JP2022527635A5 - - Google Patents
Info
- Publication number
- JP2022527635A5 JP2022527635A5 JP2021560302A JP2021560302A JP2022527635A5 JP 2022527635 A5 JP2022527635 A5 JP 2022527635A5 JP 2021560302 A JP2021560302 A JP 2021560302A JP 2021560302 A JP2021560302 A JP 2021560302A JP 2022527635 A5 JP2022527635 A5 JP 2022527635A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- cancer
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024199432A JP7877420B2 (ja) | 2019-03-27 | 2024-11-15 | Ｍａｇｅ ａ４ ｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19165387.2 | 2019-03-27 | ||
| EP19165387.2A EP3714941A1 (en) | 2019-03-27 | 2019-03-27 | Mage-a4 tcrs |
| PCT/EP2020/058779 WO2020193767A1 (en) | 2019-03-27 | 2020-03-27 | Mage a4 t cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024199432A Division JP7877420B2 (ja) | 2019-03-27 | 2024-11-15 | Ｍａｇｅ ａ４ ｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022527635A JP2022527635A (ja) | 2022-06-02 |
| JP2022527635A5 true JP2022527635A5 (enExample) | 2023-04-03 |
| JP7590982B2 JP7590982B2 (ja) | 2024-11-27 |
Family
ID=66000958
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560302A Active JP7590982B2 (ja) | 2019-03-27 | 2020-03-27 | Ｍａｇｅ ａ４ ｔ細胞受容体 |
| JP2024199432A Active JP7877420B2 (ja) | 2019-03-27 | 2024-11-15 | Ｍａｇｅ ａ４ ｔ細胞受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024199432A Active JP7877420B2 (ja) | 2019-03-27 | 2024-11-15 | Ｍａｇｅ ａ４ ｔ細胞受容体 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US12344654B2 (enExample) |
| EP (3) | EP3714941A1 (enExample) |
| JP (2) | JP7590982B2 (enExample) |
| KR (2) | KR102957751B1 (enExample) |
| CN (2) | CN114126716B (enExample) |
| AU (1) | AU2020249598A1 (enExample) |
| BR (1) | BR112021019066A2 (enExample) |
| CA (1) | CA3134076A1 (enExample) |
| CL (1) | CL2021002491A1 (enExample) |
| CO (1) | CO2021012587A2 (enExample) |
| DK (1) | DK3946621T3 (enExample) |
| EA (1) | EA202192327A1 (enExample) |
| ES (1) | ES3037919T3 (enExample) |
| FI (1) | FI3946621T3 (enExample) |
| HR (1) | HRP20250993T1 (enExample) |
| HU (1) | HUE073008T2 (enExample) |
| IL (1) | IL286569A (enExample) |
| LT (1) | LT3946621T (enExample) |
| MX (1) | MX2021011613A (enExample) |
| PL (1) | PL3946621T3 (enExample) |
| PT (1) | PT3946621T (enExample) |
| RS (1) | RS67109B1 (enExample) |
| SG (1) | SG11202110171QA (enExample) |
| SI (1) | SI3946621T1 (enExample) |
| SM (1) | SMT202500298T1 (enExample) |
| WO (1) | WO2020193767A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11654158B2 (en) | 2016-11-17 | 2023-05-23 | 2Seventy Bio, Inc. | TGFBeta signal convertor |
| WO2020123938A1 (en) | 2018-12-14 | 2020-06-18 | Bluebird Bio, Inc. | Dimerizing agent regulated immunoreceptor complexes |
| EP3714941A1 (en) | 2019-03-27 | 2020-09-30 | Medigene Immunotherapies GmbH | Mage-a4 tcrs |
| MA55911A (fr) * | 2019-05-08 | 2022-03-16 | 2Seventy Bio Inc | Lymphocytes t génétiquement modifiés |
| WO2021195503A1 (en) * | 2020-03-27 | 2021-09-30 | 2Seventy Bio, Inc. | T cell receptors |
| CN111647069B (zh) * | 2020-06-17 | 2022-06-21 | 深圳豪石生物科技有限公司 | 一种改进的tcr及其应用 |
| US12435444B2 (en) | 2021-03-09 | 2025-10-07 | Cdr-Life Ag | Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same |
| EP4304726A1 (en) * | 2021-03-09 | 2024-01-17 | CDR-Life AG | Mage-a4 peptide-mhc antigen binding proteins |
| CN115975003B (zh) * | 2021-03-09 | 2024-01-26 | 科士华(南京)生物技术有限公司 | Tcr、多肽、表达载体、宿主细胞、药物组合物和tcr获得方法 |
| EP4091627A1 (en) | 2021-05-21 | 2022-11-23 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Tcr constructs specific for magea4-derived epitopes |
| EP4370541A1 (en) | 2021-07-14 | 2024-05-22 | 2seventy bio, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
| CA3226947A1 (en) * | 2021-08-03 | 2023-02-09 | Muhammad YASSIN | Engineered tcr complex and methods of using same |
| CN116836261A (zh) * | 2022-03-24 | 2023-10-03 | 香雪生命科学技术（广东）有限公司 | 一种识别mage-a4抗原的高亲和力tcr及其序列和应用 |
| AU2023248532A1 (en) | 2022-04-08 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Multipartite receptor and signaling complexes |
| WO2023230512A1 (en) | 2022-05-26 | 2023-11-30 | 2Seventy Bio, Inc. | Compositions for maintaining lentiviral vector and uses thereof |
| EP4587046A1 (en) | 2022-09-14 | 2025-07-23 | CDR-Life AG | Mage-a4 peptide dual t cell engagers |
| CN119569851A (zh) * | 2023-09-05 | 2025-03-07 | 香雪生命科学技术（广东）有限公司 | 针对magea4的高亲和力tcr |
| WO2025219541A1 (en) * | 2024-04-19 | 2025-10-23 | Medigene Immunotherapies Gmbh | Constant uni-tabs |
| EP4635976A1 (en) * | 2024-04-19 | 2025-10-22 | Medigene Immunotherapies GmbH | Constant uni-tabs |
| CN122344246A (zh) * | 2025-01-02 | 2026-07-07 | 中国科学院微生物研究所 | Mage-a4特异性t细胞受体筛选及抗肿瘤用途 |
| CN121342955B (zh) * | 2025-12-18 | 2026-03-06 | 中山大学孙逸仙纪念医院 | T细胞受体、融合蛋白、慢病毒、tcr-t细胞及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US7157091B1 (en) | 1999-06-18 | 2007-01-02 | Ludwig Institute For Cancer Research | MAGE-A1 peptides presented by HLA class II molecules |
| PT1421115E (pt) | 2001-08-31 | 2005-07-29 | Avidex Ltd | Receptor de celulas t soluvel |
| US7311914B2 (en) | 2002-08-13 | 2007-12-25 | Ludwig Institute For Cancer Research | MAGE-A4 antigenic peptides and uses thereof |
| EP2006376A1 (en) | 2007-06-21 | 2008-12-24 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof |
| US9879065B2 (en) | 2012-09-14 | 2018-01-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing MHC class II-restricted MAGE-A3 |
| GB2508414A (en) | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
| EP2944652A1 (en) | 2014-05-13 | 2015-11-18 | Technische Universität München | Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma |
| AU2015380397B2 (en) | 2015-01-31 | 2021-10-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| GB201514875D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| GB201604492D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| IL308831A (en) * | 2016-04-08 | 2024-01-01 | Immunocore Ltd | T cell receptors |
| MX395611B (es) * | 2016-04-08 | 2025-03-25 | Adaptimmune Ltd | Receptores de celulas t. |
| KR20190062505A (ko) | 2016-10-03 | 2019-06-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Hpv-특이적 결합 분자 |
| US11654158B2 (en) | 2016-11-17 | 2023-05-23 | 2Seventy Bio, Inc. | TGFBeta signal convertor |
| MX2020001879A (es) * | 2017-08-18 | 2020-07-29 | Gritstone Oncology Inc | Proteínas de fijación al antígeno que se dirigen a antígenos compartidos. |
| EP3714941A1 (en) | 2019-03-27 | 2020-09-30 | Medigene Immunotherapies GmbH | Mage-a4 tcrs |
| MA55911A (fr) | 2019-05-08 | 2022-03-16 | 2Seventy Bio Inc | Lymphocytes t génétiquement modifiés |
-
2019
- 2019-03-27 EP EP19165387.2A patent/EP3714941A1/en not_active Withdrawn
-
2020
- 2020-03-27 BR BR112021019066A patent/BR112021019066A2/pt unknown
- 2020-03-27 EA EA202192327A patent/EA202192327A1/ru unknown
- 2020-03-27 WO PCT/EP2020/058779 patent/WO2020193767A1/en not_active Ceased
- 2020-03-27 HU HUE20719942A patent/HUE073008T2/hu unknown
- 2020-03-27 EP EP25177671.2A patent/EP4631516A3/en active Pending
- 2020-03-27 LT LTEPPCT/EP2020/058779T patent/LT3946621T/lt unknown
- 2020-03-27 PT PT207199423T patent/PT3946621T/pt unknown
- 2020-03-27 KR KR1020217035022A patent/KR102957751B1/ko active Active
- 2020-03-27 US US17/441,861 patent/US12344654B2/en active Active
- 2020-03-27 SM SM20250298T patent/SMT202500298T1/it unknown
- 2020-03-27 EP EP20719942.3A patent/EP3946621B1/en active Active
- 2020-03-27 CA CA3134076A patent/CA3134076A1/en active Pending
- 2020-03-27 PL PL20719942.3T patent/PL3946621T3/pl unknown
- 2020-03-27 JP JP2021560302A patent/JP7590982B2/ja active Active
- 2020-03-27 CN CN202080039452.4A patent/CN114126716B/zh active Active
- 2020-03-27 SG SG11202110171QA patent/SG11202110171QA/en unknown
- 2020-03-27 FI FIEP20719942.3T patent/FI3946621T3/fi active
- 2020-03-27 HR HRP20250993TT patent/HRP20250993T1/hr unknown
- 2020-03-27 KR KR1020267012572A patent/KR20260061466A/ko active Pending
- 2020-03-27 ES ES20719942T patent/ES3037919T3/es active Active
- 2020-03-27 RS RS20250809A patent/RS67109B1/sr unknown
- 2020-03-27 DK DK20719942.3T patent/DK3946621T3/da active
- 2020-03-27 SI SI202030648T patent/SI3946621T1/sl unknown
- 2020-03-27 MX MX2021011613A patent/MX2021011613A/es unknown
- 2020-03-27 AU AU2020249598A patent/AU2020249598A1/en active Pending
- 2020-03-27 CN CN202410548142.5A patent/CN118580335A/zh active Pending
-
2021
- 2021-09-22 IL IL286569A patent/IL286569A/en unknown
- 2021-09-24 CO CONC2021/0012587A patent/CO2021012587A2/es unknown
- 2021-09-24 CL CL2021002491A patent/CL2021002491A1/es unknown
-
2024
- 2024-11-15 JP JP2024199432A patent/JP7877420B2/ja active Active
-
2025
- 2025-05-23 US US19/217,625 patent/US20250346648A1/en active Pending