2012019024A2 (en) * | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
| CU24094B1 (es) | 2010-08-20 | 2015-04-29 | Novartis Ag | Anticuerpos para el receptor 3 del factor de crecimiento epidérmico(her3) |
| RU2013110875A (ru) | 2010-08-24 | 2014-09-27 | Ф.Хоффманн-Ля Рош Аг | БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv |
| MX2013002270A (es) | 2010-08-26 | 2013-05-14 | Abbvie Inc | Inmonoglubinas de dominio variable doble y usos de las mismas. |
| TW201302793A (zh) * | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| US9346889B2 (en) | 2010-10-18 | 2016-05-24 | Mediapharma S.R.L. | ErbB3 binding antibody |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| JP6033783B2 (ja) * | 2010-11-01 | 2016-11-30 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | Ｐａｎ−ｈｅｒ抗体組成物 |
| ITRM20100577A1 (it) * | 2010-11-02 | 2012-05-03 | Takis Srl | Immunoterapia contro il recettore erbb-3 |
| EP2648738A2 (en) | 2010-12-06 | 2013-10-16 | Merrimack Pharmaceuticals, Inc. | Dosage and administration for preventing cardiotoxicity in treatment with erbb2-targeted immunoliposomes comprising anthracyclin chemotherapeutic agents |
| JP2014503821A (ja) * | 2010-12-23 | 2014-02-13 | ネステク ソシエテ アノニム | 抗体ベースのアレイを用いる悪性がんの療法のための薬剤選択 |
| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| WO2012099968A1 (en) * | 2011-01-19 | 2012-07-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating skin cancer associated diseases |
| WO2012103341A1 (en) * | 2011-01-27 | 2012-08-02 | Merrimack Pharmaceuticals, Inc. | Treatment of advanced solid stage tumors using anti-erbb3 antibodies |
| CA2827118A1 (en) | 2011-02-15 | 2012-08-23 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for delivering nucleic acid to a cell |
| AR085403A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos |
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