ME03796B - Anti-lag-3 vezujući proteini - Google Patents
Anti-lag-3 vezujući proteiniInfo
- Publication number
- ME03796B ME03796B MEP-2020-152A MEP2020152A ME03796B ME 03796 B ME03796 B ME 03796B ME P2020152 A MEP2020152 A ME P2020152A ME 03796 B ME03796 B ME 03796B
- Authority
- ME
- Montenegro
- Prior art keywords
- humanized antibody
- fragment
- seq
- host cell
- chain sequence
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 7
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 4
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 101150023212 fut8 gene Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 244000273256 Phragmites communis Species 0.000 claims 1
- 235000014676 Phragmites communis Nutrition 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 230000000779 depleting effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (19)
1. Humanizovano antitelo ili njegov fragment koji je sposoban da se veže za Limfocitni Aktivacijski Gen 3 (LAG-3) i koji sadrži a) varijabilni laki lanac (VL) SEQ ID NO. 4 i b) varijabilni teški lanac (VH) SEQ ID NO. 9.
2. Humanizovano antitelo ili njegov fragment prema zahtevu 1, gde je antitelo ili njegov fragment sposoban za vezivanje za LAG-3 koji je eksprimiran na aktiviranim T-ćelijama.
3. Humanizovano antitelo ili njegov fragment prema zahtevu 1 ili 2, gde je antitelo ili njegov fragment sposoban za iscrpljivanje LAG-3+ aktiviranih humanih T ćelija.
4. Humanizovano antitelo prema bilo kom od zahteva 1 do 3, gde humanizovano antitelo sadrži konstantni region humanog IgG1.
5. Humanizovano antitelo prema zahtevu 4, koje sadrži a) sekvencu lakog lanca koja je najmanje 97% identična sa SEQ ID NO. 5, i b) sekvencu teškog lanca koja je najmanje 97% identična sa SEQ ID NO. 10.
6. Humanizovano antitelo prema zahtevu 5, koje sadrži a) sekvencu lakog lanca SEQ ID NO. 5, i b) sekvencu teškog lanca SEQ ID NO. 10.
7. Humanizovano antitelo prema bilo kom od zahteva 4 do 6, koje je ne-fukozilovano.
8. Humanizovano antitelo prema zahtevu 1, gde humanizovano antitelo ne sadrži fukozu u jezgru strukture ugljenog hidrata vezanu za Asn297.
9. Izolovani molekul nukleinske kiseline koji a) kodira humanizovano antitelo ili njegov fragment prema bilo kom od zahteva 1 do 8, ili b) sadrži SEQ ID NO. 61 koja kodira sekvencu lakog lanca i SEQ ID NO. 66 koja kodira sekvencu teškog lanca.
10. Ekspresioni vektor koji sadrži molekul nukleinske kiseline prema zahtevu 9.
11. Ćelija domaćina koja sadrži ekspresioni vektor prema zahtevu 10.
12. Ćelija domaćina prema zahtevu 11, gde je FUT8 gen koji kodira za alfa-1,6-fukoziltransferazu inaktiviran u ćeliji domaćina.
13. Humanizovano antitelo ili njegov fragment prema bilo kom od zahteva 1 do 8 kako je proizvedeno od strane ćelije domaćina prema zahtevu 11 ili 12.
14. Postupak za proizvodnju humanizovanog antitela ili njegovog fragmenta prema bilo kom od zahteva 1 do 8, koji sadrži a) gajenje u kulturi ćelije domaćina prema zahtevu 11 pod uslovima koji su pogodni za eksprimiranje humanizovanog antitela ili njegovog fragmenta i b) izolovanje humanizovanog antitela ili njegovog fragmeta.
15. Postupak za proizvodnju humanizovanog antitela prema zahtevu 7 ili 8, koji sadrži a) gajenje u kulturi ćelije domaćina prema zahtevu 12 pod uslovima koji su pogodni za eksprimiranje humanizovanog antitela, gde je FUT8 gen koji kodira alfa-1,6-fukoziltransferazu inaktiviran u rekombinantnoj ćeliji domaćina, i b) izolovanje humanizovanog antitela.
16. Farmaceutska kompozicija koja sadrži a) humanizovano antitelo ili njegov fragment prema bilo kom od zahteva 1 do 8 i b) farmaceutski prihvatljiv nosač.
17. Humanizovano antitelo ili njegov fragment kako je definisano u bilo kom od zahteva 1 do 8 za upotrebu u terapiji.
18. Humanizovano antitelo ili njegov fragment kako je definisano u bilo kom od zahteva 1 do 8 za upotrebu u lečenju autoimune bolesti koja je izabrana iz grupe koja se sastoji iz psorijaze, Kronove bolesti, reumatoidnog artritisa, primarne bilijarne ciroze, sistemskog eritemskog lupusa (SLE), Sjogrenovog sindroma, multiple skleroze, ulceroznog kolitisa i autoimunog hepatitisa; infektivne bolesti, alergijske bolesti ili kancera.
19. Humanizovano antitelo ili njegov fragment za upotrebu prema zahtevu 18, gde je bolest ulcerozni kolitis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789325P | 2013-03-15 | 2013-03-15 | |
| EP14709691.1A EP2970464B1 (en) | 2013-03-15 | 2014-03-13 | Anti-lag-3 binding proteins |
| PCT/EP2014/054967 WO2014140180A1 (en) | 2013-03-15 | 2014-03-13 | Anti-lag-3 binding proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03796B true ME03796B (me) | 2021-04-20 |
Family
ID=50272641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2020-152A ME03796B (me) | 2013-03-15 | 2014-03-13 | Anti-lag-3 vezujući proteini |
Country Status (35)
| Country | Link |
|---|---|
| US (6) | US10280221B2 (me) |
| EP (2) | EP2970464B1 (me) |
| JP (3) | JP6224739B2 (me) |
| KR (1) | KR101763352B1 (me) |
| CN (1) | CN105209494B (me) |
| AR (1) | AR095432A1 (me) |
| AU (1) | AU2014230741B2 (me) |
| CA (1) | CA2902831C (me) |
| CL (1) | CL2015002517A1 (me) |
| CR (1) | CR20150492A (me) |
| CY (1) | CY1123220T1 (me) |
| DK (1) | DK2970464T3 (me) |
| DO (1) | DOP2015000243A (me) |
| EA (1) | EA037554B1 (me) |
| ES (1) | ES2808654T3 (me) |
| HR (1) | HRP20201113T1 (me) |
| HU (1) | HUE049957T2 (me) |
| IL (1) | IL240838B (me) |
| LT (1) | LT2970464T (me) |
| MA (1) | MA38498B1 (me) |
| ME (1) | ME03796B (me) |
| MX (1) | MX351349B (me) |
| NZ (1) | NZ711355A (me) |
| PE (1) | PE20151530A1 (me) |
| PH (1) | PH12015502039B1 (me) |
| PL (1) | PL2970464T3 (me) |
| PT (1) | PT2970464T (me) |
| RS (1) | RS60538B1 (me) |
| SG (1) | SG11201506807RA (me) |
| SI (1) | SI2970464T1 (me) |
| SM (1) | SMT202000392T1 (me) |
| TW (1) | TWI658051B (me) |
| UA (1) | UA118750C2 (me) |
| UY (1) | UY35415A (me) |
| WO (1) | WO2014140180A1 (me) |
Families Citing this family (194)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20131403A1 (es) | 2010-08-23 | 2014-01-10 | Univ Texas | Anticuerpos anti-ox40 y metodos de uso de los mismos |
| US9416132B2 (en) | 2011-07-21 | 2016-08-16 | Tolero Pharmaceuticals, Inc. | Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors |
| UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
| MA38498B1 (fr) | 2013-03-15 | 2018-11-30 | Glaxosmithkline Ip Dev Ltd | Protéines de liaison anti-lag-3 |
| BR122023024195A2 (pt) | 2013-09-20 | 2023-12-26 | Bristol-Myers Squibb Company | Usos de anticorpos anti-lag-3 e anticorpos anti-pd-1 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| EA201691765A1 (ru) | 2014-03-14 | 2016-12-30 | Новартис Аг | Молекулы антител против lag-3 и их применения |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| CA3012602A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| MA41463A (fr) * | 2015-02-03 | 2017-12-12 | Anaptysbio Inc | Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3) |
| CN107849073B (zh) | 2015-05-18 | 2020-04-03 | 特雷罗药物股份有限公司 | 具有增加的生物利用度的阿伏西地前药 |
| SG10201913500TA (en) | 2015-05-29 | 2020-03-30 | Agenus Inc | Anti-ctla-4 antibodies and methods of use thereof |
| TWI773646B (zh) * | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| US10682390B2 (en) | 2015-07-16 | 2020-06-16 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
| TWI762879B (zh) | 2015-07-30 | 2022-05-01 | 美商宏觀基因股份有限公司 | Pd-1結合分子和其使用方法 |
| CN117510633A (zh) * | 2015-09-02 | 2024-02-06 | 伊缪泰普有限公司 | 抗lag-3抗体 |
| CR20180161A (es) | 2015-10-02 | 2018-05-25 | Hoffmann La Roche | Anticuerpos biespecíficos para pd1 y tim3 |
| TWI756187B (zh) | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | 抗ｌａｇ３抗體及其用途 |
| JP6945456B2 (ja) * | 2015-11-13 | 2021-10-06 | マクロジェニクス，インコーポレーテッド | Ｌａｇ‐３結合分子及びその使用方法 |
| US20190330336A1 (en) * | 2015-11-19 | 2019-10-31 | Sutro Biopharma, Inc. | Anti-lag3 antibodies, compositions comprising anti-lag3 antibodies and methods of making and using anti-lag3 antibodies |
| EP3389714A4 (en) | 2015-12-14 | 2019-11-13 | MacroGenics, Inc. | BIS-SPECIFIC MOLECULES WITH IMMUNE REACTIVITY WITH PD-1 AND CTLA-4 AND METHOD OF USE THEREOF |
| RU2018123481A (ru) | 2015-12-16 | 2020-01-20 | Мерк Шарп И Доум Корп. | Анти-lag3 антитела и антигенсвязывающие фрагменты |
| SG10201601719RA (en) * | 2016-03-04 | 2017-10-30 | Agency Science Tech & Res | Anti-LAG-3 Antibodies |
| HUE053452T2 (hu) * | 2016-05-18 | 2021-07-28 | Boehringer Ingelheim Int | Anti-PD-1 és anti-LAG3 antitestek rák kezelésére |
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