EA201991151A1 - Новые т-клеточные рецепторы и иммунотерапия с их применением - Google Patents

Новые т-клеточные рецепторы и иммунотерапия с их применением

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EA201991151A1
EA201991151A1 EA201991151A EA201991151A EA201991151A1 EA 201991151 A1 EA201991151 A1 EA 201991151A1 EA 201991151 A EA201991151 A EA 201991151A EA 201991151 A EA201991151 A EA 201991151A EA 201991151 A1 EA201991151 A1 EA 201991151A1
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Eurasian Patent Office
Prior art keywords
antigen
immunotherapy
new
application
tumor
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EA201991151A
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English (en)
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Priority claimed from PCT/EP2017/081800 external-priority patent/WO2018104438A1/en
Publication of EA201991151A1 publication Critical patent/EA201991151A1/ru

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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к антигенраспознающим структурам к опухолеассоциированным антигенам (MAGEA1). В частности, в изобретении предложены новые молекулы на основе Т-клеточного рецептора (ТКР), являющиеся селективными и специфическими для экспрессируемого опухолями антигена по изобретению. ТКР по изобретению и связывающиеся с ТАА фрагменты, полученные из этого ТКР, применимы для диагностики, лечения и профилактики раковых заболеваний, при которых экспрессируется антиген ТАА. Предложены также нуклеиновые кислоты, кодирующие антигенраспознающие структуры по изобретению, векторы, содержащие данные нуклеиновые кислоты, рекомбинантные клетки, экспрессирующие эти антигенраспознающие структуры, и фармацевтические композиции, включающие соединения по изобретению.
EA201991151A 2016-12-08 2017-12-07 Новые т-клеточные рецепторы и иммунотерапия с их применением EA201991151A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662431588P 2016-12-08 2016-12-08
PCT/EP2017/081800 WO2018104438A1 (en) 2016-12-08 2017-12-07 Novel t cell receptors and immune therapy using the same

Publications (1)

Publication Number Publication Date
EA201991151A1 true EA201991151A1 (ru) 2019-11-29

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Family Applications (1)

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EA201991151A EA201991151A1 (ru) 2016-12-08 2017-12-07 Новые т-клеточные рецепторы и иммунотерапия с их применением

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Country Link
AR (1) AR110682A1 (ru)
EA (1) EA201991151A1 (ru)

Also Published As

Publication number Publication date
AR110682A1 (es) 2019-04-24

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