CL2021002491A1 - Receptores de células t mage a4 - Google Patents
Receptores de células t mage a4Info
- Publication number
- CL2021002491A1 CL2021002491A1 CL2021002491A CL2021002491A CL2021002491A1 CL 2021002491 A1 CL2021002491 A1 CL 2021002491A1 CL 2021002491 A CL2021002491 A CL 2021002491A CL 2021002491 A CL2021002491 A CL 2021002491A CL 2021002491 A1 CL2021002491 A1 CL 2021002491A1
- Authority
- CL
- Chile
- Prior art keywords
- tcr
- mage
- cell receptors
- relates
- cell
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un receptor de células T aislado (TCR) específico para MAGE-A4 y un polipéptido que comprende una porción funcional del TCR. También están implicados un complejo de TCR multivalente, un ácido nucleico que codifica un TCR, una célula que expresa el TCR y una composición farmacéutica que comprende el TCR. La invención también se refiere al TCR para su uso como medicamento, en particular al TCR para su uso en el tratamiento del cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19165387.2A EP3714941A1 (en) | 2019-03-27 | 2019-03-27 | Mage-a4 tcrs |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021002491A1 true CL2021002491A1 (es) | 2022-06-10 |
Family
ID=66000958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021002491A CL2021002491A1 (es) | 2019-03-27 | 2021-09-24 | Receptores de células t mage a4 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20230159612A1 (es) |
EP (2) | EP3714941A1 (es) |
JP (1) | JP2022527635A (es) |
KR (1) | KR20210150440A (es) |
CN (1) | CN114126716B (es) |
AU (1) | AU2020249598A1 (es) |
BR (1) | BR112021019066A2 (es) |
CA (1) | CA3134076A1 (es) |
CL (1) | CL2021002491A1 (es) |
CO (1) | CO2021012587A2 (es) |
EA (1) | EA202192327A1 (es) |
IL (1) | IL286569A (es) |
MX (1) | MX2021011613A (es) |
SG (1) | SG11202110171QA (es) |
WO (1) | WO2020193767A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230044580A1 (en) * | 2019-05-08 | 2023-02-09 | 2Seventy Bio, Inc. | Engineered t cells |
AU2021244594A1 (en) * | 2020-03-27 | 2022-12-01 | Regeneron Pharmaceuticals, Inc. | T cell receptors |
CN111647069B (zh) * | 2020-06-17 | 2022-06-21 | 深圳豪石生物科技有限公司 | 一种改进的tcr及其应用 |
KR20230169944A (ko) | 2021-03-09 | 2023-12-18 | 씨디알-라이프 아게 | Mage-a4 펩티드-mhc 항원 결합 단백질 |
CN115975003B (zh) * | 2021-03-09 | 2024-01-26 | 科士华(南京)生物技术有限公司 | Tcr、多肽、表达载体、宿主细胞、药物组合物和tcr获得方法 |
EP4091627A1 (en) | 2021-05-21 | 2022-11-23 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Tcr constructs specific for magea4-derived epitopes |
CN117980326A (zh) | 2021-07-14 | 2024-05-03 | 2赛文缇生物公司 | 与来自抗体的结合结构域融合的经工程化的t细胞受体 |
CN116836261A (zh) * | 2022-03-24 | 2023-10-03 | 香雪生命科学技术(广东)有限公司 | 一种识别mage-a4抗原的高亲和力tcr及其序列和应用 |
WO2023196997A2 (en) | 2022-04-08 | 2023-10-12 | 2Seventy Bio, Inc. | Multipartite receptor and signaling complexes |
WO2023230512A1 (en) | 2022-05-26 | 2023-11-30 | 2Seventy Bio, Inc. | Compositions for maintaining lentiviral vector and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
ATE290020T1 (de) | 2001-08-31 | 2005-03-15 | Avidex Ltd | Löslicher t zell rezeptor |
EP2006376A1 (en) | 2007-06-21 | 2008-12-24 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Fusion protein comprising a caspase domain and a nuclear hormone receptor binding domain and methods and uses thereof |
JP6461796B2 (ja) * | 2012-09-14 | 2019-01-30 | アメリカ合衆国 | Mhcクラスii拘束性mage−a3を認識するt細胞受容体 |
CR20180531A (es) * | 2016-04-08 | 2019-06-13 | Immunocore Ltd | Receptores de células t |
ES2891321T3 (es) * | 2016-04-08 | 2022-01-27 | Adaptimmune Ltd | Receptores de células T |
CA3072816A1 (en) * | 2017-08-18 | 2019-02-21 | Gritstone Oncology, Inc. | Antigen-binding proteins targeting shared antigens |
-
2019
- 2019-03-27 EP EP19165387.2A patent/EP3714941A1/en not_active Withdrawn
-
2020
- 2020-03-27 AU AU2020249598A patent/AU2020249598A1/en active Pending
- 2020-03-27 CA CA3134076A patent/CA3134076A1/en active Pending
- 2020-03-27 KR KR1020217035022A patent/KR20210150440A/ko active Search and Examination
- 2020-03-27 US US17/441,861 patent/US20230159612A1/en active Pending
- 2020-03-27 EA EA202192327A patent/EA202192327A1/ru unknown
- 2020-03-27 BR BR112021019066A patent/BR112021019066A2/pt unknown
- 2020-03-27 SG SG11202110171QA patent/SG11202110171QA/en unknown
- 2020-03-27 WO PCT/EP2020/058779 patent/WO2020193767A1/en unknown
- 2020-03-27 MX MX2021011613A patent/MX2021011613A/es unknown
- 2020-03-27 EP EP20719942.3A patent/EP3946621A1/en active Pending
- 2020-03-27 CN CN202080039452.4A patent/CN114126716B/zh active Active
- 2020-03-27 JP JP2021560302A patent/JP2022527635A/ja active Pending
-
2021
- 2021-09-22 IL IL286569A patent/IL286569A/en unknown
- 2021-09-24 CO CONC2021/0012587A patent/CO2021012587A2/es unknown
- 2021-09-24 CL CL2021002491A patent/CL2021002491A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO2021012587A2 (es) | 2022-02-28 |
MX2021011613A (es) | 2021-12-15 |
WO2020193767A1 (en) | 2020-10-01 |
IL286569A (en) | 2021-12-01 |
US20230159612A1 (en) | 2023-05-25 |
BR112021019066A2 (pt) | 2021-11-30 |
KR20210150440A (ko) | 2021-12-10 |
CA3134076A1 (en) | 2020-10-01 |
EA202192327A1 (ru) | 2022-01-19 |
EP3946621A1 (en) | 2022-02-09 |
CN114126716A (zh) | 2022-03-01 |
SG11202110171QA (en) | 2021-10-28 |
CN114126716B (zh) | 2024-05-24 |
JP2022527635A (ja) | 2022-06-02 |
AU2020249598A1 (en) | 2021-10-28 |
EP3714941A1 (en) | 2020-09-30 |
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