CY1124997T1 - Καινοτομοι υποδοχεις τ-κυτταρων και ανοσοθεραπεια με την χρηση των ιδιων - Google Patents

Καινοτομοι υποδοχεις τ-κυτταρων και ανοσοθεραπεια με την χρηση των ιδιων

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Publication number
CY1124997T1
CY1124997T1 CY20221100071T CY221100071T CY1124997T1 CY 1124997 T1 CY1124997 T1 CY 1124997T1 CY 20221100071 T CY20221100071 T CY 20221100071T CY 221100071 T CY221100071 T CY 221100071T CY 1124997 T1 CY1124997 T1 CY 1124997T1
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Cyprus
Prior art keywords
taa
antigen recognition
cell receptors
tcr
nucleic acids
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CY20221100071T
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English (en)
Inventor
Leonie ALTEN
Sebastian Bunk
Dominik Maurer
Claudia Wagner
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Immatics Biotechnologies Gmbh
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Publication date
Priority claimed from DE102016123847.3A external-priority patent/DE102016123847B3/de
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of CY1124997T1 publication Critical patent/CY1124997T1/el

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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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Abstract

Η παρούσα εφεύρεση αφορά κατασκευές αναγνώρισης αντιγόνων έναντι του πεπτιδίου MAGEA1-003 που προέρχεται από ογκο-σχετιζόμενα αντιγόνα (ΤΑΑ) . Η εφεύρεση ειδικότερα παρέχει καινοτόμα μόρια που βασίζονται σε υποδοχείς Τ-κυττάρων (Τ cell receptor, TCR), τα οποία είναι επιλεκτικά και ειδικά για το ΤΑΑ της εφεύρεσης. Ο TCR της εφεύρεσης και τα θραύσματα πρόσδεσης ΤΑΑ που προέρχονται από αυτό, είναι χρήσιμα για τη διάγνωση, τη θεραπεία και την πρόληψη καρκινικών νόσων που εκφράζουν ΤΑΑ. Περαιτέρω παρέχονται νουκλεϊκά οξέα που κωδικοποιούν τις κατασκευές αναγνώρισης αντιγόνων της εφεύρεσης, φορείς που περιλαμβάνουν αυτά τα νουκλεϊκά οξέα, ανασυνδυασμένα κύτταρα που εκφράζουν τις κατασκευές αναγνώρισης αντιγόνων και φαρμακευτικές συνθέσεις που περιλαμβάνουν τα συστατικά της εφεύρεσης.
CY20221100071T 2016-12-08 2022-01-27 Καινοτομοι υποδοχεις τ-κυτταρων και ανοσοθεραπεια με την χρηση των ιδιων CY1124997T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662431588P 2016-12-08 2016-12-08
DE102016123847.3A DE102016123847B3 (de) 2016-12-08 2016-12-08 Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
PCT/EP2017/081800 WO2018104438A1 (en) 2016-12-08 2017-12-07 Novel t cell receptors and immune therapy using the same

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CY1124997T1 true CY1124997T1 (el) 2023-01-05

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US (2) US10702609B2 (el)
EP (1) EP4032544A3 (el)
JP (2) JP7016543B2 (el)
KR (3) KR20220038511A (el)
CL (2) CL2019001535A1 (el)
CO (1) CO2019006914A2 (el)
CY (1) CY1124997T1 (el)
DK (1) DK3551221T3 (el)
ES (1) ES2916092T3 (el)
HR (1) HRP20220131T8 (el)
HU (1) HUE058957T2 (el)
IL (1) IL267129A (el)
LT (1) LT3551221T (el)
MD (1) MD3551221T2 (el)
MX (1) MX2022015821A (el)
MY (1) MY192819A (el)
NZ (1) NZ754365A (el)
PH (1) PH12019501241A1 (el)
PL (1) PL3551221T3 (el)
PT (1) PT3551221T (el)
RS (1) RS62865B1 (el)
SI (1) SI3551221T1 (el)
TW (1) TWI803910B (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012104843A1 (en) 2011-02-06 2012-08-09 Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science Affinity maturated t cell receptors and use thereof
WO2016145578A1 (en) 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
GB201520570D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
DE102016123847B3 (de) * 2016-12-08 2018-04-05 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
MY192819A (en) * 2016-12-08 2022-09-12 Immatics Biotechnologies Gmbh Novel t cell receptors and immune therapy using the same
WO2019183924A1 (en) 2018-03-30 2019-10-03 Syz Cell Therapy Co. Improved multiple antigen specific cell therapy methods
WO2019196088A1 (en) * 2018-04-13 2019-10-17 Syz Cell Therapy Co. Methods of obtaining tumor-specific t cell receptors
MX2021014552A (es) 2019-05-27 2022-02-11 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas.
CN115427554A (zh) 2020-02-24 2022-12-02 伊玛提克斯美国公司 扩增t细胞治疗癌症和相关恶性肿瘤的方法
US20220056411A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
CR20230295A (es) 2020-12-31 2023-07-27 Immatics Us Inc Polipéptidos cd8, composiciones y métodos de uso de estos
DE102021100038A1 (de) 2020-12-31 2022-06-30 Immatics US, Inc. Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung
WO2023044488A1 (en) 2021-09-20 2023-03-23 Immatics US, Inc. Monocyte depletion of t cells populations for t-cell therapy
WO2023077102A1 (en) * 2021-10-29 2023-05-04 Yafei Hou T cell receptor recognizing s37f mutation in ctnnb1 and its application
WO2023081461A1 (en) 2021-11-08 2023-05-11 Immatics US, Inc. Methods for generating cell spheroids
WO2023137471A1 (en) 2022-01-14 2023-07-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
WO2023137472A2 (en) 2022-01-14 2023-07-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
US20230348548A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof
US20230348561A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Dominant negative tgfbeta receptor polypeptides, cd8 polypeptides, cells, compositions, and methods of using thereof
WO2023212655A1 (en) 2022-04-28 2023-11-02 Immatics US, Inc. Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof
WO2023215825A1 (en) 2022-05-05 2023-11-09 Immatics US, Inc. Methods for improving t cell efficacy
WO2024064642A2 (en) 2022-09-19 2024-03-28 Tune Therapeutics, Inc. Compositions, systems, and methods for modulating t cell function
CN117624340B (zh) * 2024-01-23 2024-04-30 北京臻知医学科技有限责任公司 识别人乙型肝炎病毒（hbv）抗原的t细胞受体（tcr）及其用途

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US20020150891A1 (en) 1994-09-19 2002-10-17 Leroy E. Hood Diagnostic and therapeutic compositions and methods which utilize the t cell receptor beta gene region
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
CA2398136A1 (en) 2000-02-08 2001-08-16 The Penn State Research Foundation Immunotherapy using interleukin 13 receptor subunit alpha 2
DK2352756T3 (da) * 2008-11-24 2012-12-03 Helmholtz Zentrum Muenchen Højaffin T-cellereceptor og anvendelse af denne
ES2734889T3 (es) 2010-09-21 2019-12-12 Us Health Receptores de células T anti-SSX-2 y materiales relacionados y métodos de uso
CA2848209C (en) * 2011-09-15 2021-06-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
EP3747899A3 (en) 2013-01-29 2021-02-24 Max-Delbrück-Centrum für Molekulare Medizin (MDC) High avidity binding molecules recognizing mage-a1
EP2971045B1 (en) 2013-03-13 2019-06-19 Health Research, Inc. Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen
EP3008173B1 (en) 2013-06-10 2021-09-15 Dana-Farber Cancer Institute, Inc. Methods and compositions for reducing immunosupression by tumor cells
US10202640B2 (en) * 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
MA40253A (fr) 2014-07-15 2017-05-24 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
US20170335290A1 (en) 2014-10-31 2017-11-23 Baylor College Of Medicine Survivin specific t-cell receptor targeting tumor but not t cells
US20220280564A1 (en) 2014-11-21 2022-09-08 Immatics US, Inc. Methods for expanding t cells for the treatment of cancer and related malignancies
CN105316362B (zh) 2015-08-19 2020-03-17 暨南大学 一种Dual-RMCE介导的TCR基因置换系统及其方法
AU2017205637B2 (en) 2016-01-06 2023-01-05 Health Research, Inc. Compositions and libraries comprising recombinant T-cell receptors and methods of using recombinant T-cell receptors
CN108884164B (zh) 2016-02-25 2022-12-27 细胞医学瑞士公司 用于免疫疗法的经修饰细胞
GB201604492D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
CN106749620B (zh) 2016-03-29 2020-09-25 广东香雪精准医疗技术有限公司 识别mage-a1抗原短肽的t细胞受体
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
EP3472208B9 (en) * 2016-06-17 2023-10-04 Medigene Immunotherapies GmbH T cell receptors and uses thereof
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
MY192819A (en) * 2016-12-08 2022-09-12 Immatics Biotechnologies Gmbh Novel t cell receptors and immune therapy using the same
DE102016123847B3 (de) * 2016-12-08 2018-04-05 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
US11702459B2 (en) 2017-03-07 2023-07-18 Universität Basel MR1 restricted T cell receptors for cancer immunotherapy
EA201992131A1 (ru) * 2017-03-15 2020-02-06 Фред Хатчинсон Кэнсер Рисерч Сентер Высокоаффинные специфичные к mage-a1 tcr и их применение
BR112020006012A2 (pt) 2017-09-29 2020-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services receptores de células t que reconhecem p53 mutado
US20200316121A1 (en) 2017-09-29 2020-10-08 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation
CA3090416A1 (en) 2018-02-09 2019-08-15 Immatics US, Inc. Methods for manufacturing t cells
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
GB201804724D0 (en) 2018-03-23 2018-05-09 Univ Oslo Hf Method of diagnosing cceliac disease
CA3097399A1 (en) 2018-04-19 2019-10-24 The Board Of Regents, The University Of Texas System T cell receptors with mage-b2 specificity and uses thereof
EA202091977A1 (ru) 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
US20220339271A1 (en) 2018-09-12 2022-10-27 Universität Basel Mr1 restricted t cell receptors for cancer immunotherapy
EA202191107A1 (ru) 2018-10-23 2021-09-17 Ридженерон Фармасьютикалз, Инк. T-клеточные рецепторы ny-eso-1 и способы их применения
GB201817821D0 (en) 2018-10-31 2018-12-19 Ospedale San Raffaele Srl TCR and peptides
EP3927727A1 (en) 2019-02-20 2021-12-29 Fred Hutchinson Cancer Research Center Binding proteins specific for ras neoantigens and uses thereof
WO2020180648A1 (en) 2019-03-01 2020-09-10 Gritstone Oncology, Inc. Selection of t cell receptors
CA3132434A1 (en) 2019-03-04 2020-09-10 University Health Network T cell receptors and methods of use thereof
KR20210149251A (ko) 2019-03-08 2021-12-08 옵시디안 테라퓨틱스, 인크. 조율가능한 조절을 위한 인간 탄산 무수화효소 2 조성물 및 방법
CN113784978A (zh) 2019-03-11 2021-12-10 弗雷德哈钦森癌症研究中心 高亲合力wt1 t细胞受体及其用途
WO2020191172A1 (en) 2019-03-19 2020-09-24 Immatics US, Inc. Cd28 t cell cultures, compositions, and methods of using thereof
US20200318068A1 (en) 2019-04-04 2020-10-08 Immatics US, Inc. Use of retinoic acid in t-cell manufacturing
US20220213167A1 (en) 2019-05-03 2022-07-07 Gigamune, Inc. Engineered cells expressing anti-tumor t cell receptors and methods of use thereof
MX2021014552A (es) 2019-05-27 2022-02-11 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas.
WO2020245326A1 (en) 2019-06-06 2020-12-10 Immatics Biotechnologies Gmbh Sorting with counter selection using sequence similar peptides
US20210032370A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Recruiting agent further binding an mhc molecule
US20210048442A1 (en) 2019-08-13 2021-02-18 Immatics Biotechnologies Gmbh Method for the characterization of peptide:mhc binding polypeptides
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20220056411A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
US20220202862A1 (en) 2020-12-31 2022-06-30 Immatics US, Inc. Cd8 polypeptides, compositions, and methods of using thereof

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