SG11202002635RA - Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation - Google Patents
Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutationInfo
- Publication number
- SG11202002635RA SG11202002635RA SG11202002635RA SG11202002635RA SG11202002635RA SG 11202002635R A SG11202002635R A SG 11202002635RA SG 11202002635R A SG11202002635R A SG 11202002635RA SG 11202002635R A SG11202002635R A SG 11202002635RA SG 11202002635R A SG11202002635R A SG 11202002635RA
- Authority
- SG
- Singapore
- Prior art keywords
- isolating
- cancer
- cells
- methods
- specific mutation
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000035772 mutation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464448—Regulators of development
- A61K39/46445—Apoptosis related proteins, e.g. survivin or livin
- A61K39/464451—Apoptosis related proteins, e.g. survivin or livin p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1121—Dendritic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762565464P | 2017-09-29 | 2017-09-29 | |
PCT/US2018/051280 WO2019067242A1 (en) | 2017-09-29 | 2018-09-17 | Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002635RA true SG11202002635RA (en) | 2020-04-29 |
Family
ID=63763012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002635RA SG11202002635RA (en) | 2017-09-29 | 2018-09-17 | Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation |
Country Status (10)
Country | Link |
---|---|
US (1) | US20200316121A1 (en) |
EP (1) | EP3688142A1 (en) |
JP (1) | JP7391015B2 (en) |
KR (1) | KR20200065026A (en) |
CN (1) | CN111344394A (en) |
AU (1) | AU2018342245B2 (en) |
CA (1) | CA3080274A1 (en) |
IL (1) | IL273516A (en) |
SG (1) | SG11202002635RA (en) |
WO (1) | WO2019067242A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102375218B1 (en) | 2016-12-08 | 2022-03-17 | 이매틱스 바이오테크놀로지스 게엠베하 | Novel t cell receptors and immune therapy using the same |
DE102016123847B3 (en) * | 2016-12-08 | 2018-04-05 | Immatics Biotechnologies Gmbh | New T cell receptors and their use in immunotherapy |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
AU2018269370A1 (en) | 2017-05-16 | 2019-12-05 | The Johns Hopkins University | Manabodies and methods of using |
US20220332785A1 (en) * | 2019-06-27 | 2022-10-20 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | T cell receptors recognizing r175h or y220c mutation in p53 |
CN112390875B (en) * | 2019-08-16 | 2023-01-24 | 香雪生命科学技术(广东)有限公司 | High-affinity T cell receptor for identifying AFP |
MX2022007598A (en) | 2019-12-20 | 2022-09-23 | Instil Bio Uk Ltd | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof. |
WO2022051449A2 (en) * | 2020-09-04 | 2022-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing r273c or y220c mutations in p53 |
CN112301088B (en) * | 2020-10-21 | 2022-12-13 | 杭州纽安津生物科技有限公司 | Method for screening neoantigen or neoantigen coding sequence |
WO2022183167A1 (en) | 2021-02-25 | 2022-09-01 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
KR20230170668A (en) * | 2021-03-08 | 2023-12-19 | 다이호야쿠힌고교 가부시키가이샤 | Cancer treatment in patients with co-occurring genetic alterations in FGFR2 and oncogenic genes |
CA3215580A1 (en) * | 2021-03-31 | 2022-10-06 | The Johns Hopkins University | Methods and materials for targeting tumor antigens |
KR20240016288A (en) * | 2021-05-07 | 2024-02-06 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | T cell receptor that recognizes C135Y, R175H, or M237I mutations in p53 |
CN117980326A (en) | 2021-07-14 | 2024-05-03 | 2赛文缇生物公司 | Engineered T cell receptors fused to binding domains from antibodies |
WO2023196996A2 (en) | 2022-04-08 | 2023-10-12 | 2Seventy Bio, Inc. | Multipartite receptor and signaling complexes |
WO2024131372A1 (en) * | 2022-12-23 | 2024-06-27 | 上海市第一人民医院 | Tcr targeting cytomegalovirus pp65, t cell expressing tcr and use of t cell |
CN116970058B (en) * | 2023-09-22 | 2023-12-15 | 成都朗谷生物科技股份有限公司 | Tumor neoantigen polypeptide aiming at TP53 gene R249S mutation and application thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08501280A (en) * | 1992-05-26 | 1996-02-13 | リュクスウニヴェルシテート レイデン | Peptides of human p53 protein and human p53 protein-specific cytotoxic T lymphocytes for use in a composition for inducing a human T cell response |
JPH0959175A (en) * | 1995-06-12 | 1997-03-04 | Meiji Milk Prod Co Ltd | Anti-tumor immuno-activating agent |
WO2004021995A2 (en) | 2002-09-06 | 2004-03-18 | The Government Of The United States Of America, Represented By The Secretary, Departement Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
GB2440736A (en) * | 2006-08-10 | 2008-02-13 | Medical Res Council | Crystals of mutant p53 polypeptidtes |
US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
AU2014407540C1 (en) * | 2014-10-02 | 2021-07-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cells having antigenic specificity for a cancer-specific mutation |
WO2016053338A1 (en) | 2014-10-02 | 2016-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating t cell receptors having antigenic specificity for a cancer-specific mutation |
KR20170075785A (en) * | 2014-11-05 | 2017-07-03 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
CN107223134B (en) * | 2014-11-26 | 2021-11-16 | 美国卫生和人力服务部 | T cell receptor for anti-mutated KRAS |
-
2018
- 2018-09-17 KR KR1020207012343A patent/KR20200065026A/en not_active Application Discontinuation
- 2018-09-17 AU AU2018342245A patent/AU2018342245B2/en active Active
- 2018-09-17 CA CA3080274A patent/CA3080274A1/en active Pending
- 2018-09-17 CN CN201880063656.4A patent/CN111344394A/en active Pending
- 2018-09-17 US US16/650,696 patent/US20200316121A1/en active Pending
- 2018-09-17 SG SG11202002635RA patent/SG11202002635RA/en unknown
- 2018-09-17 WO PCT/US2018/051280 patent/WO2019067242A1/en unknown
- 2018-09-17 EP EP18782605.2A patent/EP3688142A1/en active Pending
- 2018-09-17 JP JP2020517553A patent/JP7391015B2/en active Active
-
2020
- 2020-03-23 IL IL273516A patent/IL273516A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2019067242A1 (en) | 2019-04-04 |
KR20200065026A (en) | 2020-06-08 |
JP7391015B2 (en) | 2023-12-04 |
AU2018342245A1 (en) | 2020-04-16 |
IL273516A (en) | 2020-05-31 |
CN111344394A (en) | 2020-06-26 |
JP2020534839A (en) | 2020-12-03 |
AU2018342245B2 (en) | 2024-06-13 |
EP3688142A1 (en) | 2020-08-05 |
US20200316121A1 (en) | 2020-10-08 |
CA3080274A1 (en) | 2019-04-04 |
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